Altered Distributions and Functions of Multiple Sodium Channel Subtypes in Multiple Sclerosis and its Models

Multiple Sclerosis As A Neuronal Disease

Volumn , Issue , 2005, Pages 101-118

  Waxman, Stephen G ^a  

^a NONE   (United States)

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[No Author keywords available]

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EID: 77955021124     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012738761-1/50008-0     Document Type: Chapter

References (115)

1. S.K. Agrawal and M.G. Fehlings (1996) Mechanisms of secondary injury to spinal cord axons in vitro: role of Na+, Na+−K+-ATPase, the Na+−H+ exchanger, and the Na+−Ca2+ exchanger. J. Neurosci. 16 545-552.
2. A.N. Akopian, L. Sivilotti and J.N. Wood (1996) A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 379 257-262.
3. A.N. Akopian, V. Souslova, S. England, K. Okuse, N. Ogata, J. Ure, A. Smith, B.J. Kerr, S.B. McMahon, S. Boyce, R. Hill, L.C. Stanfa, A.H. Dickenson and J.N. Wood (1999) The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat. Neurosci. 2 541-548.
4. F. Andermann, J.B.R. Cosgrove, D. Lloyd-Smith and A.M. Walters (1959) Paroxysmal dysarthria and ataxia in multiple sclerosis. Neurology 9 21-216.
5. R.D. Andrew and F.E. Dudek (1983) Burst discharge in mammalian neuroendocrine cells involves an intrinsic regenerative mechanism. Science 221 1050-1052.
6. M.D. Baker and H. Bostock (1997) Low-threshold, persistent sodium current in rat large dorsal root ganglion neurons in culture. J. Neurophysiol 77 1503-1513.
7. D.A. Bechtold, R. Kapoor and K.J. Smith (2004) Axonal protection using flecainide in experimental autoimmune encephalomyelitis. Ann. Neurol.
8. S. Beckh, M. Noda, H. Lubbert and S. Numa (1989) Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development. EMBO J. 8 3611-3616.
9. A. Bitsch, J. Schuchardt, S. Bunkowski, T. Kuhlmann and W. Bruck (2000) Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain 123 1174-1183.
10. J.A. Black, R.E. Foster and S.G. Waxman (1982) Rat optic nerve: freeze-fracture studies during development of myelinated axons. Brain Research 258 1-10.
11. J.A. Black, K. Langworthy, A.W. Hinson, S.D. Dib-Hajj and S.G. Waxman (1997) NGF has opposing effects on Na+ channel III and SNS gene expression in spinal sensory neurons. NeuroReport 8 2331-2335.
12. J.A. Black, T.R. Cummins, C. Plumpton, Y.H. Chen, W. Hormuzdiar, J.J. Clare and S.G. Waxman (1999) Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons. J. Neurophysiol. 82 2776-2785.
13. J.A. Black, J. Fjell, S. Dib-Hajj, I.D. Duncan, L.T. O'Connor, K. Fried, Z. Gladwell, S. Tate and S.G. Waxman (1999) Abnormal expression of SNS/PN3 sodium channel in cerebellar Purkinje cells following loss of myelin in the taiep rat. NeuroReport 10 913-918.
14. J.A. Black, S. Dib-Hajj, D. Baker, J. Newcombe, M.L. Cuzner and S.G. Waxman (2000) Sensory neuron specific sodium channel SNS is abnormally expressed in the brains of mice with experimental allergic encephalomyelitis and humans with multiple sclerosis. Proc. Natl. Acad. Sci. 97 11598-11602.
15. J.A. Black, S. Dib-Hajj, K. McNabola, S. Jeste, M.A. Rizzo, J.D. Kocsis, et al. (1996) Spinal sensory neurons express multiple sodium channel alpha-subunit mRNAs. Mol. Brain Res. 43 117-131.
16. T. Boiko, M.N. Rasband, S.R. Levison, J.H. Caldwell, G. Mandel, J.S. Trimmer and G. Matthews (2001) Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon. Neuron 30 91-104.
17. H. Bostock and T.A. Sears (1978) The internodal axon membrane: electrical excitability and continuous conduction in segmental demyelination. J. Physiol. (Lond.) 280 273-301.
18. T.J. Boucher, K. Okuse, D.L.H. Bennett, J.B. Munson, J.N. Wood and S.B. McMahon (2000) Potent analgesic effects of GDNF in neuropathic pain states. Science 290 124-127.
19. W. Brysch, O.W. Creutzfeldt, K. Luno, R. Schlingensiepen and K.-H. Schlingensiepen (1991) Regional and temporal expression of sodium channel messenger RNAs in the rat brain during development. Exp. Brain Res. 86 562-567.
20. J.H. Caldwell, K.L. Schaller, R.S. Lasher, E. Peles and S.R. Levinson (2000) Sodium channel Na(v)1.6 is localized at nodes of Ranvier, dendrites, and synapses. Proc. Natl. Acad. Sci. U.S.A. 97 5616-5620.
21. W.A. Catterall (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol. Rev. 72 515-548.
22. E. Cochran, B. Bacci, Y. Chen, A. Patton, P. Gambetti and L. Autilio-Gambetti (1991) Amyloid precursor protein and ubiquitin immunoreactivity in dystrophic axons is not unique to Alzheimer's disease. Am. J. Pathol. 139 485-489.
23. M.J. Craner, A.C. Lo, J.A. Black and S.G. Waxman (2003) Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination. Brain 126 1552-1562.
24. M.J. Craner, A.C. Lo, J.A. Black, D. Baker, J. Newcombe, M.L. Cuzner and S.G. Waxman (2003) Annexin II/p11 is up-regulated in Purkinje cells in EAE and MS. NeurReport 14 555-558.
25. M.J. Craner, Y. Kataoka, A.C. Lo, J.A. Black, D. Baker and S.G. Waxman (2003) Temporal course of upregulation of Nav1.8 in Purkinje neurons parallels the progression of clinical deficit in EAE. J. Neuropath. Exp. Neurol. 62 968-976.
26. M.J. Craner, B.C. Hains, A.C. Lo, J.A. Black and S.G. Waxman (2004) Colocalization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE. Brain 127 294-303.
27. M.J. Craner, J. Newcombe, J.A. Black, C. Hartle, M.L. Cuzner and S.G. Waxman (2004) Molecular changes in neurons in MS: altered axonal expression of Na 1.2 and Na 1.6 sodium channels and Na+/Ca2+ exchanger. Proc. Natl. Acad. Sci.
28. T.R. Cummins, S.D. Dib-Hajj, J.A. Black, A.N. Akopian, J.N. Wood and S.G. Waxman (1999) A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons. J. Neurosci. 19 1-16. RC 43
29. T.R. Cummins, J.A. Black, S.D. Dib-Hajj and S.G. Waxman (2000) Glial-derived neurotrophic factor upregulates expression of functional SNS and NaN sodium channels and their currents in axotomized dorsal root ganglion neurons. J. Neurosci. 20 8754-8761.
30. T.R. Cummins, F. Aglieco, M. Renganathan, R.I. Herzog, S.D. Dib-Hajj and S.G. Waxman (2001) Na 1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences following expression in a mammalian cell line and in spinal sensory neurons. J. Neurosci. 21 5952-5961.
31. T.R. Cummins and S.G. Waxman (1997) Down-regulation of tetrodotoxin-resistant sodium currents and up-regulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons following nerve injury. J. Neurosci. 17 3503-3514.
32. T.A. Damarjian, M.J. Craner and S.G. Waxman (2004) Upregulation and colocalization of p75, TrkA and Na 1.8 in Purkinje neurons in EAE.
33. R. De Simone, R.A. Micera, P. Terassa and L. Aloe (1996) mRNA for NGF and p75 in the central nervous system of rats affected by experimental allergic encephalomyelitis. Neuropathol. Appl. Neurobiol. 22 54-59.
34. S.D. Dib-Hajj, J.A. Black, T.R. Cummins, A.M. Kenney, J.D. Kocsis and S.G. Waxman (1998) Rescue of alpha-SNS/PN3 sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo. J. Neurophysiol. 79 2668-2676.
35. S. Dib-Hajj, J.A. Black, P. Felts and S.G. Waxman (1996) Down-regulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy. Proc. Natl. Acad. Sci. 93 14950-14954.
36. S.D. Dib-Hajj, J. Fjell, T.R. Cummins, Z. Zheng, K. Fried, R. LaMotte, J.A. Black and S.G. Waxman (1999) Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain. Pain 83 591-600.
37. S.D. Dib-Hajj, I. Ishikawa, T.R. Cummins and S.G. Waxman (1997) Insertion of an SNS-specific tetrapeptide in the S3-S4 linker of D4 accelerates recovery from inactivation of skeletal muscle voltage-gated Na channel μ1 in HEK293 cells. FEBS Lett. 416 11-14.
38. S. Dugandzija-Novakovic, A.G. Koszowski, S.R. Levinson and P. Shrager (1995) Clustering of Na+ channels and node of Ranvier formation in remyelinating axons. J. Neurosci. 15 492-503.
39. I.D. Duncan, K.F. Lunn, B. Holmgren, R. Urba-Homgren and L. Brignolo-Holmes (1992) The taiep rat: a myelin mutant with an associated oligodendrocyte microtubular defect. J. Neurocytol. 21 870-884.
40. A.A. Elliott and J.R. Elliott (1993) Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia. J. Physiol. (Lond.) 463 39-56.
41. J.D. England, F. Gamboni and S.R. Levinson (1991) Increased numbers of sodium channels form along demyelinated axons. Brain Res. 548 334-337.
42. M.L.E. Espir, S.M. Watkins and H.V. Smith (1966) Paroxysmal dysarthria and other transient neurological disturbances in MS. J. Neurol. Neurosurg. Psychiatry 29 323-330.
43. P.A. Felts, S. Yokoyama, S. Dib-Hajj, J.A. Black and S.G. Waxman (1997) Sodium channel α-subunit mRNAs I, II, III, NaG, Na6 and hNE: Different expression patierns in developing rat nervous system. Mol. Brain Res. 45 71-83.
44. J. Fjell, T.R. Cummins, K. Fried, J.A. Black and S.G. Waxman (1999) In vivo NGF deprivation reduces SNS/PN3 expression and TTX-R sodium currents in IB4-negative DRG neurons. J. Neurophys. 81 803-911.
45. J. Fjell, T.R. Cummins, S.D. Dib-Hajj, K. Fried, J.A. Black and S.G. Waxman (1999) Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons. Mol. Brain Res. 67 267-282.
46. R.E. Foster, C.C. Whalen and S.G. Waxman (1980) Reorganization of the axonal membrane of demyelinated nerve fibers: morphological evidence. Science 210 661-663.
47. R.E. Foster, B. Connors and S.G. Waxman (1982) Rat optic nerve electrophysiological, pharmacological and anatomical studies during development. Dev. Brain Res. 3 361-376.
48. J. Geurts, G. Wolswijk, L. Bö, P. van der Balk, C.H. Polman, D. Troost and E. Aronica (2003) Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosis. Brain 126 1755-1766.
49. A.L. Goldin (2001) Resurgence of sodium channel research. Annu. Rev. Physiol. 63 871-894.
50. A.L. Goldin, R.L. Barchi, J.H. Caldwell, F. Hofmann, J.R. Howe, J.C. Hunter, R.G. Kallen, G. Mandel, M.H. Meisler, Y.B. Netter, M. Noda, M.M. Tamkun, S.G. Waxman, J.N. Wood and W.A. Catterall (2000) Nomeclature of voltage-gated sodium channels. Neuron 2 365-368.
51. B. Gong, K.J. Rhodes, Z. Bekele-Arcuri and J.S. Trimmer (1999) Type I and type II Na+ channel alpha-subunit polypeptides exhibit distinct spatial and temporal patterning, and association with auxiliary subunits in rat brain. J. Comp. Neurol. 412 342-352.
52. B.C. Hains, C.Y. Saab, J.P. Klein, M.J. Craner and S.G. Waxman (2004) Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury. J. Neurosci.
53. R.I. Herzog, T.R. Cummins, F. Ghassemi, S. Dib-Hajj and S.G. Waxman (2003) Distinct repriming and closed state inactivation kinetics of Nav 1.6 and Nav 1.7 sodium channels in spinal sensory neurons. J. Physiol. 551 741-751.
54. T. Imaizumi, J.D. Kocsis and S.G. Waxman (1997) Anoxic injury in the rat spinal cord: pharmacological evidence for multiple steps in Ca2+-dependent injury of the dorsal columns. J. Neurotrauma 14 299-311.
55. K. Inenaga, T. Nagamoto, H. Kannan and H. Yamashita (1993) Inward sodium current involvement in regenerative bursting activity of rat magnocellular supraoptic neurons in vitro. J. Physiol. Lond. 465 289-301.
56. M.R. Kaplan, M.H. Cho, E.M. Ullian, L.L. Isom, S.R. Levinson and B.A. Barres (2001) Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier. Neuron 30 105-119.
57. J.P. Klein, E.A. Tendi, S.D. Dib-Hajj, R.D. Fields and S.G. Waxman (2003) Patterned electrical activity modulates sodium channel expression in sensory neurons. J. Neurosci. Res. 74 192-198.
58. D.C. Kohrman, M.R. Smith, A.L. Goldin, J. Harris and M.H. Meisler (1996) A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting. J. Neurosci. 16 5993-5999.
59. B. Kornek, M.K. Storch, J. Bauer, A. Djamshidian, R. Weissert, E. Wallstroem, A. Stefferl, F. Zimprich, T. Olsson, C. Linington, M. Schmidbauer and H. Lassmann (2001) Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain 124 1114-1124.
60. T. Kuhlmann, G. Lingfeld, A. Bitsch, J. Schuchardt and W. Bruck (2002) Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain 125 2202-2212.
61. L.B. Laudiero, L. Aloe, R. Levi-Montalcini, C. Buttinelli, D. Schilter, S. Gillessen and U. Otten (1992) Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid. Neurosci. Lett. 147 9-12.
62. A. Leffler, T.R. Cummins, S.D. Dib-Hajj, W.N. Hormuzdiar, J.A. Black and S.G. Waxman (2002) Glial-derived neurotrophic factor and nerve growth factor reverse changes in repriming of TTX-sensitive Na+ currents following axotomy of dorsal root ganglion neurons. J. Neurophysiol. 88 650-660.
63. Z. Li and G.I. Hatton (1996) Oscillatory bursting of physically firing rat supraoptic neurones in Iow-Ca2+ medium: Na+influx, cytosolic Ca2+ and gap junctions. J. Physiol. Lond. 496 394-397.
64. S. Lipton and D. Tauck (1986) Voltage-dependent conductances of ganglion cells from rat retina. J. Physiol. 385 361-391.
65. R. Llinas and M. Sugimori (1980) Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J. Physiol. 305 171-195.
66. A.C. Lo, J.A. Black and S.G. Waxman (2002) Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis. Neuroreport 13 1909-1912.
67. A.C. Lo, C.Y. Saab, J.A. Black and S.G. Waxman (2003) Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo. J. Neurophysiol. 90 3566-3572.
68. J.Y. Ma, W.A. Catterall and T. Scheuer (1997) Persistent sodium currents through brain sodium channels induced by G protein betagamma subunits. Neuron 19 443-452.
69. W.B. Matthews, A. Compston, I.V. Allen and C.N. Martyn (1991) McAlpine's Multiple Sclerosis New York: Churchill Livingstone
70. N. Maurice, T. Tkatch, M. Meisler, L.K. Sprunger and D.J. Surmeier (2001) D1/D5 dopamine receptor activation differentially modulates rapidly inactivating and persistent sodium currents in prefrontal cortex pyramidal neurons. J. Neurosci. 21 2268-2277.
71. J. Newcombe and M.L. Cuzner (1993) Organization and research, application of the UK Multiple Sclerosis Society tissue bank. J. Neural Transmission. Suppl. 39 155-163.
72. S.D. Novakovic, S.R. Levinson, M. Schachner and P. Shrager (1998) Disruption and reorganization of sodium channels in experimental allergic neuritis. Muscle Nerve 21 1019-1032.
73. J. Offord and W.A. Catterall (1989) Electrical activity, cAMP, and cytosolic calcium regulate mRNA encoding sodium channel α? subunits in rat muscle cells. Neuron 2 1447-1452.
74. K. Okuse, M. Malik-Hall, M.D. Baker, W.Y.L. Poon, H. Kong, M.V. Chao and J.N. Wood (2002) Annexin II light chain regulates sensory neuron-specific sodium channel expression. Nature 47 653-656.
75. M. Ouardouz, M. Nikolaeva, E. Coderre, G.W. Zamponi, J.E. McRory, B.D. Trapp, X. Yin, W. Wang, J. Woulfe and P.K. Stys (2003) Depolarization-induced Ca2+ release in ischemic spinal cord white matter involves L-type Ca2+ channel activation of ryanodine receptors. Neuron 40 53-63.
76. E. Peles and J.L. Salzer (2000) Molecular domains of myelinated axons. Curr. Opin. Neurobiol. 10 558-565.
77. C.M.A. Pennartz, M.A. Bierlaagh and A.M.S. Geurtsen (1997) Cellular mechanisms underlying spontaneous firing in rat suprachiasmatic nucleus: involvement of a slowly inactivating component of sodium current. J. Neurophysiol. 78 1811-1825.
78. G.T. Plant, R.F. Hess and S.J. Thomas (1986) The pattern evoked electroretinogram in optic neuritis. A combined psychophysical and electrophysiological study. Brain 109 469-490.
79. W. Plummer and M.H. Meisler (1999) Evolution and diversity of sodium channel genes. Genomics 57 323-331.
80. I.M. Raman and B.P. Bean (1997) Resurgent sodium current and action potential formation, in dissociated cerebellar Purkinje neurons. J. Neurosci. 17 4517-4526.
81. I.M. Raman, L.K. Sprunger, M.H. Meisler and B.P. Bean (1997) Altered subthreshold sodium currents and disrupted firing patterns in, Purkinje neurons of Scn81 mutant mice. Neuron 19 881-891.
82. M.N. Rasband, E. Peles, J.S. Trimmer, S.R. Levinson, S.E. Lux and P. Shrager (1999) Dependence of nodal sodium channel clustering on paranodal axo-glial contact in the developing CNS. J. Neurosci. 19 7516-7528.
83. M. Renganathan, T.R. Cummins and S.G. Waxman (2001) The contribution of Nav 1.8 sodium channels to action potential electrogenesis in DRG neurons. J. Neurophysiol. 86 629-640.
84. M. Renganathan, M. Gelderblom, J.A. Black and S.G. Waxman (2003) Expression of Nav 1.8 sodium channels perturbs the firing patterns of cerebellar Purkinje cells. Brain Res. 959 235-243.
85. J.C. Rios, M. Rubin, M. St. Martin, R.T. Downey, S. Einheber, J. Rosenbluth, S.R. Levinson, M. Bhat and J.L. Salzer (2002) Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion, barrier for the node of Ranvier. J. Neurosci. 23 7001-7011.
86. J.M. Ritchie and R.B. Rogart (1977) The density of sodium channels in mammalian myelinated nerve fibers and the nature of the axonal membrane under the myelin sheath. Proc. Natl. Acad. Sci. U.S.A. 74 211-215.
87. L.J. Rosenberg, Y.D. Teng and J.R. Wrathall (1999) Effects of the sodium channel blocker tetrodotoxin on acute white matter pathology after experimental contusive spinal cord injury. J. Neurosci. 19 6122-6133.
88. C. Saab, M.J. Craner, Y. Kataoka and S.G. Waxman (2004) Abnormal Purkinje cell activity in vivo in experimental allergic encephalomyelitis. Exp. Brain Res.
89. L. Sangameswaren, S.G. Delgado, L.M. Fish, B.D. Koch, L.B. Jakeman, G.R. Stewart, P. Sze, J.C. Hunter, R.M. Eglen and R.C. Herman (1996) Structure and function of a novel voltage-gated tetrodotoxin-resistant sodium channel specific to sensory neurons. J. Biol. Chem. 271 5953-5956.
90. S. Sashihara, C.A. Greer, Y. Oh and S.G. Waxman (1996) Cell specific differential expression of Na+ channel ß1 subunit mRNA in the olfactory system during postnatal development and following denervation. J. Neurosci. 16 702-714.
91. S. Sashihara, S.G. Waxman and C.A. Greer (1997) Down-regulation of Na+ channel mRNA following sensory deprivation of tufted cells in the neonatal rat olfactory bulb. NeuroReport 8 1289-1293.
92. J.H. Schild and D.L. Kunze (1997) Experimental and modeling study of Na+ current heterogeneity in rat nodose neurons and its impact on neuronal discharge. J. Neurophysiol. 78 3198-3209.
93. R.S. Scroggs and A.P. Fox (1992) Multiple Ca2+ currents elicited by action potential waveforms in acutely isolated adult rat dorsal root ganglion neurons. J. Neurosci. 12 1789-1801.
94. A.A. Sleeper, T.R. Cummins, W. Hormuzdiar, L. Tyrrell, S.D. Dib-Hajj, S.G. Waxman and J.A. Black (2000) Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy. J. Neurosci. 20 7279-7289.
95. M.R. Smith, R.D. Smith, N.W. Plummer, M.H. Meisler and A.L. Goldin (1998) Functional analysis of the mouse Scn8a sodium channel. J. Neurosci. 18 6093-6102.
96. G. Stuart and M. Hausser (1994) Initiation and spread of sodium action potentials in cerebellar Purkinje cells. Neuron 13 703-712.
97. G. Stuart and B. Sakmann (1995) Amplification of epsps by axosomatic sodium channels in neocortical pyramidal neurons. Neuron 1065-1076.
98. P.K. Stys, S.G. Waxman and B.R. Ransom (1992) Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na+−Ca2+ exchanger. J. Neurosci. 12 430-439.
99. P.K. Stys, H. Sontheimer, B.R. Ransom and S.G. Waxman (1993) Noninactivating, tetrodotoxin-sensitive Na+ conductance in rat optic nerve axons. Proc. Natl. Acad. Sci. U.S.A. 90 6976-6980.
100. M. Tanaka, T.R. Cummins, K. Ishikawa, J.A. Black, I. Ibata and S.G. Waxman (1999) Molecular and functional remodeling of electrogenic membrane of hypothalamic neurons in response to changes in their input. Proc. Natl. Acad. Sci. U.S.A. 96 1088-1093.
101. A. Taddese and B.P. Bean (2002) Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron 33 587-600.
102. B.D. Trapp, J. Peterson, R.M. Ransohoff, R. Rudick, S. Mork and L. Bo (1998) Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 338 278-285.
103. I. Vabnick, A. Messing, S.Y. Chiu, S.R. Levinson, M. Schachner, J. Roder, C. Li, S. Novakovic and P. Shrager (1997) Sodium channel distribution in axons of hypomyelinated and MAG null mutant mice. J. Neurosci. Res. 50 321-336.
104. H. Wang, M.L. Allen, J.J. Grigg, J.L. Noebels and B.L. Tempel (1999) Hypomyelination alters K+ channel expression in mouse mutants shiverer and Trembler. Neuron 15 1337-1347.
105. S.G. Waxman (1977) Conduction in myelinated, unmyelinated, and demyelinated fibers. Arch. Neurol. 34 585-590.
106. S.G. Waxman (1998) Demyelinating diseases: New pathological insights, new therapeutic targets. N. Engl. J. Med. 338 323-325.
107. S.G. Waxman (2000) The neuron as a dynamic electrogenic machine: Modulation of sodium channel expression as a basis for functional plasticity in neurons. Phil. Trans. Roy. Soc. Lond. B 355 199-213.
108. S.G. Waxman (2001) Transcriptional channelopathies: an emerging class of disorders. Nature Rev. Neurosci. 2 652-659.
109. S.G. Waxman (2003) NO and the axonal death cascade. Ann. Neurol. 53 150-154.
110. S.G. Waxman, J.A. Black, J.D. Kocsis and J.M. Ritchie (1989) Low density of sodium channels supports action potential conduction in axons of neonatal rat optic nerve. Proc. Natl. Acad. Sci. 86 1406-1410.
111. S.G. Waxman, J.D. Kocsis and J.A. Black (1994) Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is re-expressed following axotomy. J. Neurophysiol. 72 466-471.
112. R.E. Westenbroek, D.K. Merrick and W.A. Catterall (1989) Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons. Neuron 3 695-704.
113. R.E. Westenbroek, J.L. Noebels and W.A. Catterall (1992) Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain. J. Neurosci. 12 2257-2259.
114. W.R. Whitaker, J.J. Clare, A.J. Powell, Y.H. Chen, R.L. Faull and P.C. Emson (2000) Distribution of voltage-gated sodium channel alpha-subunit and beta-subunit mRNAs in human hippocampal formation, cortex, and cerebellum. J. Comp. Neurol. 422 123-139.
115. W. Zhou and A.L. Goldin (2002) Functional differences between the Nav1.6 and Nav1.2 sodium channels. Soc. Neurosci. Abstr. 834.4