Temporal study of acetaminophen (APAP) and S-adenosyl-l-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity

Toxicology and Applied Pharmacology

Volumn 247, Issue 1, 2010, Pages 1-9

  Brown, J Michael ^a   Ball, John G ^a   Hogsett, Amy ^a   Williams, Tierra ^a   Valentovic, Monica ^a  

^a MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen; Hepatotoxicity; Methionine adenosyltransferase; S adenosyl l methionine; S adenosylhomocysteine

Indexed keywords

METHIONINE ADENOSYLTRANSFERASE; PARACETAMOL; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; WESTERN BLOTTING;

ACETAMINOPHEN; ANIMALS; BODY WEIGHT; DRUG INTERACTIONS; DRUG-INDUCED LIVER INJURY; INTRACELLULAR SPACE; LIVER; MALE; METHIONINE ADENOSYLTRANSFERASE; MICE; MICE, INBRED BALB C; ORGAN SIZE; PROTECTIVE AGENTS; S-ADENOSYLMETHIONINE;

MUS;

EID: 77954761902     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.04.018     Document Type: Article

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