Analogs of a 4-aminothieno[2,3-d]pyrimidine lead (QB13) as modulators of P-glycoprotein substrate specificity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 6102-6105

  Häcker, Hans Georg ^a   Haye, Antje de la ^a   Sterz, Katja ^a   Schnakenburg, Gregor ^a   Wiese, Michael ^a   Gütschow, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

ABC transporters; Multidrug resistance; P Glycoprotein; Quinazolines; Thienopyrimidines

Indexed keywords

4 AMINOTHIENO[2,3 D]PYRIMIDINE; ANTINEOPLASTIC AGENT; COLCHICINE; DAUNORUBICIN; GLYCOPROTEIN P; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; VINBLASTINE;

ARTICLE; CYTOTOXICITY; DRUG POTENTIATION; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; PHARMACOPHORE;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DAUNORUBICIN; DRUG RESISTANCE, NEOPLASM; HUMANS; MOLECULAR CONFORMATION; P-GLYCOPROTEIN; PYRIMIDINES; QUINAZOLINES; SUBSTRATE SPECIFICITY;

EID: 71749099189     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.023     Document Type: Article

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