Bivariate quantitative trait linkage analysis: Pleiotropy versus co- incident linkages

Genetic Epidemiology

Volumn 14, Issue 6, 1997, Pages 953-958

  Almasy, Laura ^a   Dyer, Thomas D ^a   Blangero, John ^a  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Linkage analysis; Pleiotropy; Quantitative traits; Statistical genetics

Indexed keywords

CHROMOSOME ANALYSIS; CONFERENCE PAPER; GENE CLUSTER; GENE LOCATION; GENETIC ANALYSIS; GENETIC LINKAGE; HUMAN; INCIDENCE; PLEIOTROPY; QUANTITATIVE TRAIT; STATISTICAL ANALYSIS;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 8; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); LOD SCORE; PEDIGREE; PHENOTYPE; QUANTITATIVE TRAIT, HERITABLE;

EID: 0031439473     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1997)14:6<953::AID-GEPI65>3.0.CO;2-K     Document Type: Conference Paper

References (9)

1. Almasy L, Hixson JE, VandeBerg JL, MacCluer JW, Blangero J (1996): Multipoint quantitative trait linkage analysis in general pedigrees. Am J Hum Genet 59:A173.
2. Amos CI (1994): Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 54:535-543.
3. Beaty TH, Self SG, Liang KY, Connolly MA, Chase GA, Kwiterovich PO (1985): Use of robust variance components models to analyse triglyceride data in families. Ann Hum Genet 49:315-328.
4. Blangero J (1995): Multivariate oligogenic linkage analysis of quantitative traits in general pedigrees. Am J Hum Genet 57:A11.
5. Blangero J, Almasy LA (1996): SOLAR: Sequential Oligogenic Linkage Analysis Routines. Technical Notes No. 6. Population Genetics Laboratory, Southwest Foundation for Biomedical Research, San Antonio, TX.
6. Davis S, Schroeder M, Goldin LR, Weeks DE (1996): Nonparametric simulation-based statistics for detecting linkage in general pedigrees. Am J Hum Genet 58:867-880.
7. Fulker DW, Cherny SS, Cardon LR (1995): Multipoint interval mapping of quantitative trait loci, using sib pairs. Am J Hum Genet 56:1224-1233.
8. Lange K, Weeks D, Boehnke M (1988): Programs for pedigree analysis: Mendel, Fisher, and dGene. Genet Epidemiol 5:471-472.
9. Self SG, Liang K-Y (1987): Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions. J Am Stat Assoc 82:605-610.