Detection of infectious HIV in circulating monocytes from patients on prolonged highly active antiretroviral therapy

Journal of Acquired Immune Deficiency Syndromes

Volumn 23, Issue 2, 2000, Pages 114-119

  Lambotte, O ^a   Taoufik, Y ^a,b   De Goer M G ^a   Wallon, C ^a   Goujard, C ^a   Delfraissy, J F ^a  

^a BICÊTRE HOSPITAL   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Eradication; HAART; HIV; Monocyte macrophage lineage; Persistence; Replication competent virus; Reservoir

Indexed keywords

INDINAVIR; LAMIVUDINE; STAVUDINE; ZIDOVUDINE;

ARTICLE; CLINICAL ARTICLE; ERADICATION THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; MONOCYTE; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; RESERVOIR; VIRUS DETECTION; VIRUS LOAD; VIRUS REPLICATION;

EID: 0034144463     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-200002010-00002     Document Type: Article

References (23)

1. Perelson AS, Essunger P, Cao Y, et al. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 1997;387:188-91.
2. Finzi D, Hermankova M, Pierson T, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997;278:1295-1300.
3. Wong JK, Hezareh M, Gunthard HF, et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 1997;278:1291-5.
4. Chun TW, Stuyver L, Mizell SB, et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci USA 1997;94:13193-7.
5. Schrager LK, D'Souza MP. Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy. JAMA 1998;280:67-71.
6. Meltzer MS, Skillman DR, Gomatos PJ, Kalter DC, Gendelman HE. Role of mononuclear phagocytes in the pathogenesis of Human Immunodeficiency Virus infection. Annu Rev Immunol 1990; 8:169-94.
7. Embretson J, Zupancic M, Ribas JL, et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 1993;362:359-62.
8. Cohen J. Exploring how to get at, and eradicate, hidden HIV. Science 1998;279:1854-5.
9. Taoufik Y, Froger D, Benoliel S, et al. Quantitative ELISA-polymerase chain reaction at saturation using homologous internal DNA standards and chemiluminescence revelation. Eur Cytokine Netw 1998;9:197-204.
10. Schockmel GA, Yerly S, Perrin L. Detection of low HIV-1 RNA levels in plasma. J Acquir Immune Defic Syndr Hum Retrovirol 1997;14:179-83.
11. Auger MJ, Ross JA. The biology of the macrophage. In: Lewis CE, McGee JO'D, eds. The Macrophage. New York: Oxford University Press, 1992:3-74.
12. Hirsch MS, Conway B, D'Aquila RT, et al. Antiretroviral drug resistance testing in adults with HIV infection. JAMA 1998;279: 1984-91.
13. Whitelaw DM. Observations on human monocyte kinetics after pulse labeling. Cell Tissue Kinet 1972;5:311-7.
14. Van Furth R, Raeburn JA, van Zwet TL. Characteristics of human mononuclear phagocytes. Blood 1979;54:485-500.
15. + progenitor cells from asymptomatic patients are not a major reservoir for human immunodeficiency virus-1. Blood 1995;86:1749-56.
16. Weichold FF, Zella D, Barabitskaja O, et al. Neither human immunodeficiency virus-1 (HIV-1) nor HIV-2 infects most-primitive human hematopoietic stem cells as assessed in long-term bone marrow cultures. Blood 1998;91:907-15.
17. + progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIV. J Immunol 1998;161:4169-76.
18. Pantaleo G, Perrin L. Can HIV be eradicated? AIDS 1998;12(Suppl A):S175-80.
19. Zhang L, Ramratnam B, Tenner-Racz K, et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 1999;340:1605-13.
20. Furtado MR, Callaway DS, Phair JP, et al. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med 1999;340: 1614-22.
21. Natarajan V, Bosche M, Metcalf JA, Ward DJ, Clifford Lane H, Kovacs JA. HIV-1 replication in patients with undetectable plasma virus receiving HAART. Lancet 1999;353:119-20.
22. Perno CF, Newcomb FM, Davis DA, et al. Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with Human Immunodeficiency Virus. J Infect Dis 1998;178:413-22.
23. Enting RH, Hoetelmans RMW, Lange JMA, Burger DM, Beijnen JH, Portegies P. Antiretroviral drugs and the central nervous system. AIDS 1998;12:1941-55.