-
1
-
-
77956769873
-
Application of combinatorial and parallel synthesis to medicinal chemistry
-
Bunin, B. A.; Dener, J. M.; Livingston, D. A. Application of Combinatorial and Parallel Synthesis to Medicinal Chemistry. Ann. Rep. Med. Chem. 1999, 34, 267-286.
-
(1999)
Ann. Rep. Med. Chem.
, vol.34
, pp. 267-286
-
-
Bunin, B.A.1
Dener, J.M.2
Livingston, D.A.3
-
3
-
-
0039835147
-
-
Corbett, J. W. Org. Prep. Proc. Int. 1998, 30, 489-550. Franzen, R. G. J. Comb. Chem. 2000, 2, 195-214.
-
(1998)
Org. Prep. Proc. Int.
, vol.30
, pp. 489-550
-
-
Corbett, J.W.1
-
4
-
-
0041037814
-
-
Corbett, J. W. Org. Prep. Proc. Int. 1998, 30, 489-550. Franzen, R. G. J. Comb. Chem. 2000, 2, 195-214.
-
(2000)
J. Comb. Chem.
, vol.2
, pp. 195-214
-
-
Franzen, R.G.1
-
5
-
-
0020535550
-
-
Stanazek, W. F. Drugs 1983, 25, 339-384.
-
(1983)
Drugs
, vol.25
, pp. 339-384
-
-
Stanazek, W.F.1
-
6
-
-
0023073702
-
-
Campbell, S. F.; Davey, M. J.; Hartstone, J. D.; Lewis, B. N.; Palmer, M. J. J. Med. Chem. 1987, 30, 49-57.
-
(1987)
J. Med. Chem.
, vol.30
, pp. 49-57
-
-
Campbell, S.F.1
Davey, M.J.2
Hartstone, J.D.3
Lewis, B.N.4
Palmer, M.J.5
-
7
-
-
0028018214
-
-
Clancy, J.; Tait-Kamradt, A.; Pettitpas, J.; Manousos, M.; McGuirk, P. R.; Subashi, T.; Watts, P.; Wondrack, L. Antimicrob. Agents Chemother. 1994, 38, 2008-2013.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 2008-2013
-
-
Clancy, J.1
Tait-Kamradt, A.2
Pettitpas, J.3
Manousos, M.4
McGuirk, P.R.5
Subashi, T.6
Watts, P.7
Wondrack, L.8
-
8
-
-
0031013919
-
-
NAr reactions on solid phase or in combinatorial chemistry, see the following. (a) Nugiel, D. A.; Cornelius, L. A. M.; Corbett, J. W. J. Org. Chem. 1997, 62, 201-203.
-
(1997)
J. Org. Chem.
, vol.62
, pp. 201-203
-
-
Nugiel, D.A.1
Cornelius, L.A.M.2
Corbett, J.W.3
-
9
-
-
0032556247
-
-
(b) Feng, T.; Wang, Z.; Jin, S.; Burgess, K. J. Am. Chem. Soc. 1998, 120, 10768-10769.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 10768-10769
-
-
Feng, T.1
Wang, Z.2
Jin, S.3
Burgess, K.4
-
10
-
-
0141856793
-
-
MacDonald, A. A.; DeWitt, S. H.; Hogan, E. M.; Ramage, R. Tetrahedron Lett. 1996, 37, 4815-4818.
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 4815-4818
-
-
Macdonald, A.A.1
Dewitt, S.H.2
Hogan, E.M.3
Ramage, R.4
-
13
-
-
0032537007
-
-
(f) Johnson, C. R.; Zhang, B.; Fantauzzi, P.; Hocker, M.; Yager, K. Tetrahedron 1998, 54, 4097-4106.
-
(1998)
Tetrahedron
, vol.54
, pp. 4097-4106
-
-
Johnson, C.R.1
Zhang, B.2
Fantauzzi, P.3
Hocker, M.4
Yager, K.5
-
16
-
-
0021964722
-
-
(b) Millen, J.; Riley, T. N.; Waters, I. W.; Hamrick, M. E. J. Med. Chem. 1985, 28, 12-17.
-
(1985)
J. Med. Chem.
, vol.28
, pp. 12-17
-
-
Millen, J.1
Riley, T.N.2
Waters, I.W.3
Hamrick, M.E.4
-
17
-
-
0030932342
-
-
3] in DMF, containing 1% acetic acid, conditions reported by Ellman with the corresponding 2,6-dimethoxybenzaldehyde resin (PAL resin): Boojamra, C. G.; Burow, K. M.; Thompson, L. A.; Ellman, J. A. J. Org. Chem. 1997, 62, 1240. For comparison of both the 2,6-dimethoxy-4-hydroxybenzaldehyde and 2-methoxy-4-hydroxybenzaldehyde linkers on Chiron Mimetope SynPhase crowns with either a one-pot or a two-step reductive amination process, see the following. Bui, C. T.; Bray, A. M.; Pham, Y.; Campbell, R.; Ercole, F.; Rasoul, F. A.; Maeji, N. J. Mol. Diversity 1998, 4, 155-163.
-
(1997)
J. Org. Chem.
, vol.62
, pp. 1240
-
-
Boojamra, C.G.1
Burow, K.M.2
Thompson, L.A.3
Ellman, J.A.4
-
18
-
-
0032227722
-
-
3] in DMF, containing 1% acetic acid, conditions reported by Ellman with the corresponding 2,6-dimethoxybenzaldehyde resin (PAL resin): Boojamra, C. G.; Burow, K. M.; Thompson, L. A.; Ellman, J. A. J. Org. Chem. 1997, 62, 1240. For comparison of both the 2,6-dimethoxy-4-hydroxybenzaldehyde and 2-methoxy-4-hydroxybenzaldehyde linkers on Chiron Mimetope SynPhase crowns with either a one-pot or a two-step reductive amination process, see the following. Bui, C. T.; Bray, A. M.; Pham, Y.; Campbell, R.; Ercole, F.; Rasoul, F. A.; Maeji, N. J. Mol. Diversity 1998, 4, 155-163.
-
(1998)
Mol. Diversity
, vol.4
, pp. 155-163
-
-
Bui, C.T.1
Bray, A.M.2
Pham, Y.3
Campbell, R.4
Ercole, F.5
Rasoul, F.A.6
Maeji, N.J.7
-
23
-
-
0021679886
-
-
NAr reactions of 4-aminomethylpiperidine and 3-aminopyrrolidine have been reported to proceed by nucleophilic attack of the secondary amine. For examples, see the following. (a) Egawa, H.; Miyamoto, T.; Minamida, A.; Nishimura, Y.; Okada, H.; Uno, H.; Matsumoto, J.-i. J. Med. Chem. 1984, 27, 1543-1548.
-
(1984)
J. Med. Chem.
, vol.27
, pp. 1543-1548
-
-
Egawa, H.1
Miyamoto, T.2
Minamida, A.3
Nishimura, Y.4
Okada, H.5
Uno, H.6
Matsumoto, J.-I.7
-
24
-
-
0025906086
-
-
(b) Domagala, J. M.; Bridges, A. J.; Culbertson, T. P.; Gambino, L.; Hagen, S. E.; Karrick, G.; Porter, K.; Sanchez, J. P.; Sesnie, J. A.; Spense, F. G.; Szotek, D.; Wemple, J. Med. Chem. 1991, 34, 1142-1154.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 1142-1154
-
-
Domagala, J.M.1
Bridges, A.J.2
Culbertson, T.P.3
Gambino, L.4
Hagen, S.E.5
Karrick, G.6
Porter, K.7
Sanchez, J.P.8
Sesnie, J.A.9
Spense, F.G.10
Szotek, D.11
Wemple12
-
25
-
-
0021681136
-
-
Leysen, D. C.; Haemers, A.; Bollaert, W. J. Heterocycl. Chem. 1984, 21, 1361-1366.
-
(1984)
J. Heterocycl. Chem.
, vol.21
, pp. 1361-1366
-
-
Leysen, D.C.1
Haemers, A.2
Bollaert, W.3
-
26
-
-
0042227136
-
-
Gross, E., Meienhofer, J., Eds.; Academic Press: New York
-
Barany, G.; Merrifield, R. In The Peptides, Analysis, Synthesis and Biology; Gross, E., Meienhofer, J., Eds.; Academic Press: New York, 1980; Vol. 2A, pp 123-127.
-
(1980)
The Peptides, Analysis, Synthesis and Biology
, vol.2 A
, pp. 123-127
-
-
Barany, G.1
Merrifield, R.2
-
27
-
-
0025014627
-
-
Coste, J.; Le-Nguyen, D.; Castro, B. Tetrahedron Lett. 1980, 31, 205-208.
-
(1980)
Tetrahedron Lett.
, vol.31
, pp. 205-208
-
-
Coste, J.1
Le-Nguyen, D.2
Castro, B.3
-
28
-
-
0011267872
-
-
Knorr, R.; Trzeciak, A.; Bannwarth, W.; Gillessen, D. Tetrahedron Lett. 1989, 30, 1927-1930.
-
(1989)
Tetrahedron Lett.
, vol.30
, pp. 1927-1930
-
-
Knorr, R.1
Trzeciak, A.2
Bannwarth, W.3
Gillessen, D.4
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