-
1
-
-
75149160712
-
Hypertension, society, and public policy
-
Redwood, H. Hypertension, society, and public policy. Eur. Heart J. 9 (Suppl. B), B13-B18 (2007).
-
(2007)
Eur. Heart J.
, vol.9
, Issue.SUPPL. B
-
-
Redwood, H.1
-
2
-
-
0024317130
-
Antihypertensive drug therapy and survival by treatment status in a national survey
-
Havlik, R. J. et al. Antihypertensive drug therapy and survival by treatment status in a national survey. Hypertension 13, I28-I32 (1989).
-
(1989)
Hypertension
, vol.13
-
-
Havlik, R.J.1
-
3
-
-
34250350040
-
2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
-
DOI 10.1097/HJH.0b013e3281fc975a, PII 0000487220070600000001
-
Mancia, G. et al. 2007 Guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the european Society of Hypertension (eSH) and of the european Society of Cardiology (eSC). J. Hypertens. 25, 1105-1187 (2007). (Pubitemid 46924065)
-
(2007)
Journal of Hypertension
, vol.25
, Issue.6
, pp. 1105-1187
-
-
Mancia, G.1
De Backer, G.2
Dominiczak, A.3
Cifkova, R.4
Fagard, R.5
Germano, G.6
Grassi, G.7
Heagerty, A.M.8
Kjeldsen, S.E.9
Laurent, S.10
Narkiewicz, K.11
Ruilope, L.12
Rynkiewicz, A.13
Schmieder, R.E.14
Boudier, H.A.J.S.15
Zanchetti, A.16
-
4
-
-
33745295923
-
Dogma disputed: Can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous?
-
Messerli, F. H. et al. Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous? Ann. Intern. Med. 144, 884-893 (2006).
-
(2006)
Ann. Intern. Med.
, vol.144
, pp. 884-893
-
-
Messerli, F.H.1
-
5
-
-
77951735232
-
Effects of intensive blood pressure control in type 2 diabetes
-
The Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Group.
-
The Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Group. effects of intensive blood pressure control in type 2 diabetes. N. Engl. J. Med. 362, 1575-1585 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 1575-1585
-
-
-
6
-
-
9144248446
-
Hypertension treatment and control in five european countries, Canada, and the United States
-
wolf-Maier, K. et al. Hypertension treatment and control in five european countries, Canada, and the United States. Hypertension 43, 10-17 (2004).
-
(2004)
Hypertension
, vol.43
, pp. 10-17
-
-
Wolf-Maier, K.1
-
7
-
-
0037165229
-
The role of the renin-angiotensin system in the development of cardiovascular disease
-
Unger, T. The role of the renin-angiotensin system in the development of cardiovascular disease. Am. J. Cardiol. 89, 3A-9A (2002).
-
(2002)
Am. J. Cardiol.
, vol.89
-
-
Unger, T.1
-
8
-
-
0025770664
-
Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system
-
weber, K. T. & Brilla, C. G. Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation 83, 1849-1865 (1991).
-
(1991)
Circulation
, vol.83
, pp. 1849-1865
-
-
Weber, K.T.1
Brilla, C.G.2
-
9
-
-
0033034404
-
Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: The Captopril Prevention Project (CAPPP) randomised trial
-
DOI 10.1016/S0140-6736(98)05012-0
-
Hansson, L. et al. effect of angiotensinconverting- enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPP) randomised trial. Lancet 353, 611-616 (1999). (Pubitemid 29087980)
-
(1999)
Lancet
, vol.353
, Issue.9153
, pp. 611-616
-
-
Hansson, L.1
Lindholm, L.H.2
Niskanen, L.3
Lanke, J.4
Hedner, T.5
Niklason, A.6
Luomanmaki, K.7
Dahlof, B.8
De Faire, U.9
Morlin, C.10
Karlberg, B.E.11
Wester, P.O.12
Bjorck, J.-E.13
-
10
-
-
0033589756
-
Randomised trial of old and new antihypertensive drugs in elderly patients: Cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study
-
Hansson, L. et al. Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study. Lancet 354, 1751-1756 (1999).
-
(1999)
Lancet
, vol.354
, pp. 1751-1756
-
-
Hansson, L.1
-
11
-
-
0034688194
-
Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
-
DOI 10.1056/NEJM200001203420301
-
Yusuf, S. et al. effects of an angiotensinconverting- enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention evaluation Study Investigators. N. Engl. J. Med. 342, 145-153 (2000). (Pubitemid 30051645)
-
(2000)
New England Journal of Medicine
, vol.342
, Issue.3
, pp. 145-153
-
-
Yusuf, S.1
-
12
-
-
0037160968
-
Cardiovascular morbidity and mortality in the Losartan Intervention for endpoint reduction in hypertension study (LIFe): A randomised trial against atenolol
-
Dahlöf, B. et al. Cardiovascular morbidity and mortality in the Losartan Intervention For endpoint reduction in hypertension study (LIFe): a randomised trial against atenolol. Lancet 359, 995-1003 (2000).
-
(2000)
Lancet
, vol.359
, pp. 995-1003
-
-
Dahlöf, B.1
-
13
-
-
2942635317
-
Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: The VALUe randomised trial
-
Julius, S. et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUe randomised trial. Lancet 363, 2022-2031 (2004).
-
(2004)
Lancet
, vol.363
, pp. 2022-2031
-
-
Julius, S.1
-
14
-
-
42049107348
-
Telmisartan, ramipril, or both in patients at high risk for vascular events
-
for the ONTARGeT Investigators.
-
Yusuf, S. et al. for the ONTARGeT Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N. Engl. J. Med. 358, 1547-1559 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 1547-1559
-
-
Yusuf, S.1
-
15
-
-
33846294746
-
Incident diabetes in clinical trials of antihypertensive drugs: A network meta-analysis
-
elliott, w. J. & Meyer, P. M. Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet 369, 201-207 (2007).
-
(2007)
Lancet
, vol.369
, pp. 201-207
-
-
Elliott, W.J.1
Meyer, P.M.2
-
16
-
-
69449098105
-
ONTARGeT, TRANSCeND, and PRoFeSS: New-onset diabetes, atrial fibrillation, and left ventricular hypertrophy
-
Kintscher, U. ONTARGeT, TRANSCeND, and PRoFeSS: new-onset diabetes, atrial fibrillation, and left ventricular hypertrophy. J. Hypertens. 27 (Suppl. 2), S36-S39 (2009).
-
(2009)
J. Hypertens.
, vol.27
, Issue.SUPPL. 2
-
-
Kintscher, U.1
-
17
-
-
46749157907
-
Beyond the classic angiotensinreceptor- blocker profile
-
Kurtz, T. w. Beyond the classic angiotensinreceptor- blocker profile. Nat. Clin. Pract. Cardiovasc. Med. 5 (Suppl. 1), S19-S26 (2008).
-
(2008)
Nat. Clin. Pract. Cardiovasc. Med.
, vol.5
, Issue.SUPPL. 1
-
-
Kurtz, T.W.1
-
18
-
-
70349980161
-
Next generation multifunctional angiotensin receptor blockers
-
Kurtz, T. w. & Klein, U. Next generation multifunctional angiotensin receptor blockers. Hypertens. Res. 32, 826-834 (2009).
-
(2009)
Hypertens. Res.
, vol.32
, pp. 826-834
-
-
Kurtz, T.W.1
Klein, U.2
-
19
-
-
0036690114
-
Drugs targeting the renin-angiotensin-aldosterone system
-
Zaman, M. A., Oparil, S. & Calhoun, D. A. Drugs targeting the renin-angiotensin-aldosterone system. Nat. Rev. Drug. Discov. 1, 621-636 (2002).
-
(2002)
Nat. Rev. Drug. Discov.
, vol.1
, pp. 621-636
-
-
Zaman, M.A.1
Oparil, S.2
Calhoun, D.A.3
-
20
-
-
77951700065
-
-
US FDA. Drugs@FDA: FDA Approved Drug Products [online], http://www.accessdata.fda.gov/scripts/ cder/drugsatfda/index.cfm?fuseaction= Search.Search-Drug-Name&ms=y (2010).
-
(2010)
Drugs@FDA: FDA Approved Drug Products [Online]
-
-
-
21
-
-
77955012980
-
-
DrugBase
-
DrugBase. Index Nominum [online], http:// www.justscience.de/de/drugbase/ indexnominum/kategorie.html?tx-crondavdbin- pi%5Bcategory-uid%5D=111&cHash= - deb595e371 (2010).
-
(2010)
Index Nominum [Online]
-
-
-
22
-
-
0036266596
-
Pivotal role of the renin/ prorenin receptor in angiotensin II production and cellular responses to rennin
-
Nguyen, G. et al. Pivotal role of the renin/ prorenin receptor in angiotensin II production and cellular responses to renin. J. Clin. Invest. 109, 1417-1427 (2002).
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1417-1427
-
-
Nguyen, G.1
-
23
-
-
33845608395
-
A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein
-
Schefe, J. H. et al. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ. Res. 99, 1355-1366 (2006).
-
(2006)
Circ. Res.
, vol.99
, pp. 1355-1366
-
-
Schefe, J.H.1
-
24
-
-
43449101529
-
PLZF and the (pro)renin receptor
-
Schefe, J. H., Unger, T. & Funke-Kaiser, H. PLZF and the (pro)renin receptor. J. Mol. Med. 86, 623-627 (2008).
-
(2008)
J. Mol. Med.
, vol.86
, pp. 623-627
-
-
Schefe, J.H.1
Unger, T.2
Funke-Kaiser, H.3
-
25
-
-
76349122414
-
Signal transduction of the (pro)renin receptor as a novel therapeutic target for preventing end-organ damage
-
Funke-Kaiser, H., Zollmann, F. S., Schefe, J. H. & Unger, T. Signal transduction of the (pro)renin receptor as a novel therapeutic target for preventing end-organ damage. Hypertens. Res. 33, 98-104 (2009).
-
(2009)
Hypertens. Res.
, vol.33
, pp. 98-104
-
-
Funke-Kaiser, H.1
Zollmann, F.S.2
Schefe, J.H.3
Unger, T.4
-
26
-
-
0035834159
-
Vasopeptidase inhibitors: A new therapeutic concept in cardiovascular disease?
-
Corti, R., Burnett, J. C. Jr, Rouleau, J. L., Ruschitzka, F. & Luscher, T. F. Vasopeptidase inhibitors: a new therapeutic concept in cardiovascular disease? Circulation 104, 1856-1862 (2001).
-
(2001)
Circulation
, vol.104
, pp. 1856-1862
-
-
Corti, R.1
Burnett Jr., J.C.2
Rouleau, J.L.3
Ruschitzka, F.4
Luscher, T.F.5
-
27
-
-
77950472601
-
Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB
-
Rompe, F. et al. Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB. Hypertension 55, 924-931 (2010).
-
(2010)
Hypertension
, vol.55
, pp. 924-931
-
-
Rompe, F.1
-
28
-
-
22544448655
-
The AT2 receptor-a matter of love and hate
-
Steckelings, U. M., Kaschina, e. & Unger, T. The AT2 receptor-a matter of love and hate. Peptides 26, 1401-1409 (2005).
-
(2005)
Peptides
, vol.26
, pp. 1401-1409
-
-
Steckelings, U.M.1
Kaschina, E.2
Unger, T.3
-
29
-
-
0005295227
-
Antirenin in man and animals
-
Goldblatt, H., Haas, e. & Lamfrom, H. Antirenin in man and animals. Trans. Assoc. Am. Physicians 64, 122-125 (1951).
-
(1951)
Trans. Assoc. Am. Physicians
, vol.64
, pp. 122-125
-
-
Goldblatt, H.1
Haas, E.2
Lamfrom, H.3
-
30
-
-
4043179763
-
Renin-angiotensin vaccine: Old story, new project 'efficacy versus safety'
-
Michel, J. B. Renin-angiotensin vaccine: old story, new project 'efficacy versus safety'. Clin. Sci. (Lond.) 107, 145-147 (2004).
-
(2004)
Clin. Sci. (Lond.)
, vol.107
, pp. 145-147
-
-
Michel, J.B.1
-
31
-
-
4043116249
-
Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects
-
Brown, M. J. et al. Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects. Clin. Sci. (Lond.) 107, 167-173 (2004).
-
(2004)
Clin. Sci. (Lond.)
, vol.107
, pp. 167-173
-
-
Brown, M.J.1
-
32
-
-
33845362874
-
A vaccine for hypertension based on virus-like particles: Preclinical efficacy and Phase i safety and immunogenicity
-
Ambühl, P. M. et al. A vaccine for hypertension based on virus-like particles: preclinical efficacy and Phase I safety and immunogenicity. J. Hypertens. 25, 63-72 (2007).
-
(2007)
J. Hypertens.
, vol.25
, pp. 63-72
-
-
Ambühl, P.M.1
-
33
-
-
40049106627
-
Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: A double-blind, randomised, placebo-controlled phase IIa study
-
Tissot, A. C. et al. effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study. Lancet 371, 821-827 (2008).
-
(2008)
Lancet
, vol.371
, pp. 821-827
-
-
Tissot, A.C.1
-
35
-
-
77749310836
-
Adapter proteins and promoter regulation of the angiotensin II type 2 receptor-implications for cardiac pathophysiology
-
Funke-Kaiser, H., Reinemund, J., Steckelings, U. M. & Unger, T. Adapter proteins and promoter regulation of the angiotensin II type 2 receptor-implications for cardiac pathophysiology. J. Renin. Angiotensin. Aldosterone. Syst. 11, 7-17 (2010).
-
(2010)
J. Renin. Angiotensin. Aldosterone. Syst.
, vol.11
, pp. 7-17
-
-
Funke-Kaiser, H.1
Reinemund, J.2
Steckelings, U.M.3
Unger, T.4
-
36
-
-
11144234344
-
Regulation of transport of the angiotensin AT2 receptor by a novel membraneassociated Golgi protein
-
wruck, C. J. et al. Regulation of transport of the angiotensin AT2 receptor by a novel membraneassociated Golgi protein. Arterioscler. Thromb. Vasc. Biol. 25, 57-64 (2005).
-
(2005)
Arterioscler. Thromb. Vasc. Biol.
, vol.25
, pp. 57-64
-
-
Wruck, C.J.1
-
37
-
-
0034080623
-
Signal transduction from the angiotensin II AT2 receptor
-
Nouet, S. & Nahmias, C. Signal transduction from the angiotensin II AT2 receptor. Trends Endocrinol. Metab. 11, 1-6 (2006).
-
(2006)
Trends Endocrinol. Metab.
, vol.11
, pp. 1-6
-
-
Nouet, S.1
Nahmias, C.2
-
38
-
-
0032427537
-
Molecular and cellular mechanism of angiotensin IImediated apoptosis
-
Horiuchi, M., Akishita, M. & Dzau, V. J. Molecular and cellular mechanism of angiotensin IImediated apoptosis. Endocr. Res. 24, 307-314 (1998).
-
(1998)
Endocr. Res.
, vol.24
, pp. 307-314
-
-
Horiuchi, M.1
Akishita, M.2
Dzau, V.J.3
-
39
-
-
0029065411
-
Coronary kinin generation mediates nitric oxide release after angiotensin receptor stimulation
-
Seyedi, N., Xu, X., Nasjletti, A. & Hintze, T. H. Coronary kinin generation mediates nitric oxide release after angiotensin receptor stimulation. Hypertension 26, 164-170 (1995).
-
(1995)
Hypertension
, vol.26
, pp. 164-170
-
-
Seyedi, N.1
Xu, X.2
Nasjletti, A.3
Hintze, T.H.4
-
40
-
-
0024407452
-
Inhibitors of angiotensinconverting enzyme prevent myointimal proliferation after vascular injury
-
Powell, J. S. et al. Inhibitors of angiotensinconverting enzyme prevent myointimal proliferation after vascular injury. Science 245, 186-188 (1989).
-
(1989)
Science
, vol.245
, pp. 186-188
-
-
Powell, J.S.1
-
41
-
-
8644281991
-
Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist
-
wan, Y. et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J. Med. Chem. 47, 5995-6008 (2004).
-
(2004)
J. Med. Chem.
, vol.47
, pp. 5995-6008
-
-
Wan, Y.1
-
42
-
-
58149375072
-
Angiotensin II type 2 receptor stimulation: A novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?
-
Kaschina, e. et al. Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation 118, 2523-2532 (2008).
-
(2008)
Circulation
, vol.118
, pp. 2523-2532
-
-
Kaschina, E.1
-
43
-
-
76449117787
-
Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats
-
Bosnyak, S. et al. Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats. Br. J. Pharmacol. 159, 709-716 (2010).
-
(2010)
Br. J. Pharmacol.
, vol.159
, pp. 709-716
-
-
Bosnyak, S.1
-
44
-
-
0034130979
-
Vasopeptidase inhibition has potent effects on blood pressure and resistance arteries in stroke-prone spontaneously hypertensive rats
-
Intengan, H. D. & Schiffrin, e. L. Vasopeptidase inhibition has potent effects on blood pressure and resistance arteries in stroke-prone spontaneously hypertensive rats. Hypertension 35, 1221-1225 (2000).
-
(2000)
Hypertension
, vol.35
, pp. 1221-1225
-
-
Intengan, H.D.1
Schiffrin, E.L.2
-
45
-
-
0347988111
-
Can angiotensin II type 2 receptors have deleterious effects in cardiovascular disease? Implications for therapeutic blockade of the renin-angiotensin system
-
Lévy, B. I. Can angiotensin II type 2 receptors have deleterious effects in cardiovascular disease? Implications for therapeutic blockade of the renin-angiotensin system. Circulation 109, 8-13 (2004).
-
(2004)
Circulation
, vol.109
, pp. 8-13
-
-
Lévy, B.I.1
-
46
-
-
0037341656
-
Vasopeptidase inhibition: A double-edged sword?
-
Campbell, D. J. Vasopeptidase inhibition: a double-edged sword? Hypertension 41, 383-389 (2003).
-
(2003)
Hypertension
, vol.41
, pp. 383-389
-
-
Campbell, D.J.1
-
47
-
-
0031955506
-
Effects of omapatrilat in low, normal, and high renin experimental hypertension
-
Trippodo, N. C. et al. effects of omapatrilat in low, normal, and high renin experimental hypertension. Am. J. Hypertens. 11, 363-372 (1998).
-
(1998)
Am. J. Hypertens.
, vol.11
, pp. 363-372
-
-
Trippodo, N.C.1
-
48
-
-
0035148538
-
Vasopeptidase inhibition prevents endothelial dysfunction of resistance arteries in salt-sensitive hypertension in comparison with single ACe inhibition
-
d'Uscio, L. V., Quaschning, T., Burnett, J. C. Jr & Lüscher, T. F. Vasopeptidase inhibition prevents endothelial dysfunction of resistance arteries in salt-sensitive hypertension in comparison with single ACe inhibition. Hypertension 37, 28-33 (2001).
-
(2001)
Hypertension
, vol.37
, pp. 28-33
-
-
D'Uscio, L.V.1
Quaschning, T.2
Burnett Jr., J.C.3
Lüscher, T.F.4
-
49
-
-
0000062540
-
Randomized double-blind comparison of omapatrilat with amlodipine in mild-to-moderate hypertension [abstract A063]
-
Ruilope, L. M. et al. Randomized double-blind comparison of omapatrilat with amlodipine in mild-to-moderate hypertension [abstract A063]. Am. J. Hypertens. 13, 134A (2000).
-
(2000)
Am. J. Hypertens.
, vol.13
-
-
Ruilope, L.M.1
-
50
-
-
0033059782
-
Sustained antihypertensive actions of a dual angiotensin-converting enzyme neutral endopeptidase inhibitor, sampatrilat, in black hypertensive subjects
-
Norton, G. R. et al. Sustained antihypertensive actions of a dual angiotensin-converting enzyme neutral endopeptidase inhibitor, sampatrilat, in black hypertensive subjects. Am. J. Hypertens. 12, 563-571 (1999).
-
(1999)
Am. J. Hypertens.
, vol.12
, pp. 563-571
-
-
Norton, G.R.1
-
51
-
-
0037143601
-
Comparison of omapatrilat and enalapril in patients with chronic heart failure: The Omapatrilat Versus enalapril Randomized Trial of Utility in Reducing events (OVeRTURe)
-
Packer, M. et al. Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus enalapril Randomized Trial of Utility in Reducing events (OVeRTURe). Circulation 106, 920-926 (2002).
-
(2002)
Circulation
, vol.106
, pp. 920-926
-
-
Packer, M.1
-
53
-
-
0023620145
-
Efficacy and tolerance of spironolactone in essential hypertension
-
Jeunemaitre, X. et al. efficacy and tolerance of spironolactone in essential hypertension. Am. J. Cardiol. 60, 820-825 (1987).
-
(1987)
Am. J. Cardiol.
, vol.60
, pp. 820-825
-
-
Jeunemaitre, X.1
-
54
-
-
0033517302
-
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone evaluation Study Investigators
-
Pitt, B. et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone evaluation Study Investigators. N. Engl. J. Med. 341, 709-717 (1999).
-
(1999)
N. Engl. J. Med.
, vol.341
, pp. 709-717
-
-
Pitt, B.1
-
55
-
-
77649291571
-
Aldosterone: Role in the cardiometabolic syndrome and resistant hypertension
-
whaley-Connell, A., Johnson. M. S. & Sowers, J. R. Aldosterone: role in the cardiometabolic syndrome and resistant hypertension. Prog. Cardiovasc. Dis. 52, 401-409 (2010).
-
(2010)
Prog. Cardiovasc. Dis.
, vol.52
, pp. 401-409
-
-
Whaley-Connell, A.1
Johnson, M.S.2
Sowers, J.R.3
-
56
-
-
33847048251
-
Association of adrenal steroids with hypertension and the metabolic syndrome in blacks
-
Kidambi, S. et al. Association of adrenal steroids with hypertension and the metabolic syndrome in blacks. Hypertension 49, 704-711 (2007).
-
(2007)
Hypertension
, vol.49
, pp. 704-711
-
-
Kidambi, S.1
-
57
-
-
0036898286
-
Hyperaldosteronism among black and white subjects with resistant hypertension
-
Calhoun, D. A., Nishizaka, M. K., Zaman, M. A., Thakkar, R. B. & weissmann, P. Hyperaldosteronism among black and white subjects with resistant hypertension. Hypertension 40, 892-896 (2002).
-
(2002)
Hypertension
, vol.40
, pp. 892-896
-
-
Calhoun, D.A.1
Nishizaka, M.K.2
Zaman, M.A.3
Thakkar, R.B.4
Weissmann, P.5
-
58
-
-
0038673178
-
Effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension
-
white, w. B. et al. effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension. Hypertension 41, 1021-1026 (2003).
-
(2003)
Hypertension
, vol.41
, pp. 1021-1026
-
-
White, W.B.1
-
59
-
-
1842688311
-
Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension
-
williams, G. H. et al. efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension. Am. J. Cardiol. 93, 990-996 (2004).
-
(2004)
Am. J. Cardiol.
, vol.93
, pp. 990-996
-
-
Williams, G.H.1
-
60
-
-
24944492935
-
Effects of eplerenone versus losartan in patients with low-renin hypertension
-
weinberger, M. H. et al. effects of eplerenone versus losartan in patients with low-renin hypertension. Am. Heart. J. 150, 426-433 (2005).
-
(2005)
Am. Heart. J.
, vol.150
, pp. 426-433
-
-
Weinberger, M.H.1
-
61
-
-
0036330671
-
Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients
-
Krum, H. et al. efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients. Hypertension 40, 117-123 (2002).
-
(2002)
Hypertension
, vol.40
, pp. 117-123
-
-
Krum, H.1
-
62
-
-
22844437062
-
Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure
-
DOI 10.1016/j.jacc.2005.04.038, PII S073510970501017X
-
Pitt, B. et al. for the ePHeSUS Investigators. eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure. J. Am. Coll. Cardiol. 46, 425-431 (2005). (Pubitemid 41040281)
-
(2005)
Journal of the American College of Cardiology
, vol.46
, Issue.3
, pp. 425-431
-
-
Pitt, B.1
White, H.2
Nicolau, J.3
Martinez, F.4
Gheorghiade, M.5
Aschermann, M.6
Van Veldhuisen, D.J.7
Zannad, F.8
Krum, H.9
Mukherjee, R.10
Vincent, J.11
-
63
-
-
42349101107
-
A comparison of the aldosterone-blocking agents eplerenone and spironolactone
-
Struthers, A., Krum, H. & williams, G. H. A comparison of the aldosterone-blocking agents eplerenone and spironolactone. Clin. Cardiol. 31, 153-158 (2008).
-
(2008)
Clin. Cardiol.
, vol.31
, pp. 153-158
-
-
Struthers, A.1
Krum, H.2
Williams, G.H.3
-
64
-
-
0035997359
-
Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension
-
weinberger, M. H., Roniker, B., Krause, S. L. & weiss, R. J. eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension. Am. J. Hypertens. 15, 709-716 (2002).
-
(2002)
Am. J. Hypertens.
, vol.15
, pp. 709-716
-
-
Weinberger, M.H.1
Roniker, B.2
Krause, S.L.3
Weiss, R.J.4
-
65
-
-
20544453256
-
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage
-
DOI 10.1161/CIRCULATIONAHA.104.521625
-
Fiebeler, A. et al. Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. Circulation 111, 3087-3094 (2005). (Pubitemid 40847786)
-
(2005)
Circulation
, vol.111
, Issue.23
, pp. 3087-3094
-
-
Fiebeler, A.1
Nussberger, J.2
Shagdarsuren, E.3
Rong, S.4
Hilfenhaus, G.5
Al-Saadi, N.6
Dechend, R.7
Wellner, M.8
Meiners, S.9
Maser-Gluth, C.10
Jeng, A.Y.11
Webb, R.L.12
Luft, F.C.13
Muller, D.N.14
-
66
-
-
50649107329
-
Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in wistar rats
-
Huang, B. S., white, R. A., Ahmad, M., Jeng, A. Y. & Leenen, F. H. Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in wistar rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295, R166-R172 (2008).
-
(2008)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.295
-
-
Huang, B.S.1
White, R.A.2
Ahmad, M.3
Jeng, A.Y.4
Leenen, F.H.5
-
67
-
-
64949189157
-
Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt
-
Lea, w. B. et al. Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt. Kidney Int. 75, 936-944 (2009).
-
(2009)
Kidney Int
, vol.75
, pp. 936-944
-
-
Lea, W.B.1
-
69
-
-
50849123772
-
Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: A comparison with spironolactone
-
Mulder, P. et al. Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone. Eur. Heart J. 29, 2171-2179 (2008).
-
(2008)
Eur. Heart J.
, vol.29
, pp. 2171-2179
-
-
Mulder, P.1
-
70
-
-
21244485815
-
Mineralocorticoid receptors: Distribution and activation
-
Funder, J. w. Mineralocorticoid receptors: distribution and activation. Heart Fail. Rev. 10, 15-22 (2005).
-
(2005)
Heart Fail. Rev.
, vol.10
, pp. 15-22
-
-
Funder, J.W.1
-
71
-
-
0342894669
-
Synergistic effects of ACe inhibition and Ang II antagonism on blood pressure, cardiac weight, and renin in spontaneously hypertensive rats
-
Menard, J., Campbell, D. J., Azizi, M. & Gonzales, M. F. Synergistic effects of ACe inhibition and Ang II antagonism on blood pressure, cardiac weight, and renin in spontaneously hypertensive rats. Circulation 96, 3072-3078 (1997).
-
(1997)
Circulation
, vol.96
, pp. 3072-3078
-
-
Menard, J.1
Campbell, D.J.2
Azizi, M.3
Gonzales, M.F.4
-
72
-
-
0036372173
-
Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): Comparison with enalapril
-
Nussberger, J., wuerzner, G., Jensen, C. & Brunner, H. R. Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril. Hypertension 39, e1-e8 (2002).
-
(2002)
Hypertension
, vol.39
-
-
Nussberger, J.1
Wuerzner, G.2
Jensen, C.3
Brunner, H.R.4
-
73
-
-
0347479295
-
Blood pressure lowering in essential hypertension with an oral renin inhibitor aliskiren
-
Stanton, A., Jensen, C., Nussberger, J. & O'Brien, e. Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren. Hypertension 42, 1137-1143 (2003).
-
(2003)
Hypertension
, vol.42
, pp. 1137-1143
-
-
Stanton, A.1
Jensen, C.2
Nussberger, J.3
O'Brien, E.4
-
74
-
-
39849089447
-
Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: A 6-month, randomized, double-blind trial
-
Andersen, K. et al. Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial. J. Hypertens. 26, 589-599 (2008).
-
(2008)
J. Hypertens.
, vol.26
, pp. 589-599
-
-
Andersen, K.1
-
75
-
-
60549087324
-
Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: A 12-month randomized, double-blind comparator trial with hydrochlorothiazide
-
Schmieder, R. e. et al. Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide. Circulation 119, 417-425 (2009).
-
(2009)
Circulation
, vol.119
, pp. 417-425
-
-
Schmieder, R.E.1
-
76
-
-
56749085787
-
Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension
-
Dietz, R. et al. effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension. J. Renin Angiotensin Aldosterone Syst. 9, 163-175 (2008).
-
(2008)
J. Renin Angiotensin Aldosterone Syst.
, vol.9
, pp. 163-175
-
-
Dietz, R.1
-
78
-
-
34247644329
-
Aliskiren, the first renin inhibitor for treating hypertension: Reactive renin secretion may limit its effectiveness
-
Sealey, J. e. & Laragh, J. H. Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness. Am. J. Hypertens. 20, 587-597 (2007).
-
(2007)
Am. J. Hypertens.
, vol.20
, pp. 587-597
-
-
Sealey, J.E.1
Laragh, J.H.2
-
79
-
-
74349117848
-
The increase in renin during renin inhibition: Does it result in harmful effects by the (pro)renin receptor?
-
Danser, A. H. The increase in renin during renin inhibition: does it result in harmful effects by the (pro)renin receptor? Hypertens. Res. 33, 4-10 (2009).
-
(2009)
Hypertens. Res.
, vol.33
, pp. 4-10
-
-
Danser, A.H.1
-
80
-
-
73849141617
-
Aliskiren monotherapy does not cause paradoxical blood pressure rises: Meta-analysis of data from 8 clinical trials
-
Stanton, A. V. et al. Aliskiren monotherapy does not cause paradoxical blood pressure rises: meta-analysis of data from 8 clinical trials. Hypertension 55, 54-60 (2010).
-
(2010)
Hypertension
, vol.55
, pp. 54-60
-
-
Stanton, A.V.1
-
81
-
-
34347350179
-
Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells
-
Huang, Y., Noble, N. A., Zhang, J., Xu, C. & Border, w. A. Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells. Kidney Int. 72, 45-52 (2007).
-
(2007)
Kidney Int
, vol.72
, pp. 45-52
-
-
Huang, Y.1
Noble, N.A.2
Zhang, J.3
Xu, C.4
Border, W.A.5
-
82
-
-
56749090710
-
Prorenin engages the (pro) renin receptor like renin and both ligand activities are unopposed by aliskiren
-
Schefe, J. H. et al. Prorenin engages the (pro) renin receptor like renin and both ligand activities are unopposed by aliskiren. J. Hypertens. 26, 1787-1794 (2008).
-
(2008)
J. Hypertens.
, vol.26
, pp. 1787-1794
-
-
Schefe, J.H.1
-
83
-
-
46449118638
-
Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats
-
Feldman, D. L. et al. effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats. Hypertension 52, 130-136 (2008).
-
(2008)
Hypertension
, vol.52
, pp. 130-136
-
-
Feldman, D.L.1
-
84
-
-
9644283069
-
Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin
-
Ichihara, A. et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin. J. Clin. Invest. 114, 1128-1135 (2004).
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1128-1135
-
-
Ichihara, A.1
-
85
-
-
33646160993
-
Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension
-
Ichihara, A. et al. Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension 47, 894-900 (2006).
-
(2006)
Hypertension
, vol.47
, pp. 894-900
-
-
Ichihara, A.1
-
86
-
-
54049106595
-
Cardiovascular effects of prorenin blockade in genetically spontaneously hypertensive rats on normal and high-salt diet
-
Susic, D., Zhou, X., Frohlich, e. D., Lippton, H. & Knight, M. Cardiovascular effects of prorenin blockade in genetically spontaneously hypertensive rats on normal and high-salt diet. Am. J. Physiol. Heart Circ. Physiol. 295, H1117-H1121 (2008).
-
(2008)
Am. J. Physiol. Heart Circ. Physiol.
, vol.295
-
-
Susic, D.1
Zhou, X.2
Frohlich, E.D.3
Lippton, H.4
Knight, M.5
-
87
-
-
77749239824
-
Possible roles of human (pro) renin receptor suggested by recent clinical and experimental findings
-
Ichihara, A. et al. Possible roles of human (pro) renin receptor suggested by recent clinical and experimental findings. Hypertens. Res. 33, 177-180 (2010).
-
(2010)
Hypertens. Res.
, vol.33
, pp. 177-180
-
-
Ichihara, A.1
-
88
-
-
20944444468
-
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure
-
Xu, J. et al. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. J. Clin. Invest. 115, 1275-1280 (2005).
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1275-1280
-
-
Xu, J.1
-
89
-
-
40549087923
-
Catecholamines regulate the activity, secretion, and synthesis of renalase
-
Li, G. et al. Catecholamines regulate the activity, secretion, and synthesis of renalase. Circulation 117, 1277-1282 (2008).
-
(2008)
Circulation
, vol.117
, pp. 1277-1282
-
-
Li, G.1
-
90
-
-
34248226387
-
Effect of renalase inhibition on blood pressure
-
Ghosh, S. S. et al. effect of renalase inhibition on blood pressure. J. Am. Soc. Nephrol. 17, 208A (2006).
-
(2006)
J. Am. Soc. Nephrol.
, vol.17
-
-
Ghosh, S.S.1
-
91
-
-
68249112138
-
Regulation of blood pressure and cardiovascular function by renalase
-
Desir, G. V. Regulation of blood pressure and cardiovascular function by renalase. Kidney Int. 76, 366-370 (2009).
-
(2009)
Kidney Int
, vol.76
, pp. 366-370
-
-
Desir, G.V.1
-
92
-
-
34447523333
-
Renalase gene is a novel susceptibility gene for essential hypertension: A two-stage association study in northern Han Chinese population
-
DOI 10.1007/s00109-006-0151-4
-
Zhao, Q. et al. Renalase gene is a novel susceptibility gene for essential hypertension: a two-stage association study in northern Han Chinese population. J. Mol. Med. 85, 877-885 (2007). (Pubitemid 47077106)
-
(2007)
Journal of Molecular Medicine
, vol.85
, Issue.8
, pp. 877-885
-
-
Zhao, Q.1
Fan, Z.2
He, J.3
Chen, S.4
Li, H.5
Zhang, P.6
Wang, L.7
Hu, D.8
Huang, J.9
Qiang, B.10
Gu, D.11
-
93
-
-
39149085803
-
Downregulation of cardiac renalase expression in CKD, and protective effect of renalase in acute coronary syndrome
-
Desir, G. V. et al. Downregulation of cardiac renalase expression in CKD, and protective effect of renalase in acute coronary syndrome. J. Am. Soc. Nephrol. 18, 149A (2007).
-
(2007)
J. Am. Soc. Nephrol.
, vol.18
-
-
Desir, G.V.1
-
94
-
-
24144487172
-
Renalase, a catecholaminemetabolizing hormone from the kidney
-
Luft, F. C. Renalase, a catecholaminemetabolizing hormone from the kidney. Cell Metab. 1, 358-360 (2005).
-
(2005)
Cell Metab
, vol.1
, pp. 358-360
-
-
Luft, F.C.1
-
96
-
-
73349115592
-
Renal denervation as a therapeutic approach for hypertension: Novel implications for an old concept
-
Schlaich, M. P. et al. Renal denervation as a therapeutic approach for hypertension: novel implications for an old concept. Hypertension 54, 1195-1201 (2009).
-
(2009)
Hypertension
, vol.54
, pp. 1195-1201
-
-
Schlaich, M.P.1
-
97
-
-
0036153623
-
Effects of long-term renal sympathetic denervation on heart failure after myocardial infarction in rats
-
Nozawa, T. et al. effects of long-term renal sympathetic denervation on heart failure after myocardial infarction in rats. Heart Vessels 16, 51-56 (2002).
-
(2002)
Heart Vessels
, vol.16
, pp. 51-56
-
-
Nozawa, T.1
-
98
-
-
50449148274
-
Sympathectomy in the treatment of hypertension; Review of 122 cases
-
Morrissey, D. M., Brookes, V. S. & Cooke, w. T. Sympathectomy in the treatment of hypertension; review of 122 cases. Lancet 1, 403-408 (1953).
-
(1953)
Lancet
, vol.1
, pp. 403-408
-
-
Morrissey, D.M.1
Brookes, V.S.2
Cooke, W.T.3
-
99
-
-
0000220091
-
Splanchnicectomy for essential hypertension; Results in 1,266 cases
-
Smithwick, R. H. & Thompson, J. e. Splanchnicectomy for essential hypertension; results in 1,266 cases. JAMA 152, 1501-1504 (1953).
-
(1953)
JAMA
, vol.152
, pp. 1501-1504
-
-
Smithwick, R.H.1
Thompson, J.E.2
-
100
-
-
64049084640
-
Catheter-based renal sympathetic denervation for resistant hypertension: A multicentre safety and proof-of-principle cohort study
-
Krum, H. et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373, 1275-1281 (2009).
-
(2009)
Lancet
, vol.373
, pp. 1275-1281
-
-
Krum, H.1
-
101
-
-
69349085170
-
Renal sympatheticnerve ablation for uncontrolled hypertension
-
Schlaich, M. P., Sobotka, P. A., Krum, H., Lambert, e. & esler, M. D. Renal sympatheticnerve ablation for uncontrolled hypertension. N. Engl. J. Med. 361, 932-934 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 932-934
-
-
Schlaich, M.P.1
Sobotka, P.A.2
Krum, H.3
Lambert, E.4
Esler, M.D.5
-
102
-
-
36448964430
-
LA419 a novel nitric oxide donor prevents cardiac remodeling via the endothelial nitric oxide synthase pathway: NO donors as a means of antiremodeling
-
Paulis, L. & Simko, F. LA419, a novel nitric oxide donor, prevents cardiac remodeling via the endothelial nitric oxide synthase pathway: NO donors as a means of antiremodeling. Hypertension 50, 1009-1011 (2007).
-
(2007)
Hypertension
, vol.50
, pp. 1009-1011
-
-
Paulis, L.1
Simko, F.2
-
103
-
-
36448954982
-
LA419, a novel nitric oxide donor, prevents pathological cardiac remodeling in pressure-overloaded rats via endothelial nitric oxide synthase pathway regulation
-
Ruiz-Hurtado, G., Fernandez-Velasco, M., Mourelle, M. & Delgado, C. LA419, a novel nitric oxide donor, prevents pathological cardiac remodeling in pressure-overloaded rats via endothelial nitric oxide synthase pathway regulation. Hypertension 50, 1049-1056 (2007).
-
(2007)
Hypertension
, vol.50
, pp. 1049-1056
-
-
Ruiz-Hurtado, G.1
Fernandez-Velasco, M.2
Mourelle, M.3
Delgado, C.4
-
104
-
-
34249683823
-
Recent developments in nitric oxide donor drugs
-
Miller, M. R. & Megson, I. L. Recent developments in nitric oxide donor drugs. Br. J. Pharmacol. 151, 305-321 (2007).
-
(2007)
Br. J. Pharmacol.
, vol.151
, pp. 305-321
-
-
Miller, M.R.1
Megson, I.L.2
-
105
-
-
0036178227
-
Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: In vivo studies
-
Stasch, J. P., Dembowsky, K., Perzborn, e., Stahl, e. & Schramm, M. Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies. Br. J. Pharmacol. 135, 344-355 (2002). (Pubitemid 34151166)
-
(2002)
British Journal of Pharmacology
, vol.135
, Issue.2
, pp. 344-355
-
-
Stasch, J.-P.1
Dembowsky, K.2
Perzborn, E.3
Stahl, E.4
Schramm, M.5
-
106
-
-
33745699566
-
Protective effects of BAY 41- 2272 (sGC stimulator) on hypertension, heart, and cardiomyocyte hypertrophy induced by chronic L-NAMe treatment in rats
-
Zanfolin, M. et al. Protective effects of BAY 41- 2272 (sGC stimulator) on hypertension, heart, and cardiomyocyte hypertrophy induced by chronic L-NAMe treatment in rats. J. Cardiovasc. Pharmacol. 47, 391-395 (2006).
-
(2006)
J. Cardiovasc. Pharmacol.
, vol.47
, pp. 391-395
-
-
Zanfolin, M.1
-
107
-
-
0035952993
-
NO-independent stimulators of soluble guanylate cyclase
-
DOI 10.1016/S0960-894X(01)00073-7, PII S0960894X01000737
-
Straub, A. et al. NO-independent stimulators of soluble guanylate cyclase. Bioorg. Med. Chem. Lett. 11, 781-784 (2001). (Pubitemid 32230679)
-
(2001)
Bioorganic and Medicinal Chemistry Letters
, vol.11
, Issue.6
, pp. 781-784
-
-
Straub, A.1
Stasch, J.-P.2
Alonso-Alija, C.3
Benet-Buchholz, J.4
Ducke, B.5
Feurer, A.6
Furstner, C.7
-
108
-
-
67649229211
-
Cinaciguat (BAY 58-2667) improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure
-
Lapp, H. et al. Cinaciguat (BAY 58-2667) improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure. Circulation 119, 2781-2788 (2009).
-
(2009)
Circulation
, vol.119
, pp. 2781-2788
-
-
Lapp, H.1
-
109
-
-
37749007190
-
Oral tadalafil in pulmonary artery hypertension: A prospective study
-
Aggarwal, P., Patial, R. K., Negi, P. C. & Marwaha, R. Oral tadalafil in pulmonary artery hypertension: a prospective study. Indian Heart J. 59, 329-335 (2007).
-
(2007)
Indian Heart J
, vol.59
, pp. 329-335
-
-
Aggarwal, P.1
Patial, R.K.2
Negi, P.C.3
Marwaha, R.4
-
110
-
-
67649523052
-
Tadalafil therapy for pulmonary arterial hypertension
-
for the Pulmonary Arterial Hypertension and Response to Tadalafil (PHIRST) Study Group.
-
Galiè, N. et al. for the Pulmonary Arterial Hypertension and Response to Tadalafil (PHIRST) Study Group. Tadalafil therapy for pulmonary arterial hypertension. Circulation 119, 2894-2903 (2009).
-
(2009)
Circulation
, vol.119
, pp. 2894-2903
-
-
Galiè, N.1
-
111
-
-
33747597607
-
Phosphodiesterase-5 inhibitors and their hemodynamic effects
-
Prisant, L. M. Phosphodiesterase-5 inhibitors and their hemodynamic effects. Curr. Hypertens. Rep. 8, 345-351 (2006).
-
(2006)
Curr. Hypertens. Rep.
, vol.8
, pp. 345-351
-
-
Prisant, L.M.1
-
112
-
-
73349135641
-
Tadalafil, a long-acting inhibitor of PDe5, improves pulmonary hemodynamics and survival rate of monocrotaline-induced pulmonary artery hypertension in rats
-
Sawamura, F., Kato, M., Fujita, K., Nakazawa, T. & Beardsworth, A. Tadalafil, a long-acting inhibitor of PDe5, improves pulmonary hemodynamics and survival rate of monocrotaline-induced pulmonary artery hypertension in rats. J. Pharmacol. Sci. 111, 235-243 (2009).
-
(2009)
J. Pharmacol. Sci.
, vol.111
, pp. 235-243
-
-
Sawamura, F.1
Kato, M.2
Fujita, K.3
Nakazawa, T.4
Beardsworth, A.5
-
113
-
-
58449113001
-
Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway
-
Hsu, S. et al. Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway. Cardiovasc. Res. 81, 301-309 (2009).
-
(2009)
Cardiovasc. Res.
, vol.81
, pp. 301-309
-
-
Hsu, S.1
-
114
-
-
46749124422
-
The role of sildenafil in the treatment of stroke
-
Bednar, M. M. The role of sildenafil in the treatment of stroke. Curr. Opin. Investig. Drugs 9, 754-759 (2008).
-
(2008)
Curr. Opin. Investig. Drugs
, vol.9
, pp. 754-759
-
-
Bednar, M.M.1
-
115
-
-
30944437637
-
Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage
-
Rodriguez-Iturbe, B. et al. early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage. Kidney Int. 68, 2131-2142 (2005).
-
(2005)
Kidney Int
, vol.68
, pp. 2131-2142
-
-
Rodriguez-Iturbe, B.1
-
116
-
-
33750314056
-
Pharmacologic treatment for pulmonary arterial hypertension
-
Sastry, B. K. Pharmacologic treatment for pulmonary arterial hypertension. Curr. Opin. Cardiol. 21, 561-568 (2006).
-
(2006)
Curr. Opin. Cardiol.
, vol.21
, pp. 561-568
-
-
Sastry, B.K.1
-
117
-
-
0036634351
-
Darusentan: An effective endothelin A receptor antagonist for treatment of hypertension
-
for the HeAT Investigators.
-
Nakov, R., Pfarr, e. & eberle, S. for the HeAT Investigators. Darusentan: an effective endothelin A receptor antagonist for treatment of hypertension. Am. J. Hypertens. 15, 583-589 (2002).
-
(2002)
Am. J. Hypertens.
, vol.15
, pp. 583-589
-
-
Nakov, R.1
Pfarr, E.2
Eberle, S.3
-
118
-
-
43049099531
-
Efficacy and safety of darusentan in patients with resistant hypertension: Results from a randomized, double-blind, placebo-controlled dose-ranging study
-
Black, H. R. et al. efficacy and safety of darusentan in patients with resistant hypertension: results from a randomized, double-blind, placebo-controlled dose-ranging study. J. Clin. Hypertens. (Greenwich) 9, 760-769 (2007).
-
(2007)
J. Clin. Hypertens. (Greenwich)
, vol.9
, pp. 760-769
-
-
Black, H.R.1
-
119
-
-
70350133404
-
A selective endothelinreceptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: A randomised, double-blind, placebo-controlled trial
-
weber, M. A. et al. A selective endothelinreceptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial. Lancet 374, 1423-1431 (2009).
-
(2009)
Lancet
, vol.374
, pp. 1423-1431
-
-
Weber, M.A.1
-
120
-
-
0037137297
-
Hemodynamic and neurohumoral effects of selective endothelin A (eT(A)) receptor blockade in chronic heart failure: The Heart Failure eT(A) Receptor Blockade Trial (HeAT)
-
Luescher, T. F. et al. Hemodynamic and neurohumoral effects of selective endothelin A (eT(A)) receptor blockade in chronic heart failure: the Heart Failure eT(A) Receptor Blockade Trial (HeAT). Circulation 106, 2666-2672 (2002).
-
(2002)
Circulation
, vol.106
, pp. 2666-2672
-
-
Luescher, T.F.1
-
121
-
-
3242810591
-
Long-term effects of darusentan on left-ventricular remodeling and clinical outcomes in the endothelinA Receptor Antagonist Trial in Heart Failure (eARTH): Randomised, double-blind, placebo-controlled trial
-
Anand, I. et al. Long-term effects of darusentan on left-ventricular remodeling and clinical outcomes in the endothelinA Receptor Antagonist Trial in Heart Failure (eARTH): randomised, double-blind, placebo-controlled trial. Lancet 364, 347-354 (2004).
-
(2004)
Lancet
, vol.364
, pp. 347-354
-
-
Anand, I.1
-
122
-
-
66649116553
-
Soluble epoxide hydrolase, a target with multiple opportunities for cardiovascular drug discovery
-
Marino, J. P. Jr. Soluble epoxide hydrolase, a target with multiple opportunities for cardiovascular drug discovery. Curr. Top. Med. Chem. 9, 452-463 (2009).
-
(2009)
Curr. Top. Med. Chem.
, vol.9
, pp. 452-463
-
-
Marino Jr., J.P.1
-
123
-
-
36849008650
-
Cardiovascular diseases: Protective effects of melatonin
-
Tengattini, S. et al. Cardiovascular diseases: protective effects of melatonin. J. Pineal Res. 44, 16-25 (2008).
-
(2008)
J. Pineal Res.
, vol.44
, pp. 16-25
-
-
Tengattini, S.1
-
124
-
-
41749116214
-
Blood pressure modulation and cardiovascular protection by melatonin: Potential mechanisms behind
-
Paulis, L. & Simko, F. Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind. Physiol. Res. 56, 671-684 (2007).
-
(2007)
Physiol. Res.
, vol.56
, pp. 671-684
-
-
Paulis, L.1
Simko, F.2
-
125
-
-
34250830245
-
Drospirenone, a new progestogen, for postmenopausal women with hypertension
-
Mallareddy, M., Hanes, V. & white, w. B. Drospirenone, a new progestogen, for postmenopausal women with hypertension. Drugs Aging 24, 453-466 (2007).
-
(2007)
Drugs Aging
, vol.24
, pp. 453-466
-
-
Mallareddy, M.1
Hanes, V.2
White, W.B.3
-
126
-
-
77955013412
-
-
The Pharmaceutical Research and Manufacturers of America (PhRMA)
-
The Pharmaceutical Research and Manufacturers of America (PhRMA). New Medicines Database [online], http:// newmeds.phrma.org (2010)
-
(2010)
New Medicines Database [Online]
-
-
|