RNA-mediated gene silencing in hematopoietic cells

Journal of Biomedicine and Biotechnology

Volumn 2006, Issue , 2006, Pages

  Venturini, Letizia ^a   Eder, Matthias ^a   Scherr, Michaela ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 [6 METHOXY 7 [3 (1 PIPERIDINYL)PROPOXY] 4 QUINAZOLINYL] 1 PIPERAZINECARBOXYLIC ACID (4 ISOPROPOXYPHENYL)AMIDE; BCR ABL PROTEIN; COMPLEMENTARY RNA; DOUBLE STRANDED RNA; FLT3 LIGAND; HYBRID PROTEIN; IMATINIB; INTERLEUKIN 3; MESSENGER RNA; MICRORNA; MICRORNA 142; MICRORNA 181; MICRORNA 223; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; RNA; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

ANIMAL CELL; CAENORHABDITIS ELEGANS; CANCER; EUKARYOTE; GENE EXPRESSION; GENE FUSION; GENE SEQUENCE; GENE SILENCING; HEMATOLOGIC MALIGNANCY; HEMATOPOIESIS; HEMATOPOIETIC CELL; IN VITRO STUDY; IN VIVO STUDY; INFECTION; LEUKEMOGENESIS; METHODOLOGY; MOLECULAR BIOLOGY; NONHUMAN; REGULATORY MECHANISM; REVIEW; RNA BINDING; RNA DEGRADATION; RNA INTERFERENCE; RNA TRANSLATION;

EUKARYOTA;

EID: 33746850115     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/JBB/2006/87340     Document Type: Review

References (167)

1. A Fire S Xu M K Montgomery S A Kostas S E Driver C C Mello Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 6669 1998 806 811
2. S N Covey N S Al-Kaff A Lángara D S Turner Plants combat infection by gene silencing. Nature 385 6619 1997 781 782
3. J A Lindbo L Silva-Rosales W M Proebsting W G Dougherty Induction of a highly specific antiviral state in transgenic plants: implications for regulation of gene expression and virus resistance. Plant Cell 5 12 1993 1749 1759
4. C Napoli C Lemieux R Jorgensen Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 2 4 1990 279 289
5. F G Ratcliff S A MacFarlane D C Baulcombe baulcombe@bbsrc.ac.uk Gene silencing without DNA: RNA-mediated cross-protection between viruses. Plant Cell 11 7 1999 1207 1216
6. R van Blokland M ten Lohuis P Meyer Condensation of chromatin in transcriptional regions of an inactivated plant transgene: evidence for an active role of transcription in gene silencing. Molecular and General Genetics 257 1 1997 1 13
7. A R Van Der Krol L A Mur M Beld J NM Mol A R Stuitje Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression. Plant Cell 2 4 1990 291 299
8. V Ambros vra@dartmouth.edu The functions of animal microRNAs. Nature 431 7006 2004 350 355
9. D P Bartel dbartel@wi.mit.edu MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116 2 2004 281 297
10. W Filipowicz filipowi@fmi.ch RNAi: the nuts and bolts of the RISC machine. Cell 122 1 2005 17 20
11. G J Hannon hannon@cshl.edu J J Rossi JRossi@coh.org Unlocking the potential of the human genome with RNA interference. Nature 431 7006 2004 371 378
12. L He G J Hannon MicroRNAs: small RNAs with a big role in gene regulation. Nature Reviews Genetics 5 7 2004 522 531
13. M A Matzke marjori.matzke@gmi.oeaw.ac.at J A Birchler BirchlerJ@missouri.edu RNAi-mediated pathways in the nucleus. Nature Reviews Genetics 6 1 2005 24 35
14. G Meister T Tuschl ttuschl@rockefeller.edu Mechanisms of gene silencing by double-stranded RNA. Nature 431 7006 2004 343 349
15. Y Tomari P D Zamore phillip.zamore@umassmed.edu Perspective: machines for RNAi. Genes and Development 19 5 2005 517 529
16. P D Zamore B Haley Ribo-gnome: the big world of small RNAs. Science 309 5740 2005 1519 1524
17. O Voinnet olivier.voinnet@ibmp-ulp.u-strasbg.fr Induction and suppression of RNA silencing: insights from viral infections. Nature Reviews Genetics 6 3 2005 206 220
18. A A Aravin N M Naumova A V Tulin V V Vagin Y M Rozovsky V A Gvozdev Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline. Current Biology 11 13 2001 1017 1027
19. E Bernstein A A Caudy S M Hammond G J Hannon Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409 6818 2001 363 366
20. H Tabara E Yigit H Siomi C C Mello The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-Box helicase to direct RNAi in C. elegans. Cell 109 7 2002 861 871
21. S M Elbashir W Lendeckel T Tuschl RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes and Development 15 2 2001 188 200
22. B J Reinhart F J Slack M Basson The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403 6772 2000 901 906
23. C-Z Chen L Li H F Lodish lodish@wi.mit.edu D P Bartel MicroRNAs modulate hematopoietic lineage differentiation. Science 303 5654 2004 83 86
24. J Brennecke D R Hipfner A Stark R B Russell S M Cohen cohen@embl.de bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113 1 2003 25 36
25. X Cai C H Hagedorn B R Cullen culle002@mc.duke.edu Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10 12 2004 1957 1966
26. Y Lee M Kim J Han MicroRNA genes are transcribed by RNA polymerase II. EMBO Journal 23 20 2004 4051 4060
27. V N Kim narrykim@snu.ac.kr MicroRNA biogenesis: coordinated cropping and dicing. Nature Reviews. Molecular Cell Biology 6 5 2005 376 385
28. N R Smalheiser smalheiser@psych.uic.edu EST analyses predict the existence of a population of chimeric microRNA precursor-mRNA transcripts expressed in normal human and mouse tissues. Genome Biology 4 7 2003 403
29. F Fazi A Rosa A Fatica A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPα regulates human granulopoiesis. Cell 123 5 2005 819 831
30. K A O'Donnell E A Wentzel K I Zeller C V Dang J T Mendell jmendell@jhmi.edu c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435 7043 2005 839 843
31. Y Zhao E Samal D Srivastava dsrivastava@gladstone.ucsf.edu Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 436 7048 2005 214 220
32. A M Denli B BJ Tops R HA Plasterk R F Ketting G J Hannon hannon@cshl.org Processing of primary microRNAs by the Microprocessor complex. Nature 432 7014 2004 231 235
33. R I Gregory K-P Yan G Amuthan The Microprocessor complex mediates the genesis of microRNAs. Nature 432 7014 2004 235 240
34. J Han Y Lee K-H Yeom Y-K Kim H Jin V N Kim The Drosha-DGCR8 complex in primary microRNA processing. Genes and Development 18 24 2004 3016 3027
35. Y Lee C Ahn J Han The nuclear RNase III Drosha initiates microRNA processing. Nature 425 6956 2003 415 419
36. Y Zeng R Yi B R Cullen Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha. EMBO Journal 24 1 2005 138 148
37. M T Bohnsack K Czaplinski D Görlich dg@zmbh.uni-heidelberg.de Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 10 2 2004 185 191
38. E Lund S Güttinger A Calado J E Dahlberg dahlberg@wisc.edu U Kutay ulrike.kutay@bc.biol.ethz.ch Nuclear export of microRNA precursors. Science 303 5654 2004 95 98
39. M Y Park G Wu A Gonzalez-Sulser H Vaucheret R S Poethig spoethig@sas.upenn.edu Nuclear processing and export of microRNAs in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America 102 10 2005 3691 3696
40. R Yi Y Qin I G Macara B R Cullen Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes and Development 17 24 2003 3011 3016
41. G Hutvägner J McLachlan A E Pasquinelli E Bälint T Tuschl P D Zamore A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293 5531 2001 834 838
42. R F Ketting S EJ Fischer E Bernstein T Sijen G J Hannon R HA Plasterk Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes and Development 15 20 2001 2654 2659
43. S W Knight B L Bass A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science 293 5538 2001 2269 2271
44. A Khvorova A Reynolds S D Jayasena sumedhaj@amgen.com Functional siRNAs and miRNAs exhibit strand bias. Cell 115 2 2003 209 216
45. D S Schwarz G Hutvágner T Du Z Xu N Aronin P D Zamore Asymmetry in the assembly of the RNAi enzyme complex. Cell 115 2 2003 199 208
46. G Hutvágner P D Zamore A microRNA in a multiple-turnover RNAi enzyme complex. Science 297 5589 2002 2056 2060
47. E Maniataki Z Mourelatos mourelaz@uphs.upenn.edu A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes and Development 19 24 2005 2979 2990
48. J Liu M A Carmell F V Rivas Argonaute2 is the catalytic engine of mammalian RNAi. Science 305 5689 2004 1437 1441
49. G Meister M Landthaler A Patkaniowska Y Dorsett G Teng T Tuschl Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Molecular Cell 15 2 2004 185 197
50. J B Ma K Ye D J Patel pateld@mskcc.org Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature 429 6989 2004 318 322
51. J J Song S K Smith G J Hannon L Joshua-Tor leemor@cshl.edu Crystal structure of argonaute and its implications for RISC slicer activity. Science 305 5689 2004 1434 1437
52. M W Rhoades B J Reinhart L P Lim C B Burge B Bartel D P Bartel Prediction of plant microRNA targets. Cell 2002 110 4 513 520
53. J Kim A Krichevsky Y Grad Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proceedings of the National Academy of Sciences of the United States of America 101 1 2004 360 365
54. J G Doench C P Petersen P A Sharp sharppa@mit.edu siRNAs can function as miRNAs. Genes and Development 17 4 2003 438 442
55. C Llave Z Xie K D Kasschau J C Carrington Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA. Science 297 5589 2002 2053 2056
56. J H Mansfield B D Harfe R Nissen MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nature Genetics 36 10 2004 1079 1083
57. S Yekta I H Shih D P Bartel MicroRNA-directed cleavage of HOXB8 mRNA. Science 304 5670 2004 594 596
58. Y Zeng R Yi B R Cullen MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proceedings of the National Academy of Sciences of the United States of America 2003 100 17 9779 9784
59. M F Mette W Aufsatz J Van der Winden M A Matzke A J.M Matzke Transcriptional silencing and promoter methylation triggered by double-stranded RNA. EMBO Journal 19 19 2000 5194 5201
60. Z Lippman R Martienssen martiens@cshl.edu The role of RNA interference in heterochromatic silencing. Nature 431 7006 2004 364 370
61. K V Morris kmorris@coh.org S WL Chan S E Jacobsen D J Looney Small interfering RNA-induced transcriptional gene silencing in human cells. Science 2004 305 5688 1289 1292
62. E Bernstein C D Allis alliscd@mail.rockefeller.edu RNA meets chromatin. Genes and Development 19 14 2005 1635 1655
63. M A Matzke J A Birchler RNAi-mediated pathways in the nucleus. Nature Reviews Genetics 6 1 2005 24 35
64. T Dalmay A Hamilton S Rudd S Angell D C Baulcombe An RNA-dependent RNA polymerase gene in arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus. Cell 101 5 2000 543 553
65. T Sijen J Fleenor F Simmer On the role of RNA amplification in dsRNA-triggered gene silencing. Cell 107 4 2001 465 476
66. T A Volpe C Kidner I M Hall G Teng S IS Grewal R A Martienssen Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297 5588 2002 1833 1837
67. G R Stark starkg@cesmtp.ccf.org I M Kerr Kerr@icrf.icnet.uk B RG Williams williab@cesmtp.ccf.org R H Silverman silverr@cesmtp.ccf.org R D Schreiber schreiber@immunology.wustl.edu How cells respond to interferons. Annual Review of Biochemistry 67 1998 227 264
68. S M Elbashir J Harborth W Lendeckel A Yalcin K Weber T Tuschl Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 6836 2001 494 498
69. N J Caplen S Parrish F Imani A Fire R A Morgan Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proceedings of the National Academy of Sciences of the United States of America 2001 98 17 9742 9747
70. D H Kim M A Behlke S D Rose M S Chang S Choi J J Rossi Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nature Biotechnology 23 2 2005 222 226
71. S D Rose D H Kim M Amarzguioui Functional polarity is introduced by Dicer processing of short substrate RNAs. Nucleic Acids Research 33 13 2005 4140 4156
72. D Siolas C Lerner J Burchard Synthetic shRNAs as potent RNAi triggers. Nature Biotechnology 23 2 2005 227 231
73. Y S Lee K Nakahara J W Pham Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell 117 1 2004 69 81
74. A Reynolds D Leake Q Boese S Scaringe W S Marshall A Khvorova khvorova.a@dharmacon.com Rational siRNA design for RNA interference. Nature Biotechnology 22 3 2004 326 330
75. M Amarzguioui T Holen E Babaie H Prydz hans.prydz@biotek.uio.no Tolerance for mutations and chemical modifications in a siRNA. Nucleic Acids Research 31 2 2003 589 595
76. J T Chi H Y Chang N N Wang D S Chang N Dunphy P O Brown pbrown@pmgm2.stanford.edu Genomewide view of gene silencing by small interfering RNAs. Proceedings of the National Academy of Sciences of the United States of America 100 11 2003 6343 6346
77. S M Elbashir J Martinez A Patkaniowska W Lendeckel T Tuschl Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO Journal 20 23 2001 6877 6888
78. T Holen M Amarzguioui M T Wiiger E Babaie H Prydz Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor. Nucleic Acids Research 30 8 2002 1757 1766
79. A L Jackson aimee_jackson@merck.com S R Bartz steven_bartz@merck.com J Schelter Expression profiling reveals off-target gene regulation by RNAi. Nature Biotechnology 21 6 2003 635 637
80. D Semizarov dimitri.semizarov@abbott.com L Frost A Sarthy P Kroeger D N Halbert S W Fesik stephen.fesik@abbott.com Specificity of short interfering RNA determined through gene expression signatures. Proceedings of the National Academy of Sciences of the United States of America 100 11 2003 6347 6352
81. Y Zeng B R Cullen Sequence requirements for micro RNA processing and function in human cells. RNA 9 1 2003 112 123
82. J G Doench P A Sharp Specificity of microRNA target selection in translational repression. Genes and Development 18 5 2004 504 511
83. S Saxena Z O Jonsson A Dutta ad8q@virginia.edu Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells. Journal of Biological Chemistry 278 45 2003 44312 44319
84. K Huppi S E Martin N J Caplen ncaplen@mail.nih.gov Defining and assaying RNAi in mammalian cells. Molecular Cell 17 1 2005 1 10
85. T Holen torgeir.holen@medisin.uio.no S E Moe J G Sorbo T J Meza O P Ottersen A Klungland Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo. Nucleic Acids Research 33 15 2005 4704 4710
86. R Kretschmer-Kazemi Far kretschmer@imm.uni-luebeck.de G Sczakiel sczakiel@imm.uni-luebeck.de The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides. Nucleic Acids Research 2003 31 15 4417 4424
87. D A Braasch S Jensen Y Liu RNA interference in mammalian cells by chemically-modified RNA. Biochemistry 42 26 2003 7967 7975
88. Y-L Chiu T M Rana tariq.rana@umassmed.edu siRNA function in RNAi: a chemical modification analysis. RNA 9 9 2003 1034 1048
89. O Donze D Picard RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase. Nucleic Acids Research 2002 30 10 e46
90. M Sohail G Doran J Riedemann V Macaulay E M Southern A simple and cost-effective method for producing small interfering RNAs with high efficacy. Nucleic Acids Research 2003 31 7 e38
91. J W Myers J E Ferrell Silencing gene expression with Dicer-generated siRNA pools. Methods in Molecular Biology 309 2005 93 196
92. H Zhang F A Kolb V Brondani E Billy W Filipowicz Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO Journal 21 21 2002 5875 5885
93. T R Brummelkamp R Bernards R Agami A system for stable expression of short interfering RNAs in mammalian cells. Science 296 5567 2002 550 553
94. G Sui C Soohoo E B Affar A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 99 8 2002 5515 5520
95. N S Lee T Dohjima G Bauer Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nature Biotechnology 20 5 2002 500 505
96. J-Y Yu S L DeRuiter D L Turner RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 99 9 2002 6047 6052
97. M Chen L Zhang H-Y Zhang A universal plasmid library encoding all permutations of small interfering RNA. Proceedings of the National Academy of Sciences of the United States of America 102 7 2005 2356 2361
98. L Zheng J Liu S Batalov An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 101 1 2004 135 140
99. P J Paddison A A Caudy E Bernstein G J Hannon D S Conklin Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes and Development 16 8 2002 948 958
100. P J Paddison A A Caudy R Sachidanandam G J Hannon Short hairpin activated gene silencing in mammalian cells. Methods in Molecular Biology 265 2004 85 100
101. Y Zeng B R Cullen Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences. Journal of Biological Chemistry 280 30 2005 27595 27603
102. S Matsukura P A Jones D Takai Establishment of conditional vectors for hairpin siRNA knockdowns. Nucleic Acids Research 2003 31 15 e77
103. M van de Wetering I Oving V Muncan Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Reports 4 6 2003 609 615
104. S Gupta R A Schoer J E Egan G J Hannon V Mittal mittal@cshl.org Inducible, reversible, and stable RNA interference in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 101 7 2004 1927 1932
105. M Scherr K Battmer A Ganser M Eder Modulation of gene expression by lentiviral-mediated delivery of small interfering RNA. Cell Cycle 2 3 2003 251 257
106. G Tiscornia O Singer M Ikawa I M Verma verma@salk.edu A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proceedings of the National Academy of Sciences of the United States of America 100 4 2003 1844 1848
107. T Kunath G Gish H Lickert N Jones T Pawson pawson@mshri.on.ca J Rossant rossant@mshri.on.ca Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Nature Biotechnology 21 5 2003 559 561
108. L Fritsch L A Martinez R Sekhri Conditional gene knock-down by CRE-dependent short interfering RNAs. EMBO Reports 5 2 2004 178 182
109. J Soutschek jsoutschek@alnylam.de A Akinc B Bramlage Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432 7014 2004 173 178
110. D V Morrissey morrisseyd@sirna.com J A Lockridge L Shaw Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nature Biotechnology 2005 23 8 1002 1007
111. E Song P Zhu S-K Lee Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nature Biotechnology 23 6 2005 709 717
112. S S Case M A Price C T Jordan Stable transduction of quiescent CD 34+ CD 38- human hematopoietic cells by HIV-1-based lentiviral vectors. Proceedings of the National Academy of Sciences of the United States of America 96 6 1999 2988 2993
113. A Luther-Wyrsch E Costello M Thali Stable transduction with lentiviral vectors and amplification of immature hematopoietic progenitors from cord blood of preterm human fetuses. Human Gene Therapy 12 4 2001 377 389
114. N Uchida nuchida@stemcell.net R E Sutton A M Friera HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America 95 20 1998 11939 11944
115. M Scherr K Battmer I Dallmann A Ganser M Eder Inhibition of GM-CSF receptor function by stable RNA interference in a NOD/SCID mouse hematopoietic stem cell transplantation model. Oligonucleotides 13 5 2003 353 363
116. T Schomber C P Kalberer A Wodnar-Filipowicz R C Skoda radek.skoda@unibas.ch Gene silencing by lentivirus-mediated delivery of siRNA in human CD 34+ cells. Blood 103 12 2004 4511 4513
117. M Wilda U Fuchs W Wossmann A Borkhardt Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene 2002 21 37 5716 5724
118. M Scherr K Battmer T Winkler O Heidenreich A Ganser M Eder Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood 101 4 2003 1566 1569
119. L Wohlbold H Van der Kuip C Miething Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571). Blood 102 6 2003 2236 2239
120. M Scherr K Battmer B Schultheis A Ganser M Eder Stable RNA interference (RNAi) as an option for anti-bcr-abl therapy. Gene Therapy 12 1 2005 12 21
121. L Wohlbold H van der Kuip A Moehring G Granot M Oren H-P Vornlocher W E Aulitzky All common p210 and p190 Bcr-abl variants can be targeted by RNA interference [3]. Leukemia 19 2 2005 290 292
122. J Rangatia D Bonnet Transient or long-term silencing of BCR-ABL alone induces cell cycle and proliferation arrest, apoptosis and differentiation. Leukemia 20 1 2006 68 76
123. O Heidenreich olaf.heidenreich@uni-tuebingen.de J Krauter H Riehle AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells. Blood 101 8 2003 3157 3163
124. J Chen N R Wall K Kocher Stable expression of small interfering RNA sensitizes TEL-PDGFβR to inhibition with imatinib or rapamycin. Journal of Clinical Investigation 113 12 2004 1784 1791
125. M Thomas A Geßner H-P Vornlocher P Hadwiger J Greil O Heidenreich Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells. Blood 106 10 2005 3559 3566
126. U Ritter C Damm-Welk U Fuchs R M Bohle A Borkhardt W Woessmann Design and evaluation of chemically synthesized siRNA targeting the NPM-ALK fusion site in anaplastic large cell lymphoma (ALCL). Oligonucleotides 13 5 2003 365 373
127. R Piva R Chiarle roberto.chiarle@unito.it A D Manazza Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas. Blood 107 2 2006 689 697
128. D K Walters waltersd@ohsu.edu E P Stoffregen M C Heinrich M W Deininger B J Druker RNAi-induced down-regulation of FLT3 expression in AML cell lines increases sensitivity to MLN518. Blood 105 7 2005 2952 2954
129. G Q Daley R A Van Etten D Baltimore Induction of chronic myelogenous leukemia in mice by the P210(bcr/abl) gene of the Philadelphia chromosome. Science 247 4944 1990 824 830
130. C S Huettner P Zhang R A Van Etten D G Tenen dtenen@caregroup.harvard.edu Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nature Genetics 24 1 2000 57 60
131. T G Lugo A-M Pendergast A J Muller O N Witte Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 247 4946 1990 1079 1082
132. H Kantarjian C Sawyers A Hochhaus International STI571 CML Study Group. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. New England Journal of Medicine 346 9 2002 645 652
133. B J Druker C L Sawyers H Kantarjian Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. New England Journal of Medicine 344 14 2001 1038 1042 Erratum in: New England Journal of Medicine. 2001;345(3):232
134. H Miyoshi T Kozu K Shimizu The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO Journal 12 7 1993 2715 2721
135. T R Golub G F Barker M Lovett D G Gilliland Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77 2 1994 307 316
136. P Ernst J Wang S J Korsmeyer The role of MLL in hematopoiesis and leukemia. Current Opinion in Hematology 9 4 2002 282 287
137. P H Domer S S Fakharzadeh C-S Chen Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. Proceedings of the National Academy of Sciences of the United States of America 90 16 1993 7884 7888
138. Y Gu T Nakamura H Alder The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71 4 1992 701 708
139. N R McCabe R C Burnett H J Gill Cloning of cDNAs of the MLL gene that detect DNA rearrangements and altered RNA transcripts in human leukemic cells with 11q23 translocations. Proceedings of the National Academy of Sciences of the United States of America 89 24 1992 11794 11798
140. C-H Pui P S Gaynon J M Boyett Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region. Lancet 359 9321 2002 1909 1915
141. S W Morris M N Kirstein M B Valentine Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263 5151 1994 1281 1284
142. Y Yamamoto H Kiyoi Y Nakano Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood 97 8 2001 2434 2439
143. S Yokota H Kiyoi M Nakao Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines. Leukemia 11 10 1997 1605 1609
144. N Felli L Fontana E Pelosi MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proceedings of the National Academy of Sciences of the United States of America 102 50 2005 18081 18086
145. H S Radomska C S Huettner P Zhang T Cheng D T Scadden D G Tenen dtenen@bidmc.harvard.edu CCAAT/enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Molecular and Cellular Biology 18 7 1998 4301 4314
146. D G Tenen Disruption of differentiation in human cancer: AML shows the way. Nature Reviews Cancer 3 2 2003 89 101
147. X Wang E Scott C L Sawyers A D Friedman adfrdman@jhmi.edu C/EBPα bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts. Blood 94 2 1999 560 571
148. R M Gronostajski gronosr@ccf.org Roles of the NFI/CTF gene family in transcription and development. Gene 249 1-2 2000 31 45
149. C Santoro N Mermod P C Andrews R Tjian A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. Nature 334 6179 1988 218 224
150. B P Lewis I-H Shih M W Jones-Rhoades D P Bartel C B Burge cburge@mit.edu Prediction of mammalian microRNA targets. Cell 115 7 2003 787 798
151. G A Calin C Sevignani C D Dumitru Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proceedings of the National Academy of Sciences of the United States of America 101 9 2004 2999 3004
152. M Metzler P L Strissel R Strick Emergence of translocation t(9;11)-positive leukemia during treatment of childhood acute lymphoblastic leukemia. Genes Chromosomes and Cancer 41 3 2004 291 296
153. G A Calin C D Dumitru M Shimizu Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America 99 24 2002 15524 15529
154. A Cimmino G A Calin M Fabbri miR-15 and miR-16 induce apoptosis by targeting BCL2. Proceedings of the National Academy of Sciences of the United States of America 102 39 2005 13944 13949
155. A Ota H Tagawa S Karnan Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Research 64 9 2004 3087 3095
156. L He J M Thomson M T Hemann A microRNA polycistron as a potential human oncogene. Nature 435 7043 2005 828 833
157. J Lu G Getz E A Miska MicroRNA expression profiles classify human cancers. Nature 435 7043 2005 834 838
158. G A Calin C-G Liu C Sevignani MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proceedings of the National Academy of Sciences of the United States of America 101 32 2004 11755 11760
159. G A Calin M Ferracin A Cimmino A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. New England Journal of Medicine 353 17 2005 1793 1801
160. K Berns E M Hijmans J Mullenders A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428 6981 2004 431 437
161. T Futami M Miyagishi K Taira Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectors. Journal of Biological Chemistry 280 1 2005 826 831
162. R Kittler G Putz L Pelletier An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division. Nature 432 7020 2004 1036 1040
163. B Luo A D Heard H F Lodish Small interfering RNA production by enzymatic engineering of DNA (SPEED). Proceedings of the National Academy of Sciences of the United States of America 101 15 2004 5494 5499
164. S Matsumoto M Miyagishi makoto-m@chembio.t.u-tokyo.ac.jp H Akashi R Nagai K Taira taira@chembio.t.u-tokyo.ac.jp Analysis of double-stranded RNA-induced apoptosis pathways using interferon-response noninducible small interfering RNA expression vector library. Journal of Biological Chemistry 280 27 2005 25687 25696
165. P J Paddison J M Silva D S Conklin A resource for large-scale RNA-interference-based screens in mammals. Nature 428 6981 2004 427 431
166. G Sen T S Wehrman J W Myers H M Blau hblau@stanford.edu Restriction enzyme-generated siRNA (REGS) vectors and libraries. Nature Genetics 36 2 2004 183 189
167. D Shirane K Sugao S Namiki M Tanabe M Iino K Hirose kenzo@m.u-tokyo.ac.jp Enzymatic production of RNAi libraries from cDNAs. Nature Genetics 36 2 2004 190 196