Incorporating Type 1 diabetes prevention into clinical practice

Clinical Diabetes

Volumn 28, Issue 2, 2010, Pages 61-70

  Gregory, Justin M ^a   Lilley, Jessica S ^b   Misfeldt, Amanda A ^c   Buscariollo, Daniela L ^c   Russell, William E ^d   Moore, Daniel J ^c  

^a UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; GAD VACCINE; INSULIN; RITUXIMAB; UNCLASSIFIED DRUG; VITAMIN D;

AUTOIMMUNE DISEASE; CELL REGENERATION; CLINICAL PRACTICE; CLINICAL TRIAL; DISEASE COURSE; GLUCOSE HOMEOSTASIS; HEALTH CARE PERSONNEL; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MORBIDITY; PANCREAS ISLET BETA CELL; PATHOGENESIS; REVIEW; RISK FACTOR; VITAMIN SUPPLEMENTATION;

EID: 77954739369     PISSN: 08918929     EISSN: None     Source Type: Journal    
DOI: 10.2337/diaclin.28.2.61     Document Type: Review

References (86)

1. Centers for Disease Control and Prevention: National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2007. Available online from http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2007.pdf
2. Duncan GE: Prevalence of diabetes and impaired fasting glucose levels among U.S. adolescents: National Health and Nutrition Examination Survey, 1999-2002. Arch Pediatr Adolesc Med 160:523-528, 2006
3. Lipton RB, Drum M, Burnet D, Rich B, Cooper A, Baumann E, Hagopian W: Obesity at the onset of diabetes in an ethnically diverse population of children: what does it mean for epidemiologists and clinicians? Pediatrics 115:e553-e560, 2005
4. DCCT Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977-986, 1993
5. Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P, Zinman B: Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 353:2643-2653, 2005
6. Dabelea D, Bell RA, D'Agostino RB Jr, Imperatore G, Johansen JM, Linder B, Liu LL, Loots B, Marcovina S, Mayer-Davis EJ, Pettitt DJ, Waitzfelder B: Incidence of diabetes in youth in the United States. JAMA 297:2716-2724, 2007
7. Liese AD, D'Agostino RB Jr, Hamman RF, Kilgo PD, Lawrence JM, Liu LL, Loots B, Linder B, Marcovina S, Rodriguez B, Standiford D, Williams DE: The burden of diabetes mellitus among U.S. youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics 118:1510-1518, 2006
8. Dahlquist G, Blom L, Holmgren G, Hagglof B, Larsson Y, Sterky G, Wall S: The epidemiology of diabetes in Swedish children 0-14 years: a six-year prospective study. Diabetologia 28:802-808, 1985
9. Lammi N, Blomstedt PA, Moltchanova E, Eriksson JG, Tuomilehto J, Karvonen M: Marked temporal increase in the incidence of type 1 and type 2 diabetes among young adults in Finland. Diabetologia 51:897-899, 2008
10. Vehik K, Hamman RF, Lezotte D, Norris JM, Klingensmith G, Bloch C, Rewers M, Dabelea D: Increasing incidence of type 1 diabetes in 0 to 17-year-old Colorado youth. Diabetes Care 30:503-509, 2007
11. DIAMOND Project Group: Incidence and trends of childhood type 1 diabetes worldwide 1990-1999. Diabet Med 23:857-866, 2006
12. Onkamo P, Vaananen S, Karvonen M, Tuomilehto J: Worldwide increase in incidence of type I diabetes: the analysis of the data on published incidence trends. Diabetologia 42:1395-1403, 1999
13. Concannon P, Chen WM, Julier C, Morahan G, Akolkar B, Erlich HA, Hilner JE, Nerup J, Nierras C, Pociot F, Todd JA, Rich SS: Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes 58:1018-1022, 2009
14. Mason DR, Scott RS, Darlow BA: Epidemiology of insulin-dependent diabetes mellitus in Canterbury, New Zealand. Diabetes Res Clin Pract 3:21-29, 1987
15. Olmos P, A'Hern R, Heaton DA, Millward BA, Risley D, Pyke DA, Leslie RD: The significance of the concordance rate for type 1 (insulin-dependent) diabetes in identical twins. Diabetologia 31:747-750, 1988
16. King ML, Shaikh A, Bidwell D, Voller A, Banatvala JE: Coxsackie-B-virus-specific IgM responses in children with insulin-dependent (juvenile-onset; type I) diabetes mellitus. Lancet 1:1397-1399, 1983
17. Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK: Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest 94:2125-2129, 1994
18. Virtanen SM, Hypponen E, Laara E, Vahasalo P, Kulmala P, Savola K, Rasanen L, Aro A, Knip M, Akerblom HK: Cow's milk consumption, disease-associated autoantibodies and type 1 diabetes mellitus: a follow-up study in siblings of diabetic children. Diabet Med 15:730-738, 1998
19. Foulis AK, Liddle CN, Farquharson MA, Richmond JA, Weir RS: The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 29:267-274, 1986
20. Bingley PJ, Mahon JL, Gale EA: Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT). Diabetes Care 31:146-150, 2008
21. Keskinen P, Korhonen S, Kupila A, Veijola R, Erkkila S, Savolainen H, Arvilommi P, Simell T, Ilonen J, Knip M, Simell O: First-phase insulin response in young healthy children at genetic and immunological risk for type I diabetes. Diabetologia 45:1639-1648, 2002
22. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, Kahn R, Kitzmiller J, Knowler WC, Lebovitz H, Lernmark A, Nathan D, Palmer J, Rizza R, Saudek C, Shaw J, Steffes M, Stern M, Tuomilehto J, Zimmet P: Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26:3160-3167, 2003
23. Haller MJ, Atkinson MA, Schatz D: Type 1 diabetes mellitus: etiology, presentation, and management. Pediatr Clin North Am 52:1553-1578, 2005
24. Mahon JL, Sosenko JM, Rafkin-Mervis L, Krause-Steinrauf H, Lachin JM, Thompson C, Bingley PJ, Bonifacio E, Palmer JP, Eisenbarth GS, Wolfsdorf J, Skyler JS: The TrialNet Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial results. Pediatr Diabetes 10:97-104, 2009
25. Huang X, Moore DJ, Ketchum RJ, Nunemaker CS, Kovatchev B, McCall AL, Brayman KL: Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation. Endocr Rev 29:603-630, 2008
26. Orban T, Sosenko JM, Cuthbertson D, Krischer JP, Skyler JS, Jackson R, Yu L, Palmer JP, Schatz D, Eisenbarth G: Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1 (DPT-1). Diabetes Care 32:2269-2274, 2009
27. Barker JM, Barriga KJ, Yu L, Miao D, Erlich HA, Norris JM, Eisenbarth GS, Rewers M: Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). J Clin Endocrinol Metab 89:3896-3902, 2004
28. Razack NN, Wherrett DK: Type 1 diabetes: New horizons in prediction and prevention. Paediatr Child Health 10:35-37, 2005
29. Sabbah E, Savola K, Kulmala P, Veijola R, Vahasalo P, Karjalainen J, Akerblom HK, Knip M: Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. J Clin Endocrinol Metab 84:1534-1539, 1999
30. Hoppu S, Harkonen T, Ronkainen MS, Simell S, Hekkala A, Toivonen A, Ilonen J, Simell O, Knip M: IA-2 antibody isotypes and epitope specificity during the prediabetic process in children with HLA-conferred susceptibility to type I diabetes. Clin Exp Immunol 144:59-66, 2006
31. Kupila A, Muona P, Simell T, Arvilommi P, Savolainen H, Hamalainen AM, Korhonen S, Kimpimaki T, Sjoroos M, Ilonen J, Knip M, Simell O: Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort. Diabetologia 44:290-297, 2001
32. Bonifacio E, Hummel M, Walter M, Schmid S, Ziegler AG: IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes. Diabetes Care 27:2695-2700, 2004
33. Hamalainen AM, Ronkainen MS, Akerblom HK, Knip M: Postnatal elimination of transplacentally acquired disease associated antibodies in infants born to families with type 1 diabetes. J Clin Endocrinol Metab 85:4249-4253, 2000
34. Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, Chase HP, Eisenbarth GS: Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 auto antibodies. Diabetes 45:926-933, 1996
35. Wang J, Miao D, Babu S, Yu J, Barker J, Klingensmith G, Rewers M, Eisenbarth GS, Yu L: Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity. J Clin Endocrinol Metab 92:88-92, 2007
36. Murphy R, Ellard S, Hattersley AT: Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. Nat Clin Pract Endocrinol Metab 4:200-213, 2008
37. Eisenbarth GS, Jeffrey J: The natural history of type 1A diabetes. Arq Bras Endocrinol Metabol 52:146-155, 2008
38. Ilonen J, Sjoroos M, Knip M, Veijola R, Simell O, Akerblom HK, Paschou P, Bozas E, Havarani B, Malamitsi-Puchner A, Thymelli J, Vazeou A, Bartsocas CS: Estimation of genetic risk for type 1 diabetes. Am J Med Genet 115:30-36, 2002
39. Steck AK, Zhang W, Bugawan TL, Barriga KJ, Blair A, Erlich HA, Eisenbarth GS, Norris JM, Rewers MJ: Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes? Diabetes 58:1028-1033, 2009
40. Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA: A single course of anti-CD3 monoclonal antibody hOKT3gamma1(AlaAla) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 54:1763-1769, 2005
41. Bjork E, Kampe O, Andersson A, Karlsson FA: Expression of the 64 kDa/ glutamic acid decarboxylase rat islet cell autoantigen is influenced by the rate of insulin secretion. Diabetologia 35:490-493, 1992
42. Diabetes Prevention Trial-Type 1 Diabetes Study Group: Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 346:1685-1691, 2002
43. Karounos DG, Bryson JS, Cohen DA: Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice. J Clin Invest 100:1344-1348, 1997
44. Thivolet CH, Goillot E, Bedossa P, Durand A, Bonnard M, Orgiazzi J: Insulin prevents adoptive cell transfer of diabetes in the autoimmune non-obese diabetic mouse. Diabetologia 34:314-319, 1991
45. Skyler JS: Update on worldwide efforts to prevent type 1 diabetes. Ann N Y Acad Sci 1150:190-196, 2008
46. Skyler JS, Krischer JP, Wolfsdorf J, Cowie C, Palmer JP, Greenbaum C, Cuthbertson D, Rafkin-Mervis LE, Chase HP, Leschek E: Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1. Diabetes Care 28:1068-1076, 2005
47. Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J, Masteller EL, McDevitt H, Bonyhadi M, Bluestone JA: In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199:1455-1465, 2004
48. Moore DJ, Kim JI, Sonawane S, Yeh H, Deng S, Lee Kt, Markmann JF: Progress toward antibody-induced transplantation tolerance. Crit Rev Immunol 27:167-218, 2007
49. Herold KC, Hagopian W, Auger JA, Poumian-Ruiz E, Taylor L, Donaldson D, Gitelman SE, Harlan DM, Xu D, Zivin RA, Bluestone JA: Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 346:1692-1698, 2002
50. Hu CY, Rodriguez-Pinto D, Du W, Ahuja A, Henegariu O, Wong FS, Shlomchik MJ, Wen L: Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest 117:3857-3867, 2007
51. Xiu Y, Wong CP, Bouaziz JD, Hamaguchi Y, Wang Y, Pop SM, Tisch RM, Tedder TF: B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype specific differences in Fc gamma R effector functions. J Immunol 180:2863-2875, 2008
52. Pescovitz MD, Greenbaum CJ, Krause-Steinrauf H, Becker DJ, Gitelman SE, Goland R, Gottlieb PA, Marks JB, McGee PF, Moran AM, Raskin P, Rodriguez H, Schatz DA, Wherrett D, Wilson DM, Lachin JM, Skyler JS: Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N Engl J Med 361:2143-2152, 2009
53. Larsen CM, Faulenbach M, Vaag A, Volund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY: Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 356:1517-1526, 2007
54. Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC: Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells. Endocrinology 148:5136-5144, 2007
55. Shapiro AMJ, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems J-A, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DER, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JRT: International trial of the Edmonton Protocol for islet transplantation. N Engl J Med 355:1318-1330, 2006
56. Ackermann AM, Gannon M: Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J Mol Endocrinol 38:193-206, 2007
57. Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC: Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 48:2221-2228, 2005
58. Meier JJ, Lin JC, Butler AE, Galasso R, Martinez DS, Butler PC: Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 49:1838-1844, 2006
59. Gu G, Dubauskaite J, Melton DA: Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457, 2002
60. Todorov IP, Omori KMD, Pascual MBS, Rawson JBS, Nair IP, Valiente LBS, Vuong TBS, Matsuda TMDP, Orr CBS, Ferreri KP, Smith CVMD, Kandeel FMDP, Mullen YMDP: Generation of human islets through expansion and differentiation of non-islet pancreatic cells discarded (pancreatic discard) after islet isolation. Pancreas 32:130-138, 2006
61. Guo T, Hebrok M: Stem cells to pancreatic beta-cells: new sources for diabetes cell therapy. Endocrine Rev 30:214-227, 2009
62. Zhang D, Jiang W, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H: Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res 19:429-438, 2009
63. Borch-Johnsen K, Joner G, Mandrup-Poulsen T, Christy M, Zachau-Christiansen B, Kastrup K, Nerup J: Relation between breast-feeding and incidence rates of insulin dependent diabetes mellitus: a hypothesis. Lancet 2:1083-1086, 1984
64. Sadauskaite-Kuehne V, Ludvigsson J, Padaiga Z, Jasinskiene E, Samuelsson U: Longer breastfeeding is an independent protective factor against development of type 1 diabetes mellitus in childhood. Diabetes Metab Res Rev 20:150-157, 2004
65. Virtanen SM, Rasanen L, Ylonen K, Aro A, Clayton D, Langholz B, Pitkaniemi J, Savilahti E, Lounamaa R, Tuomilehto J, et al.: Early introduction of dairy products associated with increased risk of IDDM in Finnish children. Diabetes 42:1786-1790, 1993
66. Zinkernagel RM: Maternal antibodies, childhood infections, and autoimmune diseases. N Engl J Med 345:1331-1335, 2001
67. Luopajarvi K, Savilahti E, Virtanen SM, Ilonen J, Knip M, Akerblom HK, Vaarala O: Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood. Pediatr Diabetes 9:434-441, 2008
68. TRIGR Study Group: Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR). Pediatr Diabetes 8:117-137, 2007
69. Gartner LM, Morton J, Lawrence RA, Naylor AJ, O'Hare D, Schanler RJ, Eidelman AI: Breastfeeding and the use of human milk. Pediatrics 115:496-506, 2005
70. Mathieu C, Gysemans C, Giulietti A, Bouillon R: Vitamin D and diabetes. Diabetologia 48:1247-1257, 2005
71. Zella JB, DeLuca HF: Vitamin D and autoimmune diabetes. J Cell Biochem 88:216-222, 2003
72. Zipitis CS, Akobeng AK: Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child 93:512-517, 2008
73. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M: Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 122:398-417, 2008
74. Wagner CL, Greer FR: Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics 122:1142-1152, 2008
75. Barker JM: Clinical review: Type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screening. J Clin Endocrinol Metab 91:1210-1217, 2006
76. Tillil H, Kobberling J: Age-corrected empirical genetic risk estimates for first degree relatives of IDDM patients. Diabetes 36:93-99, 1987
77. Tuomilehto J, Podar T, Tuomilehto-Wolf E, Virtala E: Evidence for importance of gender and birth cohort for risk of IDDM in offspring of IDDM parents. Diabetologia 38:975-982, 1995
78. Hyttinen V, Kaprio J, Kinnunen L, Koskenvuo M, Tuomilehto J: Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study. Diabetes 52:1052-1055, 2003
79. Redondo MJ, Rewers M, Yu L, Garg S, Pilcher CC, Elliott RB, Eisenbarth GS: Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes: prospective twin study. BMJ 318:698-702, 1999
80. Redondo MJ, Jeffrey J, Fain PR, Eisenbarth GS, Orban T: Concordance for islet autoimmunity among monozygotic twins. N Engl J Med 359:2849-2850, 2008
81. Georgia S, Bhushan A: Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 114:963-968, 2004
82. Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, Sicinski P, White MF: Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol 25:3752-3762, 2005
83. Zhang H, Ackermann AM, Gusarova GA, Lowe D, Feng X, Kopsombut UG, Costa RH, Gannon M: The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass. Mol Endocrinol 20:1853-1866, 2006
84. Gradwohl G, Dierich A, LeMeur M, Guillemot F: Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A 97:1607-1611, 2000
85. Ackermann Misfeldt A, Costa RH, Gannon M: Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1. Diabetes 57:3069-3077, 2008
86. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA: In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455:627-632, 2008