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Volumn 18, Issue 2, 2009, Pages 135-141

Ki-67 as a prognostic molecular marker in routine clinical use in breast cancer patients

Author keywords

Breast cancer; Disease free survival; Ki 67; Overall survival; Prognosis prediction

Indexed keywords

BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HORMONE RECEPTOR; KI 67 ANTIGEN; MOLECULAR MARKER;

EID: 64649087149     PISSN: 09609776     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.breast.2009.02.009     Document Type: Article
Times cited : (74)

References (37)
  • 1
    • 27244436804 scopus 로고    scopus 로고
    • Meeting highlights: international expert consensus on the primary therapy of early breast cancer 2005
    • Goldhirsch A., Glick J.H., Gelber R.D., Coates A.S., Thurlimann B., and Senn H.J. Meeting highlights: international expert consensus on the primary therapy of early breast cancer 2005. Ann Oncol 16 (2005) 1569-1583
    • (2005) Ann Oncol , vol.16 , pp. 1569-1583
    • Goldhirsch, A.1    Glick, J.H.2    Gelber, R.D.3    Coates, A.S.4    Thurlimann, B.5    Senn, H.J.6
  • 2
    • 34547852275 scopus 로고    scopus 로고
    • Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer 2007
    • Goldhirsch A., Wood W.C., Gelber R.D., Coates A.S., Thurlimann B., and Senn H.J. Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer 2007. Ann Oncol 18 (2007) 1133-1144
    • (2007) Ann Oncol , vol.18 , pp. 1133-1144
    • Goldhirsch, A.1    Wood, W.C.2    Gelber, R.D.3    Coates, A.S.4    Thurlimann, B.5    Senn, H.J.6
  • 3
    • 21244450011 scopus 로고    scopus 로고
    • Prognose-und Prädiktivfaktoren - Entscheidungshilfen bei der Therapiewahl für Patientinnen mit Mammakarzinom
    • Fasching P.A., Lux M.P., Beckmann K., Strick R., and Beckmann M.W. Prognose-und Prädiktivfaktoren - Entscheidungshilfen bei der Therapiewahl für Patientinnen mit Mammakarzinom. Gynäkologe 38 (2005) 388-397
    • (2005) Gynäkologe , vol.38 , pp. 388-397
    • Fasching, P.A.1    Lux, M.P.2    Beckmann, K.3    Strick, R.4    Beckmann, M.W.5
  • 4
    • 70449185514 scopus 로고
    • Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years
    • Bloom H.J., and Richardson W.W. Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer 11 (1957) 359-377
    • (1957) Br J Cancer , vol.11 , pp. 359-377
    • Bloom, H.J.1    Richardson, W.W.2
  • 5
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up
    • Elston C.W., and Ellis I.O. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19 (1991) 403-410
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 6
    • 0027404657 scopus 로고
    • Method for grading breast cancer
    • Elston E.W., and Ellis I.O. Method for grading breast cancer. J Clin Pathol 46 (1993) 189-190
    • (1993) J Clin Pathol , vol.46 , pp. 189-190
    • Elston, E.W.1    Ellis, I.O.2
  • 7
    • 24044552649 scopus 로고    scopus 로고
    • Breast carcinoma malignancy grading by Bloom-Richardson system vs proliferation index: reproducibility of grade and advantages of proliferation index
    • Meyer J.S., Alvarez C., Milikowski C., Olson N., Russo I., Russo J., et al. Breast carcinoma malignancy grading by Bloom-Richardson system vs proliferation index: reproducibility of grade and advantages of proliferation index. Mod Pathol 18 (2005) 1067-1078
    • (2005) Mod Pathol , vol.18 , pp. 1067-1078
    • Meyer, J.S.1    Alvarez, C.2    Milikowski, C.3    Olson, N.4    Russo, I.5    Russo, J.6
  • 8
    • 0033994180 scopus 로고    scopus 로고
    • Histologic grading in breast cancer-reproducibility between seven pathologic departments. South Sweden breast cancer group
    • Boiesen P., Bendahl P.O., Anagnostaki L., Domanski H., Holm E., Idvall I., et al. Histologic grading in breast cancer-reproducibility between seven pathologic departments. South Sweden breast cancer group. Acta Oncol 39 (2000) 41-45
    • (2000) Acta Oncol , vol.39 , pp. 41-45
    • Boiesen, P.1    Bendahl, P.O.2    Anagnostaki, L.3    Domanski, H.4    Holm, E.5    Idvall, I.6
  • 9
    • 0020694123 scopus 로고
    • Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation
    • Gerdes J., Schwab U., Lemke H., and Stein H. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31 (1983) 13-20
    • (1983) Int J Cancer , vol.31 , pp. 13-20
    • Gerdes, J.1    Schwab, U.2    Lemke, H.3    Stein, H.4
  • 10
    • 0029927284 scopus 로고    scopus 로고
    • Localisation of the Ki-67 antigen within the nucleolus. Evidence for a fibrillarin-deficient region of the dense fibrillar component
    • Kill I.R. Localisation of the Ki-67 antigen within the nucleolus. Evidence for a fibrillarin-deficient region of the dense fibrillar component. J Cell Sci 109 6 (1996) 1253-1263
    • (1996) J Cell Sci , vol.109 , Issue.6 , pp. 1253-1263
    • Kill, I.R.1
  • 11
    • 0030061063 scopus 로고    scopus 로고
    • The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression
    • Starborg M., Gell K., Brundell E., and Hoog C. The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. J Cell Sci 109 1 (1996) 143-153
    • (1996) J Cell Sci , vol.109 , Issue.1 , pp. 143-153
    • Starborg, M.1    Gell, K.2    Brundell, E.3    Hoog, C.4
  • 12
    • 27244443082 scopus 로고    scopus 로고
    • Proliferation marker Ki-67 in early breast cancer
    • Urruticoechea A., Smith I.E., and Dowsett M. Proliferation marker Ki-67 in early breast cancer. J Clin Oncol 23 (2005) 7212-7220
    • (2005) J Clin Oncol , vol.23 , pp. 7212-7220
    • Urruticoechea, A.1    Smith, I.E.2    Dowsett, M.3
  • 13
    • 34248595234 scopus 로고    scopus 로고
    • Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients
    • de Azambuja E., Cardoso F., de Castro Jr. G., Colozza M., Mano M.S., Durbecq V., et al. Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients. Br J Cancer 96 (2007) 1504-1513
    • (2007) Br J Cancer , vol.96 , pp. 1504-1513
    • de Azambuja, E.1    Cardoso, F.2    de Castro Jr., G.3    Colozza, M.4    Mano, M.S.5    Durbecq, V.6
  • 14
    • 39149102890 scopus 로고    scopus 로고
    • Predictive value of tumor Ki-67 expression in two randomized trials of adjuvant chemoendocrine therapy for node-negative breast cancer
    • Viale G., Regan M.M., Mastropasqua M.G., Maffini F., Maiorano E., Colleoni M., et al. Predictive value of tumor Ki-67 expression in two randomized trials of adjuvant chemoendocrine therapy for node-negative breast cancer. J Natl Cancer Inst 100 (2008) 207-212
    • (2008) J Natl Cancer Inst , vol.100 , pp. 207-212
    • Viale, G.1    Regan, M.M.2    Mastropasqua, M.G.3    Maffini, F.4    Maiorano, E.5    Colleoni, M.6
  • 15
    • 0034896073 scopus 로고    scopus 로고
    • Measures of cell turnover (proliferation and apoptosis) and their association with survival in breast cancer
    • Liu S., Edgerton S.M., Moore II D.H., and Thor A.D. Measures of cell turnover (proliferation and apoptosis) and their association with survival in breast cancer. Clin Cancer Res 7 (2001) 1716-1723
    • (2001) Clin Cancer Res , vol.7 , pp. 1716-1723
    • Liu, S.1    Edgerton, S.M.2    Moore II, D.H.3    Thor, A.D.4
  • 16
    • 0030462119 scopus 로고    scopus 로고
    • Proliferation marker MIB-1 correlates well with proliferative activity evaluated by BrdU in breast cancer: an immunohistochemical study including correlation with PCNA, p53, c-erbB-2 and estrogen receptor status
    • Moriki T., Takahashi T., Kataoka H., Hiroi M., Yamane T., and Hara H. Proliferation marker MIB-1 correlates well with proliferative activity evaluated by BrdU in breast cancer: an immunohistochemical study including correlation with PCNA, p53, c-erbB-2 and estrogen receptor status. Pathol Int 46 (1996) 953-961
    • (1996) Pathol Int , vol.46 , pp. 953-961
    • Moriki, T.1    Takahashi, T.2    Kataoka, H.3    Hiroi, M.4    Yamane, T.5    Hara, H.6
  • 17
    • 0030069047 scopus 로고    scopus 로고
    • Long term prognostic value of growth fraction determination by Ki-67 immunostaining in primary operable breast cancer
    • Pierga J.Y., Leroyer A., Viehl P., Mosseri V., Chevillard S., and Magdelenat H. Long term prognostic value of growth fraction determination by Ki-67 immunostaining in primary operable breast cancer. Breast Cancer Res Treat 37 (1996) 57-64
    • (1996) Breast Cancer Res Treat , vol.37 , pp. 57-64
    • Pierga, J.Y.1    Leroyer, A.2    Viehl, P.3    Mosseri, V.4    Chevillard, S.5    Magdelenat, H.6
  • 19
    • 0028797073 scopus 로고
    • Assessment of the new proliferation marker MIB1 in breast carcinoma using image analysis: associations with other prognostic factors and survival
    • Pinder S.E., Wencyk P., Sibbering D.M., Bell J.A., Elston C.W., Nicholson R., et al. Assessment of the new proliferation marker MIB1 in breast carcinoma using image analysis: associations with other prognostic factors and survival. Br J Cancer 71 (1995) 146-149
    • (1995) Br J Cancer , vol.71 , pp. 146-149
    • Pinder, S.E.1    Wencyk, P.2    Sibbering, D.M.3    Bell, J.A.4    Elston, C.W.5    Nicholson, R.6
  • 20
    • 0028114608 scopus 로고
    • Thymidine labeling index and Ki-67 growth fraction in breast cancer: comparison and correlation with prognosis
    • Rudas M., Gnant M.F., Mittlbock M., Neumayer R., Kummer A., Jakesz R., et al. Thymidine labeling index and Ki-67 growth fraction in breast cancer: comparison and correlation with prognosis. Breast Cancer Res Treat 32 (1994) 165-175
    • (1994) Breast Cancer Res Treat , vol.32 , pp. 165-175
    • Rudas, M.1    Gnant, M.F.2    Mittlbock, M.3    Neumayer, R.4    Kummer, A.5    Jakesz, R.6
  • 21
    • 0026047275 scopus 로고
    • Ki-67 immunostaining in node-negative stage I/II breast carcinoma. Significant correlation with prognosis
    • Sahin A.A., Ro J., Ro J.Y., Blick M.B., el-Naggar A.K., Ordonez N.G., et al. Ki-67 immunostaining in node-negative stage I/II breast carcinoma. Significant correlation with prognosis. Cancer 68 (1991) 549-557
    • (1991) Cancer , vol.68 , pp. 549-557
    • Sahin, A.A.1    Ro, J.2    Ro, J.Y.3    Blick, M.B.4    el-Naggar, A.K.5    Ordonez, N.G.6
  • 22
    • 0026587510 scopus 로고
    • Measurement of bromodeoxyuridine labeling index, Ki-67 score and Ag-NOR count in breast carcinomas. Comparison with DNA ploidy
    • Sasaki K., Matsumura K., Murakami T., and Tsuji T. Measurement of bromodeoxyuridine labeling index, Ki-67 score and Ag-NOR count in breast carcinomas. Comparison with DNA ploidy. Oncology 49 (1992) 147-153
    • (1992) Oncology , vol.49 , pp. 147-153
    • Sasaki, K.1    Matsumura, K.2    Murakami, T.3    Tsuji, T.4
  • 23
    • 0037089663 scopus 로고    scopus 로고
    • Correlation between MIB-1 and other proliferation markers: clinical implications of the MIB-1 cutoff value
    • Spyratos F., Ferrero-Pous M., Trassard M., Hacene K., Phillips E., Tubiana-Hulin M., et al. Correlation between MIB-1 and other proliferation markers: clinical implications of the MIB-1 cutoff value. Cancer 94 (2002) 2151-2159
    • (2002) Cancer , vol.94 , pp. 2151-2159
    • Spyratos, F.1    Ferrero-Pous, M.2    Trassard, M.3    Hacene, K.4    Phillips, E.5    Tubiana-Hulin, M.6
  • 24
    • 20244374922 scopus 로고    scopus 로고
    • Ki-67 expression in breast carcinoma: its association with grading systems, clinical parameters, and other prognostic factors - a surrogate marker?
    • Trihia H., Murray S., Price K., Gelber R.D., Golouh R., Goldhirsch A., et al. Ki-67 expression in breast carcinoma: its association with grading systems, clinical parameters, and other prognostic factors - a surrogate marker?. Cancer 97 (2003) 1321-1331
    • (2003) Cancer , vol.97 , pp. 1321-1331
    • Trihia, H.1    Murray, S.2    Price, K.3    Gelber, R.D.4    Golouh, R.5    Goldhirsch, A.6
  • 25
    • 0025739566 scopus 로고
    • Immunohistochemical evaluation of growth fractions in human breast cancers using monoclonal antibody Ki-67
    • Weikel W., Beck T., Mitze M., and Knapstein P.G. Immunohistochemical evaluation of growth fractions in human breast cancers using monoclonal antibody Ki-67. Breast Cancer Res Treat 18 (1991) 149-154
    • (1991) Breast Cancer Res Treat , vol.18 , pp. 149-154
    • Weikel, W.1    Beck, T.2    Mitze, M.3    Knapstein, P.G.4
  • 26
    • 0026099714 scopus 로고
    • Ki-67 immunostaining in human breast tumors and its relationship to prognosis
    • Wintzer H.O., Zipfel I., Schulte-Monting J., Hellerich U., and von Kleist S. Ki-67 immunostaining in human breast tumors and its relationship to prognosis. Cancer 67 (1991) 421-428
    • (1991) Cancer , vol.67 , pp. 421-428
    • Wintzer, H.O.1    Zipfel, I.2    Schulte-Monting, J.3    Hellerich, U.4    von Kleist, S.5
  • 27
    • 0030010161 scopus 로고    scopus 로고
    • Prognostic value of Ki-67 compared to S-phase fraction in axillary node-negative breast cancer
    • Brown R.W., Allred C.D., Clark G.M., Osborne C.K., and Hilsenbeck S.G. Prognostic value of Ki-67 compared to S-phase fraction in axillary node-negative breast cancer. Clin Cancer Res 2 (1996) 585-592
    • (1996) Clin Cancer Res , vol.2 , pp. 585-592
    • Brown, R.W.1    Allred, C.D.2    Clark, G.M.3    Osborne, C.K.4    Hilsenbeck, S.G.5
  • 28
    • 0035914249 scopus 로고    scopus 로고
    • Relationship between tumour shrinkage and reduction in Ki67 expression after primary chemotherapy in human breast cancer
    • Bottini A., Berruti A., Bersiga A., Brizzi M.P., Bruzzi P., Aguggini S., et al. Relationship between tumour shrinkage and reduction in Ki67 expression after primary chemotherapy in human breast cancer. Br J Cancer 85 (2001) 1106-1112
    • (2001) Br J Cancer , vol.85 , pp. 1106-1112
    • Bottini, A.1    Berruti, A.2    Bersiga, A.3    Brizzi, M.P.4    Bruzzi, P.5    Aguggini, S.6
  • 29
    • 0032904256 scopus 로고    scopus 로고
    • Correlation between p53, c-erbB-2, and topoisomerase II alpha expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications
    • Rudolph P., Olsson H., Bonatz G., Ratjen V., Bolte H., Baldetorp B., et al. Correlation between p53, c-erbB-2, and topoisomerase II alpha expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications. J Pathol 187 (1999) 207-216
    • (1999) J Pathol , vol.187 , pp. 207-216
    • Rudolph, P.1    Olsson, H.2    Bonatz, G.3    Ratjen, V.4    Bolte, H.5    Baldetorp, B.6
  • 30
    • 0027309375 scopus 로고
    • Relationship between EGF-R, c-erbB-2 protein expression and Ki67 immunostaining in breast cancer and hormone sensitivity
    • Nicholson R.I., McClelland R.A., Finlay P., Eaton C.L., Gullick W.J., Dixon A.R., et al. Relationship between EGF-R, c-erbB-2 protein expression and Ki67 immunostaining in breast cancer and hormone sensitivity. Eur J Cancer 29A (1993) 1018-1023
    • (1993) Eur J Cancer , vol.29 A , pp. 1018-1023
    • Nicholson, R.I.1    McClelland, R.A.2    Finlay, P.3    Eaton, C.L.4    Gullick, W.J.5    Dixon, A.R.6
  • 31
    • 34548252289 scopus 로고    scopus 로고
    • Assessment of biomarker expression in predicting pathologic response to neoadjuvant chemotherapy in patients with locally advanced breast cancer
    • Chhieng D.C., Rodriguez-Burford C., Meleth S., Grizzle W.E., and Ferguson S.M. Assessment of biomarker expression in predicting pathologic response to neoadjuvant chemotherapy in patients with locally advanced breast cancer. Breast J 13 (2007) 534-535
    • (2007) Breast J , vol.13 , pp. 534-535
    • Chhieng, D.C.1    Rodriguez-Burford, C.2    Meleth, S.3    Grizzle, W.E.4    Ferguson, S.M.5
  • 32
    • 38849149595 scopus 로고    scopus 로고
    • Prognostic impact of clinicopathologic parameters in stage II/III breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer
    • Keam B., Im S.A., Kim H.J., Oh D.Y., Kim J.H., Lee S.H., et al. Prognostic impact of clinicopathologic parameters in stage II/III breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer. BMC Cancer 7 (2007) 203
    • (2007) BMC Cancer , vol.7 , pp. 203
    • Keam, B.1    Im, S.A.2    Kim, H.J.3    Oh, D.Y.4    Kim, J.H.5    Lee, S.H.6
  • 33
    • 33846965616 scopus 로고    scopus 로고
    • Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer
    • Dowsett M., Smith I.E., Ebbs S.R., Dixon J.M., Skene A., A'Hern R., et al. Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer. J Natl Cancer Inst 99 (2007) 167-170
    • (2007) J Natl Cancer Inst , vol.99 , pp. 167-170
    • Dowsett, M.1    Smith, I.E.2    Ebbs, S.R.3    Dixon, J.M.4    Skene, A.5    A'Hern, R.6
  • 34
    • 33745171131 scopus 로고    scopus 로고
    • EUSOMA accreditation of breast units
    • Blamey R.W., and Cataliotti L. EUSOMA accreditation of breast units. Eur J Cancer 42 (2006) 1331-1337
    • (2006) Eur J Cancer , vol.42 , pp. 1331-1337
    • Blamey, R.W.1    Cataliotti, L.2
  • 35
    • 33847147313 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
    • Wolff A.C., Hammond M.E., Schwartz J.N., Hagerty K.L., Allred D.C., Cote R.J., et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol 25 (2007) 118-145
    • (2007) J Clin Oncol , vol.25 , pp. 118-145
    • Wolff, A.C.1    Hammond, M.E.2    Schwartz, J.N.3    Hagerty, K.L.4    Allred, D.C.5    Cote, R.J.6
  • 37
    • 0029966953 scopus 로고    scopus 로고
    • Monoclonal antibodies Ki-S3 and Ki-S5 yield new data on the 'Ki-67' proteins
    • Heidebrecht H.J., Buck F., Haas K., Wacker H.H., and Parwaresch R. Monoclonal antibodies Ki-S3 and Ki-S5 yield new data on the 'Ki-67' proteins. Cell Prolif 29 (1996) 413-425
    • (1996) Cell Prolif , vol.29 , pp. 413-425
    • Heidebrecht, H.J.1    Buck, F.2    Haas, K.3    Wacker, H.H.4    Parwaresch, R.5


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