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Volumn 32, Issue 2, 2006, Pages 130-138

Generation of human islets through expansion and differentiation of non-islet pancreatic cells discarded (pancreatic discard) after islet isolation

Author keywords

Ex vivo human islet generation; Islet precursors; Non islet pancreatic cell differentiation

Indexed keywords

AMYLASE; C PEPTIDE; CYTOKERATIN 19; CYTOKERATIN 7; GLUCOSE; INSULIN; TRANSCRIPTION FACTOR PDX 1; TRYPSIN;

EID: 33646060715     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpa.0000202945.78331.93     Document Type: Article
Times cited : (40)

References (52)
  • 1
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000;343:230-238.
    • (2000) N Engl J Med , vol.343 , pp. 230-238
    • Shapiro, A.M.1    Lakey, J.R.2    Ryan, E.A.3
  • 2
    • 0036070177 scopus 로고    scopus 로고
    • Pancreatic stem cells
    • Bonner-Weir S, Sharma A. Pancreatic stem cells. J Pathol. 2002;197(4):519-526.
    • (2002) J Pathol , vol.197 , Issue.4 , pp. 519-526
    • Bonner-Weir, S.1    Sharma, A.2
  • 3
    • 0037303120 scopus 로고    scopus 로고
    • Stem/progenitor cells derived from adult tissues: Potential for the treatment of diabetes mellitus
    • Lechner A, Habener JF. Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus. Am J Physiol Endocrinol Metab. 2003;284:E259-E266.
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Lechner, A.1    Habener, J.F.2
  • 4
    • 0141501989 scopus 로고    scopus 로고
    • Development of cell markers for the identification and expansion of islet progenitor cells
    • Zhang YQ, Sarvetnick N. Development of cell markers for the identification and expansion of islet progenitor cells. Diabetes Metab Res Rev. 2003;19(5):363-374.
    • (2003) Diabetes Metab Res Rev , vol.19 , Issue.5 , pp. 363-374
    • Zhang, Y.Q.1    Sarvetnick, N.2
  • 5
    • 3042758642 scopus 로고    scopus 로고
    • Stem-cell therapy for diabetes mellitus
    • Hussain MA, Theise ND. Stem-cell therapy for diabetes mellitus. Lancet. 2004;364(9429):203-205.
    • (2004) Lancet , vol.364 , Issue.9429 , pp. 203-205
    • Hussain, M.A.1    Theise, N.D.2
  • 6
    • 13744261497 scopus 로고    scopus 로고
    • Regeneration of the pancreatic beta cell
    • Trucco M. Regeneration of the pancreatic beta cell. J Clin Invest. 2005;115(1):5-12.
    • (2005) J Clin Invest , vol.115 , Issue.1 , pp. 5-12
    • Trucco, M.1
  • 7
    • 4344669147 scopus 로고    scopus 로고
    • Xenotransplantation: Infectious risk revisited
    • Fishman JA, Patience C. Xenotransplantation: infectious risk revisited. Am J Transplant. 2004;4(9):1383-1390.
    • (2004) Am J Transplant , vol.4 , Issue.9 , pp. 1383-1390
    • Fishman, J.A.1    Patience, C.2
  • 8
    • 0035906902 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells into insulin secreting structures similar to pancreatic islets
    • Lumelsky N, Blondel O, Laeng P, et al. Differentiation of embryonic stem cells into insulin secreting structures similar to pancreatic islets. Science. 2001;292:1389-1394.
    • (2001) Science , vol.292 , pp. 1389-1394
    • Lumelsky, N.1    Blondel, O.2    Laeng, P.3
  • 9
    • 0037058934 scopus 로고    scopus 로고
    • Growth factor inhibitors promote differentiation for insulin producing tissue from embryonic stem cells
    • Hori Y, Rulifson IC, Tsai BC, et al. Growth factor inhibitors promote differentiation for insulin producing tissue from embryonic stem cells. Proc Natl Acad Sci U S A. 2002;99:16105-16110.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 16105-16110
    • Hori, Y.1    Rulifson, I.C.2    Tsai, B.C.3
  • 10
    • 4644222526 scopus 로고    scopus 로고
    • Artifactual insulin release from differentiated embryonic stem cells
    • Hansson M, Tonning A, Frandsen U, et al. Artifactual insulin release from differentiated embryonic stem cells. Diabetes. 2004;53(10):2603-2609.
    • (2004) Diabetes , vol.53 , Issue.10 , pp. 2603-2609
    • Hansson, M.1    Tonning, A.2    Frandsen, U.3
  • 11
    • 13144279290 scopus 로고    scopus 로고
    • The generation of insulin-producing cells from embryonic stem cells-a discussion of controversial findings
    • Kania G, Blyszczuk P, Wobus AM. The generation of insulin-producing cells from embryonic stem cells-a discussion of controversial findings. Int J Dev Biol. 2004;48(10):1061-1064.
    • (2004) Int J Dev Biol , vol.48 , Issue.10 , pp. 1061-1064
    • Kania, G.1    Blyszczuk, P.2    Wobus, A.M.3
  • 12
    • 19544386310 scopus 로고    scopus 로고
    • Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells
    • Fujikawa T, Oh SH, Pi L, et al. Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells. Am J Pathol. 2005;166(6):1781-1791.
    • (2005) Am J Pathol , vol.166 , Issue.6 , pp. 1781-1791
    • Fujikawa, T.1    Oh, S.H.2    Pi, L.3
  • 13
    • 19344362213 scopus 로고    scopus 로고
    • Differentiation of insulin-producing cells from human neural progenitor cells
    • Hori Y, Gu X, Xie X, et al. Differentiation of insulin-producing cells from human neural progenitor cells. PLoS Med. 2005;2(4):e103.
    • (2005) PLoS Med , vol.2 , Issue.4
    • Hori, Y.1    Gu, X.2    Xie, X.3
  • 14
    • 0038413922 scopus 로고    scopus 로고
    • NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
    • Kojima H, Fujimiya M, Matsumura K, et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med. 2003;9(5):596-603.
    • (2003) Nat Med , vol.9 , Issue.5 , pp. 596-603
    • Kojima, H.1    Fujimiya, M.2    Matsumura, K.3
  • 15
    • 0037628628 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin producing cells
    • Suzuki A, Nakauchi H, Taniguchi H. Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin producing cells. Proc Natl Acad Sci U S A. 2003;100:5034-5039.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5034-5039
    • Suzuki, A.1    Nakauchi, H.2    Taniguchi, H.3
  • 16
    • 0038472015 scopus 로고    scopus 로고
    • Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells
    • Zalzman M, Gupta S, Giri RK, et al. Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci U S A. 2003;100(12):7253-7258.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.12 , pp. 7253-7258
    • Zalzman, M.1    Gupta, S.2    Giri, R.K.3
  • 17
    • 9444255761 scopus 로고    scopus 로고
    • High glucose is necessary for complete maturation of Pdxl-VP16-expressing hepatic cells into functional insulin-producing cells
    • Cao LZ, Tang DQ, Horb ME, et al. High glucose is necessary for complete maturation of Pdxl-VP16-expressing hepatic cells into functional insulin-producing cells. Diabetes. 2004;53(12):3168-3178.
    • (2004) Diabetes , vol.53 , Issue.12 , pp. 3168-3178
    • Cao, L.Z.1    Tang, D.Q.2    Horb, M.E.3
  • 18
    • 0034608816 scopus 로고    scopus 로고
    • In vitro cultivation of human islets from expanded ductal tissue
    • Bonner-Weir S, Taneja M, Weir GC, et al. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci U S A. 2000;97:7999-8004.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7999-8004
    • Bonner-Weir, S.1    Taneja, M.2    Weir, G.C.3
  • 19
    • 0034100823 scopus 로고    scopus 로고
    • Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells
    • Ramiya VK, Maraist M, Arfors KE, et al. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med. 2000;6:278-282.
    • (2000) Nat Med , vol.6 , pp. 278-282
    • Ramiya, V.K.1    Maraist, M.2    Arfors, K.E.3
  • 20
    • 0043268785 scopus 로고    scopus 로고
    • Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture
    • Gao R, Ustinov J, Pulkkinen MA, et al. Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes. 2003;52(8):2007-2015.
    • (2003) Diabetes , vol.52 , Issue.8 , pp. 2007-2015
    • Gao, R.1    Ustinov, J.2    Pulkkinen, M.A.3
  • 21
    • 11144283080 scopus 로고    scopus 로고
    • Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue
    • Lechner A, Nolan AL, Blacken RA, et al. Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue. Biochem Biophys Res Commun. 2005;327(2):581-588.
    • (2005) Biochem Biophys Res Commun , vol.327 , Issue.2 , pp. 581-588
    • Lechner, A.1    Nolan, A.L.2    Blacken, R.A.3
  • 22
    • 0032533441 scopus 로고    scopus 로고
    • Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas
    • Bouwens L. Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas. Microsc Res Tech. 1998;43:332-336.
    • (1998) Microsc Res Tech , vol.43 , pp. 332-336
    • Bouwens, L.1
  • 23
    • 0033815611 scopus 로고    scopus 로고
    • Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in vitro: Further evidence for pluripotent pancreatic stem cells in humans
    • Gmyr V, Kerr-Conte J, Belaich S, et al. Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in vitro: further evidence for pluripotent pancreatic stem cells in humans. Diabetes. 2000;49(10):1671-1680.
    • (2000) Diabetes , vol.49 , Issue.10 , pp. 1671-1680
    • Gmyr, V.1    Kerr-Conte, J.2    Belaich, S.3
  • 24
    • 12944327377 scopus 로고    scopus 로고
    • In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells
    • Baeyens L, De Breuck S, Lardon J, et al. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia. 2005;48(1):49-57.
    • (2005) Diabetologia , vol.48 , Issue.1 , pp. 49-57
    • Baeyens, L.1    De Breuck, S.2    Lardon, J.3
  • 25
    • 0035119871 scopus 로고    scopus 로고
    • Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine and hepatic phenotypes
    • Zulewski H, Abraham EJ, Gerlach MJ, et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine and hepatic phenotypes. Diabetes. 2001;50:521-533.
    • (2001) Diabetes , vol.50 , pp. 521-533
    • Zulewski, H.1    Abraham, E.J.2    Gerlach, M.J.3
  • 26
    • 1242293779 scopus 로고    scopus 로고
    • Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice
    • Abraham EJ, Kodama S, Lin JC, et al. Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice. Am J Pathol. 2004;164(3):817-830.
    • (2004) Am J Pathol , vol.164 , Issue.3 , pp. 817-830
    • Abraham, E.J.1    Kodama, S.2    Lin, J.C.3
  • 27
    • 1542361215 scopus 로고    scopus 로고
    • Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker
    • February
    • Street CN, Lakey JR, Seeberger K, et al. Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker. J Endocrinol. February 2004;180(2):213-225.
    • (2004) J Endocrinol , vol.180 , Issue.2 , pp. 213-225
    • Street, C.N.1    Lakey, J.R.2    Seeberger, K.3
  • 28
    • 0036230386 scopus 로고    scopus 로고
    • Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas
    • Selander L, Edlund H. Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas. Mech Dev. 2002;113(2):189-192.
    • (2002) Mech Dev , vol.113 , Issue.2 , pp. 189-192
    • Selander, L.1    Edlund, H.2
  • 29
    • 0141866856 scopus 로고    scopus 로고
    • Characterization and isolation of promoter-defined nestin-positive cells from the human fetal pancreas
    • Humphrey RK, Bucay N, Beattie GM, et al. Characterization and isolation of promoter-defined nestin-positive cells from the human fetal pancreas. Diabetes. 2003;52(10):2519-2525.
    • (2003) Diabetes , vol.52 , Issue.10 , pp. 2519-2525
    • Humphrey, R.K.1    Bucay, N.2    Beattie, G.M.3
  • 30
    • 8644274861 scopus 로고    scopus 로고
    • Potential of hematopoietic stem cell therapy in hepatology: A critical review
    • Masson S, Harrison DJ, Plevris JN, et al. Potential of hematopoietic stem cell therapy in hepatology: a critical review. Stem Cells. 2004;22(6):897-907.
    • (2004) Stem Cells , vol.22 , Issue.6 , pp. 897-907
    • Masson, S.1    Harrison, D.J.2    Plevris, J.N.3
  • 31
    • 15244349136 scopus 로고    scopus 로고
    • Stem cell biology and the plasticity polemic
    • Quesenberry PJ, Dooner G, Colvin G, et al. Stem cell biology and the plasticity polemic. Exp Hematol. 2005;33(4):389-394.
    • (2005) Exp Hematol , vol.33 , Issue.4 , pp. 389-394
    • Quesenberry, P.J.1    Dooner, G.2    Colvin, G.3
  • 32
    • 0033995277 scopus 로고    scopus 로고
    • Improved quality and yield of islets isolated from human pancreata using a two-step digestion method
    • Kenmochi T, Miyamoto M, Une S, et al. Improved quality and yield of islets isolated from human pancreata using a two-step digestion method. Pancreas. 2000;20(2):184-190.
    • (2000) Pancreas , vol.20 , Issue.2 , pp. 184-190
    • Kenmochi, T.1    Miyamoto, M.2    Une, S.3
  • 33
    • 0031908239 scopus 로고    scopus 로고
    • HsMCM2/BM28: A novel proliferation marker for human tumors and normal tissues
    • Todorov IT, Werness BA, Wang HQ, et al. HsMCM2/BM28: a novel proliferation marker for human tumors and normal tissues. Lab Invest. 1998;78(1):73-78.
    • (1998) Lab Invest , vol.78 , Issue.1 , pp. 73-78
    • Todorov, I.T.1    Werness, B.A.2    Wang, H.Q.3
  • 34
    • 0023897727 scopus 로고
    • A simple method of staining fresh and cultured islets
    • Latif ZA, Noel J, Alejandro R. A simple method of staining fresh and cultured islets. Transplantation. 1988;45(4):827-830.
    • (1988) Transplantation , vol.45 , Issue.4 , pp. 827-830
    • Latif, Z.A.1    Noel, J.2    Alejandro, R.3
  • 35
    • 0033286202 scopus 로고    scopus 로고
    • The REG gene family and REG proteins: With special attention to the regeneration of pancreatic beta-cells
    • Okamoto H. The REG gene family and REG proteins: with special attention to the regeneration of pancreatic beta-cells. J Hepatobiliary Pancreat Surg. 1999;6(3):254-262.
    • (1999) J Hepatobiliary Pancreat Surg , vol.6 , Issue.3 , pp. 254-262
    • Okamoto, H.1
  • 36
    • 0026608889 scopus 로고
    • Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas
    • Hall PA, Lemoine NR. Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas. J Pathol. 1992;166(2):97-103.
    • (1992) J Pathol , vol.166 , Issue.2 , pp. 97-103
    • Hall, P.A.1    Lemoine, N.R.2
  • 37
    • 0028147867 scopus 로고
    • Normal human pancreas cultures display functional ductal characteristics
    • Vila MR, Lloreta J, Real FX. Normal human pancreas cultures display functional ductal characteristics. Lab Invest. 1994;71(3):423-431.
    • (1994) Lab Invest , vol.71 , Issue.3 , pp. 423-431
    • Vila, M.R.1    Lloreta, J.2    Real, F.X.3
  • 38
    • 0034068602 scopus 로고    scopus 로고
    • Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
    • Ferber S, Halkin A, Cohen H, et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med. 2000;6(5):568-572.
    • (2000) Nat Med , vol.6 , Issue.5 , pp. 568-572
    • Ferber, S.1    Halkin, A.2    Cohen, H.3
  • 39
    • 0036301577 scopus 로고    scopus 로고
    • Pancreatic organogenesis - Developmental mechanisms and implications for therapy
    • Edlund H. Pancreatic organogenesis - developmental mechanisms and implications for therapy. Nat Rev Genet. 2002;3:524-532.
    • (2002) Nat Rev Genet , vol.3 , pp. 524-532
    • Edlund, H.1
  • 40
    • 0028361162 scopus 로고
    • Expression of neural cell adhesion molecule (N-CAM) in rat islets and its role in islet cell type segregation
    • Cirulli V, Baetens D, Rutishauser U, et al. Expression of neural cell adhesion molecule (N-CAM) in rat islets and its role in islet cell type segregation. J Cell Sci. 1994;107(pt 6):1429-1436.
    • (1994) J Cell Sci , vol.107 , Issue.6 PART , pp. 1429-1436
    • Cirulli, V.1    Baetens, D.2    Rutishauser, U.3
  • 41
    • 0029793745 scopus 로고    scopus 로고
    • Cadherins regulate aggregation of pancreatic beta-cells in vivo
    • Dahl U, Sjodin A, Semb H. Cadherins regulate aggregation of pancreatic beta-cells in vivo. Development. 1996;122(9):2895-2902.
    • (1996) Development , vol.122 , Issue.9 , pp. 2895-2902
    • Dahl, U.1    Sjodin, A.2    Semb, H.3
  • 42
    • 0027265403 scopus 로고
    • Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells
    • Otonkoski T, Beattie GM, Mally MI, et al. Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells. J Clin Invest. 1993;92(3):1459-1466.
    • (1993) J Clin Invest , vol.92 , Issue.3 , pp. 1459-1466
    • Otonkoski, T.1    Beattie, G.M.2    Mally, M.I.3
  • 43
    • 0037357951 scopus 로고    scopus 로고
    • GLP-1 receptor agonists are growth and differentiation factors for pancreatic beta cells
    • Egan JM, Bulotta A, Hui H, et al. GLP-1 receptor agonists are growth and differentiation factors for pancreatic beta cells. Diabetes Metab Res Rev. 2003;19:115-123.
    • (2003) Diabetes Metab Res Rev , vol.19 , pp. 115-123
    • Egan, J.M.1    Bulotta, A.2    Hui, H.3
  • 44
    • 0036772979 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic beta-cell death
    • Liu W, Chin-Chance C, Lee EJ, et al. Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic beta-cell death. Endocrinology. 2002;143(10):3802-3812.
    • (2002) Endocrinology , vol.143 , Issue.10 , pp. 3802-3812
    • Liu, W.1    Chin-Chance, C.2    Lee, E.J.3
  • 45
    • 0038235819 scopus 로고    scopus 로고
    • Keratinocyte growth factor and beta-cell differentiation in human fetal pancreatic endocrine precursor cells
    • Movassat J, Beattie GM, Lopez AD, et al. Keratinocyte growth factor and beta-cell differentiation in human fetal pancreatic endocrine precursor cells. Diabetologia. 2003;46(6):822-829.
    • (2003) Diabetologia , vol.46 , Issue.6 , pp. 822-829
    • Movassat, J.1    Beattie, G.M.2    Lopez, A.D.3
  • 46
    • 0027194337 scopus 로고
    • Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells
    • Wang TC, Bonner-Weir S, Oates PS, et al. Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest. 1993;92(3):1349-1356.
    • (1993) J Clin Invest , vol.92 , Issue.3 , pp. 1349-1356
    • Wang, T.C.1    Bonner-Weir, S.2    Oates, P.S.3
  • 47
    • 0036310118 scopus 로고    scopus 로고
    • Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue
    • Rooman I, Lardon J, Bouwens L. Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes. 2002;51(3):686-690.
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 686-690
    • Rooman, I.1    Lardon, J.2    Bouwens, L.3
  • 48
    • 0024538388 scopus 로고
    • Functional maturation of porcine fetal pancreatic explants
    • Tsunoda T, Furui H, Klandorf K, et al. Functional maturation of porcine fetal pancreatic explants. Transplant Proc. 1989;21(1 pt 3): 2667-2668.
    • (1989) Transplant Proc , vol.21 , Issue.1 PART 3 , pp. 2667-2668
    • Tsunoda, T.1    Furui, H.2    Klandorf, K.3
  • 49
    • 0029924055 scopus 로고    scopus 로고
    • Pancreatic thread protein is mitogenic to pancreatic-derived cells in culture
    • Zenilman ME, Magnuson TH, Swinson K, et al. Pancreatic thread protein is mitogenic to pancreatic-derived cells in culture. Gastroenterology. 1996;110:1208-1214.
    • (1996) Gastroenterology , vol.110 , pp. 1208-1214
    • Zenilman, M.E.1    Magnuson, T.H.2    Swinson, K.3
  • 50
    • 0029990981 scopus 로고    scopus 로고
    • Large scale isolation, growth, and function of porcine neonatal islet cells
    • Korbutt CG, Elliott JF, Ao Z, et al. Large scale isolation, growth, and function of porcine neonatal islet cells. J Clin Invest. 1996;97:2119-2129.
    • (1996) J Clin Invest , vol.97 , pp. 2119-2129
    • Korbutt, C.G.1    Elliott, J.F.2    Ao, Z.3
  • 51
    • 33646018505 scopus 로고
    • Growth and functional maturation of cryopreserved human fetal pancreata
    • Shiogama T, Mullen Y, Klandorf H, et al. Growth and functional maturation of cryopreserved human fetal pancreata. Diabetes. 1986;38(suppl 1):284.
    • (1986) Diabetes , vol.38 , Issue.1 SUPPL. , pp. 284
    • Shiogama, T.1    Mullen, Y.2    Klandorf, H.3
  • 52
    • 0033048421 scopus 로고    scopus 로고
    • Transplantation of human fetal pancreas: Fresh vs. cultured fetal islets or ICCS
    • Beattie GM, Lopez AD, Otonkoski T, et al. Transplantation of human fetal pancreas: fresh vs. cultured fetal islets or ICCS. J Mol Med. 1999;77(1):70-73.
    • (1999) J Mol Med , vol.77 , Issue.1 , pp. 70-73
    • Beattie, G.M.1    Lopez, A.D.2    Otonkoski, T.3


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