Geranylgeranylacetone protects mice from dextran sulfate sodium-induced colitis

Scandinavian Journal of Gastroenterology

Volumn 40, Issue 9, 2005, Pages 1049-1057

  Ohkawara, Tatsuya ^a   Nishihira, Jun ^b   Takeda, Hiroshi ^a   Miyashita, Kencho ^a   Kato, Kanji ^a   Kato, Mototsugu ^a   Sugiyama, Toshiro ^c   Asaka, Masahiro ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b GeneticLab ^*  (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Cytokine; Dextran sulfate sodium induced colitis; Geranylgeranylacetone; Heat shock protein; Inflammatory bowel disease

Indexed keywords

DEXTRAN SULFATE; GAMMA INTERFERON; HEAT SHOCK PROTEIN 25; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; MYELOPEROXIDASE; TEPRENONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ARTICLE; COLITIS; CONTROLLED STUDY; DIARRHEA; DISEASE ACTIVITY; ENTERITIS; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECTUM HEMORRHAGE; STATISTICAL ANALYSIS; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ULCER AGENTS; BLOTTING, WESTERN; COLITIS; COLON; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; DITERPENES; FOLLOW-UP STUDIES; HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED BALB C; SEVERITY OF ILLNESS INDEX;

EID: 24744444076     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520510023161     Document Type: Article

References (38)

1. Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002;347:417-29.
2. Sartor RB. Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases. Am J Gastroenterol 1997;92 Suppl 12:55-11S.
3. Papadakis KA, Targan SR. Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu Rev Med 2000;51:289-98.
4. de Jong YP, Abadia-Molina AC, Satoskar AR, Clarke K, Rietdijk ST, Faubion WA, et al. Development of chronic colitis is dependent on the cytokine MIF. Nat Immunol 2001;2:1061-6.
5. Ohkawara T, Nishihira J, Takeda H, Hige S, Kato M, Sugiyama T, et al. Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice. Gastroenterology 2002;123:256-70.
6. van Dullemen HM, van Deventer SJ, Hommes DW, Bijl HA, Jansen J, Tytgat GN, et al. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 1995;109:129-35.
7. Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997;337:1029-35.
8. Bickston SJ, Lichtenstein GR, Arseneau KO, Cohen RB, Cominelli F. The relationship between infliximab treatment and lymphoma in Crohn's disease. Gastroenterology 1999;117:1433-7.
9. Keane J, Gershon S, Wise RP, Mirabile-Levens E, Kasznica J, Schwieterman WD, et al. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 2001;345:1098-104.
10. Pockley AG. Heat shock protein as regulators of the immune response. Lancet 2003;362:469-76.
11. Nakamura K, Rokutan K, Marui N, Aoike A, Kawai K. Induction of heat shock proteins and their implication in protection against ethanol-induced damage in cultured guinea pig gastric mucosal cells. Gastroenterology 1991;101:161-6.
12. Mestril R, Chi SH, Sayen MR, O'Reilly K, Dillmann WH. Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against stimulated ischemia-induced injury. J Clin Invest 1994;93:759-67.
13. Fujimori S, Otaka M, Otani S, Jin M, Okuyama A, Itoh S, et al. Induction of a 72-kDa heat shock protein and cytoprotection against thioacetamide-induced liver injury in rats. Dig Dis Sci 1997;42:1987-94.
14. Marber MS, Mestril R, Chi SH, Sayen MR, Yellon DM, Dillmann WH. Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. J Clin Invest 1995;95:1446-56.
15. Hutter JJ, Mestril R, Tam EK, Sievers RE, Dillmann WH, Wolfe CL. Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo. Circulation 1996;94:1408-11.
16. Ludwig D, Stahl M, Ibrahim ET, Wenzel BE, Drabicki D, Wecke A, et al. Enhanced intestinal expression of heat shock protein 70 in patients with inflammatory bowel disease. Dig Dis Sci 1999;44:1440-7.
17. Terano A, Shiga J, Hiraishi H, Ota S, Sugimoto T. Protective action of tetraprenylacetone against ethanol-induced damage in rat gastric mucosa. Digestion 1986;35:182-8.
18. Pappas TN, Mulvihill SJ, Goto Y, Debas HT. Advances in drug therapy for peptic ulcer disease. Arch Surg 1987;122: 447-50.
19. Bilski J, Sarosiek J, Murty VL, Aono M, Moriga M, Slomiany A, et al. Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone. Biochem Pharmacol 1987;36:4059-65.
20. Fujimoto M, Yamanaka T, Bessho M, Igarashi T. Effects of geranylgeranylacetone on gastrointestinal secretion. Eur J Pharmacol 1982;77:113-8.
21. Ito M, Tanaka T, Suzuki Y. Increasing action of teprenone, a new antiulcer agent, on high-molecular-weight glycoprotein in gastric mucus during the healing process of acetic acid-induced ulcer in rats. Jpn J Pharmacol 1986;41:117-25.
22. Hirakawa T, Rokutan K, Nikawa T, Kishi K. Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology 1996;111:325-37.
23. Yamagami K, Yamamoto Y, Ishikawa Y, Yonezawa K, Toyokuni S, Yamaoka Y. Effects of geranyl-geranyl-acetone administration before heat shock preconditioning for conferring tolerance against ischemia-reperfusion injury in rat livers. J Lab Clin Med 2000;135:465-75.
24. Ooie T, Takahashi N, Saikawa T, Nawata T, Arikawa M, Yamanaka K, et al. Single oral dose of geranylgeranylacetone induces heat-shock protein 72 and renders protection against ischemia/repermsion injury in rat heart. Circulation 2001;104:1837-43.
25. Unoshima M, Iwasaka H, Eto J, Takita-Sonoda Y, Noguchi T, Nishizono A. Antiviral effects of geranylgeranylacetone: enhancement of MxA expression and phosphorylation of PKR during influenza virus infection. Antimicrob Agents Chemother 2003;47:2914-21.
26. Cooper HS, Murthy SN, Shah RS, Sedergran DJ. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 1993;69:238-49.
27. Krawisz JE, Sharon P, Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 1984;87:1344-50.
28. Benjamin IJ, McMIllan DR. Stress (heat shock) proteins molecular chaperones. Circ Res ;;83 1998;27:117-32.
29. Baca-Estrada ME, Gupta RS, Stead RH, Croitoru K. Intestinal expression and cellular immune responses to human heat-shock protein 60 in Crohn's disease. Dig Dis Sci 1994;39:498-506.
30. Stahl M, Ludwig D, Fellermann K, Stange EF. Intestinal expression of human heat shock protein 90 in patients with Crohn's disease and ulcerative colitis. Dig Dis Sci 1998;43:1079-87.
31. Oda H, Miyake H, Iwata T, Kusumoto K, Rokutan K, Tashiro S. Geranylgeranylacetone suppresses inflammatory responses and improves survival after massive hepatectomy in rats. J Gastrointest Surg 2002;6:464-73.
32. Tsuruma T, Yagihashi A, Koide S, Araya J, Tarumi K, Watanabe N, et al. Geranylgeranylacetone induces heat shock protein-73 in rat small intestine. Transplant Proc 1999;31:572-3.
33. Venkatraman A, Ramakrishna BS, Shaji RV, Nanda Kumar NS, Pulimood A, Patra S. Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-κB. Am J Physiol Gastrointest Liver Physiol 2003;285:G177-84.
34. Van Molle W, Wielockx B, Mahieu T, Takada M, Taniguchi T, Sekikawa K, et al. HSP70 protects against TNF-induced lethal inflammatory shock. Immunity 2002;16:685-95.
35. Kojima K, Musch MW, Ren H, Boone DL, Hendrickson BA, Ma A, et al. Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells. Gastroenterology 2003;124:1395-407.
36. Otani S, Otaka M, Jin M, Okuyama A, Itoh S, Iwabuchi A, et al. Effect of preinduction of heat shock proteins on acetic acid-induced colitis in rats. Dig Dis Sci 1997;42:833-46.
37. Urayama S, Musch MW, Retsky J, Madonna MB, Straus D, Chang EB. Dexamethasone protection of rat IEC against oxidant injury mediated by induction of heat shock protein 72. J Clin Invest 1998;102:1860-5.
38. Burress GC, Musch MW, Jurivich DA, Welk J, Chang EB. Effects of mesalamine on the hsp72 stress response in rat IEC-18 intestinal epithelial cells. Gastroenterology 1997;113:1474-9.