Proinflammatory response of immature human dendritic cells is mediated by dectin-1 after exposure to Aspergillus fumigatus germ tubes

Journal of Infectious Diseases

Volumn 197, Issue 6, 2008, Pages 924-931

  Mezger, Markus ^a   Kneitz, Susanne ^a   Wozniok, Iwona ^a   Kurzai, Oliver ^a   Einsele, Hermann ^a   Loeffler, Juergen ^a,b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD209 ANTIGEN; CHEMOKINE; DECTIN 1; DECTIN 1 ANTIBODY; INTERLEUKIN 12; PENTRAXIN 3; PROTEIN ANTIBODY; PROTEIN CARD9; RECEPTOR PROTEIN; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZYMOSAN;

ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; FUNGUS IDENTIFICATION; GENE EXPRESSION; GENETIC TRANSFECTION; GENOME; HUMAN; HUMAN CELL; INFLAMMATION; MICROARRAY ANALYSIS; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION;

EID: 40949109798     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/528694     Document Type: Article

References (45)

1. Brown JM. Fungal infections in bone marrow transplant patients. Curr Opin Infect Dis 2004; 17:347-52.
2. Latgé JP. The pathobiology of Aspergillus fumigatus. Trends Microbiol 2001; 9:382-9.
3. Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol 2006; 117:979-87.
4. Roeder A, Kirschning CJ, Rupec RA, Schaller M, Weindl G, Korting HC. Toll-like receptors as key mediators in innate antifungal immunity. Med Mycol 2004; 42:485-98.
5. Levitz SM. Interactions of Toll-like receptors with fungi. Microbes Infect 2004; 6:1351-5.
6. Meier A, Kirschning CJ, Nikolaus T, Wagner H, Heesemann J, Ebel F. Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol 2003; 5:561-70.
7. Netea MG, Warris A, Van der Meer JW, et al. Aspergillus fumigatus evades immune recognition during germination through loss of Toll-like receptor-4-mediated signal transduction. J Infect Dis 2003; 188:320-6.
8. Bottazzi B, Garlanda C, Salvatori G, Jeannin P, Manfredi A, Mantovani A. Pentraxins as a key component of innate immunity. Curr Opin Immunol 2006; 18:10-5.
9. Garlanda C, Hirsch E, Bozza S, et al. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature 2002; 420: 182-6.
10. Brown GD. Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat Rev Immunol 2006; 6:33-43.
11. East L, Isacke CM. The mannose receptor family. Biochim Biophys Acta 2002; 1572:364-86.
12. Cambi A, Koopman M, Figdor CG. How C-type lectins detect pathogens. Cell Microbiol 2005; 7:481-8.
13. Serrano-Gomez D, Dominguez-Soto A, Ancochea J, Jimenez-Heffernan JA, Leal JA, Corbi AL. Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages. J Immunol 2004; 173:5635-43.
14. Cambi A, Gijzen K, de Vries JM, et al. The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells. Eur J Immunol 2003; 33:532-8.
15. Caparros E, Munoz P, Sierra-Filardi E, et al. DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production. Blood 2006; 107:3950-8.
16. Willment JA, Marshall AS, Reid DM, et al. The human β-glucan receptor is widely expressed and functionally equivalent to murine dectin-1 on primary cells. Eur J Immunol 2005; 35:1539-47.
17. Brown GD, Herre J, Williams DL, Willment JA, Marshall AS, Gordon S. Dectin-1 mediates the biological effects of beta-glucans. J Exp Med 2003; 197:1119-24.
18. Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med 2003; 197:1107-17.
19. Luther K, Torosantucci A, Brakhage AA, Heesemann J, Ebel F. Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 β-glucan receptor and Toll-like receptor 2. Cell Microbiol 2006; 9:368-81.
20. Gersuk GM, Underhill DM, Zhu L, Marr KA. Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states. J Immunol 2006; 176:3717-24.
21. Gantner BN, Simmons RM, Underhill DM. Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J 2005; 24:1277-86.
22. Gross O, Gewies A, Finger K, et al. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 2006; 442:651-6.
23. Gunzer M, Weishaupt C, Hillmer A, et al. A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo. Blood 2004; 104:2801-9.
24. Gentleman R, Carey V, Huber W, Irizarry R, Dudoit S. Bioinformatics and computational biology solutions using R and Bioconductor. New York: Springer, 2005.
25. Huber W, von Heydebreck A, Sültmann H, Poustka A, Vingron M. Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 2002; 18(Suppl 1):S96-104.
26. Smyth GK, Yang YH, Speed T. Statistical issues in cDNA microarray data analysis. Methods Mol Biol 2003; 224:111-36.
27. Wittwer CT, Ririe KM, Andrew RV, David DA, Gundry RA, Balis UJ. The LightCycler: a microvolume multisample fluorimeter with rapid temperature. Biotechniques 1997; 22:176-81.
28. Johnson MR, Wang K, Smith JB, Heslin MJ, Diasio RB. Quantitation of dihydropyrimidine dehydrogenase expression by real-time reverse transcription polymerase chain reaction. Anal Biochem 2000; 278:175-84.
29. Burns S, Thrasher AJ. Dendritic cells: the bare bones of immunity. Curr Biol 2004; 14:965-7.
30. Braedel S, Radsak M, Einsele H, et al. Aspergillus fumigatus antigens activate innate immune cells via Toll-like receptors 2 and 4. Br J Haematol 2004; 125:392-9.
31. Zhang B, Schmoyer D, Kirov S, Snoddy J. GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies. BMC Bioinformatics 2004; 5:16.
32. Cortez KJ, Lyman CA, Kottilil S, et al. Functional genomics of innate host defense molecules in normal human monocytes in response to Aspergillus fumigatus. Infect Immun 2006; 74:2353-65.
33. Williams IR. CCR6 and CCL20: partners in intestinal immunity and lymphorganogenesis. Ann N Y Acad Sci 2006; 1072:52-61.
34. Appay V, Rowland-Jones SL. RANTES: a versatile and controversial chemokine. Trends Immunol 2001; 22:83-7.
35. Phadke AP, Mehrad B. Cytokines in host defense against Aspergillus: recent advances. Med Mycol 2005; 43(Suppl 1):S173-6.
36. Gaziano R, Bozza S, Bellocchio S, et al. Anti-Aspergillus fumigatus efficacy of pentraxin 3 alone and in combination with antifungals. Antimicrob Agents Chemother 2004; 48:4414-21.
37. Hohl TM, Rivera A, Pamer EG. Immunity to fungi. Curr Opin Immunol 2006; 18:465-72.
38. Bellocchio S, Montagnoli C, Bozza S, et al. The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol 2004; 172: 3059-69.
39. Chignard M, Balloy V, Sallenave JM, Si-Tahar M. Role of Toll-like receptors in lung innate defense against invasive aspergillosis. Distinct impact in immunocompetent and immunocompromised hosts. Clin Immunol 2007; 124:238-43.
40. Prechtel AT, Turza NM, Theodoridis AA, Kummer M, Steinkasserer A. Small interfering RNA (siRNA) delivery into monocyte-derived dendritic cells by electroporation. J Immunol Methods 2006; 311:139-52.
41. Visintin A, Mazzoni A, Spitzer JH, Wyllie DH, Dower SK, Segal DM. Regulation of Toll-like receptors in human monocytes and dendritic cells. J Immunol 2001; 166:249-55.
42. Hohl TM, Van Epps HL, Rivera A, et al. Aspergillus fumigatus triggers inflammatory responses by stage-specific β-glucan display. PLoS Pathog 2005; 1:232-40.
43. Steele C, Rapaka RR, Metz A, et al. The β-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog 2005; 1: e42.
44. Underhill DM, Rossnagle E, Lowell CA, Simmons RM. Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 2005; 106:2543-50.
45. Rogers NC, Slack EC, Edwards AD, et al. Syk-dependent cytokine induction by dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 2005; 22:507-17.