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Volumn 11, Issue 7, 2010, Pages 801-811

Micrornas in leukemias: Emerging diagnostic tools and therapeutic targets

Author keywords

Antagomir; Diagnostic; Hematopoiesis; Leukemia; Microrna; Mir; Therapeutic

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BCR ABL PROTEIN; CORE BINDING FACTOR; CORE BINDING FACTOR BETA; HIGH MOBILITY GROUP A PROTEIN; IMATINIB; LIPOSOME; LOCKED NUCLEIC ACID; MICRORNA; PROMYELOCYTIC LEUKEMIA PROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR RUNX1; VIRUS VECTOR;

EID: 77954755289     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945010791320872     Document Type: Article
Times cited : (8)

References (93)
  • 1
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75: 843-54.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 2
    • 0034708122 scopus 로고    scopus 로고
    • The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    • Reinhart BJ, Slack FJ, Basson M, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 2000; 403: 901-6.
    • (2000) Nature , vol.403 , pp. 901-906
    • Reinhart, B.J.1    Slack, F.J.2    Basson, M.3
  • 3
    • 0034597777 scopus 로고    scopus 로고
    • Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
    • Pasquinelli AE, Reinhart BJ, Slack F, et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 2000; 408: 86-9.
    • (2000) Nature , vol.408 , pp. 86-89
    • Pasquinelli, A.E.1    Reinhart, B.J.2    Slack, F.3
  • 4
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science 2004; 303: 83-6.
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 6
    • 25444520537 scopus 로고    scopus 로고
    • Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2
    • Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 2005; 102: 13944-9.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13944-13949
    • Cimmino, A.1    Calin, G.A.2
  • 7
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004; 101: 2999-3004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2999-3004
    • Calin, G.A.1    Sevignani, C.2    Dumitru, C.D.3
  • 8
    • 8144225486 scopus 로고    scopus 로고
    • MicroRNA genes are transcribed by RNA polymerase II
    • Lee Y, Kim M, Han J, et al. MicroRNA genes are transcribed by RNA polymerase II. EMBO J 2004; 23: 4051-60.
    • (2004) EMBO J , vol.23 , pp. 4051-4060
    • Lee, Y.1    Kim, M.2    Han, J.3
  • 9
    • 10644234841 scopus 로고    scopus 로고
    • The Drosha-DGCR8 complex in primary microRNA processing
    • Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 2004; 18: 3016-27.
    • (2004) Genes Dev , vol.18 , pp. 3016-3027
    • Han, J.1    Lee, Y.2    Yeom, K.H.3    Kim, Y.K.4    Jin, H.5    Kim, V.N.6
  • 10
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • Lee Y, Ahn C, Han J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003; 425: 415-9.
    • (2003) Nature , vol.425 , pp. 415-419
    • Lee, Y.1    Ahn, C.2    Han, J.3
  • 12
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvagner G, McLachlan J, Pasquinelli AE, Balint E, Tuschl T, Zamore PD. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 2001; 293: 834-8.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvagner, G.1    McLachlan, J.2    Pasquinelli, A.E.3    Balint, E.4    Tuschl, T.5    Zamore, P.D.6
  • 13
    • 77954742028 scopus 로고    scopus 로고
    • miR-10 in development and cancer
    • Lund AH. miR-10 in development and cancer. Cell Death Differ 2009.
    • (2009) Cell Death Differ
    • Lund, A.H.1
  • 14
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120: 15-20.
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 15
    • 67650519133 scopus 로고    scopus 로고
    • The RNA-induced silencing complex: A versatile gene-silencing machine
    • Pratt AJ, MacRae IJ. The RNA-induced silencing complex: a versatile gene-silencing machine. J Biol Chem 2009; 284: 17897-901.
    • (2009) J Biol Chem , vol.284 , pp. 17897-901
    • Pratt, A.J.1    Macrae, I.J.2
  • 16
    • 23944514849 scopus 로고    scopus 로고
    • Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
    • Bagga S, Bracht J, Hunter S, et al. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 2005; 122: 553-63.
    • (2005) Cell , vol.122 , pp. 553-563
    • Bagga, S.1    Bracht, J.2    Hunter, S.3
  • 17
    • 34547441263 scopus 로고    scopus 로고
    • Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR
    • Lytle JR, Yario TA, Steitz JA. Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR. Proc Natl Acad Sci USA 2007; 104: 9667-72.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 9667-9672
    • Lytle, J.R.1    Yario, T.A.2    Steitz, J.A.3
  • 18
    • 67650087599 scopus 로고    scopus 로고
    • New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites
    • Lee I, Ajay SS, Yook JI, et al. New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites. Genome Res 2009; 19: 1175-83.
    • (2009) Genome Res , vol.19 , pp. 1175-1183
    • Lee, I.1    Ajay, S.S.2    Yook, J.I.3
  • 19
    • 34548671165 scopus 로고    scopus 로고
    • Isolation of microRNA targets using biotinylated synthetic microRNAs
    • Orom UA, Lund AH. Isolation of microRNA targets using biotinylated synthetic microRNAs. Methods 2007; 43: 162-5.
    • (2007) Methods , vol.43 , pp. 162-165
    • Orom, U.A.1    Lund, A.H.2
  • 20
    • 55149109188 scopus 로고    scopus 로고
    • Regulation of microRNA processing in development, differentiation and cancer
    • Schmittgen TD. Regulation of microRNA processing in development, differentiation and cancer. J Cell Mol Med 2008; 12: 1811-9.
    • (2008) J Cell Mol Med , vol.12 , pp. 1811-1819
    • Schmittgen, T.D.1
  • 21
    • 24644489402 scopus 로고    scopus 로고
    • MicroRNA profiling of the murine hematopoietic system
    • Monticelli S, Ansel KM, Xiao C, et al. MicroRNA profiling of the murine hematopoietic system. Genome Biol 2005; 6: R71.
    • (2005) Genome Biol , vol.6
    • Monticelli, S.1    Ansel, K.M.2    Xiao, C.3
  • 22
    • 33644866985 scopus 로고    scopus 로고
    • Hematopoietic-specific microRNA expression in human cells
    • Ramkissoon SH, Mainwaring LA, Ogasawara Y, et al. Hematopoietic-specific microRNA expression in human cells. Leuk Res 2006; 30: 643-7.
    • (2006) Leuk Res , vol.30 , pp. 643-647
    • Ramkissoon, S.H.1    Mainwaring, L.A.2    Ogasawara, Y.3
  • 23
    • 33847304124 scopus 로고    scopus 로고
    • CD34+ hematopoietic stem-progenitor cell microRNA expression and function: A circuit diagram of differentiation control
    • Georgantas 3rd RW, Hildreth R, Morisot S, et al. CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci USA 2007; 104: 2750-5.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2750-2755
    • Georgantas 3rd, R.W.1    Hildreth, R.2    Morisot, S.3
  • 24
    • 51649111487 scopus 로고    scopus 로고
    • Differential expression of microRNAs in hematopoietic cell lineages
    • Merkerova M, Belickova M, Bruchova H. Differential expression of microRNAs in hematopoietic cell lineages. Eur J Haematol 2008; 81: 304-10.
    • (2008) Eur J Haematol , vol.81 , pp. 304-310
    • Merkerova, M.1    Belickova, M.2    Bruchova, H.3
  • 25
    • 28344438648 scopus 로고    scopus 로고
    • A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis
    • Fazi F, Rosa A, Fatica A, et al. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell 2005; 123: 819-31.
    • (2005) Cell , vol.123 , pp. 819-831
    • Fazi, F.1    Rosa, A.2    Fatica, A.3
  • 26
    • 34347383305 scopus 로고    scopus 로고
    • MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation
    • Fontana L, Pelosi E, Greco P, et al. MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol 2007; 9: 775-87.
    • (2007) Nat Cell Biol , vol.9 , pp. 775-787
    • Fontana, L.1    Pelosi, E.2    Greco, P.3
  • 27
    • 66549105485 scopus 로고    scopus 로고
    • Gfi1 regulates miR-21 and miR-196b to control myelopoiesis
    • Velu CS, Baktula AM, Grimes HL. Gfi1 regulates miR-21 and miR-196b to control myelopoiesis. Blood 2009; 113: 4720-8.
    • (2009) Blood , vol.113 , pp. 4720-4728
    • Velu, C.S.1    Baktula, A.M.2    Grimes, H.L.3
  • 28
    • 29144440077 scopus 로고    scopus 로고
    • MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation
    • Felli N, Fontana L, Pelosi E, et al. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci USA 2005; 102: 18081-6.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18081-18086
    • Felli, N.1    Fontana, L.2    Pelosi, E.3
  • 30
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002; 99: 15524-9.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3
  • 31
    • 34547854381 scopus 로고    scopus 로고
    • The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia
    • Calin GA, Pekarsky Y, Croce CM. The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia. Best Pract Res Clin Haematol 2007; 20: 425-37.
    • (2007) Best Pract Res Clin Haematol , vol.20 , pp. 425-437
    • Calin, G.A.1    Pekarsky, Y.2    Croce, C.M.3
  • 32
    • 33846190181 scopus 로고    scopus 로고
    • Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181
    • Pekarsky Y, Santanam U, Cimmino A, et al. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res 2006; 66: 11590-3.
    • (2006) Cancer Res , vol.66 , pp. 11590-11593
    • Pekarsky, Y.1    Santanam, U.2    Cimmino, A.3
  • 33
    • 0037076279 scopus 로고    scopus 로고
    • Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression
    • Bichi R, Shinton SA, Martin ES, et al. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci USA 2002; 99: 6955-60.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6955-6960
    • Bichi, R.1    Shinton, S.A.2    Martin, E.S.3
  • 34
    • 36149000639 scopus 로고    scopus 로고
    • MicroRNAs in the pathogeny of chronic lymphocytic leukaemia
    • Nicoloso MS, Kipps TJ, Croce CM, Calin GA. MicroRNAs in the pathogeny of chronic lymphocytic leukaemia. Br J Haematol 2007; 139: 709-16.
    • (2007) Br J Haematol , vol.139 , pp. 709-716
    • Nicoloso, M.S.1    Kipps, T.J.2    Croce, C.M.3    Calin, G.A.4
  • 35
    • 33644779735 scopus 로고    scopus 로고
    • The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation
    • Naguibneva I, Ameyar-Zazoua M, Polesskaya A, et al. The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation. Nat Cell Biol 2006; 8: 278-84.
    • (2006) Nat Cell Biol , vol.8 , pp. 278-284
    • Naguibneva, I.1    Ameyar-Zazoua, M.2    Polesskaya, A.3
  • 36
    • 27244434788 scopus 로고    scopus 로고
    • A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    • Calin GA, Ferracin M, Cimmino A, et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 2005; 353: 1793-801.
    • (2005) N Engl J Med , vol.353 , pp. 1793-1801
    • Calin, G.A.1    Ferracin, M.2    Cimmino, A.3
  • 37
    • 46849114097 scopus 로고    scopus 로고
    • Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase
    • Wu J, Meng F, Kong LY, et al. Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase. J Natl Cancer Inst 2008; 100: 926-39.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 926-939
    • Wu, J.1    Meng, F.2    Kong, L.Y.3
  • 38
    • 67651174451 scopus 로고    scopus 로고
    • Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors
    • Grosso S, Puissant A, Dufies M, et al. Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors. Mol Cancer Ther 2009; 8: 1924-33.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1924-1933
    • Grosso, S.1    Puissant, A.2    Dufies, M.3
  • 39
    • 58149328931 scopus 로고    scopus 로고
    • miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression
    • Pickering MT, Stadler BM, Kowalik TF. miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression. Oncogene 2009; 28: 140-5.
    • (2009) Oncogene , vol.28 , pp. 140-145
    • Pickering, M.T.1    Stadler, B.M.2    Kowalik, T.F.3
  • 40
    • 48249098902 scopus 로고    scopus 로고
    • Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM
    • Fontana L, Fiori ME, Albini S, et al. Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS One 2008; 3: e2236.
    • (2008) PLoS One , vol.3
    • Fontana, L.1    Fiori, M.E.2    Albini, S.3
  • 41
    • 57749114617 scopus 로고    scopus 로고
    • Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth
    • Agirre X, Jimenez-Velasco A, San Jose-Eneriz E, et al. Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth. Mol Cancer Res 2008; 6: 1830-40.
    • (2008) Mol Cancer Res , vol.6 , pp. 1830-1840
    • Agirre, X.1    Jimenez-Velasco, A.2    San Jose-Eneriz, E.3
  • 42
    • 44449149903 scopus 로고    scopus 로고
    • Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression
    • Bueno MJ, Perez de Castro I, Gomez de Cedron M, et al. Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell 2008; 13: 496-506.
    • (2008) Cancer Cell , vol.13 , pp. 496-506
    • Bueno, M.J.1    Perez de Castro, I.2    Gomez de Cedron, M.3
  • 43
    • 70350090620 scopus 로고    scopus 로고
    • MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABL1-mutations
    • San Jose-Eneriz E, Roman-Gomez J, Jimenez-Velasco A, et al. MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABL1-mutations. Mol Cancer 2009; 8: 69.
    • (2009) Mol Cancer , vol.8 , pp. 69
    • San Jose-Eneriz, E.1    Roman-Gomez, J.2    Jimenez-Velasco, A.3
  • 44
    • 37349032529 scopus 로고    scopus 로고
    • Molfetta GA, et al. miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia
    • Zanette DL, Rivadavia F, Molfetta GA, et al. miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia. Braz J Med Biol Res 2007; 40: 1435-40.
    • (2007) Braz J Med Biol Res , vol.40 , pp. 1435-1440
    • Zanette, D.L.1    Rivadavia, F.2
  • 45
    • 59249099105 scopus 로고    scopus 로고
    • Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia
    • Nagel S, Venturini L, Przybylski GK, et al. Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia. Leuk Lymphoma 2009; 50: 101-108.
    • (2009) Leuk Lymphoma , vol.50 , pp. 101-108
    • Nagel, S.1    Venturini, L.2    Przybylski, G.K.3
  • 46
    • 38049123402 scopus 로고    scopus 로고
    • MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
    • Mi S, Lu J, Sun M, et al. MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci USA 2007; 104: 19971-6.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19971-19976
    • Mi, S.1    Lu, J.2    Sun, M.3
  • 47
    • 70350233444 scopus 로고    scopus 로고
    • Characterization of B- and T-lineage acute lymphoblastic leukemia by integrated analysis of MicroRNA and mRNA expression profiles
    • Fulci V, Colombo T, Chiaretti S, et al. Characterization of B- and T-lineage acute lymphoblastic leukemia by integrated analysis of MicroRNA and mRNA expression profiles. Genes Chromosomes Cancer 2009; 48: 1069-82.
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 1069-1082
    • Fulci, V.1    Colombo, T.2    Chiaretti, S.3
  • 48
    • 60149100762 scopus 로고    scopus 로고
    • Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia
    • Schotte D, Chau JC, Sylvester G, et al. Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia. Leukemia 2009; 23: 313-22.
    • (2009) Leukemia , vol.23 , pp. 313-322
    • Schotte, D.1    Chau, J.C.2    Sylvester, G.3
  • 49
    • 42449141513 scopus 로고    scopus 로고
    • MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
    • Garzon R, Volinia S, Liu CG, et al. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 2008; 111: 3183-9.
    • (2008) Blood , vol.111 , pp. 3183-3189
    • Garzon, R.1    Volinia, S.2    Liu, C.G.3
  • 50
    • 46749108531 scopus 로고    scopus 로고
    • MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia
    • Jongen-Lavrencic M, Sun SM, Dijkstra MK, Valk PJ, Lowenberg B. MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia. Blood 2008; 111: 5078-85.
    • (2008) Blood , vol.111 , pp. 5078-5085
    • Jongen-Lavrencic, M.1    Sun, S.M.2    Dijkstra, M.K.3    Valk, P.J.4    Lowenberg, B.5
  • 51
    • 55749099505 scopus 로고    scopus 로고
    • Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
    • Li Z, Lu J, Sun M, et al. Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci USA 2008; 105: 15535-40.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15535-40
    • Li, Z.1    Lu, J.2    Sun, M.3
  • 53
    • 52149092181 scopus 로고    scopus 로고
    • Clinical significance of the most common chromosome translocations in adult acute myeloid leukemia
    • Mrozek K, Bloomfield CD. Clinical significance of the most common chromosome translocations in adult acute myeloid leukemia. J Natl Cancer Inst Monogr 2008; (39): 52-7.
    • (2008) J Natl Cancer Inst Monogr , Issue.39 , pp. 52-57
    • Mrozek, K.1    Bloomfield, C.D.2
  • 55
    • 73949118737 scopus 로고    scopus 로고
    • MicroRNA 29b functions in acute myeloid leukemia
    • Garzon R, Heaphy CE, Havelange V, et al. MicroRNA 29b functions in acute myeloid leukemia. Blood 2009; 114: 5331-41.
    • (2009) Blood , vol.114 , pp. 5331-5341
    • Garzon, R.1    Heaphy, C.E.2    Havelange, V.3
  • 56
    • 59149104026 scopus 로고    scopus 로고
    • Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias
    • Li Z, Luo RT, Mi S, et al. Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias. Cancer Res 2009; 69: 1109-16.
    • (2009) Cancer Res , vol.69 , pp. 1109-1116
    • Li, Z.1    Luo, R.T.2    Mi, S.3
  • 58
    • 44949221144 scopus 로고    scopus 로고
    • MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression
    • Erfurth FE, Popovic R, Grembecka J, et al. MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression. Proc Natl Acad Sci USA 2008; 105: 7517-22.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7517-7522
    • Erfurth, F.E.1    Popovic, R.2    Grembecka, J.3
  • 59
    • 2142654329 scopus 로고    scopus 로고
    • MicroRNA-directed cleavage of HOXB8 mRNA
    • Yekta S, Shih IH, Bartel DP. MicroRNA-directed cleavage of HOXB8 mRNA. Science 2004; 304: 594-6.
    • (2004) Science , vol.304 , pp. 594-596
    • Yekta, S.1    Shih, I.H.2    Bartel, D.P.3
  • 60
    • 65349148562 scopus 로고    scopus 로고
    • Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization
    • Popovic R, Riesbeck LE, Velu CS, et al. Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization. Blood 2009; 113: 3314-22.
    • (2009) Blood , vol.113 , pp. 3314-3322
    • Popovic, R.1    Riesbeck, L.E.2    Velu, C.S.3
  • 61
    • 42949083345 scopus 로고    scopus 로고
    • MicroRNA expression in cytogenetically normal acute myeloid leukemia
    • Marcucci G, Radmacher MD, Maharry K, et al. MicroRNA expression in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008; 358: 1919-28.
    • (2008) N Engl J Med , vol.358 , pp. 1919-1928
    • Marcucci, G.1    Radmacher, M.D.2    Maharry, K.3
  • 62
    • 41649119008 scopus 로고    scopus 로고
    • Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin
    • Garzon R, Garofalo M, Martelli MP, et al. Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci USA 2008; 105: 3945-50.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3945-3950
    • Garzon, R.1    Garofalo, M.2    Martelli, M.P.3
  • 63
    • 0037733977 scopus 로고    scopus 로고
    • Antisense technologies. Improvement through novel chemical modifications
    • Kurreck J. Antisense technologies. Improvement through novel chemical modifications. Eur J Biochem 2003; 270: 1628-44.
    • (2003) Eur J Biochem , vol.270 , pp. 1628-1644
    • Kurreck, J.1
  • 65
    • 33745299723 scopus 로고    scopus 로고
    • Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
    • Grimm D, Streetz KL, Jopling CL, et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 2006; 441: 537-41.
    • (2006) Nature , vol.441 , pp. 537-541
    • Grimm, D.1    Streetz, K.L.2    Jopling, C.L.3
  • 66
    • 1242316928 scopus 로고    scopus 로고
    • Biodistribution of phosphodiester and phosphorothioate siRNA
    • Braasch DA, Paroo Z, Constantinescu A, et al. Biodistribution of phosphodiester and phosphorothioate siRNA. Bioorg Med Chem Lett 2004; 14: 1139-43.
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 1139-1143
    • Braasch, D.A.1    Paroo, Z.2    Constantinescu, A.3
  • 67
    • 0035113736 scopus 로고    scopus 로고
    • Locked nucleic acid (LNA): Fine-tuning the recognition of DNA and RNA
    • Braasch DA, Corey DR. Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA. Chem Biol 2001; 8: 1-7.
    • (2001) Chem Biol , vol.8 , pp. 1-7
    • Braasch, D.A.1    Corey, D.R.2
  • 68
    • 32944454941 scopus 로고    scopus 로고
    • Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
    • Judge AD, Bola G, Lee AC, MacLachlan I. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol Ther 2006; 13: 494-505.
    • (2006) Mol Ther , vol.13 , pp. 494-505
    • Judge, A.D.1    Bola, G.2    Lee, A.C.3    Maclachlan, I.4
  • 69
    • 34250679405 scopus 로고    scopus 로고
    • Specificity, duplex degradation and subcellular localization of antagomirs
    • Krutzfeldt J, Kuwajima S, Braich R, et al. Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic Acids Res 2007; 35: 2885-92.
    • (2007) Nucleic Acids Res , vol.35 , pp. 2885-2892
    • Krutzfeldt, J.1    Kuwajima, S.2    Braich, R.3
  • 70
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with 'antagomirs'
    • Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005; 438: 685-9.
    • (2005) Nature , vol.438 , pp. 685-689
    • Krutzfeldt, J.1    Rajewsky, N.2    Braich, R.3
  • 71
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • Soutschek J, Akinc A, Bramlage B, et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 2004; 432: 173-8.
    • (2004) Nature , vol.432 , pp. 173-178
    • Soutschek, J.1    Akinc, A.2    Bramlage, B.3
  • 72
    • 33646185371 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in non-human primates
    • Zimmermann TS, Lee AC, Akinc A, et al. RNAi-mediated gene silencing in non-human primates. Nature 2006; 441: 111-4.
    • (2006) Nature , vol.441 , pp. 111-114
    • Zimmermann, T.S.1    Lee, A.C.2    Akinc, A.3
  • 73
    • 35148845281 scopus 로고    scopus 로고
    • Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway
    • John M, Constien R, Akinc A, et al. Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway. Nature 2007; 449: 745-7.
    • (2007) Nature , vol.449 , pp. 745-747
    • John, M.1    Constien, R.2    Akinc, A.3
  • 74
    • 0032473890 scopus 로고    scopus 로고
    • LNA (locked nucleic acids): Synthesis of the adenine, cytosine, guanine,5-methylcytosine, thymine, and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition
    • Koshkin AA, Singh SK, Nielsen P, et al. LNA (locked nucleic acids): synthesis of the adenine, cytosine, guanine,5-methylcytosine, thymine, and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition. Tetrahedron 1998: 3607-30.
    • (1998) Tetrahedron , pp. 3607-3630
    • Koshkin, A.A.1    Singh, S.K.2    Nielsen, P.3
  • 75
    • 0032560835 scopus 로고    scopus 로고
    • Stability and structural features of the duplexes containing nucleoside analogues with fixed N-type conformation, 2'-O,4'C'methyleneribonucleosides
    • Obika S, Nanbu D, Hari Y, et al. Stability and structural features of the duplexes containing nucleoside analogues with fixed N-type conformation, 2'-O,4'C'methyleneribonucleosides. Tetrahedron Lett 1998: 5401-4.
    • (1998) Tetrahedron Lett , pp. 5401-5404
    • Obika, S.1    Nanbu, D.2    Hari, Y.3
  • 76
    • 13744250159 scopus 로고    scopus 로고
    • Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
    • Elmen J, Thonberg H, Ljungberg K, et al. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Res 2005; 33: 439-47.
    • (2005) Nucleic Acids Res , vol.33 , pp. 439-447
    • Elmen, J.1    Thonberg, H.2    Ljungberg, K.3
  • 77
    • 45549091185 scopus 로고    scopus 로고
    • Locked nucleic acid holds promise in the treatment of cancer
    • Frieden M, Orum H. Locked nucleic acid holds promise in the treatment of cancer. Curr Pharm Des 2008; 14: 1138-42.
    • (2008) Curr Pharm Des , vol.14 , pp. 1138-1142
    • Frieden, M.1    Orum, H.2
  • 78
    • 6344277190 scopus 로고    scopus 로고
    • LNA (locked nucleic acid): High-affinity targeting of complementary RNA and DNA
    • Vester B, Wengel J. LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA. Biochem 2004; 43: 13233-41.
    • (2004) Biochem , vol.43 , pp. 13233-41
    • Vester, B.1    Wengel, J.2
  • 79
    • 2442496406 scopus 로고    scopus 로고
    • Sequence-dependent thermodynamic parameters for locked nucleic acid (LNA)-DNA duplex formation
    • McTigue PM, Peterson RJ, Kahn JD. Sequence-dependent thermodynamic parameters for locked nucleic acid (LNA)-DNA duplex formation. Biochemistry 2004; 43: 5388-405.
    • (2004) Biochemistry , vol.43 , pp. 5388-5405
    • McTigue, P.M.1    Peterson, R.J.2    Kahn, J.D.3
  • 80
    • 0032539693 scopus 로고    scopus 로고
    • A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics
    • SantaLucia J Jr. A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. Proc Natl Acad Sci USA 1998; 95: 1460-5.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1460-1465
    • Santalucia Jr., J.1
  • 81
    • 63349085394 scopus 로고    scopus 로고
    • A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference
    • Lu Y, Xiao J, Lin H, et al. A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference. Nucleic Acids Res 2009; 37: e24.
    • (2009) Nucleic Acids Res , vol.37
    • Lu, Y.1    Xiao, J.2    Lin, H.3
  • 82
    • 51049092308 scopus 로고    scopus 로고
    • Factors affecting the clearance and biodistribution of polymeric nanoparticles
    • Alexis F, Pridgen E, Molnar LK, Farokhzad OC. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm 2008; 5: 505-15.
    • (2008) Mol Pharm , vol.5 , pp. 505-515
    • Alexis, F.1    Pridgen, E.2    Molnar, L.K.3    Farokhzad, O.C.4
  • 83
    • 70349707110 scopus 로고    scopus 로고
    • Gene therapy: The first approved gene-based medicines, molecular mechanisms and clinical indications
    • Raty JK, Pikkarainen JT, Wirth T, Yla-Herttuala S. Gene therapy: the first approved gene-based medicines, molecular mechanisms and clinical indications. Curr Mol Pharmacol 2008; 1: 13-23.
    • (2008) Curr Mol Pharmacol , vol.1 , pp. 13-23
    • Raty, J.K.1    Pikkarainen, J.T.2    Wirth, T.3    Yla-Herttuala, S.4
  • 84
    • 33746833330 scopus 로고    scopus 로고
    • Targeting lentiviral vectors to specific cell types in vivo
    • Yang L, Bailey L, Baltimore D, Wang P. Targeting lentiviral vectors to specific cell types in vivo. Proc Natl Acad Sci USA 2006; 103: 11479-84.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11479-84
    • Yang, L.1    Bailey, L.2    Baltimore, D.3    Wang, P.4
  • 85
    • 66449136951 scopus 로고    scopus 로고
    • Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
    • Kota J, Chivukula RR, O'Donnell KA, et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 2009; 137: 1005-17.
    • (2009) Cell , vol.137 , pp. 1005-1017
    • Kota, J.1    Chivukula, R.R.2    O'Donnell, K.A.3
  • 86
    • 38049066025 scopus 로고    scopus 로고
    • Lentivirus-mediated antagomir expression for specific inhibition of miRNA function
    • Scherr M, Venturini L, Battmer K, et al. Lentivirus-mediated antagomir expression for specific inhibition of miRNA function. Nucleic Acids Res 2007; 35: e149.
    • (2007) Nucleic Acids Res , vol.35
    • Scherr, M.1    Venturini, L.2    Battmer, K.3
  • 87
    • 34548316982 scopus 로고    scopus 로고
    • MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells
    • Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods 2007; 4: 721-6.
    • (2007) Nat Methods , vol.4 , pp. 721-726
    • Ebert, M.S.1    Neilson, J.R.2    Sharp, P.A.3
  • 88
    • 33746850115 scopus 로고    scopus 로고
    • RNA-Mediated Gene Silencing in Hematopoietic Cells
    • Venturini L, Eder M, Scherr M. RNA-Mediated Gene Silencing in Hematopoietic Cells. J Biomed Biotechnol 2006; 2006: 87340.
    • (2006) J Biomed Biotechnol , vol.2006 , pp. 87340
    • Venturini, L.1    Eder, M.2    Scherr, M.3
  • 89
    • 66449136951 scopus 로고    scopus 로고
    • Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
    • Kota J, Chivukula RR, O'Donnell KA, et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 2009; 137: 1005-17.
    • (2009) Cell , vol.137 , pp. 1005-1017
    • Kota, J.1    Chivukula, R.R.2    O'Donnell, K.A.3
  • 90
    • 36849044732 scopus 로고    scopus 로고
    • Nonviral delivery of synthetic siRNAs in vivo
    • Akhtar S, Benter IF. Nonviral delivery of synthetic siRNAs in vivo. J Clin Invest 2007; 117: 3623-32.
    • (2007) J Clin Invest , vol.117 , pp. 3623-3632
    • Akhtar, S.1    Benter, I.F.2
  • 91
    • 34548532823 scopus 로고    scopus 로고
    • Targeted delivery systems of small interfering RNA by systemic administration
    • Kawakami S, Hashida M. Targeted delivery systems of small interfering RNA by systemic administration. Drug Metab Pharmacokinet 2007; 22: 142-51.
    • (2007) Drug Metab Pharmacokinet , vol.22 , pp. 142-151
    • Kawakami, S.1    Hashida, M.2
  • 92
    • 66149115277 scopus 로고    scopus 로고
    • IFNalpha activates dormant haematopoietic stem cells in vivo
    • Essers MA, Offner S, Blanco-Bose WE, et al. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 2009; 458: 904-8.
    • (2009) Nature , vol.458 , pp. 904-908
    • Essers, M.A.1    Offner, S.2    Blanco-Bose, W.E.3
  • 93
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391: 806-11.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6


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