메뉴 건너뛰기




Volumn 3, Issue 6, 2006, Pages 695-703

A truncated Ah receptor blocks the hypoxia and estrogen receptor signaling pathways: A viable approach for breast cancer treatment

Author keywords

Ah receptor; Arnt; Estrogen receptor; GREB1; HIF 1 ; Protein drugs

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; ESTROGEN RECEPTOR; FRUCTOSE BISPHOSPHATE ALDOLASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; LACTATE DEHYDROGENASE; LUCIFERASE; MYC PROTEIN; PROTEIN GREB1; PROTEIN PS2; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ARNT; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 33846228762     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp0600438     Document Type: Article
Times cited : (21)

References (52)
  • 1
    • 0037145025 scopus 로고    scopus 로고
    • The role of chaperone proteins in the aryl hydrocarbon receptor core complex
    • Petrulis, J. R.; Perdew, G. H. The role of chaperone proteins in the aryl hydrocarbon receptor core complex. Chem. Biol. Interact. 2002, 141, 25-40.
    • (2002) Chem. Biol. Interact , vol.141 , pp. 25-40
    • Petrulis, J.R.1    Perdew, G.H.2
  • 2
    • 0037212635 scopus 로고    scopus 로고
    • 32P-labelled protein probes using a modified thioredoxin fusion protein expression system in Escherichia coli
    • 32P-labelled protein probes using a modified thioredoxin fusion protein expression system in Escherichia coli. Biomol. Eng. 2003, 20, 1-5.
    • (2003) Biomol. Eng , vol.20 , pp. 1-5
    • Delucchi, A.B.1    Jensen, K.A.2    Chan, W.K.3
  • 3
    • 1342346637 scopus 로고    scopus 로고
    • 2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. J. Appl. Physiol. 2004, 96, 1173-1177.
    • 2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. J. Appl. Physiol. 2004, 96, 1173-1177.
  • 4
    • 0029103274 scopus 로고
    • Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer
    • Liu, Y.; Cox, S. R.; Morita, T.; Kourembanas, S. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer. Circ. Res. 1995, 77, 638-643.
    • (1995) Circ. Res , vol.77 , pp. 638-643
    • Liu, Y.1    Cox, S.R.2    Morita, T.3    Kourembanas, S.4
  • 5
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe, J. A.; Jiang, B. H.; Iyer, N. V.; Agani, F.; Leung, S. W.; Koos, R. D.; Semenza, G. L. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 1996, 16, 4604-4613.
    • (1996) Mol. Cell. Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6    Semenza, G.L.7
  • 6
    • 0032795850 scopus 로고    scopus 로고
    • Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes
    • Kietzmann, T.; Roth, U.; Jungermann, K. Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood 1999, 94, 4177-4185.
    • (1999) Blood , vol.94 , pp. 4177-4185
    • Kietzmann, T.1    Roth, U.2    Jungermann, K.3
  • 7
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza, G. L.; Roth, P. H.; Fang, H. M.; Wang, G. L. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 1994, 269, 23757-23763.
    • (1994) J. Biol. Chem , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 8
    • 0029101515 scopus 로고
    • Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements
    • Firth, J. D.; Ebert, B. L.; Ratcliffe, P. J. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. J. Biol. Chem. 1995, 270, 21021-21027.
    • (1995) J. Biol. Chem , vol.270 , pp. 21021-21027
    • Firth, J.D.1    Ebert, B.L.2    Ratcliffe, P.J.3
  • 9
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza, G. L.; Jiang, B. H.; Leung, S. W.; Passantino, R.; Concordet, J. P.; Maire, P.; Giallongo, A. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem. 1996, 271, 32529-32537.
    • (1996) J. Biol. Chem , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6    Giallongo, A.7
  • 10
    • 0032741858 scopus 로고    scopus 로고
    • Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene
    • Graven, K. K.; Yu, Q.; Pan, D.; Roncarati, J. S.; Farber, H. W. Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene. Biochim. Biophys. Acta 1999, 1447, 208-218.
    • (1999) Biochim. Biophys. Acta , vol.1447 , pp. 208-218
    • Graven, K.K.1    Yu, Q.2    Pan, D.3    Roncarati, J.S.4    Farber, H.W.5
  • 12
    • 30544441340 scopus 로고    scopus 로고
    • Breast cancer, menopause, and long-term survivorship: Critical issues for the 21st century
    • Ganz, P. A. Breast cancer, menopause, and long-term survivorship: critical issues for the 21st century. Am. J. Med. 2005, 118, 136-141.
    • (2005) Am. J. Med , vol.118 , pp. 136-141
    • Ganz, P.A.1
  • 13
    • 0036216692 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: Pathophysiology and therapeutics
    • Semenza, G. L. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med. 2002, 8, 562-67.
    • (2002) Trends Mol. Med , vol.8 , pp. 562-567
    • Semenza, G.L.1
  • 15
    • 0036219609 scopus 로고    scopus 로고
    • Hsp90 inhibitors as novel cancer chemotherapeutic agents
    • Neckers, L. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol. Med. 2002, 8, S55-S61.
    • (2002) Trends Mol. Med , vol.8
    • Neckers, L.1
  • 16
    • 0036569704 scopus 로고    scopus 로고
    • Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells
    • Mabjeesh, N. J.; Post, D. E.; Willard, M. T.; Kaur, B.; Van Meir, E. G.; Simons, J. W.; Zhong, H. Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res. 2002 62, 2478-2482.
    • (2002) Cancer Res , vol.62 , pp. 2478-2482
    • Mabjeesh, N.J.1    Post, D.E.2    Willard, M.T.3    Kaur, B.4    Van Meir, E.G.5    Simons, J.W.6    Zhong, H.7
  • 17
    • 25444465116 scopus 로고    scopus 로고
    • Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function
    • Escuin, D.; Kline, E. R.; Giannakakou, P. Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function. Cancer Res. 2005, 65, 9021-9028.
    • (2005) Cancer Res , vol.65 , pp. 9021-9028
    • Escuin, D.1    Kline, E.R.2    Giannakakou, P.3
  • 18
    • 1242271198 scopus 로고    scopus 로고
    • Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: Mechanism and therapeutic implications
    • Rapisarda, A.; Uranchimeg, B.; Sordet, O.; Pommier, Y.; Shoemaker, R. H.; Melillo, G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res. 2004, 64, 1475-1482.
    • (2004) Cancer Res , vol.64 , pp. 1475-1482
    • Rapisarda, A.1    Uranchimeg, B.2    Sordet, O.3    Pommier, Y.4    Shoemaker, R.H.5    Melillo, G.6
  • 20
    • 25444523184 scopus 로고    scopus 로고
    • Kong, D.; Park, E. J.; Stephen, A. G.; Calvani, M.; Cardellina, J. H.; Monks, A.; Fisher, R. J.; Shoemaker, R. H.; Melillo, G. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005, 65, 9047-9055.
    • Kong, D.; Park, E. J.; Stephen, A. G.; Calvani, M.; Cardellina, J. H.; Monks, A.; Fisher, R. J.; Shoemaker, R. H.; Melillo, G. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005, 65, 9047-9055.
  • 21
    • 0033405294 scopus 로고    scopus 로고
    • The hypoxic cell: A target for selective cancer therapy-eighteenth Bruce F. Cain Memorial Award lecture
    • Brown, J. M. The hypoxic cell: a target for selective cancer therapy-eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res. 1999, 59, 5863-5870.
    • (1999) Cancer Res , vol.59 , pp. 5863-5870
    • Brown, J.M.1
  • 22
    • 33646353445 scopus 로고    scopus 로고
    • Mature results from a randomized Phase II trial of cisplatin plus 5-fluorouracil and radiotherapy with or without tirapazamine in patients with resectable Stage IV head and neck squamous cell carcinomas
    • Le, Q. T.; Taira, A.; Budenz, S.; Jo Dorie, M.; Goffinet, D. R.; Fee, W. E.; Goode, R.; Bloch, D.; Koong, A.; Martin Brown, J.; Pinto, H. A. Mature results from a randomized Phase II trial of cisplatin plus 5-fluorouracil and radiotherapy with or without tirapazamine in patients with resectable Stage IV head and neck squamous cell carcinomas. Cancer 2006, 106, 1940-1949.
    • (2006) Cancer , vol.106 , pp. 1940-1949
    • Le, Q.T.1    Taira, A.2    Budenz, S.3    Jo Dorie, M.4    Goffinet, D.R.5    Fee, W.E.6    Goode, R.7    Bloch, D.8    Koong, A.9    Martin Brown, J.10    Pinto, H.A.11
  • 24
    • 0033958620 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1
    • Klinge, C. M.; Kaur, K.; Swanson, H. I. The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1. Arch. Biochem. Biophys. 2000, 373, 163-174.
    • (2000) Arch. Biochem. Biophys , vol.373 , pp. 163-174
    • Klinge, C.M.1    Kaur, K.2    Swanson, H.I.3
  • 25
    • 20444381667 scopus 로고    scopus 로고
    • ERalpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription
    • Beischlag, T. V.; Perdew, G. H. ERalpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription. J. Biol. Chem. 2005, 280, 21607-21611.
    • (2005) J. Biol. Chem , vol.280 , pp. 21607-21611
    • Beischlag, T.V.1    Perdew, G.H.2
  • 26
    • 0035977882 scopus 로고    scopus 로고
    • Molecular biology of the Ah receptor and its role in carcinogenesis
    • Safe, S. Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicol. Lett. 2001, 120, 1-7.
    • (2001) Toxicol. Lett , vol.120 , pp. 1-7
    • Safe, S.1
  • 27
    • 0030908818 scopus 로고    scopus 로고
    • Identification of a motif within the 5′ regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression
    • Gillesby, B. E.; Stanostefano, M.; Porter, W.; Safe, S.; Wu, Z. F.; Zacharewski, T. R. Identification of a motif within the 5′ regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression. Biochemistry 1997, 36, 6080-6089.
    • (1997) Biochemistry , vol.36 , pp. 6080-6089
    • Gillesby, B.E.1    Stanostefano, M.2    Porter, W.3    Safe, S.4    Wu, Z.F.5    Zacharewski, T.R.6
  • 28
    • 0032526627 scopus 로고    scopus 로고
    • Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes
    • Wang, F.; Hoivik, D.; Pollenz, R.; Safe, S. Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes. Nucleic Acids Res. 1998, 26, 3044-3052.
    • (1998) Nucleic Acids Res , vol.26 , pp. 3044-3052
    • Wang, F.1    Hoivik, D.2    Pollenz, R.3    Safe, S.4
  • 29
    • 0037637542 scopus 로고    scopus 로고
    • The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription
    • Brunnberg, S.; Pettersson, K.; Rydin, E.; Matthews, J.; Hanberg, A.; Pongratz, I. The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 6517-6522.
    • (2003) Proc. Natl. Acad. Sci. U.S.A , vol.100 , pp. 6517-6522
    • Brunnberg, S.1    Pettersson, K.2    Rydin, E.3    Matthews, J.4    Hanberg, A.5    Pongratz, I.6
  • 30
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak, K. J.; Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 31
    • 0034282518 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
    • Birner, P.; Schindl, M.; Obermair, A.; Plank, C.; Breitenecker, G.; Oberhuber, G. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 2000, 60, 4693-4696.
    • (2000) Cancer Res , vol.60 , pp. 4693-4696
    • Birner, P.1    Schindl, M.2    Obermair, A.3    Plank, C.4    Breitenecker, G.5    Oberhuber, G.6
  • 36
    • 0031019835 scopus 로고    scopus 로고
    • Oxygen- and dioxin- regulated gene expression in mouse hepatoma cells
    • Gassmann, M.; Kvietikova, I.; Rolfs, A.; Wenger, R. H. Oxygen- and dioxin- regulated gene expression in mouse hepatoma cells. Kidney Int. 1997, 51, 567-574.
    • (1997) Kidney Int , vol.51 , pp. 567-574
    • Gassmann, M.1    Kvietikova, I.2    Rolfs, A.3    Wenger, R.H.4
  • 37
    • 0033597313 scopus 로고    scopus 로고
    • Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation
    • Chan, W. K.; Yao, G.; Gu, Y. Z.; Bradfield, C. A. Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation. J. Biol. Chem. 1999, 274, 12115-12123.
    • (1999) J. Biol. Chem , vol.274 , pp. 12115-12123
    • Chan, W.K.1    Yao, G.2    Gu, Y.Z.3    Bradfield, C.A.4
  • 38
    • 0032731702 scopus 로고    scopus 로고
    • Analysis of aryl hydrocarbon receptor-mediated signaling during physiological hypoxia reveals lack of competition for the aryl hydrocarbon nuclear translocator transcription factor
    • Pollenz, R. S.; Davarinos, N. A.; Shearer, T. P. Analysis of aryl hydrocarbon receptor-mediated signaling during physiological hypoxia reveals lack of competition for the aryl hydrocarbon nuclear translocator transcription factor. Mol. Pharmacol. 1999, 56, 1127-1137.
    • (1999) Mol. Pharmacol , vol.56 , pp. 1127-1137
    • Pollenz, R.S.1    Davarinos, N.A.2    Shearer, T.P.3
  • 39
    • 0034992644 scopus 로고    scopus 로고
    • Interactions between aryl hydrocarbon receptor (AhR) and hypoxia signaling pathways
    • Nie, M.; Blankenship, A. L.; Giesy, J. P. Interactions between aryl hydrocarbon receptor (AhR) and hypoxia signaling pathways. Environ. Toxicol. Pharmacol. 2001, 10, 17-27.
    • (2001) Environ. Toxicol. Pharmacol , vol.10 , pp. 17-27
    • Nie, M.1    Blankenship, A.L.2    Giesy, J.P.3
  • 40
    • 1542476903 scopus 로고    scopus 로고
    • Prasch, A. L.; Andreasen, E. A.; Peterson, R. E.; Heideman, W. Interactions between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and hypoxia signaling pathways in zebrafish: hypoxia decreases responses to TCDD in zebrafish embryos. Toxicol. Sci. 2004, 78, 68-77.
    • Prasch, A. L.; Andreasen, E. A.; Peterson, R. E.; Heideman, W. Interactions between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and hypoxia signaling pathways in zebrafish: hypoxia decreases responses to TCDD in zebrafish embryos. Toxicol. Sci. 2004, 78, 68-77.
  • 41
    • 0029888061 scopus 로고    scopus 로고
    • The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells
    • Wood, S. M.; Gleadle, J. M.; Pugh, C. W.; Hankinson, O.; Ratcliffe, P. J. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells. J. Biol. Chem. 1996, 271, 15117-15123.
    • (1996) J. Biol. Chem , vol.271 , pp. 15117-15123
    • Wood, S.M.1    Gleadle, J.M.2    Pugh, C.W.3    Hankinson, O.4    Ratcliffe, P.J.5
  • 42
    • 0029655655 scopus 로고    scopus 로고
    • Dioxin-induced CYP1A1 transcription in vivo: The aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure
    • Ko, H. P.; Okino, S. T.; Ma, Q.; Whitlock, J. P., Jr. Dioxin-induced CYP1A1 transcription in vivo: the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure. Mol. Cell. Biol. 1996, 16, 430-436.
    • (1996) Mol. Cell. Biol , vol.16 , pp. 430-436
    • Ko, H.P.1    Okino, S.T.2    Ma, Q.3    Whitlock Jr., J.P.4
  • 43
    • 0026377424 scopus 로고
    • Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer
    • Watson, P. H.; Pon, R. T.; Shiu, R. P. Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer. Cancer Res. 1991, 51, 3996-4000.
    • (1991) Cancer Res , vol.51 , pp. 3996-4000
    • Watson, P.H.1    Pon, R.T.2    Shiu, R.P.3
  • 45
    • 0037764668 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah- responsiveness in MCF-7 and HepG2 cancer cells
    • Abdelrahim, M.; Smith III, R.; Safe, S. Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah- responsiveness in MCF-7 and HepG2 cancer cells. Mol. Pharmacol. 2003, 63, 1373-1381.
    • (2003) Mol. Pharmacol , vol.63 , pp. 1373-1381
    • Abdelrahim, M.1    Smith III, R.2    Safe, S.3
  • 46
    • 33746564251 scopus 로고    scopus 로고
    • Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A
    • Murray, T. J.; Yang, X.; Sherr, D. H. Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A. Breast Cancer Res. 2006, 8, R17.
    • (2006) Breast Cancer Res , vol.8
    • Murray, T.J.1    Yang, X.2    Sherr, D.H.3
  • 48
    • 0036531825 scopus 로고    scopus 로고
    • Antitumor effect of TAT-oxygen- dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells
    • Harada, H.; Hiraoka, M.; Kizaka-Kondoh, S. Antitumor effect of TAT-oxygen- dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells. Cancer Res. 2002, 62, 2013-2018.
    • (2002) Cancer Res , vol.62 , pp. 2013-2018
    • Harada, H.1    Hiraoka, M.2    Kizaka-Kondoh, S.3
  • 49
    • 33646678222 scopus 로고    scopus 로고
    • Antitumor protein therapy; application of the protein transduction domain to the development of a protein drug for cancer treatment
    • Harada, H.; Kizaka-Kondoh, S.; Hiraoka, M. Antitumor protein therapy; application of the protein transduction domain to the development of a protein drug for cancer treatment. Breast Cancer 2006, 13, 16-26.
    • (2006) Breast Cancer , vol.13 , pp. 16-26
    • Harada, H.1    Kizaka-Kondoh, S.2    Hiraoka, M.3
  • 50
    • 0037442965 scopus 로고    scopus 로고
    • Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: Therapeutic effect of a novel polyarginine-conjugated Smac peptide
    • Yang, L.; Mashima, T.; Sato, S.; Mochizuki, M.; Sakamoto, H.; Yamori, T.; Oh-Hara, T.; Tsuruo, T. Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide. Cancer Res. 2003, 63, 831-837.
    • (2003) Cancer Res , vol.63 , pp. 831-837
    • Yang, L.1    Mashima, T.2    Sato, S.3    Mochizuki, M.4    Sakamoto, H.5    Yamori, T.6    Oh-Hara, T.7    Tsuruo, T.8
  • 51
    • 0035266403 scopus 로고    scopus 로고
    • The 104-123 amino acid sequence of the beta-domain of von Hippel-Lindau gene product is sufficient to inhibit renal tumor growth and invasion
    • Datta, K.; Sundberg, C.; Karumanchi, S. A.; Mukhopadhyay, D. The 104-123 amino acid sequence of the beta-domain of von Hippel-Lindau gene product is sufficient to inhibit renal tumor growth and invasion. Cancer Res. 2001, 61, 1768-1775.
    • (2001) Cancer Res , vol.61 , pp. 1768-1775
    • Datta, K.1    Sundberg, C.2    Karumanchi, S.A.3    Mukhopadhyay, D.4
  • 52
    • 0036822698 scopus 로고    scopus 로고
    • Transducible peptide therapy for uveal melanoma and retinoblastoma
    • Harbour, J. W.; Worley, L.; Ma, D.; Cohen, M. Transducible peptide therapy for uveal melanoma and retinoblastoma. Arch. Ophthalmol. 2002, 120, 1341-1346.
    • (2002) Arch. Ophthalmol , vol.120 , pp. 1341-1346
    • Harbour, J.W.1    Worley, L.2    Ma, D.3    Cohen, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.