메뉴 건너뛰기




Volumn 197, Issue 3, 2008, Pages 479-486

Gliotoxin production in Aspergillus fumigatus contributes to host-specific differences in virulence

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; GLIOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEPTIDE SYNTHASE; SUPEROXIDE;

EID: 39349096343     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/525044     Document Type: Article
Times cited : (167)

References (24)
  • 1
    • 17644412298 scopus 로고    scopus 로고
    • The epipolythiodioxopiperazine (ETP) class of fungal toxins: Distribution, mode of action, functions and biosynthesis
    • Gardiner DM, Waring P, Howlett BJ. The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis. Microbiology 2005; 151:1021-32.
    • (2005) Microbiology , vol.151 , pp. 1021-1032
    • Gardiner, D.M.1    Waring, P.2    Howlett, B.J.3
  • 2
    • 4444376010 scopus 로고    scopus 로고
    • The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans
    • Gardiner DM, Cozijnsen AJ, Wilson LM, Pedras MS, Howlett BJ. The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans. Mol Microbiol 2004; 53:1307-18.
    • (2004) Mol Microbiol , vol.53 , pp. 1307-1318
    • Gardiner, D.M.1    Cozijnsen, A.J.2    Wilson, L.M.3    Pedras, M.S.4    Howlett, B.J.5
  • 3
    • 21744453939 scopus 로고    scopus 로고
    • Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus
    • Gardiner DM, Howlett BJ. Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus. FEMS Microbiol Lett 2005; 248:241-8.
    • (2005) FEMS Microbiol Lett , vol.248 , pp. 241-248
    • Gardiner, D.M.1    Howlett, B.J.2
  • 4
    • 33845507811 scopus 로고    scopus 로고
    • GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence
    • Bok JW, Chung D, Balajee SA, et al. GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Infect Immun 2006; 74:6761-8.
    • (2006) Infect Immun , vol.74 , pp. 6761-6768
    • Bok, J.W.1    Chung, D.2    Balajee, S.A.3
  • 5
    • 33747175703 scopus 로고    scopus 로고
    • The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice
    • Pardo J, Urban C, Galvez EM, et al. The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. J Cell Biol 2006; 174:509-19.
    • (2006) J Cell Biol , vol.174 , pp. 509-519
    • Pardo, J.1    Urban, C.2    Galvez, E.M.3
  • 7
    • 30744456811 scopus 로고    scopus 로고
    • Frequency and species distribution of gliotoxin-producing Aspergillus isolates recovered from patients at a tertiary-care cancer center
    • Lewis RE, Wiederhold NP, Lionakis MS, Prince RA, Kontoyiannis DP. Frequency and species distribution of gliotoxin-producing Aspergillus isolates recovered from patients at a tertiary-care cancer center. J Clin Microbiol 2005; 43:6120-2.
    • (2005) J Clin Microbiol , vol.43 , pp. 6120-6122
    • Lewis, R.E.1    Wiederhold, N.P.2    Lionakis, M.S.3    Prince, R.A.4    Kontoyiannis, D.P.5
  • 8
    • 0014011862 scopus 로고
    • The induction and repression of nitrate reductase in the fungus Aspergillus nidulans
    • Cove DJ. The induction and repression of nitrate reductase in the fungus Aspergillus nidulans. Biochim Biophys Acta 1966; 113:51-6.
    • (1966) Biochim Biophys Acta , vol.113 , pp. 51-56
    • Cove, D.J.1
  • 9
    • 16544392041 scopus 로고    scopus 로고
    • A mitogen-activated protein kinase that senses nitrogen regulates conidial germination and growth in Aspergillus fumigatus
    • Xue T, Nguyen CK, Romans A, May GS. A mitogen-activated protein kinase that senses nitrogen regulates conidial germination and growth in Aspergillus fumigatus. Eukaryot Cell 2004; 3:557-60.
    • (2004) Eukaryot Cell , vol.3 , pp. 557-560
    • Xue, T.1    Nguyen, C.K.2    Romans, A.3    May, G.S.4
  • 10
    • 0003121852 scopus 로고
    • Improved vectors for selecting resistance to hygromycin
    • Available at:, Accessed 3 January 2008
    • Carrol AM, Sweigard JA, Valent B. Improved vectors for selecting resistance to hygromycin. Fungal Genet Newslett 1994; 41:22. Available at: http://www.Fgsc.net/newslet.html. Accessed 3 January 2008.
    • (1994) Fungal Genet Newslett , vol.41 , pp. 22
    • Carrol, A.M.1    Sweigard, J.A.2    Valent, B.3
  • 11
    • 2542425574 scopus 로고    scopus 로고
    • Negative selection using thymidine kinase increases the efficiency of recovery of transformants with targeted genes in the filamentous fungus Leptosphaeria maculans
    • Gardiner DM, Howlett BJ. Negative selection using thymidine kinase increases the efficiency of recovery of transformants with targeted genes in the filamentous fungus Leptosphaeria maculans. Curr Genet 2004; 45:249-55.
    • (2004) Curr Genet , vol.45 , pp. 249-255
    • Gardiner, D.M.1    Howlett, B.J.2
  • 12
    • 8644272378 scopus 로고    scopus 로고
    • Isogenic auxotrophic mutant strains in the Aspergillus fumigatus genome reference strain AF293
    • Xue T, Nguyen CK, Romans A, Kontoyiannis DP, May GS. Isogenic auxotrophic mutant strains in the Aspergillus fumigatus genome reference strain AF293. Arch Microbiol 2004; 182:346-53.
    • (2004) Arch Microbiol , vol.182 , pp. 346-353
    • Xue, T.1    Nguyen, C.K.2    Romans, A.3    Kontoyiannis, D.P.4    May, G.S.5
  • 13
    • 0016700864 scopus 로고
    • Detection of specific sequences among DNA fragments separated by gel electrophoresis
    • Southern EM. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 1975; 98:503-17.
    • (1975) J Mol Biol , vol.98 , pp. 503-517
    • Southern, E.M.1
  • 14
    • 0002584062 scopus 로고
    • Two new easy to use vectors for transformations
    • Available at:, Accessed 3 January 2008
    • Silar P. Two new easy to use vectors for transformations. Fungal Genet Newslett 1995; 42:73. Available at: http://www.Fgsc.net/newslet.hmtl. Accessed 3 January 2008.
    • (1995) Fungal Genet Newslett , vol.42 , pp. 73
    • Silar, P.1
  • 15
    • 33644762960 scopus 로고    scopus 로고
    • Comparison of three methodologies for the determination of pulmonary fungal burden in experimental murine aspergillosis
    • Sheppard DC, Marr KA, Fredricks DN, Chiang LY, Doedt T, Filler SG. Comparison of three methodologies for the determination of pulmonary fungal burden in experimental murine aspergillosis. Clin Microbiol Infect 2006; 12:376-80.
    • (2006) Clin Microbiol Infect , vol.12 , pp. 376-380
    • Sheppard, D.C.1    Marr, K.A.2    Fredricks, D.N.3    Chiang, L.Y.4    Doedt, T.5    Filler, S.G.6
  • 17
    • 0026446588 scopus 로고
    • Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell-mediated immune responses and substantial protective immunity in a guinea pig model of pulmonary tuberculosis
    • Pal PG, Horwitz MA. Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell-mediated immune responses and substantial protective immunity in a guinea pig model of pulmonary tuberculosis. Infect Immun 1992; 60:4781-92.
    • (1992) Infect Immun , vol.60 , pp. 4781-4792
    • Pal, P.G.1    Horwitz, M.A.2
  • 18
    • 33749505685 scopus 로고    scopus 로고
    • Standardization of an experimental murine model of invasive pulmonary aspergillosis
    • Sheppard DC, Graybill JR, Najvar LK, et al. Standardization of an experimental murine model of invasive pulmonary aspergillosis. Antimicrob Agents Chemother 2006; 50:3501-3.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3501-3503
    • Sheppard, D.C.1    Graybill, J.R.2    Najvar, L.K.3
  • 19
    • 33645360264 scopus 로고    scopus 로고
    • Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida species
    • Chamilos G, Lionakis MS, Lewis RE, et al. Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida species. J Infect Dis 2006; 193:1014-22.
    • (2006) J Infect Dis , vol.193 , pp. 1014-1022
    • Chamilos, G.1    Lionakis, M.S.2    Lewis, R.E.3
  • 20
    • 15544363784 scopus 로고    scopus 로고
    • Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence
    • Lionakis MS, Lewis RE, May GS, et al. Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence. J Infect Dis 2005; 191:1188-95.
    • (2005) J Infect Dis , vol.191 , pp. 1188-1195
    • Lionakis, M.S.1    Lewis, R.E.2    May, G.S.3
  • 21
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86:973-83.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 22
    • 33745172848 scopus 로고    scopus 로고
    • Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production
    • Cramer RA Jr, Gamcsik MP, Brooking RM, et al. Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. Eukaryot Cell 2006; 5:972-80.
    • (2006) Eukaryot Cell , vol.5 , pp. 972-980
    • Cramer Jr, R.A.1    Gamcsik, M.P.2    Brooking, R.M.3
  • 23
    • 33748663951 scopus 로고    scopus 로고
    • Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model
    • Kupfahl C, Heinekamp T, Geginat G, et al. Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model. Mol Microbiol 2006; 62:292-302.
    • (2006) Mol Microbiol , vol.62 , pp. 292-302
    • Kupfahl, C.1    Heinekamp, T.2    Geginat, G.3
  • 24
    • 11144252243 scopus 로고    scopus 로고
    • Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis
    • Balloy V, Huerre M, Latge JP, Chignard M. Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis. Infect Immun 2005; 73:494-503.
    • (2005) Infect Immun , vol.73 , pp. 494-503
    • Balloy, V.1    Huerre, M.2    Latge, J.P.3    Chignard, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.