Expedient parallel synthesis of 2-amino-4-heteroarylpyrimidines

Organic Letters

Volumn 7, Issue 19, 2005, Pages 4113-4116

  Bursavich, Matthew G ^a   Lombardi, Sabrina ^a   Gilbert, Adam M ^a  

^a WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIMIDINE DERIVATIVE;

AMINATION; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

AMINATION; MOLECULAR STRUCTURE; PYRIMIDINES;

EID: 25444526685     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol051339z     Document Type: Article

References (15)

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4. Drager, G.; Solodenko, W.; Messinger, J.; Schon, U.; Kirschning, A. Tetrahedron Lett. 2002, 43, 1401.
5. For other methods to potentially access 2-amino-4-heteroarylpyrimidines, see: Collis, A. J.; Foster, M. L.; Halley, F.; Maslen, C.; McLay, I. M.; Page, K. M.; Redford, E. J.; Souness, J. E.; Wilsher, N. E. Bioorg. Med. Chem. Lett. 2001, 11, 693.
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14. Resynthesis of 8a and 8c with the enantiomerically pure amino acids and subsequent purification via preparatory HPLC revealed a minimal degree of epimerization. The desired products 8a and 8c were isolated in 93% and 76% respective chiral purity.
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