Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 16, 2010, Pages 6099-6108

  Datta, Shreya ^a   Bucks, Megan E ^a   Koley, Dipankar ^a   Lim, Pei Xin ^a   Savinov, Sergey N ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Cyclic peptides; Genetic selection; Hdm2; Hdmx; Protein protein interactions

Indexed keywords

HDMX PROTEIN; HDMX PROTEIN INHIBITOR; PEPTIDE LIBRARY; PROTEIN; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN MDM2 INHIBITOR; PROTEIN P53; PROTEIN P53 INHIBITOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELECTIVITY; GENETIC SELECTION; MUTAGENESIS; NONHUMAN; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; WILD TYPE;

AMINO ACID SEQUENCE; BINDING SITES; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; MODELS, MOLECULAR; MUTAGENESIS; NUCLEAR PROTEINS; PEPTIDES; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77955466705     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.053     Document Type: Article

References (48)

1. F. Toledo, and G.M. Wahl Nat. Rev. 6 2006 909
2. M.R. Junttila, and G.I. Evan Nat. Rev. Cancer 9 2009 821
3. J.C. Marine, M.A. Dyer, and A.G. Jochemsen J. Cell Sci. 120 2007 371
4. M. Wade, and G. Wahl Mol. Cancer Res. 7 2009 1
5. S. Tanimura, S. Ohtsuka, K. Mitsui, K. Shirouzu, A. Yoshimura, and M. Ohtsubo FEBS Lett. 447 1999 5
6. J. Kallen, A. Goepfert, A. Blechschmidt, A. Izaac, M. Geiser, G. Tavares, P. Ramage, P. Furet, K. Masuya, and J. Lisztwan J. Biol. Chem. 284 2009 8812
7. P.H. Kussie, S. Gorina, V. Marechal, B. Elenbaas, J. Moreau, A.J. Levine, and N.P. Pavletich Science 274 1996 948
8. F. Toledo, and G.M. Wahl Int. J. Biochem. Cell Biol. 39 2007 1476
9. J.C. Badciong, and A.L. Haas J. Biol. Chem. 277 2002 49668
10. E. Meulmeester, Y. Pereg, Y. Shiloh, and A.G. Jochemsen Cell Cycle 4 2005 1166
11. K. Onel, and C. Cordon-Cardo Mol. Cancer Res. 2 2004 1
12. Y.F.M. Ramos, R. Stad, J. Attema, L.T. Peltenburg, A.J. van der Eb, and A.G. Jochemsen Cancer Res. 61 2001 1839
13. D. Danovi, E. Meulmeester, D. Pasini, D. Migliorini, M. Capra, R. Frenk, P. de Graaf, S. Francoz, P. Gasparini, A. Gobbi, K. Helin, P.G. Pelicci, A.G. Jochemsen, and J.C. Marine Mol. Cell. Biol. 24 2004 5835
14. P. Chene Nat. Rev. Cancer 3 2003 102
15. P.M. Fischer Int. J. Pept. Res. Ther. 12 2006 3
16. J.K. Murray, and S.H. Gellman Pept. Sci. 88 2007 657
17. D. Reed, Y. Shen, A. Shelat, A. Arnold, A. Ferreira, F. Zhu, N. Mills, D. Smithson, C. Regni, D. Bashford, S. Cicero, B. Schulman, A.G. Jochemsen, K. Guy, and M.A. Dyer J. Biol. Chem. 285 2010 10786
18. A.R. Horswill, S.N. Savinov, and S.J. Benkovic Proc. Natl. Acad. Sci. U.S.A. 101 2004 15591
19. J.K. Joung, E.I. Ramm, and C.O. Pabo Proc. Natl. Acad. Sci. U.S.A. 97 2000 7382
20. G. Di Lallo, L. Castagnoli, P. Ghelardini, and L. Paolozzi Microbiology 147 2001 1651
21. A. Haldimann, and B.L. Wanner J. Bacteriol. 183 2001 6384
22. J. Jinqiu Chen, S. Pongor, and A. Simoncsits Nucleic Acids Res. 25 1997 2047
23. J. Miller Experiments in Molecular Genetics 1972 Cold Spring Harbor Laboratory New York pp 352-355
24. C.P. Scott, E. Abel-Santos, M. Wall, D.C. Wahnon, and S.J. Benkovic Proc. Natl. Acad. Sci. U.S.A. 96 1999 13638
25. H. Kessler, R. Gratias, G. Hessler, M. Gurrath, and G. Muller Pure Appl. Chem. 68 1996 1201
26. F.W. Okumu, G.M. Pauletti, D.G. Vander Velde, T.J. Siahaan, and R.T. Borchardt Pharm. Res. 14 1997 169
27. R.C. Ladner Trends Biotechnol. 13 1995 426
28. C. Adessi, and C. Soto Curr. Med. Chem. 9 2002 963
29. R. Fasan, R.L.A. Dias, K. Moehle, O. Zerbe, J.W. Vrifbloed, D. Obrecht, and J.A. Robinson Angew. Chem., Int. Ed. 43 2004 2109
30. V. Bottger, A. Bottger, S.F. Howard, S.M. Picksley, P. Chene, C. Garcia-Echeverria, H.K. Hochkeppel, and D.P. Lane Oncogene 13 1996 2141
31. M. Pazgier, M. Liu, G. Zou, W. Yuan, C. Li, C. Li, J. Li, J. Monbo, D. Zella, S. Tarasov, and W. Lu Proc. Natl. Acad. Sci. U.S.A. 106 2009 4665
32. J.A. Kritzer, R. Zutshi, M. Cheah, F.A. Ran, R. Webman, T.M. Wongjirad, and A. Schepartz ChemBioChem 7 2006 29
33. G.A. LaRusch, M.W. Jackson, J.D. Dunbar, R.S. Warren, D.B. Donner, and L.D. Mayo Cancer Res. 67 2007 450
34. C. Li, M. Pazgier, C. Li, W. Yuan, M. Liu, G. Wei, W. Lu, and W. Lu J. Mol. Biol. 398 2010 200
35. O. Schon, A. Friedler, M. Bycroft, S.M. Freund, and A.R. Fersht J. Mol. Biol. 323 2002 491
36. V. Böttger, A. Böttger, C. Garcia-Echeverria, Y.F. Ramos, A.J. van der Eb, A.G. Jochemsen, and D.P. Lane Oncogene 18 1999 9199
37. G. Popowicz, A. Czarna, U. Rothweiler, A. Szwagierczak, M. Krajewski, L. Weber, and T. Holak Cell Cycle 6 2007 2386
38. M. Wade, E.T. Wong, M. Tang, L.T. Vassilev, and G.M. Wahl J. Biol. Chem. 281 2006 33036
39. B. Hu, D.M. Gilkes, B. Farooqi, S.M. Sebti, and J. Chen J. Biol. Chem. 281 2006 33030
40. S. Shangary, D. Qin, D. McEachern, M. Liu, R.S. Miller, S. Qiu, Z. Nikolovska-Coleska, K. Ding, G. Wang, J. Chen, D. Bernard, J. Zhang, Y. Lu, Q. Gu, R.B. Shah, K.J. Pienta, X. Ling, S. Kang, M. Guo, Y. Sun, D. Yand, and S. Wang Proc. Natl. Acad. Sci. U.S.A. 105 2008 3933
41. K. Ding, Y. Lu, Z. Nikolovska-Coleska, G. Wang, S. Qiu, S. Shangary, W. Gao, D. Qin, J. Stuckey, and K. Krajewski J. Med. Chem. 49 2006 3432
42. Datta, S. Ph.D. Thesis, Purdue University, August 2010.
43. K. Kalle, and J.P. Tam Tetrahedron Lett. 39 1998 9327
44. L. Zhang, and J.P. Tam J. Am. Chem. Soc. 121 1999 3311
45. T.A. Naumann, S.N. Savinov, and S.J. Benkovic Biotechnol. Bioeng. 92 2005 820
46. R. Platt, C. Drescher, S.K. Park, and G.J. Philips Plasmid 43 2000 12
47. S.A. Kane, C.A. Fleener, Y.S. Zhang, L.J. Davis, A.L. Musselman, and P.S. Huang Anal. Biochem. 278 2000 29
48. Villafane, O. C. Ph.D. Thesis, Purdue University, December 2009.