Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice

Biochemical Pharmacology

Volumn 80, Issue 6, 2010, Pages 920-931

  Tanaka, Ken Ichiro ^a   Tanaka, Yuta ^a   Namba, Takushi ^a   Azuma, Arata ^b   Mizushima, Tohru ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Bleomycin; Epithelial mesenchymal transition; Geranylgeranylacetone; Heat shock protein 70; Idiopathic pulmonary fibrosis; Transforming growth factor 1

Indexed keywords

BLEOMYCIN; HEAT SHOCK PROTEIN 70; TEPRENONE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL PROTECTION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME REPRESSION; EPITHELIUM CELL; FIBROBLAST; FIBROSING ALVEOLITIS; IN VITRO STUDY; INFLAMMATION; LUNG INJURY; MALE; MESENCHYME CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; BLEOMYCIN; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INFLAMMATION MEDIATORS; MICE; MICE, TRANSGENIC; PULMONARY FIBROSIS;

EID: 77954760957     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.05.025     Document Type: Article

References (59)

1. American Thoracic Society Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med 2000, 161:646-664.
2. Bjoraker J.A., Ryu J.H., Edwin M.K., Myers J.L., Tazelaar H.D., Schroeder D.R., et al. Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998, 157:199-203.
3. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002, 165:277-304.
4. Walter N., Collard H.R., King T.E. Current perspectives on the treatment of idiopathic pulmonary fibrosis. Proc Am Thorac Soc 2006, 3:330-338.
5. Moore B.B., Hogaboam C.M. Murine models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2008, 294:L152-L160.
6. Kinnula V.L., Myllarniemi M. Oxidant-antioxidant imbalance as a potential contributor to the progression of human pulmonary fibrosis. Antioxid Redox Signal 2008, 10:727-738.
7. Sheppard D. Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc 2006, 3:413-417.
8. Kisseleva T., Brenner D.A. Fibrogenesis of parenchymal organs. Proc Am Thorac Soc 2008, 5:338-342.
9. Willis B.C., Borok Z. TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 2007, 293:L525-L534.
10. Bartram U., Speer C.P. The role of transforming growth factor beta in lung development and disease. Chest 2004, 125:754-765.
11. Kasai H., Allen J.T., Mason R.M., Kamimura T., Zhang Z. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 2005, 6:56.
12. Kim K.K., Kugler M.C., Wolters P.J., Robillard L., Galvez M.G., Brumwell A.N., et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci USA 2006, 103:13180-13185.
13. Kim Y., Kugler M.C., Wei Y., Kim K.K., Li X., Brumwell A.N., et al. Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts. J Cell Biol 2009, 184:309-322.
14. Wu Z., Yang L., Cai L., Zhang M., Cheng X., Yang X., et al. Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. Respir Res 2007, 8:1.
15. Kim K.K., Wei Y., Szekeres C., Kugler M.C., Wolters P.J., Hill M.L., et al. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 2009, 119:213-224.
16. Mathew A., Morimoto R.I. Role of the heat-shock response in the life and death of proteins. Ann N Y Acad Sci 1998, 851:99-111.
17. Hirakawa T., Rokutan K., Nikawa T., Kishi K. Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology 1996, 111:345-357.
18. Tang D., Kang R., Xiao W., Wang H., Calderwood S.K., Xiao X. The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages. J Immunol 2007, 179:1236-1244.
19. Weiss Y.G., Maloyan A., Tazelaar J., Raj N., Deutschman C.S. Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. J Clin Invest 2002, 110:801-806.
20. Koh Y., Lim C.M., Kim M.J., Shim T.S., Lee S.D., Kim W.S., et al. Heat shock response decreases endotoxin-induced acute lung injury in rats. Respirology 1999, 4:325-330.
21. Hagiwara S., Iwasaka H., Matsumoto S., Noguchi T., Yoshioka H. Association between heat stress protein 70 induction and decreased pulmonary fibrosis in an animal model of acute lung injury. Lung 2007, 185:287-293.
22. Singleton K.D., Wischmeyer P.E. Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis. Am J Physiol Lung Cell Mol Physiol 2006, 290:L956-L961.
23. Tanaka K., Namba T., Arai Y., Fujimoto M., Adachi H., Sobue G., et al. Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. J Biol Chem 2007, 282:23240-23252.
24. Woessner J.F. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 1961, 93:440-447.
25. Mima S., Tsutsumi S., Ushijima H., Takeda M., Fukuda I., Yokomizo K., et al. Induction of claudin-4 by nonsteroidal anti-inflammatory drugs and its contribution to their chemopreventive effect. Cancer Res 2005, 65:1868-1876.
26. Lovgren A.K., Jania L.A., Hartney J.M., Parsons K.K., Audoly L.P., Fitzgerald G.A., et al. COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2006, 291:L144-L156.
27. Plumier J.C., Ross B.M., Currie R.W., Angelidis C.E., Kazlaris H., Kollias G., et al. Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery. J Clin Invest 1995, 95:1854-1860.
28. Ishii H., Mukae H., Kakugawa T., Iwashita T., Kaida H., Fujii T., et al. Increased expression of collagen-binding heat shock protein 47 in murine bleomycin-induced pneumopathy. Am J Physiol Lung Cell Mol Physiol 2003, 285:L957-L963.
29. Inoue K., Takano H., Yanagisawa R., Sakurai M., Abe S., Yoshino S., et al. Effects of nanoparticles on lung physiology in the presence or absence of antigen. Int J Immunopathol Pharmacol 2007, 20:737-744.
30. Peinado H., Olmeda D., Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?. Nat Rev Cancer 2007, 7:415-428.
31. Thiery J.P., Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 2006, 7:131-142.
32. Suemasu S., Tanaka K., Namba T., Ishihara T., Katsu T., Fujimoto M., et al. A role for HSP70 in protecting against indomethacin-induced gastric lesions. J Biol Chem 2009, 284:19705-19715.
33. Tanaka K., Tsutsumi S., Arai Y., Hoshino T., Suzuki K., Takaki E., et al. Genetic evidence for a protective role of heat shock factor 1 against irritant-induced gastric lesions. Mol Pharmacol 2007, 71:985-993.
34. Asano T., Tanaka K., Yamakawa N., Adachi H., Sobue G., Goto H., et al. HSP70 confers protection against indomethacin-induced lesions of the small intestine. J Pharmacol Exp Ther 2009, 330:458-467.
35. Matsuda M., Hoshino T., Yamashita Y., Tanaka K.I., Maji D., Sato K., et al. Prevention of ultraviolet B radiation-induced epidermal damage by expression of heat shock protein 70. J Biol Chem 2009.
36. Gupte A.A., Bomhoff G.L., Swerdlow R.H., Geiger P.C. Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet. Diabetes 2009, 58:567-578.
37. Katsuno M., Sang C., Adachi H., Minamiyama M., Waza M., Tanaka F., et al. Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease. Proc Natl Acad Sci USA 2005, 102:16801-16806.
38. Kuboki S., Schuster R., Blanchard J., Pritts T.A., Wong H.R., Lentsch A.B. Role of heat shock protein 70 in hepatic ischemia-reperfusion injury in mice. Am J Physiol Gastrointest Liver Physiol 2007, 292:G1141-G1149.
39. Ohkawara T., Nishihira J., Takeda H., Miyashita K., Kato K., Kato M., et al. Geranylgeranylacetone protects mice from dextran sulfate sodium-induced colitis. Scand J Gastroenterol 2005, 40:1049-1057.
40. Fujibayashi T., Hashimoto N., Jijiwa M., Hasegawa Y., Kojima T., Ishiguro N. Protective effect of geranylgeranylacetone, an inducer of heat shock protein 70, against drug-induced lung injury/fibrosis in an animal model. BMC Pulm Med 2009, 9:45.
41. Terano A., Hiraishi H., Ota S., Sugimoto T. Geranylgeranylacetone, a novel anti-ulcer drug, stimulates mucus synthesis and secretion in rat gastric cultured cells. Digestion 1986, 33:206-210.
42. Kunisaki C., Sugiyama M. Effect of teprenone on acute gastric mucosal lesions induced by cold-restraint stress. Digestion 1992, 53:45-53.
43. Ushijima H., Tanaka K., Takeda M., Katsu T., Mima S., Mizushima T. Geranylgeranylacetone protects membranes against nonsteroidal anti-inflammatory drugs. Mol Pharmacol 2005, 68:1156-1161.
44. Thannickal V.J., Horowitz J.C. Evolving concepts of apoptosis in idiopathic pulmonary fibrosis. Proc Am Thorac Soc 2006, 3:350-356.
45. Saleh A., Srinivasula S.M., Balkir L., Robbins P.D., Alnemri E.S. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol 2000, 2:476-483.
46. Beere H.M., Wolf B.B., Cain K., Mosser D.D., Mahboubi A., Kuwana T., et al. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2000, 2:469-475.
47. Ravagnan L., Gurbuxani S., Susin S.A., Maisse C., Daugas E., Zamzami N., et al. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol 2001, 3:839-843.
48. Jaattela M., Wissing D., Kokholm K., Kallunki T., Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J 1998, 17:6124-6134.
49. Li X., Zhang H., Soledad-Conrad V., Zhuang J., Uhal B.D. Bleomycin-induced apoptosis of alveolar epithelial cells requires angiotensin synthesis de novo. Am J Physiol Lung Cell Mol Physiol 2003, 284:L501-L507.
50. Lee V.Y., Schroedl C., Brunelle J.K., Buccellato L.J., Akinci O.I., Kaneto H., et al. Bleomycin induces alveolar epithelial cell death through JNK-dependent activation of the mitochondrial death pathway. Am J Physiol Lung Cell Mol Physiol 2005, 289:L521-L528.
51. Weiss Y.G., Bromberg Z., Raj N., Raphael J., Goloubinoff P., Ben-Neriah Y., et al. Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome. Crit Care Med 2007, 35:2128-2138.
52. Sullivan D.E., Ferris M., Pociask D., Brody A.R. The latent form of TGFbeta(1) is induced by TNFalpha through an ERK specific pathway and is activated by asbestos-derived reactive oxygen species in vitro and in vivo. J Immunotoxicol 2008, 5:145-149.
53. Mao H., Li Z., Zhou Y., Zhuang S., An X., Zhang B., et al. HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol 2008, 295:F202-F214.
54. Luo X., Zuo X., Zhou Y., Zhang B., Shi Y., Liu M., et al. Extracellular heat shock protein 70 inhibits tumour necrosis factor-alpha induced proinflammatory mediator production in fibroblast-like synoviocytes. Arthritis Res Ther 2008, 10:R41.
55. He S., Liu X., Yang Y., Huang W., Xu S., Yang S., et al. Mechanisms of transforming growth factor beta/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts. Br J Dermatol 2009.
56. Huber M.A., Azoitei N., Baumann B., Grunert S., Sommer A., Pehamberger H., et al. NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 2004, 114:569-581.
57. Moeller A., Ask K., Warburton D., Gauldie J., Kolb M. The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?. Int J Biochem Cell Biol 2008, 40:362-382.
58. Ask K., Labiris R., Farkas L., Moeller A., Froese A., Farncombe T., et al. Comparison between conventional and " clinical" assessment of experimental lung fibrosis. J Transl Med 2008, 6:16.
59. Luppi F., Cerri S., Beghe B., Fabbri L.M., Richeldi L. Corticosteroid and immunomodulatory agents in idiopathic pulmonary fibrosis. Respir Med 2004, 98:1035-1044.