Interaction of phagocytes with filamentous fungi

Current Opinion in Microbiology

Volumn 13, Issue 4, 2010, Pages 409-415

  Brakhage, Axel A ^a,b   Bruns, Sandra ^a,b   Thywissen, Andreas ^a,b   Zipfel, Peter F ^a,b   Behnsen, Judith ^a,b  

^a HANS KNÖLL INSTITUTE   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHYLATOXIN; CD11B ANTIGEN; CD18 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CXCL3 CHEMOKINE; DECTIN 1; FUMAGILLIN; GLIOTOXIN; GLYCOGEN SYNTHASE KINASE 3; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; LECTIN RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; REACTIVE OXYGEN METABOLITE; SECONDARY LYMPHOID TISSUE CHEMOKINE; SUPEROXIDE DISMUTASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ASPERGILLOSIS; ASPERGILLUS; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; CD4+ T LYMPHOCYTE; COMPLEMENT SYSTEM; CONIDIUM; CYTOKINE PRODUCTION; DENDRITIC CELL; EFFECTOR CELL; FUNGAL SPORE GERMINATION; FUNGUS; FUNGUS HYPHAE; HOST PARASITE INTERACTION; HOST RESISTANCE; HYDROPHOBICITY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INFECTION SENSITIVITY; INNATE IMMUNITY; INVASIVE ASPERGILLOSIS; LEUKOCYTE ACTIVATION; MACROPHAGE; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PHAGOCYTOSIS; PROGNOSIS; REVIEW; TH1 CELL;

ANIMALS; ASPERGILLOSIS; ASPERGILLUS; DENDRITIC CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; HYPHAE; IMMUNITY, INNATE; MACROPHAGES; NEUTROPHILS; PHAGOCYTES; PHAGOCYTOSIS; SPORES, FUNGAL;

ASPERGILLUS; ASPERGILLUS FUMIGATUS; FUNGI;

EID: 77955426412     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mib.2010.04.009     Document Type: Review

References (47)

1. Antoniadou A. Outbreaks of zygomycosis in hospitals. Clin Microbiol Infect 2009, 15(Suppl 5):55-59.
2. Dagenais T.R., Keller N.P. Pathogenesis of Aspergillus fumigatus in invasive Aspergillosis. Clin Microbiol Rev 2009, 22:447-465.
3. Brakhage AA, Zipfel PF: Overview about fungal pathogens. In Immunology of Infectious Diseases. Edited by Kaufmann SHE, Rouse B, Sacks D. ASM Press; 2010:in press.
4. Romani L. Immunity to fungal infections. Nat Rev Immunol 2004, 4:1-23.
5. Luther K., Torosantucci A., Brakhage A.A., Heesemann J., Ebel F. Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2. Cell Microbiol 2007, 9:368-381.
6. Aimanianda V., Bayry J., Bozza S., Kniemeyer O., Perruccio K., Elluru S.R., Clavaud C., Paris S., Brakhage A.A., Kaveri S.V., et al. Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature 2009, 460:1117-1121.
7. Werner J.L., Metz A.E., Horn D., Schoeb T.R., Hewitt M.M., Schwiebert L.M., Faro-Trindade I., Brown G.D., Steele C. Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J Immunol 2009, 182:4938-4946.
8. Dagenais T.R., Giles S.S., Aimanianda V., Latge J.P., Hull C.M., Keller N.P. Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer. Infect Immun 2010, 78:823-829.
9. Gersuk G.M., Underhill D.M., Zhu L., Marr K.A. Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states. J Immunol 2006, 176:3717-3724.
10. Steele C., Rapaka R.R., Metz A., Pop S.M., Williams D.L., Gordon S., Kolls J.K., Brown G.D. The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog 2005, 1:e42.
11. Chai L.Y., Kullberg B.J., Vonk A.G., Warris A., Cambi A., Latge J.P., Joosten L.A., van der Meer J.W., Netea M.G. Modulation of Toll-like receptor 2 (TLR2) and TLR4 responses by Aspergillus fumigatus. Infect Immun 2009, 77:2184-2192.
12. Philippe B., Ibrahim-Granet O., Prevost M.C., Gougerot-Pocidalo M.A., Sanchez Perez M., Van der Meeren A., Latge J.P. Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates. Infect Immun 2003, 71:3034-3042.
13. Lambou K., Lamarre C., Beau R., Dufour N., Latge J.P. Functional analysis of the superoxide dismutase family in Aspergillus fumigatus. Mol Microbiol 2010, 75:910-923.
14. Lessing F., Kniemeyer O., Wozniok I., Loeffler J., Kurzai O., Haertl A., Brakhage A.A. The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model. Eukaryot Cell 2007, 6:2290-2302.
15. Lamarre C., Ibrahim-Granet O., Du C., Calderone R., Latgé J.P. Characterization of the SKN7 ortholog of Aspergillus fumigatus. Fungal Genet Biol 2007, 44:682-690.
16. Jahn B., Koch A., Schmidt A., Wanner G., Gehringer H., Bhakdi S., Brakhage A.A. Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence. Infect Immun 1997, 65:5110-5117.
17. Jahn B., Langfelder K., Schneider U., Schindel C., Brakhage A.A. PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus conidia by human monocyte-derived macrophages. Cell Microbiol 2002, 4:793-803.
18. Kennedy A.D., Willment J.A., Dorward D.W., Williams D.L., Brown G.D., DeLeo F.R. Dectin-1 promotes fungicidal activity of human neutrophils. Eur J Immunol 2007, 37:467-478.
19. Bruns S, Kniemeyer O, Hasenberg M, Aimanianda V, Nietzsche N, Thywissen A, Jeron A, Latgé JP, Brakhage AA, Gunzer M. Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA. PLoS Pathog 2010, 6:e1000873.
20. Chai LY, Netea MG, Sugui J, Vonk AG, van de Sande WW, Warris A, Kwon-Chung KJ, Kullberg BJ: Aspergillus fumigatus conidial melanin modulates host cytokine response. Immunobiology 2009:in press.
21. Mircescu M.M., Lipuma L., van Rooijen N., Pamer E.G., Hohl T.M. Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection. J Infect Dis 2009, 200:647-656.
22. Sugui J.A., Kim H.S., Zarember K.A., Chang Y.C., Gallin J.I., Nierman W.C., Kwon-Chung K.J. Genes differentially expressed in conidia and hyphae of Aspergillus fumigatus upon exposure to human neutrophils. PLoS One 2008, 3:e2655.
23. Fallon J.P., Reeves E.P., Kavanagh K.A. Inhibition of neutrophil function following exposure to the Aspergillus fumigatus toxin, fumagillin. J Med Microbiol 2010, 59:625-633.
24. Spikes S., Xu R., Nguyen C.K., Chamilos G., Kontoyiannis D.P., Jacobson R.H., Ejzykowicz D.E., Chiang L.Y., Filler S.G., May G.S. Gliotoxin production in Aspergillus fumigatus contributes to host-specific differences in virulence. J Infect Dis 2008, 197:479-486.
25. Urban C.F., Ermert D., Schmid M., Abu-Abed U., Goosmann C., Nacken W., Brinkmann V., Jungblut P.R., Zychlinsky A. Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans. PLoS Pathog 2009, 5:e1000639.
26. Bianchi M., Hakkim A., Brinkmann V., Siler U., Seger R.A., Zychlinsky A., Reichenbach J. Restoration of NET formation by gene therapy in CGD controls aspergillosis. Blood 2009, 114:2619-2622.
27. Bozza S., Gaziano R., Spreca A., Bacci A., Montagnoli C., di Francesco P., Romani L. Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus. J Immunol 2002, 168:1362-1371.
28. Behnsen J., Narang P., Hasenberg M., Gunzer F., Bilitewski U., Klippel N., Rohde M., Brock M., Brakhage A.A., Gunzer M. Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans. PLoS Pathog 2007, 3:e13.
29. Gafa V., Remoli M.E., Giacomini E., Gagliardi M.C., Lande R., Severa M., Grillot R., Coccia E.M. In vitro infection of human dendritic cells by Aspergillus fumigatus conidia triggers the secretion of chemokines for neutrophil and Th1 lymphocyte recruitment. Microbes Infect 2007, 9:971-980.
30. Mezger M., Kneitz S., Wozniok I., Kurzai O., Einsele H., Loeffler J. Proinflammatory response of immature human dendritic cells is mediated by dectin-1 after exposure to Aspergillus fumigatus germ tubes. J Infect Dis 2008, 197:924-931.
31. Spinnler K., Mezger M., Steffens M., Sennefelder H., Kurzai O., Einsele H., Loeffler J. Role of Glycogen Synthase Kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus. Med Mycol 2010, 48:589-597.
32. Hartigan A.J., Westwick J., Jarai G., Hogaboam C.M. CCR7 deficiency on dendritic cells enhances fungal clearance in a murine model of pulmonary invasive aspergillosis. J Immunol 2009, 183:5171-5179.
33. Zipfel P.F., Hallstrom T., Hammerschmidt S., Skerka C. The complement fitness factor H. role in human diseases and for immune escape of pathogens, like pneumococci. Vaccine 2008, 26(Suppl 8):I67-I74.
34. Zipfel P.F., Skerka C. Complement regulators and inhibitory proteins. Nat Rev Immunol 2009, 9:729-740.
35. Kozel T.R., Wilson M.A., Farrell T.P., Levitz S.M. Activation of C3 and binding to Aspergillus fumigatus conidia and hyphae. Infect Immun 1989, 57:3412-3417.
36. Zmetek Granja L.F., Pinto L., Almeida C.A., Alviano D.S., Da Silva M.H., Ejzemberg R., Alviano C.S. Spores of Mucor ramosissimus, Mucor plumbeus and Mucor circinelloides and their ability to activate human complement system in vitro. Med Mycol 2009, 1-7.
37. Dumestre-Perard C., Lamy B., Aldebert D., Lemaire-Vieille C., Grillot R., Brion J.P., Gagnon J., Cesbron J.Y. Aspergillus conidia activate the complement by the mannan-binding lectin C2 bypass mechanism. J Immunol 2008, 181:7100-7105.
38. Tsai H.F., Chang Y.C., Washburn R.G., Wheeler M.H., Kwon-Chung K.J. The developmentally regulated alb1 gene of Aspergillus fumigatus: its role in modulation of conidial morphology and virulence. J Bacteriol 1998, 180:3031-3038.
39. Langfelder K., Jahn B., Gehringer H., Schmidt A., Wanner G., Brakhage A.A. Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence. Med Microbiol Immunol 1998, 187:79-89.
40. Henwick S., Hetherington S.V., Patrick C.C. Complement binding to Aspergillus conidia correlates with pathogenicity. J Lab Clin Med 1993, 122:27-35.
41. Svirshchevskaya E.V., Shevchenko M.A., Huet D., Femenia F., Latgé J.P., Boireau P., Berkova N.P. Susceptibility of mice to invasive aspergillosis correlates with delayed cell influx into the lungs. Int J Immunogenet 2009, 36:289-299.
42. Behnsen J., Hartmann A., Schmaler J., Gehrke A., Brakhage A.A., Zipfel P.F. The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system. Infect Immun 2008, 76:820-827.
43. Vogl G., Lesiak I., Jensen D.B., Perkhofer S., Eck R., Speth C., Lass-Florl C., Zipfel P.F., Blom A.M., Dierich M.P., et al. Immune evasion by acquisition of complement inhibitors: the mould Aspergillus binds both factor H and C4b binding protein. Mol Immunol 2008, 45:1485-1493.
44. Rambach G., Dum D., Mohsenipour I., Hagleitner M., Wurzner R., Lass-Florl C., Speth C. Secretion of a fungal protease represents a complement evasion mechanism in cerebral aspergillosis. Mol Immunol 2010, 47:1438-1449.
45. Behnsen J, Lessing F, Schindler S, Wartenberg D, Jacobsen ID, Thoen M, Zipfel PF, Brakhage AA: Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4 and C5. Infect Immun 2010, in press.
46. Rambach G., Maier H., Vago G., Mohsenipour I., Lass-Florl C., Defant A., Würzner R., Dierich M.P., Speth C. Complement induction and complement evasion in patients with cerebral aspergillosis. Microbes Infect 2008, 10:1567-1576.
47. Askew D.S. Aspergillus fumigatus: virulence genes in a street-smart mold. Curr Opin Microbiol 2008, 11:331-337.