Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 1, 2009, Pages 119-132

  Okano, Masahiko ^a   Mito, Jun ^a   Maruyama, Yasufumi ^a   Masuda, Hirofumi ^a   Niwa, Tomoko ^a   Nakagawa, Shin ichiro ^a   Nakamura, Yoshitaka ^a   Matsuura, Akira ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

4 Aminoquinazoline; Nociceptin; ORL1 antagonist; Orphanin FQ; Structure activity relationships

Indexed keywords

4 AMINOQUINAZOLINE DERIVATIVE; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; N [2 [[2 [(4 CHLOROPHENYL)CARBONYL]AMINO 6 METHYLQUINAZOLIN 4 YL]AMINO]CYCLOHEXYL]GUANIDINE; OPIATE ANTAGONIST; OPIATE RECEPTOR LIKE 1 ANTAGONIST; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

DRUG DISCOVERY; MODELS, MOLECULAR; QUINAZOLINES; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57649183705     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.11.012     Document Type: Article

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