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Volumn 52, Issue 2, 2008, Pages 146-155

The natural history of type 1A diabetes

Author keywords

Anti islet autoimmunity; Autoantibodies; HLA, genetic; Type 1 diabetes

Indexed keywords

HLA DQ ANTIGEN; HLA DR ANTIGEN; INSULIN; INSULIN ANTIBODY;

EID: 43249094488     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/S0004-27302008000200002     Document Type: Review
Times cited : (43)

References (55)
  • 1
    • 34447134186 scopus 로고    scopus 로고
    • Update in type 1 diabetes
    • Eisenbarth GS. Update in type 1 diabetes. J Clin Endocrinol Metab. 2007;92(7):2403-7.
    • (2007) J Clin Endocrinol Metab , vol.92 , Issue.7 , pp. 2403-2407
    • Eisenbarth, G.S.1
  • 2
    • 40349084011 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • Diagnosis and classification of diabetes mellitus. Diabetes Care. 2008;31 Suppl 1:S55-S60.
    • (2008) Diabetes Care , vol.31 , Issue.SUPPL. 1
  • 3
    • 84969213492 scopus 로고    scopus 로고
    • 000 cases of seven common diseases and 3,000 shared controls
    • Genome-wide association study of 14
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447(7145):661-78.
    • (2007) Nature , vol.447 , Issue.7145 , pp. 661-678
  • 4
    • 35248878595 scopus 로고    scopus 로고
    • Accepting clocks that tell time poorly: Fluid-phase versus standard ELISA autoantibody assays
    • Liu E, Eisenbarth GS. Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays. Clin Immunol. 2007;125(2):120-6.
    • (2007) Clin Immunol , vol.125 , Issue.2 , pp. 120-126
    • Liu, E.1    Eisenbarth, G.S.2
  • 5
    • 33744900639 scopus 로고    scopus 로고
    • Lessons on autoimmune diabetes from animal models
    • Yang Y, Santamaria P. Lessons on autoimmune diabetes from animal models. Clin Sci (Lond). 2006;110(6):627-39.
    • (2006) Clin Sci (Lond) , vol.110 , Issue.6 , pp. 627-639
    • Yang, Y.1    Santamaria, P.2
  • 6
    • 34748917229 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes
    • Norris JM, Yin X, Lamb MM, Barriga K, Seifert J, Hoffman M et al. Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes. JAMA. 2007;298(12):1420-8.
    • (2007) JAMA , vol.298 , Issue.12 , pp. 1420-1428
    • Norris, J.M.1    Yin, X.2    Lamb, M.M.3    Barriga, K.4    Seifert, J.5    Hoffman, M.6
  • 7
    • 0022617990 scopus 로고
    • Type I diabetes mellitus. A chronic autoimmune disease
    • Eisenbarth GS. Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med. 1986;314:1360-8.
    • (1986) N Engl J Med , vol.314 , pp. 1360-1368
    • Eisenbarth, G.S.1
  • 8
    • 28444434811 scopus 로고    scopus 로고
    • IPEX and FOXP3: Clinical and research perspectives
    • Wildin RS, Freitas A. IPEX and FOXP3: Clinical and research perspectives. J Autoimmun. 2005;25 Suppl:56-62.
    • (2005) J Autoimmun , vol.25 , Issue.SUPPL. , pp. 56-62
    • Wildin, R.S.1    Freitas, A.2
  • 10
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003;4(4):330-6.
    • (2003) Nat Immunol , vol.4 , Issue.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 12
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    • Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet. 2007;39(7):857-64.
    • (2007) Nat Genet , vol.39 , Issue.7 , pp. 857-864
    • Todd, J.A.1    Walker, N.M.2    Cooper, J.D.3    Smyth, D.J.4    Downes, K.5    Plagnol, V.6
  • 13
    • 0029953008 scopus 로고    scopus 로고
    • The role of HLA class II genes in insulin-dependent diabetes mellitus: Molecular analysis of 180 Caucasian, multiplex families
    • Noble JA, Valdes AM, Cook M, Klitz W, Thomson G, Erlich HA. The role of HLA class II genes in insulin-dependent diabetes mellitus: Molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet. 1996;59(5):1134-48.
    • (1996) Am J Hum Genet , vol.59 , Issue.5 , pp. 1134-1148
    • Noble, J.A.1    Valdes, A.M.2    Cook, M.3    Klitz, W.4    Thomson, G.5    Erlich, H.A.6
  • 14
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDM2 susceptibility locus for type I diabetes
    • Pugliese A, Zeller M, Fernandez A, Zalcberg LJ, Bartlett RJ, Ricordi C et al. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDM2 susceptibility locus for type I diabetes. Nat Genet. 1997;15(3):293-7.
    • (1997) Nat Genet , vol.15 , Issue.3 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez, A.3    Zalcberg, L.J.4    Bartlett, R.J.5    Ricordi, C.6
  • 15
    • 12144291502 scopus 로고    scopus 로고
    • A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
    • Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M et al. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet. 2004;36(4):337-8.
    • (2004) Nat Genet , vol.36 , Issue.4 , pp. 337-338
    • Bottini, N.1    Musumeci, L.2    Alonso, A.3    Rahmouni, S.4    Nika, K.5    Rostamkhani, M.6
  • 16
    • 8544274482 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus (IDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
    • Marron MP, Raffel LJ, Garchon HJ, Jacob CO, Serrano-Rios M, Martinez LM et al. Insulin-dependent diabetes mellitus (IDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Hum Mol Genet. 1997;6(8):1275-82.
    • (1997) Hum Mol Genet , vol.6 , Issue.8 , pp. 1275-1282
    • Marron, M.P.1    Raffel, L.J.2    Garchon, H.J.3    Jacob, C.O.4    Serrano-Rios, M.5    Martinez, L.M.6
  • 18
    • 34548461747 scopus 로고    scopus 로고
    • Baschal EE, Aly TA, Babu SR, Fernando MS, Yu L, Miao D et al. HLA-DPB1*0402 Protects Against Type 1A Diabetic Autoimmunity in the Highest Risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY Population. diab. 2007;56(Epub ahead of print):2405-9.
    • Baschal EE, Aly TA, Babu SR, Fernando MS, Yu L, Miao D et al. HLA-DPB1*0402 Protects Against Type 1A Diabetic Autoimmunity in the Highest Risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY Population. diab. 2007;56(Epub ahead of print):2405-9.
  • 19
    • 0025331496 scopus 로고
    • Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus
    • Baisch JM, Weeks T, Giles R, Hoover M, Stastny P, Capra JD. Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. N Engl J Med. 1990;322(26):1836-41.
    • (1990) N Engl J Med , vol.322 , Issue.26 , pp. 1836-1841
    • Baisch, J.M.1    Weeks, T.2    Giles, R.3    Hoover, M.4    Stastny, P.5    Capra, J.D.6
  • 21
    • 0033756922 scopus 로고    scopus 로고
    • DR and DQ associated protection from type 1 diabetes: Comparison of DRB1*1401 and DQA1*0102-DQB1*0602
    • Redondo MJ, Kawasaki E, Mulgrew CL, Noble JA, Erlich HA, Freed BM et al. DR and DQ associated protection from type 1 diabetes: comparison of DRB1*1401 and DQA1*0102-DQB1*0602. J Clin Endocrinol Metab. 2000;85(10):3793-7.
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.10 , pp. 3793-3797
    • Redondo, M.J.1    Kawasaki, E.2    Mulgrew, C.L.3    Noble, J.A.4    Erlich, H.A.5    Freed, B.M.6
  • 23
    • 3242732770 scopus 로고    scopus 로고
    • Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease
    • Blomhoff A, Lie BA, Myhre AG, Kemp EH, Weetman AP, Akselsen HE et al. Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease. J Clin Endocrinol Metab. 2004;89(7):3474-6.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.7 , pp. 3474-3476
    • Blomhoff, A.1    Lie, B.A.2    Myhre, A.G.3    Kemp, E.H.4    Weetman, A.P.5    Akselsen, H.E.6
  • 24
    • 0031911947 scopus 로고    scopus 로고
    • Hanifi MP, de Knijf P, Roep BO, van der AB, Naipal A, Gorus F et al. Genetic structure of IDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry. Diabetes. 1998;47(2):263-9.
    • Hanifi MP, de Knijf P, Roep BO, van der AB, Naipal A, Gorus F et al. Genetic structure of IDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry. Diabetes. 1998;47(2):263-9.
  • 25
    • 2442650465 scopus 로고    scopus 로고
    • Allelic variation in class I K gene as candidate for a second component of MHC-linked susceptibility to type 1 diabetes in non-obese diabetic mice
    • Inoue K, Ikegami H, Fujisawa T, Noso S, Nojima K, Babaya N et al. Allelic variation in class I K gene as candidate for a second component of MHC-linked susceptibility to type 1 diabetes in non-obese diabetic mice. Diabetologia. 2004;47(4):739-47.
    • (2004) Diabetologia , vol.47 , Issue.4 , pp. 739-747
    • Inoue, K.1    Ikegami, H.2    Fujisawa, T.3    Noso, S.4    Nojima, K.5    Babaya, N.6
  • 26
    • 0033566664 scopus 로고    scopus 로고
    • Cutting edge: Homologous recombination of the MHC class I K region defines new MHC-linked diabetogenic susceptibility gene(s) in non-obese diabetic mice
    • Hattori M, Yamato E, Itoh N, Senpuku H, Fujisawa T, Yoshino M et al. Cutting edge: homologous recombination of the MHC class I K region defines new MHC-linked diabetogenic susceptibility gene(s) in non-obese diabetic mice. J Immunol. 1999;163(4):1721-4.
    • (1999) J Immunol , vol.163 , Issue.4 , pp. 1721-1724
    • Hattori, M.1    Yamato, E.2    Itoh, N.3    Senpuku, H.4    Fujisawa, T.5    Yoshino, M.6
  • 28
    • 2542484935 scopus 로고    scopus 로고
    • Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up
    • Barker JM, Goehrig SH, Barriga K, Hoffman M, Slover R, Eisenbarth GS et al. Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up. Diabetes Care. 2004;27(6):1399-404.
    • (2004) Diabetes Care , vol.27 , Issue.6 , pp. 1399-1404
    • Barker, J.M.1    Goehrig, S.H.2    Barriga, K.3    Hoffman, M.4    Slover, R.5    Eisenbarth, G.S.6
  • 29
    • 4043091960 scopus 로고    scopus 로고
    • Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    • Barker JM, Barriga K, Yu L, Miao D, Erlich H, Norris JN et al. Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). J Clin Endocrinol Metab. 2004;89:3896-902.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3896-3902
    • Barker, J.M.1    Barriga, K.2    Yu, L.3    Miao, D.4    Erlich, H.5    Norris, J.N.6
  • 30
    • 4344690190 scopus 로고    scopus 로고
    • Mature high-affinity immune responses to (pro) insulin anticipate the autoimmune cascade that leads to type 1 diabetes
    • Achenbach P, Koczwara K, Knopff A, Naserke H, Ziegler AG, Bonifacio E. Mature high-affinity immune responses to (pro) insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest. 2004;114(4):589-97.
    • (2004) J Clin Invest , vol.114 , Issue.4 , pp. 589-597
    • Achenbach, P.1    Koczwara, K.2    Knopff, A.3    Naserke, H.4    Ziegler, A.G.5    Bonifacio, E.6
  • 31
    • 0029995958 scopus 로고    scopus 로고
    • Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
    • Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA et al. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes. 1996;45(7):926-93.
    • (1996) Diabetes , vol.45 , Issue.7 , pp. 926-993
    • Verge, C.F.1    Gianani, R.2    Kawasaki, E.3    Yu, L.4    Pietropaolo, M.5    Jackson, R.A.6
  • 32
    • 36749011882 scopus 로고    scopus 로고
    • The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    • Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A. 2007;104(43):17040-5.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.43 , pp. 17040-17045
    • Wenzlau, J.M.1    Juhl, K.2    Yu, L.3    Moua, O.4    Sarkar, S.A.5    Gottlieb, P.6
  • 33
    • 33846126592 scopus 로고    scopus 로고
    • Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity
    • Wang J, Miao D, Babu S, Yu J, Barker J, Klingensmith G et al. Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity. J Clin Endocrinol Metab. 2007;92(1):88-92.
    • (2007) J Clin Endocrinol Metab , vol.92 , Issue.1 , pp. 88-92
    • Wang, J.1    Miao, D.2    Babu, S.3    Yu, J.4    Barker, J.5    Klingensmith, G.6
  • 34
    • 0023722804 scopus 로고
    • Concentration of insulin autoantibodies at onset of type I diabetes. Inverse log-linear correlation with age
    • Vardi P, Ziegler AG, Matthews JH, Dib S, Keller RJ, Ricker AT et al. Concentration of insulin autoantibodies at onset of type I diabetes. Inverse log-linear correlation with age. Diabetes Care. 1988;11(9):736-9.
    • (1988) Diabetes Care , vol.11 , Issue.9 , pp. 736-739
    • Vardi, P.1    Ziegler, A.G.2    Matthews, J.H.3    Dib, S.4    Keller, R.J.5    Ricker, A.T.6
  • 35
    • 33644761984 scopus 로고    scopus 로고
    • Palmer JP, Hampe CS, Chiu H, Goel A, Brooks-Worrell BM. Is latent autoimmune diabetes in adults distinct from type 1 diabetes or just type 1 diabetes at an older age? Diabetes. 2005;54 Suppl 2:S62-7.:S62-S67.
    • Palmer JP, Hampe CS, Chiu H, Goel A, Brooks-Worrell BM. Is latent autoimmune diabetes in adults distinct from type 1 diabetes or just type 1 diabetes at an older age? Diabetes. 2005;54 Suppl 2:S62-7.:S62-S67.
  • 37
    • 34249665017 scopus 로고    scopus 로고
    • GAD autoantibody affinity and epitope specificity identify distinct immunization profiles in children at risk for type 1 diabetes
    • Mayr A, Schlosser M, Grober N, Kenk H, Ziegler AG, Bonifacio E et al. GAD autoantibody affinity and epitope specificity identify distinct immunization profiles in children at risk for type 1 diabetes. Diabetes. 2007;56(6):1527-33.
    • (2007) Diabetes , vol.56 , Issue.6 , pp. 1527-1533
    • Mayr, A.1    Schlosser, M.2    Grober, N.3    Kenk, H.4    Ziegler, A.G.5    Bonifacio, E.6
  • 39
    • 33646428917 scopus 로고    scopus 로고
    • Initial results of screening of non - diabetic organ donors for expression of islet autoantibodies
    • Gianani R, Putnam A, Still T, Yu L, Miao D, Gill RG et al. Initial results of screening of non - diabetic organ donors for expression of islet autoantibodies. J Clin Endocrinol Metab. 2006;91:1855-61.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1855-1861
    • Gianani, R.1    Putnam, A.2    Still, T.3    Yu, L.4    Miao, D.5    Gill, R.G.6
  • 40
    • 0025951776 scopus 로고    scopus 로고
    • Foulis AK, McGill M, Farquharson MA. Insulitis in type 1 (insulin-dependent) diabetes mellitus in man - macrophages, lymphocytes, and interferon-gamma containing cells. J Pathol. 1991;165(2):97-103.
    • Foulis AK, McGill M, Farquharson MA. Insulitis in type 1 (insulin-dependent) diabetes mellitus in man - macrophages, lymphocytes, and interferon-gamma containing cells. J Pathol. 1991;165(2):97-103.
  • 41
    • 34848851427 scopus 로고    scopus 로고
    • Modestly increased beta-cell apoptosis but no increased beta-cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis
    • Butler AE, Galasso R, Meier JJ, Basu R, Rizza RA, Butler PC. Modestly increased beta-cell apoptosis but no increased beta-cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis. Diabetologia. 2007;50(11):2323-31.
    • (2007) Diabetologia , vol.50 , Issue.11 , pp. 2323-2331
    • Butler, A.E.1    Galasso, R.2    Meier, J.J.3    Basu, R.4    Rizza, R.A.5    Butler, P.C.6
  • 42
    • 38449111219 scopus 로고    scopus 로고
    • Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes
    • Monti P, Scirpoli M, Rigamonti A, Mayr A, Jaeger A, Bonfanti R et al. Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes. J Immunol. 2007;179(9):5785-92.
    • (2007) J Immunol , vol.179 , Issue.9 , pp. 5785-5792
    • Monti, P.1    Scirpoli, M.2    Rigamonti, A.3    Mayr, A.4    Jaeger, A.5    Bonfanti, R.6
  • 43
    • 27844518834 scopus 로고    scopus 로고
    • Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects
    • Danke NA, Yang J, Greenbaum C, Kwok WW. Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects. J Autoimmun. 2005;25(4):303-11.
    • (2005) J Autoimmun , vol.25 , Issue.4 , pp. 303-311
    • Danke, N.A.1    Yang, J.2    Greenbaum, C.3    Kwok, W.W.4
  • 44
    • 33845634821 scopus 로고    scopus 로고
    • Pre-type 1 diabetes dysmetabolism: Maximal sensitivity achieved with both oral and intravenous glucose tolerance testing
    • Barker JM, McFann K, Harrison LC, Fourlanos S, Krischer J, Cuthbertson D et al. Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing. J Pediatr. 2007;150(1):31-6.
    • (2007) J Pediatr , vol.150 , Issue.1 , pp. 31-36
    • Barker, J.M.1    McFann, K.2    Harrison, L.C.3    Fourlanos, S.4    Krischer, J.5    Cuthbertson, D.6
  • 45
    • 33744995996 scopus 로고    scopus 로고
    • Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1
    • Sosenko JM, Palmer JP, Greenbaum CJ, Mahon J, Cowie C, Krischer JP et al. Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care. 2006;29(3):643-9.
    • (2006) Diabetes Care , vol.29 , Issue.3 , pp. 643-649
    • Sosenko, J.M.1    Palmer, J.P.2    Greenbaum, C.J.3    Mahon, J.4    Cowie, C.5    Krischer, J.P.6
  • 46
    • 33750140236 scopus 로고    scopus 로고
    • Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    • Stene LC, Barriga K, Hoffman M, Kean J, Klingensmith G, Norris JM et al. Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). Pediatr Diabetes. 2006;7(5):247-53.
    • (2006) Pediatr Diabetes , vol.7 , Issue.5 , pp. 247-253
    • Stene, L.C.1    Barriga, K.2    Hoffman, M.3    Kean, J.4    Klingensmith, G.5    Norris, J.M.6
  • 47
    • 34848887156 scopus 로고    scopus 로고
    • Recovery from diabetes in mice by beta-cell regeneration
    • Nir T, Melton DA, Dor Y. Recovery from diabetes in mice by beta-cell regeneration. J Clin Invest. 2007;117(9):2553-61.
    • (2007) J Clin Invest , vol.117 , Issue.9 , pp. 2553-2561
    • Nir, T.1    Melton, D.A.2    Dor, Y.3
  • 48
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004;429(6987):41-6.
    • (2004) Nature , vol.429 , Issue.6987 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 49
    • 34249012115 scopus 로고    scopus 로고
    • Ablamunits V, Sherry NA, Kushner JA, Herold KC. Autoimmunity and beta-cell regeneration in mouse and human type 1 diabetes: the peace is not enough. Ann N Y Acad Sci. 2007;1103:19-32. Epub@2007 Mar 21:19-32.
    • Ablamunits V, Sherry NA, Kushner JA, Herold KC. Autoimmunity and beta-cell regeneration in mouse and human type 1 diabetes: the peace is not enough. Ann N Y Acad Sci. 2007;1103:19-32. Epub@2007 Mar 21:19-32.
  • 50
    • 0035076548 scopus 로고    scopus 로고
    • Heterogeneity of type I diabetes: Analysis of monozygotic twins in Great Britain and the United States
    • Redondo MJ, Yu L, Hawa M, Mackenzie T, Pyke DA, Eisenbarth GS et al. Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States. Diabetologia. 2001;44(3):354-62.
    • (2001) Diabetologia , vol.44 , Issue.3 , pp. 354-362
    • Redondo, M.J.1    Yu, L.2    Hawa, M.3    Mackenzie, T.4    Pyke, D.A.5    Eisenbarth, G.S.6
  • 51
    • 34547643406 scopus 로고    scopus 로고
    • B-cell depletion with rituximab in the treatment of autoimmune diseases. Graves' ophthalmopathy the latest addition to an expanding family
    • Nielsen CH, El Fassi D, Hasselbalch HC, Bendtzen K, Hegedus L. B-cell depletion with rituximab in the treatment of autoimmune diseases. Graves' ophthalmopathy the latest addition to an expanding family. Expert Opin Biol Ther. 2007;7(7):1061-78.
    • (2007) Expert Opin Biol Ther , vol.7 , Issue.7 , pp. 1061-1078
    • Nielsen, C.H.1    El Fassi, D.2    Hasselbalch, H.C.3    Bendtzen, K.4    Hegedus, L.5
  • 52
    • 34547691507 scopus 로고    scopus 로고
    • Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: The 50-year medalist study
    • Keenan HA, Costacou T, Sun JK, Doria A, Cavellerano J, Coney J et al. Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study. Diabetes Care. 2007;30(8):1995-7.
    • (2007) Diabetes Care , vol.30 , Issue.8 , pp. 1995-1997
    • Keenan, H.A.1    Costacou, T.2    Sun, J.K.3    Doria, A.4    Cavellerano, J.5    Coney, J.6
  • 54
    • 24644479189 scopus 로고    scopus 로고
    • Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes
    • Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R et al. Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes. J Clin Invest. 2005;115(9):2454-61.
    • (2005) J Clin Invest , vol.115 , Issue.9 , pp. 2454-2461
    • Turvey, S.E.1    Swart, E.2    Denis, M.C.3    Mahmood, U.4    Benoist, C.5    Weissleder, R.6
  • 55
    • 38349073954 scopus 로고    scopus 로고
    • VMAT2 gene expression and function as it applies to imaging beta-cell mass
    • Harris PE, Ferrara C, Barba P, Polito T, Freeby M, Maffei A. VMAT2 gene expression and function as it applies to imaging beta-cell mass. J Mol Med. 2008;86(1):5-16.
    • (2008) J Mol Med , vol.86 , Issue.1 , pp. 5-16
    • Harris, P.E.1    Ferrara, C.2    Barba, P.3    Polito, T.4    Freeby, M.5    Maffei, A.6


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