메뉴 건너뛰기




Volumn 25, Issue 7, 2010, Pages 1555-1563

Genome-wide pleiotropy of osteoporosis-related phenotypes: The Framingham study

Author keywords

Bone mineral density; Femoral geometry; Genetic correlations; Genome wide association; Pleiotropy; Quantitative ultrasound; Single nucleotide polymorphisms

Indexed keywords

AGED; ARTICLE; BONE DENSITY; BONE MINERAL; CORRELATION ANALYSIS; ECHOGRAPHY; ENVIRONMENTAL FACTOR; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HEEL; HIP; HUMAN; MAJOR CLINICAL STUDY; OSTEOPOROSIS; PHENOTYPE; PLEIOTROPY; SINGLE NUCLEOTIDE POLYMORPHISM; SPINE;

EID: 77954717620     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.38     Document Type: Article
Times cited : (48)

References (61)
  • 1
    • 33750209491 scopus 로고    scopus 로고
    • An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
    • DOI 10.1007/s00198-006-0172-4
    • Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006;17:1726-1733. (Pubitemid 44607392)
    • (2006) Osteoporosis International , vol.17 , Issue.12 , pp. 1726-1733
    • Johnell, O.1    Kanis, J.A.2
  • 2
    • 33645238237 scopus 로고    scopus 로고
    • Femur strength index predicts hip fracture independent of bone density and hip axis length
    • Faulkner KG, Wacker WK, Barden HS, et al. Femur strength index predicts hip fracture independent of bone density and hip axis length. Osteoporos Int. 2006;17:593-599.
    • (2006) Osteoporos Int , vol.17 , pp. 593-599
    • Faulkner, K.G.1    Wacker, W.K.2    Barden, H.S.3
  • 3
    • 0032931920 scopus 로고    scopus 로고
    • How to use ultrasound for risk assessment: A need for defining strategies
    • DOI 10.1007/s001980050135
    • Gluer CC, Hans D. How to use ultrasound for risk assessment: a need for defining strategies. Osteoporos Int. 1999;9:193-195. (Pubitemid 29182367)
    • (1999) Osteoporosis International , vol.9 , Issue.3 , pp. 193-195
    • Gluer, C.-C.1    Hans, D.2
  • 4
    • 0029986509 scopus 로고    scopus 로고
    • Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures
    • Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures [see comments]. BMJ. 1996;312:1254-1259. (Pubitemid 26147662)
    • (1996) British Medical Journal , vol.312 , Issue.7041 , pp. 1254-1259
    • Marshall, D.1    Johnell, O.2    Wedel, H.3
  • 5
    • 33645238573 scopus 로고    scopus 로고
    • The use of multiple sites for the diagnosis of osteoporosis
    • Kanis JA, Johnell O, Oden A, et al. The use of multiple sites for the diagnosis of osteoporosis. Osteoporos Int. 2006;17:527-534.
    • (2006) Osteoporos Int , vol.17 , pp. 527-534
    • Kanis, J.A.1    Johnell, O.2    Oden, A.3
  • 7
    • 56749107611 scopus 로고    scopus 로고
    • Prediction of Incident Hip Fracture Risk by Femur Geometry Variables Measured by Hip Structural Analysis in the Study of Osteoporotic Fractures
    • Kaptoge S, Beck TJ, Reeve J, et al. Prediction of Incident Hip Fracture Risk by Femur Geometry Variables Measured by Hip Structural Analysis in the Study of Osteoporotic Fractures. J Bone Miner Res. 2008;23:1892-1904.
    • (2008) J Bone Miner Res , vol.23 , pp. 1892-1904
    • Kaptoge, S.1    Beck, T.J.2    Reeve, J.3
  • 8
    • 0036378851 scopus 로고    scopus 로고
    • Evidence for a major gene for bone mineral density/content in human pedigrees identified via probands with extreme bone mineral density
    • Deng HW, Livshits G, Yakovenko K, et al. Evidence for a major gene for bone mineral density/content in human pedigrees identified via probands with extreme bone mineral density. Ann Hum Genet. 2002;66:61-74.
    • (2002) Ann Hum Genet , vol.66 , pp. 61-74
    • Deng, H.W.1    Livshits, G.2    Yakovenko, K.3
  • 10
    • 0031856655 scopus 로고    scopus 로고
    • Genetic and environmental contributions to the association between quantitative ultrasound and bone mineral density measurements: A twin study
    • DOI 10.1359/jbmr.1998.13.8.1318
    • Howard GM, Nguyen TV, Harris M, Kelly PJ, Eisman JA. Genetic and environmental contributions to the association between quantitative ultrasound and bone mineral density measurements: a twin study. J Bone Miner Res. 1998;13:1318-1327. (Pubitemid 28373334)
    • (1998) Journal of Bone and Mineral Research , vol.13 , Issue.8 , pp. 1318-1327
    • Howard, G.M.1    Nguyen, T.V.2    Harris, M.3    Kelly, P.J.4    Eisman, J.A.5
  • 11
    • 0036078514 scopus 로고    scopus 로고
    • Genetic control of susceptibility to osteoporosis
    • Ralston SH. Genetic control of susceptibility to osteoporosis. J Clin Endocrinol Metab. 2002;87:2460-2466.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2460-2466
    • Ralston, S.H.1
  • 12
    • 58849092456 scopus 로고    scopus 로고
    • A genome wide linkage scan of metacarpal size and geometry in the Framingham Study
    • Karasik D, Shimabuku NA, Zhou Y, et al. A genome wide linkage scan of metacarpal size and geometry in the Framingham Study. Am J Hum Biol. 2008;20:663-670.
    • (2008) Am J Hum Biol , vol.20 , pp. 663-670
    • Karasik, D.1    Shimabuku, N.A.2    Zhou, Y.3
  • 13
    • 0036136714 scopus 로고    scopus 로고
    • Relevance of the genes for bone mass variation to susceptibility to osteoporotic fractures and its implications to gene search for complex human diseases
    • Deng HW, Mahaney MC, Williams JT, et al. Relevance of the genes for bone mass variation to susceptibility to osteoporotic fractures and its implications to gene search for complex human diseases. Genet Epidemiol. 2002;22:12-25.
    • (2002) Genet Epidemiol , vol.22 , pp. 12-25
    • Deng, H.W.1    Mahaney, M.C.2    Williams, J.T.3
  • 14
    • 21644444684 scopus 로고    scopus 로고
    • Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD
    • DOI 10.1359/jbmr.2005.20.1.67
    • Andrew T, Antioniades L, Scurrah KJ, Macgregor AJ, Spector TD. Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD. J Bone Miner Res. 2005;20:67-74. (Pubitemid 41716220)
    • (2005) Journal of Bone and Mineral Research , vol.20 , Issue.1 , pp. 67-74
    • Andrew, T.1    Antioniades, L.2    Scurrah, K.J.3    MacGregor, A.J.4    Spector, T.D.5
  • 15
    • 16844371643 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD
    • DOI 10.1007/s00198-004-1704-4
    • Villadsen MM, Bunger MH, Carstens M, Stenkjaer L, Langdahl BL. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD. Osteoporos Int. 2005;16:411-416. (Pubitemid 40487399)
    • (2005) Osteoporosis International , vol.16 , Issue.4 , pp. 411-416
    • Villadsen, M.M.1    Bunger, M.H.2    Carstens, M.3    Stenkjaer, L.4    Langdahl, B.L.5
  • 16
    • 0041808714 scopus 로고    scopus 로고
    • Association of 5′ estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk
    • van Meurs JB, Schuit SC, Weel AE, et al. Association of 5′ estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk. Hum Mol Genet. 2003;12: 1745-1754.
    • (2003) Hum Mol Genet , vol.12 , pp. 1745-1754
    • Van Meurs, J.B.1    Schuit, S.C.2    Weel, A.E.3
  • 17
  • 18
    • 70350221000 scopus 로고    scopus 로고
    • For the GEnetic Factors for Osteoporosis (GEFOS) Consortium. Collaborative meta-analysis: Associations of 150 candidate genes with osteoporisis and osteoporotic fracture
    • Richards JB, Kavvoura FK, Rivadeneira F, et al. For the GEnetic Factors For Osteoporosis (GEFOS) Consortium. Collaborative meta-analysis: Associations of 150 candidate genes with osteoporisis and osteoporotic fracture. Ann Int Med. 2009;151:528-537.
    • (2009) Ann Int Med , vol.151 , pp. 528-537
    • Richards, J.B.1    Kavvoura, F.K.2    Rivadeneira, F.3
  • 19
    • 34249677477 scopus 로고    scopus 로고
    • Genetic and environmental determinants of volumetric and areal BMD in multi-generational families of African ancestry: The Tobago Family Health Study
    • Wang X, Kammerer CM, Wheeler VW, Patrick AL, Bunker CH, Zmuda JM. Genetic and environmental determinants of volumetric and areal BMD in multi-generational families of African ancestry: the Tobago Family Health Study. J Bone Miner Res. 2007;22:527-536.
    • (2007) J Bone Miner Res , vol.22 , pp. 527-536
    • Wang, X.1    Kammerer, C.M.2    Wheeler, V.W.3    Patrick, A.L.4    Bunker, C.H.5    Zmuda, J.M.6
  • 20
    • 0036708162 scopus 로고    scopus 로고
    • Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: The Framingham Study
    • Karasik D, Myers RH, Cupples LA, et al. Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: the Framingham Study. J Bone Miner Res. 2002;17:1718-1727.
    • (2002) J Bone Miner Res , vol.17 , pp. 1718-1727
    • Karasik, D.1    Myers, R.H.2    Cupples, L.A.3
  • 21
    • 33846473055 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide scans provides evidence for sex- And site-specific regulation of bone mass
    • Ioannidis JP, Ng MY, Sham PC, et al. Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass. J Bone Miner Res. 2007;22:173-183.
    • (2007) J Bone Miner Res , vol.22 , pp. 173-183
    • Ioannidis, J.P.1    Ng, M.Y.2    Sham, P.C.3
  • 22
    • 1542286077 scopus 로고    scopus 로고
    • Genome screen for a combined bone phenotype using principal component analysis: The Framingham study
    • Karasik D, Cupples LA, Hannan MT, Kiel DP. Genome screen for a combined bone phenotype using principal component analysis: the Framingham study. Bone. 2004;34:547-556.
    • (2004) Bone , vol.34 , pp. 547-556
    • Karasik, D.1    Cupples, L.A.2    Hannan, M.T.3    Kiel, D.P.4
  • 23
    • 54349097569 scopus 로고    scopus 로고
    • A bivariate whole genome linkage study identified genomic regions influencing both BMD and bone structure
    • Liu XG, Liu YJ, Liu J, et al. A bivariate whole genome linkage study identified genomic regions influencing both BMD and bone structure. J Bone Miner Res. 2008;23:1806-1814.
    • (2008) J Bone Miner Res , vol.23 , pp. 1806-1814
    • Liu, X.G.1    Liu, Y.J.2    Liu, J.3
  • 25
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007;316:1331-1336.
    • (2007) Science , vol.316 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2    Lyssenko, V.3
  • 26
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 2007;316:1341-1345.
    • (2007) Science , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3
  • 27
    • 34249996115 scopus 로고    scopus 로고
    • A common allele on chromosome 9 associated with coronary heart disease
    • McPherson R, Pertsemlidis A, Kavaslar N, et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007;316:1488-1491.
    • (2007) Science , vol.316 , pp. 1488-1491
    • McPherson, R.1    Pertsemlidis, A.2    Kavaslar, N.3
  • 28
    • 0038670579 scopus 로고    scopus 로고
    • The human phenome project
    • Freimer N, Sabatti C. The human phenome project. Nat Genet. 2003;34:15-21.
    • (2003) Nat Genet , vol.34 , pp. 15-21
    • Freimer, N.1    Sabatti, C.2
  • 30
    • 70350646912 scopus 로고    scopus 로고
    • Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies
    • Rivadeneira F, Styrkársdóttir U, Estrada K, et al. Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies. Nature Genetics. 2009;41:1199-1206.
    • (2009) Nature Genetics , vol.41 , pp. 1199-1206
    • Rivadeneira, F.1    Styrkársdóttir, U.2    Estrada, K.3
  • 31
    • 44349167229 scopus 로고    scopus 로고
    • Multiple genetic loci for bone mineral density and fractures
    • Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, et al. Multiple genetic loci for bone mineral density and fractures. N Engl J Med. 2008;358:2355-2365.
    • (2008) N Engl J Med , vol.358 , pp. 2355-2365
    • Styrkarsdottir, U.1    Halldorsson, B.V.2    Gretarsdottir, S.3
  • 33
    • 66149086142 scopus 로고    scopus 로고
    • Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk
    • Drenos F, Talmud PJ, Casas JP, et al. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. Hum Mol Genet. 2009;18:2305-2316.
    • (2009) Hum Mol Genet , vol.18 , pp. 2305-2316
    • Drenos, F.1    Talmud, P.J.2    Casas, J.P.3
  • 34
    • 0041331738 scopus 로고    scopus 로고
    • Age, gender, and body mass effects on quantitative trait loci for bone mineral density: The Framingham study
    • Karasik D, Cupples LA, Hannan MT, Kiel DP. Age, gender, and body mass effects on quantitative trait loci for bone mineral density: the Framingham study. Bone. 2003;33:308-316.
    • (2003) Bone , vol.33 , pp. 308-316
    • Karasik, D.1    Cupples, L.A.2    Hannan, M.T.3    Kiel, D.P.4
  • 35
    • 49549091386 scopus 로고    scopus 로고
    • Contribution of gender-specific genetic factors to osteoporosis risk
    • Karasik D, Ferrari SL. Contribution of gender-specific genetic factors to osteoporosis risk. Ann Hum Genet. 2008;72:696-714.
    • (2008) Ann Hum Genet , vol.72 , pp. 696-714
    • Karasik, D.1    Ferrari, S.L.2
  • 36
    • 0034107179 scopus 로고    scopus 로고
    • Risk factors for longitudinal bone loss in elderly men and women: The Framingham Osteoporosis Study
    • Hannan MT, Felson DT, Dawson-Hughes B, et al. Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res. 2000;15:710-720.
    • (2000) J Bone Miner Res , vol.15 , pp. 710-720
    • Hannan, M.T.1    Felson, D.T.2    Dawson-Hughes, B.3
  • 37
    • 0036708162 scopus 로고    scopus 로고
    • Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: The Framingham Study
    • Karasik D, Myers R, Cupples L, et al. Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: The Framingham Study. J Bone Miner Res. 2002;17:1718-1727.
    • (2002) J Bone Miner Res , vol.17 , pp. 1718-1727
    • Karasik, D.1    Myers, R.2    Cupples, L.3
  • 38
    • 33846602219 scopus 로고    scopus 로고
    • Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study
    • DOI 10.1016/j.bone.2006.09.020, PII S8756328206007393
    • Demissie S, Dupuis J, Cupples LA, Beck TJ, Kiel DP, Karasik D. Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study. Bone. 2007;40:743-750. (Pubitemid 46187216)
    • (2007) Bone , vol.40 , Issue.3 , pp. 743-750
    • Demissie, S.1    Dupuis, J.2    Cupples, L.A.3    Beck, T.J.4    Kiel, D.P.5    Karasik, D.6
  • 39
    • 0034174221 scopus 로고    scopus 로고
    • Elderly cohort study subjects unable to return for follow-up have lower bone mass than those who can return
    • McLean RR, Hannan MT, Epstein BE, et al. Elderly cohort study subjects unable to return for follow-up have lower bone mass than those who can return. Am J Epidemiol. 2000;151:689-692.
    • (2000) Am J Epidemiol , vol.151 , pp. 689-692
    • McLean, R.R.1    Hannan, M.T.2    Epstein, B.E.3
  • 40
    • 20544434692 scopus 로고    scopus 로고
    • In vivo short-term precision of hip structure analysis variables in comparison with bone mineral density using paired dual-energy X-ray absorptiometry scans from multi-center clinical trials
    • Khoo BC, Beck TJ, Qiao QH, et al. In vivo short-term precision of hip structure analysis variables in comparison with bone mineral density using paired dual-energy X-ray absorptiometry scans from multi-center clinical trials. Bone. 2005;37:112-121.
    • (2005) Bone , vol.37 , pp. 112-121
    • Khoo, B.C.1    Beck, T.J.2    Qiao, Q.H.3
  • 41
    • 0018639203 scopus 로고
    • Some health benefits of physical activity. The Framingham Study
    • Kannel WB, Sorlie P. Some health benefits of physical activity. The Framingham Study. Arch Intern Med. 1979;139:857-861.
    • (1979) Arch Intern Med , vol.139 , pp. 857-861
    • Kannel, W.B.1    Sorlie, P.2
  • 42
    • 0033820011 scopus 로고    scopus 로고
    • Robust LOD scores for variance component-based linkage analysis
    • Blangero J, Williams JT, Almasy L. Robust LOD scores for variance component-based linkage analysis. Genet Epidemiol. 2000;19 (Suppl 1): S8-14.
    • (2000) Genet Epidemiol , vol.19 , Issue.SUPPL. 1
    • Blangero, J.1    Williams, J.T.2    Almasy, L.3
  • 43
    • 0031439473 scopus 로고    scopus 로고
    • Bivariate quantitative trait linkage analysis: Pleiotropy versus co- Incident linkages
    • DOI 10.1002/(SICI)1098-2272(1997)14:6<953::AID-GEPI65>3.0.CO;2-K
    • Almasy L, Dyer TD, Blangero J. Bivariate quantitative trait linkage analysis: pleiotropy versus co- incident linkages. Genet Epidemiol. 1997;14:953-958. (Pubitemid 28027515)
    • (1997) Genetic Epidemiology , vol.14 , Issue.6 , pp. 953-958
    • Almasy, L.1    Dyer, T.D.2    Blangero, J.3
  • 44
    • 0033365292 scopus 로고    scopus 로고
    • Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results
    • Williams JT, Van Eerdewegh P, Almasy L, Blangero J. Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results. Am J Hum Genet. 1999;65:1134-1147.
    • (1999) Am J Hum Genet , vol.65 , pp. 1134-1147
    • Williams, J.T.1    Van Eerdewegh, P.2    Almasy, L.3    Blangero, J.4
  • 45
    • 0022649864 scopus 로고
    • The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods
    • Boerwinkle E, Chakraborty R, Sing CF. The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods. Ann Hum Genet. 1986;50:181-194.
    • (1986) Ann Hum Genet , vol.50 , pp. 181-194
    • Boerwinkle, E.1    Chakraborty, R.2    Sing, C.F.3
  • 46
    • 38449106930 scopus 로고    scopus 로고
    • Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: The Rotterdam Study
    • Rivadeneira F, Zillikens MC, De Laet CE, et al. Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: the Rotterdam Study. J Bone Miner Res. 2007;22:1781-1790.
    • (2007) J Bone Miner Res , vol.22 , pp. 1781-1790
    • Rivadeneira, F.1    Zillikens, M.C.2    De Laet, C.E.3
  • 47
    • 67349253027 scopus 로고    scopus 로고
    • Women and men with hip fractures have a longer femoral neck moment arm and greater impact load in a sideways fall
    • Wang Q, Teo JW, Ghasem-Zadeh A, Seeman E. Women and men with hip fractures have a longer femoral neck moment arm and greater impact load in a sideways fall. Osteoporos Int. 2008;20:1151-1156.
    • (2008) Osteoporos Int , vol.20 , pp. 1151-1156
    • Wang, Q.1    Teo, J.W.2    Ghasem-Zadeh, A.3    Seeman, E.4
  • 48
    • 0030483252 scopus 로고    scopus 로고
    • Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics
    • DOI 10.1002/jor.1100140613
    • Wilsman NJ, Farnum CE, Leiferman EM, Fry M, Barreto C. Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics. J Orthop Res. 1996;14:927-936. (Pubitemid 27044462)
    • (1996) Journal of Orthopaedic Research , vol.14 , Issue.6 , pp. 927-936
    • Wilsman, N.J.1    Farnum, C.E.2    Leiferman, E.M.3    Fry, M.4    Barreto, C.5
  • 49
    • 0032717355 scopus 로고    scopus 로고
    • Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development
    • Lanske B, Amling M, Neff L, Guiducci J, Baron R, Kronenberg HM. Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development. J Clin Invest. 1999; 104:399-407. (Pubitemid 29534324)
    • (1999) Journal of Clinical Investigation , vol.104 , Issue.4 , pp. 399-407
    • Lanske, B.1    Amling, M.2    Neff, L.3    Guiducci, J.4    Baron, R.5    Kronenberg, H.M.6
  • 50
    • 0036785121 scopus 로고    scopus 로고
    • The Maka femur and its bearing on the antiquity of human walking: Applying contemporary concepts of morphogenesis to the human fossil record
    • Lovejoy CO, Meindl RS, Ohman JC, Heiple KG, White TD. The Maka femur and its bearing on the antiquity of human walking: applying contemporary concepts of morphogenesis to the human fossil record. Am J Phys Anthropol. 2002;119:97-133.
    • (2002) Am J Phys Anthropol , vol.119 , pp. 97-133
    • Lovejoy, C.O.1    Meindl, R.S.2    Ohman, J.C.3    Heiple, K.G.4    White, T.D.5
  • 51
    • 44449177084 scopus 로고    scopus 로고
    • Genetics of the musculoskeletal system: A pleiotropic approach
    • DOI 10.1359/jbmr.080218
    • Karasik D, Kiel DP. Genetics of the musculoskeletal system: a pleiotropic approach. J Bone Miner Res. 2008;23:788-802. (Pubitemid 351768797)
    • (2008) Journal of Bone and Mineral Research , vol.23 , Issue.6 , pp. 788-802
    • Karasik, D.1    Kiel, D.P.2
  • 52
    • 33747619846 scopus 로고    scopus 로고
    • The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice
    • DOI 10.1111/j.1525-142X.2006.00120.x
    • Wolf JB, Pomp D, Eisen EJ, Cheverud JM, Leamy LJ. The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice. Evol Dev. 2006;8:468-476. (Pubitemid 44267807)
    • (2006) Evolution and Development , vol.8 , Issue.5 , pp. 468-476
    • Wolf, J.B.1    Pomp, D.2    Eisen, E.J.3    Cheverud, J.M.4    Leamy, L.J.5
  • 53
    • 55549147191 scopus 로고    scopus 로고
    • Personal genomes: The case of the missing heritability
    • Maher B. Personal genomes: The case of the missing heritability. Nature. 2008;456:18-21.
    • (2008) Nature , vol.456 , pp. 18-21
    • Maher, B.1
  • 54
    • 0030854184 scopus 로고    scopus 로고
    • Genetics of complex disease: Approaches, problems, and solutions
    • Schork NJ. Genetics of complex disease: approaches, problems, and solutions. Am J Respir Crit Care Med. 1997;156:S103-109.
    • (1997) Am J Respir Crit Care Med , vol.156
    • Schork, N.J.1
  • 55
    • 70349560566 scopus 로고    scopus 로고
    • Phenomics: The systematic study of phenotypes on a genome-wide scale
    • Bilder RM, Sabb FW, Cannon TD, et al. Phenomics: The systematic study of phenotypes on a genome-wide scale. Neuroscience. 2009;164:30-42.
    • (2009) Neuroscience , vol.164 , pp. 30-42
    • Bilder, R.M.1    Sabb, F.W.2    Cannon, T.D.3
  • 56
    • 33746623411 scopus 로고    scopus 로고
    • Structural model analysis of multiple quantitative traits
    • Li R, Tsaih SW, Shockley K, et al. Structural model analysis of multiple quantitative traits. PLoS Genet. 2006;2:e114.
    • (2006) PLoS Genet , vol.2
    • Li, R.1    Tsaih, S.W.2    Shockley, K.3
  • 57
  • 58
    • 50249187303 scopus 로고    scopus 로고
    • On multiple-testing correction in genome-wide association studies
    • Moskvina V, Schmidt KM. On multiple-testing correction in genome-wide association studies. Genet Epidemiol. 2008;32:567-573.
    • (2008) Genet Epidemiol , vol.32 , pp. 567-573
    • Moskvina, V.1    Schmidt, K.M.2
  • 59
    • 33846080223 scopus 로고    scopus 로고
    • Computational approaches to phenotyping: High-throughput phenomics
    • Lussier YA, Liu Y. Computational approaches to phenotyping: high-throughput phenomics. Proc Am Thorac Soc. 2007;4: 18-25.
    • (2007) Proc Am Thorac Soc , vol.4 , pp. 18-25
    • Lussier, Y.A.1    Liu, Y.2
  • 60
    • 0032231766 scopus 로고    scopus 로고
    • Multiple phenotype modeling in gene-mapping studies of quantitative traits: Power advantages
    • Allison DB, Thiel B, St Jean P, Elston RC, Infante MC, Schork NJ. Multiple phenotype modeling in gene-mapping studies of quantitative traits: power advantages. Am J Hum Genet. 1998;63:1190-1201.
    • (1998) Am J Hum Genet , vol.63 , pp. 1190-1201
    • Allison, D.B.1    Thiel, B.2    St Jean, P.3    Elston, R.C.4    Infante, M.C.5    Schork, N.J.6
  • 61
    • 48949118906 scopus 로고    scopus 로고
    • Bivariate combined linkage and association mapping of quantitative trait loci
    • Jung J, Zhong M, Liu L, Fan R. Bivariate combined linkage and association mapping of quantitative trait loci. Genet Epidemiol. 2008;32:396-412.
    • (2008) Genet Epidemiol , vol.32 , pp. 396-412
    • Jung, J.1    Zhong, M.2    Liu, L.3    Fan, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.