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Volumn 9, Issue 7, 2008, Pages 754-759

The role of sildenafil in the treatment of stroke

Author keywords

Cyclic GMP; Neurogenesis; Neuroplasticity; Neurorestoration; Sildenafil; Stroke

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; CHORIONIC GONADOTROPIN BETA SUBUNIT; CHORIONIC GONADOTROPIN DERIVATIVE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC GMP; ERYTHROPOIETIN; ERYTHROPOIETIN DERIVATIVE; GLYCERYL TRINITRATE; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; MYELIN ASSOCIATED GLYCOPROTEIN; NITRATE; NITRIC OXIDE; NTX 265; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHODIESTERASE V INHIBITOR; PHOSPHOKINASE G; PHOSPHOTRANSFERASE; PROTEIN KINASE B; PROTEIN NOGO A; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; SILDENAFIL; TADALAFIL; ZAPRINAST;

EID: 46749124422     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (28)

References (53)
  • 1
    • 33846857559 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2007 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Rosamond W, Flegal K, Friday G, Furie K, Go A, Greenlund K, Haase N, Ho M, Howard V, Kissela B, Kittner S et al: Heart disease and stroke statistics - 2007 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation (2007) 115(5):e69-e171.
    • (2007) Circulation , vol.115 , Issue.5
    • Rosamond, W.1    Flegal, K.2    Friday, G.3    Furie, K.4    Go, A.5    Greenlund, K.6    Haase, N.7    Ho, M.8    Howard, V.9    Kissela, B.10    Kittner, S.11
  • 2
    • 0032557171 scopus 로고    scopus 로고
    • Rising stroke rates spur efforts to identify risks, prevent disease
    • Stephenson J: Rising stroke rates spur efforts to identify risks, prevent disease. J Am Med Assoc (1998) 279(16):1239-1240.
    • (1998) J Am Med Assoc , vol.279 , Issue.16 , pp. 1239-1240
    • Stephenson, J.1
  • 4
    • 34748912364 scopus 로고    scopus 로고
    • Acute ischemic stroke treatment in 2007
    • Goldstein LB: Acute ischemic stroke treatment in 2007. Circulation (2007) 116(13):1504-1514.
    • (2007) Circulation , vol.116 , Issue.13 , pp. 1504-1514
    • Goldstein, L.B.1
  • 5
    • 34547799633 scopus 로고    scopus 로고
    • Stroke treatment - light at the end of the tunnel?
    • Garber K: Stroke treatment - light at the end of the tunnel? Nat Biotechnol (2007) 25(8):838-840.
    • (2007) Nat Biotechnol , vol.25 , Issue.8 , pp. 838-840
    • Garber, K.1
  • 7
    • 0036843061 scopus 로고    scopus 로고
    • Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats
    • Zhang RL, Wang Y, Zhang L, Zhang Z, Tsang W, Lu M, Zhang L, Chopp M: Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke (2002) 33(11):2675-2680.
    • (2002) Stroke , vol.33 , Issue.11 , pp. 2675-2680
    • Zhang, R.L.1    Wang, Y.2    Zhang, L.3    Zhang, Z.4    Tsang, W.5    Lu, M.6    Zhang, L.7    Chopp, M.8
  • 8
    • 16844372455 scopus 로고    scopus 로고
    • Functional recovery in aged and young rats after embolic stroke: Treatment with a phosphodiesterase type 5 inhibitor
    • An important translational study documenting the capacity for aged animals to experience similar degrees of post-stroke improvement to that observed in young animals, •
    • Zhang L, Zhang RL, Wang Y, Zhang C, Zhang ZG, Meng H, Chopp M: Functional recovery in aged and young rats after embolic stroke: Treatment with a phosphodiesterase type 5 inhibitor. Stroke (2005) 36(4):847-852. • An important translational study documenting the capacity for aged animals to experience similar degrees of post-stroke improvement to that observed in young animals.
    • (2005) Stroke , vol.36 , Issue.4 , pp. 847-852
    • Zhang, L.1    Zhang, R.L.2    Wang, Y.3    Zhang, C.4    Zhang, Z.G.5    Meng, H.6    Chopp, M.7
  • 9
    • 33748338787 scopus 로고    scopus 로고
    • Jin K, Wang X, Xie L, Mao XO, Zhu W, Wang Y, Shen J, Mao Y, Banwait S, Greenberg DA: Evidence for stroke-induced neurogenesis in the human brain. Proc Natl Acad Sci USA (2006) 103(35):13198-13202. • This study builds upon earlier research in animals and humans by demonstrating the existence of post-stroke neurogenesis in humans.
    • Jin K, Wang X, Xie L, Mao XO, Zhu W, Wang Y, Shen J, Mao Y, Banwait S, Greenberg DA: Evidence for stroke-induced neurogenesis in the human brain. Proc Natl Acad Sci USA (2006) 103(35):13198-13202. • This study builds upon earlier research in animals and humans by demonstrating the existence of post-stroke neurogenesis in humans.
  • 10
    • 46749138634 scopus 로고    scopus 로고
    • Newborn neurons may help heal brain after stroke
    • Frankish H: Newborn neurons may help heal brain after stroke. Lancet Neurology (2006) 5(10):820.
    • (2006) Lancet Neurology , vol.5 , Issue.10 , pp. 820
    • Frankish, H.1
  • 11
    • 37849025433 scopus 로고    scopus 로고
    • Neuroplasticity and brain repair after stroke
    • A timely review of post-stroke events and the therapeutic approaches being studied, •
    • Cramer SC, Riley JD: Neuroplasticity and brain repair after stroke. Curr Opin Neurol (2008) 21(1):76-82. • A timely review of post-stroke events and the therapeutic approaches being studied.
    • (2008) Curr Opin Neurol , vol.21 , Issue.1 , pp. 76-82
    • Cramer, S.C.1    Riley, J.D.2
  • 14
    • 46749101323 scopus 로고    scopus 로고
    • Stem Cell Therapeutics announces receipt of no objection letter from Health Canada for its phase IIb clinical trial in stroke
    • Stem Cell Therapeutics Corp:, December 04
    • Stem Cell Therapeutics Corp: Stem Cell Therapeutics announces receipt of no objection letter from Health Canada for its phase IIb clinical trial in stroke. Press Release (2007): December 04. www.marketwire.com/mw/ release.do?id=799216
    • (2007) Press Release
  • 15
    • 46749102470 scopus 로고    scopus 로고
    • Stem Cell Therapeutics Corp: Stem Cell Therapeutics Corp. announces positive interim results from its currently enrolling phase IIa clinical program for NTx™-265 in acute stroke. Press Release (2007): April 11. www.bioalberta.com/news_details1.asp?ID=54
    • Stem Cell Therapeutics Corp: Stem Cell Therapeutics Corp. announces positive interim results from its currently enrolling phase IIa clinical program for NTx™-265 in acute stroke. Press Release (2007): April 11. www.bioalberta.com/news_details1.asp?ID=54
  • 16
    • 37049035903 scopus 로고    scopus 로고
    • Recombinant human erythropoietin in the treatment of human brain disease: Focus on cognition
    • Ehrenreich H, Bartels C, Sargin D, Stawicki S, Krampe H: Recombinant human erythropoietin in the treatment of human brain disease: Focus on cognition. J Renal Nutr (2008) 18(1):146-153.
    • (2008) J Renal Nutr , vol.18 , Issue.1 , pp. 146-153
    • Ehrenreich, H.1    Bartels, C.2    Sargin, D.3    Stawicki, S.4    Krampe, H.5
  • 17
    • 46749112200 scopus 로고    scopus 로고
    • 'Stem cell Trial of Recovery Enhancement After Stroke 2' (STEMS2): Pilot randomised placebo-controlled trial of granulocyte-colony stimulating factor in mobilising bone marrow stem cells in sub-acute stroke. Current Controlled Trials, London, UK (2008). www.controlled-trials.com/ cctspringview2/mrct/showTrial. html?mrid=240533&srch
    • 'Stem cell Trial of Recovery Enhancement After Stroke 2' (STEMS2): Pilot randomised placebo-controlled trial of granulocyte-colony stimulating factor in mobilising bone marrow stem cells in sub-acute stroke. Current Controlled Trials, London, UK (2008). www.controlled-trials.com/ cctspringview2/mrct/showTrial. html?mrid=240533&srch
  • 18
    • 46749126123 scopus 로고    scopus 로고
    • University of Nottingham, Nottingham, UK , April 30
    • Efficacy of nitric oxide in stroke trial: University of Nottingham, Nottingham, UK (2008): April 30. www.enos.ac.uk
    • (2008) Efficacy of nitric oxide in stroke trial
  • 20
    • 0013784893 scopus 로고
    • Autoradiographic and histologic evidence of postnatal neurogenesis in rats
    • •• Seminal research demonstrating neurogenesis in the adult mammalian brain
    • Altman J, Das GD: Autoradiographic and histologic evidence of postnatal neurogenesis in rats. J Comp Neurol (1965) 124(3):319-335. •• Seminal research demonstrating neurogenesis in the adult mammalian brain.
    • (1965) J Comp Neurol , vol.124 , Issue.3 , pp. 319-335
    • Altman, J.1    Das, G.D.2
  • 21
    • 0031789814 scopus 로고    scopus 로고
    • Neurogenesis in the adult human hippocampus
    • A classic study demonstrating the existence of adult human neurogenesis and the implications of this finding for understanding the extent of brain plasticity and the capacity for NR, ••
    • Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH: Neurogenesis in the adult human hippocampus. Nat Med (1998) 4(11):1313-1317. •• A classic study demonstrating the existence of adult human neurogenesis and the implications of this finding for understanding the extent of brain plasticity and the capacity for NR.
    • (1998) Nat Med , vol.4 , Issue.11 , pp. 1313-1317
    • Eriksson, P.S.1    Perfilieva, E.2    Björk-Eriksson, T.3    Alborn, A.M.4    Nordborg, C.5    Peterson, D.A.6    Gage, F.H.7
  • 22
    • 0034213060 scopus 로고    scopus 로고
    • Recovery recapitulates ontogeny
    • An excellent early review comparing operant mechanisms responsible for embryologic CNS development and brain plasticity after stroke, ••
    • Cramer SC, Chopp M: Recovery recapitulates ontogeny. Trends Neurosci (2000) 23(6):265-271. •• An excellent early review comparing operant mechanisms responsible for embryologic CNS development and brain plasticity after stroke.
    • (2000) Trends Neurosci , vol.23 , Issue.6 , pp. 265-271
    • Cramer, S.C.1    Chopp, M.2
  • 23
    • 0029586276 scopus 로고
    • Age-related production of new granule cells in the adult dentate gyrus
    • Seki T, Arai Y: Age-related production of new granule cells in the adult dentate gyrus. Neuroreport (1995) 6(18):2479-2482.
    • (1995) Neuroreport , vol.6 , Issue.18 , pp. 2479-2482
    • Seki, T.1    Arai, Y.2
  • 24
    • 33646365892 scopus 로고    scopus 로고
    • Delayed treatment with sildenafil enhances neurogenesis and improves functional recovery in aged rats after focal cerebral ischemia
    • Zhang RL, Zhang Z, Zhang L, Wang Y, Zhang C, Chopp M: Delayed treatment with sildenafil enhances neurogenesis and improves functional recovery in aged rats after focal cerebral ischemia. J Neurosci Res (2006) 83(7):1213-1219.
    • (2006) J Neurosci Res , vol.83 , Issue.7 , pp. 1213-1219
    • Zhang, R.L.1    Zhang, Z.2    Zhang, L.3    Wang, Y.4    Zhang, C.5    Chopp, M.6
  • 25
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
    • A landmark paper demonstrating that endothelium-derived relaxing factor is NO, •
    • Palmer RM, Ferrige AG, Moncada S: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (1987) 327(6122):524-526. • A landmark paper demonstrating that endothelium-derived relaxing factor is NO.
    • (1987) Nature , vol.327 , Issue.6122 , pp. 524-526
    • Palmer, R.M.1    Ferrige, A.G.2    Moncada, S.3
  • 26
    • 0027975453 scopus 로고
    • Nitric oxide: A physiologic messenger molecule
    • Bredt DS, Snyder SH: Nitric oxide: A physiologic messenger molecule. Annu Rev Biochem (1994) 63:175-195.
    • (1994) Annu Rev Biochem , vol.63 , pp. 175-195
    • Bredt, D.S.1    Snyder, S.H.2
  • 28
    • 0034754052 scopus 로고    scopus 로고
    • A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats
    • Zhang R, Zhang L, Zhang Z, Wang Y, Lu M, LaPointe M, Chopp M: A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats. Ann Neurol (2001) 50(5):602-611.
    • (2001) Ann Neurol , vol.50 , Issue.5 , pp. 602-611
    • Zhang, R.1    Zhang, L.2    Zhang, Z.3    Wang, Y.4    Lu, M.5    LaPointe, M.6    Chopp, M.7
  • 29
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • Dirnagl U, Iadecola C, Moskowitz MA: Pathobiology of ischaemic stroke: An integrated view. Trends Neurosci (1999) 22(9):391-397.
    • (1999) Trends Neurosci , vol.22 , Issue.9 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 31
    • 23844554901 scopus 로고    scopus 로고
    • Jackson G, Gillies H, Osterloh I: Past, present, and future: A 7-year update of Viagra (sildenafil citrate). Int J Clin Pract (2005) 59(6):680-691. • A thorough review of the discovery and clinical experience with sildenafil.
    • Jackson G, Gillies H, Osterloh I: Past, present, and future: A 7-year update of Viagra (sildenafil citrate). Int J Clin Pract (2005) 59(6):680-691. • A thorough review of the discovery and clinical experience with sildenafil.
  • 32
    • 0037458918 scopus 로고    scopus 로고
    • Nitric oxide enhances angiogenesis via the synthesis of vascular endothelial growth factor and cGMP after stroke in the rat
    • Zhang R, Wang L, Zhang L, Chen J, Zhu Z, Zhang Z, Chopp M: Nitric oxide enhances angiogenesis via the synthesis of vascular endothelial growth factor and cGMP after stroke in the rat. Circ Res (2003) 92(3):308-313.
    • (2003) Circ Res , vol.92 , Issue.3 , pp. 308-313
    • Zhang, R.1    Wang, L.2    Zhang, L.3    Chen, J.4    Zhu, Z.5    Zhang, Z.6    Chopp, M.7
  • 33
    • 33750317276 scopus 로고    scopus 로고
    • Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke
    • Zhang L, Zhang Z, Zhang RL, Cui Y, LaPointe M, Silver B, Chopp M: Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke. Brain Res (2006) 1118(1):192-198.
    • (2006) Brain Res , vol.1118 , Issue.1 , pp. 192-198
    • Zhang, L.1    Zhang, Z.2    Zhang, R.L.3    Cui, Y.4    LaPointe, M.5    Silver, B.6    Chopp, M.7
  • 35
    • 33745155419 scopus 로고    scopus 로고
    • Goldstein LB, Adams R, Alberts MJ, Appel LJ, Brass LM, Bushnell CD, Culebras A, Degraba TJ, Gorelick PB, Guyton JR, Hart RG et al: Primary prevention of ischemic stroke: A guideline from the American Heart Association/American Stroke Association Stroke Council: Cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Stroke (2006) 37(6):1583- 1633.
    • Goldstein LB, Adams R, Alberts MJ, Appel LJ, Brass LM, Bushnell CD, Culebras A, Degraba TJ, Gorelick PB, Guyton JR, Hart RG et al: Primary prevention of ischemic stroke: A guideline from the American Heart Association/American Stroke Association Stroke Council: Cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Stroke (2006) 37(6):1583- 1633.
  • 36
    • 0036888773 scopus 로고    scopus 로고
    • Coronary and systemic hemodynamic effects of sildenafil citrate: From basic science to clinical studies in patients with cardiovascular disease
    • A comprehensive review of sildenafil relating its biochemical effects to its cardiovascular actions under physiological and pathophysiological conditions, •
    • Gillies HC, Roblin D, Jackson G: Coronary and systemic hemodynamic effects of sildenafil citrate: From basic science to clinical studies in patients with cardiovascular disease. Intl J Cardiol (2002) 86(2-3):131-141. • A comprehensive review of sildenafil relating its biochemical effects to its cardiovascular actions under physiological and pathophysiological conditions.
    • (2002) Intl J Cardiol , vol.86 , Issue.2-3 , pp. 131-141
    • Gillies, H.C.1    Roblin, D.2    Jackson, G.3
  • 37
    • 0034063871 scopus 로고    scopus 로고
    • Immunohistochemical localization of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in rat tissues
    • Kotera J, Fujishige K, Omori K: Immunohistochemical localization of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in rat tissues. J Histochem Cytochem (2000) 48(5):685-693.
    • (2000) J Histochem Cytochem , vol.48 , Issue.5 , pp. 685-693
    • Kotera, J.1    Fujishige, K.2    Omori, K.3
  • 40
    • 0022410974 scopus 로고
    • The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion
    • Kuroiwa T, Ting P, Martinez H, Klatzo I: The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion. Acta Neuropathol (1985) 68(2):122-129.
    • (1985) Acta Neuropathol , vol.68 , Issue.2 , pp. 122-129
    • Kuroiwa, T.1    Ting, P.2    Martinez, H.3    Klatzo, I.4
  • 41
    • 33846191628 scopus 로고    scopus 로고
    • Angiogenesis and improved cerebral blood flow in the ischemic boundary area detected by MRI after administration of sildenafil to rats with embolic stroke
    • Li L, Jiang Q, Zhang L, Ding G, Zhang ZG, Li Q, Ewing JR, Lu M, Panda S, Ledbetter KA, Whitton P et al: Angiogenesis and improved cerebral blood flow in the ischemic boundary area detected by MRI after administration of sildenafil to rats with embolic stroke. Brain Res (2007) 1132(1):185-192.
    • (2007) Brain Res , vol.1132 , Issue.1 , pp. 185-192
    • Li, L.1    Jiang, Q.2    Zhang, L.3    Ding, G.4    Zhang, Z.G.5    Li, Q.6    Ewing, J.R.7    Lu, M.8    Panda, S.9    Ledbetter, K.A.10    Whitton, P.11
  • 42
    • 24144449540 scopus 로고    scopus 로고
    • Phosphodiesterase 5 inhibitor, zaprinast, selectively increases cerebral blood flow in the ischemic penumbra in the rat brain
    • Feng G, Maso S, Hideaki N: Phosphodiesterase 5 inhibitor, zaprinast, selectively increases cerebral blood flow in the ischemic penumbra in the rat brain. Neurological Res (2005) 27(6):638-643.
    • (2005) Neurological Res , vol.27 , Issue.6 , pp. 638-643
    • Feng, G.1    Maso, S.2    Hideaki, N.3
  • 43
    • 0036713960 scopus 로고    scopus 로고
    • The phosphodiesterase 5 inhibitor sildenafil has no effect on cerebral blood flow or blood velocity, but nevertheless induces headache in healthy subjects
    • Kruuse C, Thomsen LL, Jacobsen TB, Olesen J: The phosphodiesterase 5 inhibitor sildenafil has no effect on cerebral blood flow or blood velocity, but nevertheless induces headache in healthy subjects. J Cereb Blood Flow Metab (2002) 22(9):1124-1131.
    • (2002) J Cereb Blood Flow Metab , vol.22 , Issue.9 , pp. 1124-1131
    • Kruuse, C.1    Thomsen, L.L.2    Jacobsen, T.B.3    Olesen, J.4
  • 47
    • 3042838912 scopus 로고    scopus 로고
    • Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity
    • Lee JK, Kim JE, Sivula M, Strittmatter SM: Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. J Neurosci (2004) 24(27):6209-6217.
    • (2004) J Neurosci , vol.24 , Issue.27 , pp. 6209-6217
    • Lee, J.K.1    Kim, J.E.2    Sivula, M.3    Strittmatter, S.M.4
  • 48
    • 24944455102 scopus 로고    scopus 로고
    • Activation of the P13-K/ Akt pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone
    • Wang L, Zhang ZG, Zhang RL, Chopp M: Activation of the P13-K/ Akt pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone. J Cereb Blood Flow Metab (2005) 25(9):1150-1158.
    • (2005) J Cereb Blood Flow Metab , vol.25 , Issue.9 , pp. 1150-1158
    • Wang, L.1    Zhang, Z.G.2    Zhang, R.L.3    Chopp, M.4
  • 49
    • 0037112206 scopus 로고    scopus 로고
    • Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus
    • Nakagawa S, Kim J, Lee R, Chen J, Fujioka T, Malberg J, Tsuji S, Duman RS: Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus. J Neurosci (2002) 22(22):9868-9876.
    • (2002) J Neurosci , vol.22 , Issue.22 , pp. 9868-9876
    • Nakagawa, S.1    Kim, J.2    Lee, R.3    Chen, J.4    Fujioka, T.5    Malberg, J.6    Tsuji, S.7    Duman, R.S.8
  • 50
    • 33748978945 scopus 로고    scopus 로고
    • Neurorestorative treatment of stroke: Cell and pharmacological approaches
    • A focused review of the role and inter-relationships of statins, erythropoietin, sildenafil/NO pathway and cell-based strategies as therapeutics in a new paradigm for stroke treatment, •
    • Chen J, Chopp M: Neurorestorative treatment of stroke: Cell and pharmacological approaches. NeuroRx (2006) 3(4):466-473. • A focused review of the role and inter-relationships of statins, erythropoietin, sildenafil/NO pathway and cell-based strategies as therapeutics in a new paradigm for stroke treatment.
    • (2006) NeuroRx , vol.3 , Issue.4 , pp. 466-473
    • Chen, J.1    Chopp, M.2
  • 51
    • 34848926902 scopus 로고    scopus 로고
    • Blockade of phosphodiesterase type 5 enhances rat neurohypophysial excitability and electrically evoked oxytocin release
    • Zhang Z, Klyachko V, Jackson MB: Blockade of phosphodiesterase type 5 enhances rat neurohypophysial excitability and electrically evoked oxytocin release. J Physiol (2007) 584(1):137-147.
    • (2007) J Physiol , vol.584 , Issue.1 , pp. 137-147
    • Zhang, Z.1    Klyachko, V.2    Jackson, M.B.3
  • 52
    • 33646337394 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of neural repair after stroke: Making waves
    • A contemporary overview of the natural history of NR following stroke, •
    • Carmichael ST: Cellular and molecular mechanisms of neural repair after stroke: Making waves. Ann Neurol (2006) 59(5):735-742 • A contemporary overview of the natural history of NR following stroke.
    • (2006) Ann Neurol , vol.59 , Issue.5 , pp. 735-742
    • Carmichael, S.T.1
  • 53
    • 0346096686 scopus 로고    scopus 로고
    • Neurogenesis and brain injury: Managing a renewable resource for repair
    • An overview of adult neurogenesis, limitations for self repair, and physiological and pharmacological strategies for upregulation, •
    • Hallbergson AF, Gnatenco C, Peterson DA: Neurogenesis and brain injury: Managing a renewable resource for repair. J Clin Invest (2003) 112(8):1128-1133. • An overview of adult neurogenesis, limitations for self repair, and physiological and pharmacological strategies for upregulation.
    • (2003) J Clin Invest , vol.112 , Issue.8 , pp. 1128-1133
    • Hallbergson, A.F.1    Gnatenco, C.2    Peterson, D.A.3


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