메뉴 건너뛰기




Volumn 65, Issue 4, 1999, Pages 1134-1147

Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALCOHOLISM; ARTICLE; COVARIANCE; EVENT RELATED POTENTIAL; FEMALE; GENETIC LINKAGE; HUMAN; MAJOR CLINICAL STUDY; MALE; MAXIMUM LIKELIHOOD METHOD; MULTIVARIATE ANALYSIS; PEDIGREE; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SIMULATION; VARIANCE;

EID: 0033365292     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302570     Document Type: Article
Times cited : (194)

References (80)
  • 1
    • 0000650222 scopus 로고
    • Note on selection from a multivariate normal population
    • Aitken AC (1934) Note on selection from a multivariate normal population. Proc Edinb Math Soc Bull 4:106-110
    • (1934) Proc Edinb Math Soc Bull , vol.4 , pp. 106-110
    • Aitken, A.C.1
  • 2
    • 0031966959 scopus 로고    scopus 로고
    • Multipoint quantitative-trait linkage analysis in general pedigrees
    • Almasy I., Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211
    • (1998) Am J Hum Genet , vol.62 , pp. 1198-1211
    • Almasy, I.1    Blangero, J.2
  • 3
    • 0031439473 scopus 로고    scopus 로고
    • Bivariate quantitative trait linkage analysis: Pleiotropy versus co-incident linkages
    • Almasy L, Dyer TD, Blangero J (1997) Bivariate quantitative trait linkage analysis: pleiotropy versus co-incident linkages. Genet Epidemiol 14:953-958
    • (1997) Genet Epidemiol , vol.14 , pp. 953-958
    • Almasy, L.1    Dyer, T.D.2    Blangero, J.3
  • 4
    • 0028058128 scopus 로고
    • Robust variance-components approach for assessing genetic linkage in pedigrees
    • Amos CI (1994) Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 54:535-543
    • (1994) Am J Hum Genet , vol.54 , pp. 535-543
    • Amos, C.I.1
  • 5
    • 0025170498 scopus 로고
    • A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype
    • Amos CI, Elston RC, Bonney GE, Keats BJB, Berenson GS (1990) A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype. Am J Hum Genet 47:247-254
    • (1990) Am J Hum Genet , vol.47 , pp. 247-254
    • Amos, C.I.1    Elston, R.C.2    Bonney, G.E.3    Keats, B.J.B.4    Berenson, G.S.5
  • 6
    • 0027772252 scopus 로고
    • A comparison of univariate and multivariate tests for genetic linkage
    • Amos CI, Laing AE (1993) A comparison of univariate and multivariate tests for genetic linkage. Genet Epidemiol 10:671-676
    • (1993) Genet Epidemiol , vol.10 , pp. 671-676
    • Amos, C.I.1    Laing, A.E.2
  • 7
    • 0029875522 scopus 로고    scopus 로고
    • Assessing genetic linkage and association with robust components of variance approaches
    • Amos CI, Zhu DK, Boerwinkle E (1996) Assessing genetic linkage and association with robust components of variance approaches. Ann Hum Genet 60:143-160
    • (1996) Ann Hum Genet , vol.60 , pp. 143-160
    • Amos, C.I.1    Zhu, D.K.2    Boerwinkle, E.3
  • 9
    • 0023181001 scopus 로고
    • Robust inference for variance components models in families ascertained through probands. I. Conditioning on the proband's phenotype
    • Beaty TH, Liang KY (1987) Robust inference for variance components models in families ascertained through probands. I. Conditioning on the proband's phenotype. Genet Epidemiol 4:203-210
    • (1987) Genet Epidemiol , vol.4 , pp. 203-210
    • Beaty, T.H.1    Liang, K.Y.2
  • 10
    • 0023223801 scopus 로고
    • Robust inference for variance components models in families ascertained through probands. II. Analysis of spirometric measures
    • Beaty TH, Liang KY, Seerey S, Cohen BH (1987) Robust inference for variance components models in families ascertained through probands. II. Analysis of spirometric measures. Genet Epidemiol 4:211-221
    • (1987) Genet Epidemiol , vol.4 , pp. 211-221
    • Beaty, T.H.1    Liang, K.Y.2    Seerey, S.3    Cohen, B.H.4
  • 12
    • 0021144410 scopus 로고
    • Event-related brain potentials in boys at risk for alcoholism
    • Begleiter H, Porjesz B, Bihari B, Kissin B (1984) Event-related brain potentials in boys at risk for alcoholism. Science 225:1493-1496
    • (1984) Science , vol.225 , pp. 1493-1496
    • Begleiter, H.1    Porjesz, B.2    Bihari, B.3    Kissin, B.4
  • 15
    • 0027720035 scopus 로고
    • Statistical genetic approaches to human adaptability
    • Blangero J (1993) Statistical genetic approaches to human adaptability. Hum Biol 65:941-966
    • (1993) Hum Biol , vol.65 , pp. 941-966
    • Blangero, J.1
  • 16
    • 0029624319 scopus 로고
    • Genetic analysis of a common oligogenic trait with quantitative correlates: Summary of GAW9 results
    • _ (1995) Genetic analysis of a common oligogenic trait with quantitative correlates: summary of GAW9 results. Genet Epidemiol 12:689-706
    • (1995) Genet Epidemiol , vol.12 , pp. 689-706
  • 17
    • 0000306844 scopus 로고    scopus 로고
    • Incorporating quantitative traits in genomic scans of psychiatric diseases: Alcoholism and event-related potentials
    • Blangero J, Almasy L, Williams JT, Porjesz B, Reich T, Begleiter H, COGA Collaborators (1997) Incorporating quantitative traits in genomic scans of psychiatric diseases: alcoholism and event-related potentials. Am J Med Genet 74:602
    • (1997) Am J Med Genet , vol.74 , pp. 602
    • Blangero, J.1    Almasy, L.2    Williams, J.T.3    Porjesz, B.4    Reich, T.5    Begleiter, H.6
  • 19
    • 0021297613 scopus 로고
    • Ascertainment and goodness of fit of variance component models for pedigree data
    • Boehnke M, Lange K (1984) Ascertainment and goodness of fit of variance component models for pedigree data. Prog Clin Biol Res 147:173-192
    • (1984) Prog Clin Biol Res , vol.147 , pp. 173-192
    • Boehnke, M.1    Lange, K.2
  • 20
    • 0022545964 scopus 로고
    • Univariate and bivariate analyses of cholesterol and triglyceride levels in pedigrees
    • Boehnke M, Moll PP, Lange K, Weidman WH, Kottke BA (1986) Univariate and bivariate analyses of cholesterol and triglyceride levels in pedigrees. Am J Med Genet 23:775-792
    • (1986) Am J Med Genet , vol.23 , pp. 775-792
    • Boehnke, M.1    Moll, P.P.2    Lange, K.3    Weidman, W.H.4    Kottke, B.A.5
  • 21
    • 0023694035 scopus 로고
    • Combined linkage segregation analysis using regressive models
    • Bonney GE, Lathrop GM, Lalouel J-M (1988) Combined linkage segregation analysis using regressive models. Am J Hum Genet 43:29-37
    • (1988) Am J Hum Genet , vol.43 , pp. 29-37
    • Bonney, G.E.1    Lathrop, G.M.2    Lalouel, J.-M.3
  • 22
    • 0025080556 scopus 로고
    • Combined segregation and linkage analysis of genetic hemochromatosis using affection status, serum iron, and HLA
    • Borecki IB, Lathrop GM, Bonney GE, Yaouanq J, Rao DC (1990) Combined segregation and linkage analysis of genetic hemochromatosis using affection status, serum iron, and HLA. Am J Hum Genet 47:542-550
    • (1990) Am J Hum Genet , vol.47 , pp. 542-550
    • Borecki, I.B.1    Lathrop, G.M.2    Bonney, G.E.3    Yaouanq, J.4    Rao, D.C.5
  • 23
    • 0021203889 scopus 로고
    • A genetic and environmental analysis of a twin family study of alcohol use, anxiety, and depression
    • Clifford CA, Hopper JL, Fulker DW, Murray RM (1984) A genetic and environmental analysis of a twin family study of alcohol use, anxiety, and depression. Genet Epidemiol 1:63-79
    • (1984) Genet Epidemiol , vol.1 , pp. 63-79
    • Clifford, C.A.1    Hopper, J.L.2    Fulker, D.W.3    Murray, R.M.4
  • 24
    • 0031017322 scopus 로고    scopus 로고
    • A major quantitative trait locus determining scrum leptin levels and fat mass is located on human chromosome 2
    • Comuzzie AG, Hixson JE, Almasy L, Mitchell BD, Mahaney MC, Dyer TD, Stern MP, et al (1997) A major quantitative trait locus determining scrum leptin levels and fat mass is located on human chromosome 2. Nat Genet 15:273-276
    • (1997) Nat Genet , vol.15 , pp. 273-276
    • Comuzzie, A.G.1    Hixson, J.E.2    Almasy, L.3    Mitchell, B.D.4    Mahaney, M.C.5    Dyer, T.D.6    Stern, M.P.7
  • 25
    • 0001572346 scopus 로고
    • An interpretation of familial aggregation based on multiple genetic and environmental factors
    • Crittenden LB (1961) An interpretation of familial aggregation based on multiple genetic and environmental factors. Ann N Y Acad Sci 91:769-780
    • (1961) Ann N Y Acad Sci , vol.91 , pp. 769-780
    • Crittenden, L.B.1
  • 26
    • 84889134993 scopus 로고    scopus 로고
    • Genetic analysis of personality traits and alcoholism using a mixed discrete-continuous trait variance component model
    • (in press)
    • Czerwinski SA, Mahaney MC, Williams JT, Almasy L, Blangero J. Genetic analysis of personality traits and alcoholism using a mixed discrete-continuous trait variance component model. Genet Epidemiol (in press)
    • Genet Epidemiol
    • Czerwinski, S.A.1    Mahaney, M.C.2    Williams, J.T.3    Almasy, L.4    Blangero, J.5
  • 27
    • 0031444117 scopus 로고    scopus 로고
    • Assessing linkage on chromosome 5 using components of variance approach: Univariate versus multivariate
    • De Andrade M, Thiel TJ, Yu LP, Amos CI (1997) Assessing linkage on chromosome 5 using components of variance approach: univariate versus multivariate. Genet Epidemiol 14:773-778
    • (1997) Genet Epidemiol , vol.14 , pp. 773-778
    • De Andrade, M.1    Thiel, T.J.2    Yu, L.P.3    Amos, C.I.4
  • 28
    • 21144478473 scopus 로고
    • Solution of multiple trait animal models with missing data on some traits
    • Ducrocq V, Besbes B (1993) Solution of multiple trait animal models with missing data on some traits. J Anim Breed Genet 110:81-92
    • (1993) J Anim Breed Genet , vol.110 , pp. 81-92
    • Ducrocq, V.1    Besbes, B.2
  • 29
    • 0031472342 scopus 로고    scopus 로고
    • A variance component approach to dichotomous trait linkage analysis using a threshold model
    • Duggirala R, Williams JT, Williams-Blangero S, Blangero J (1997) A variance component approach to dichotomous trait linkage analysis using a threshold model. Genet Epidemiol 14:987-992
    • (1997) Genet Epidemiol , vol.14 , pp. 987-992
    • Duggirala, R.1    Williams, J.T.2    Williams-Blangero, S.3    Blangero, J.4
  • 30
    • 0016531626 scopus 로고
    • Study of the genetic transmission of hypercholesterolemia and hypertriglyceridemia in a 195 member kindred
    • Elston RC, Namboodiri KK, Glueck CJ, Fallat R, Tsang R, Leuba V (1975) Study of the genetic transmission of hypercholesterolemia and hypertriglyceridemia in a 195 member kindred. Ann Hum Genet 39:67-87
    • (1975) Ann Hum Genet , vol.39 , pp. 67-87
    • Elston, R.C.1    Namboodiri, K.K.2    Glueck, C.J.3    Fallat, R.4    Tsang, R.5    Leuba, V.6
  • 31
    • 77955058518 scopus 로고
    • The inheritance of liability to certain diseases, estimated from the incidence among relatives
    • Falconer DS (1965) The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann Hum Genet 29:51-76
    • (1965) Ann Hum Genet , vol.29 , pp. 51-76
    • Falconer, D.S.1
  • 34
    • 0028947057 scopus 로고
    • Multipoint interval mapping of quantitative trait loci, using sib pairs
    • Fulker DW, Cherny SS, Cardon LR (1995) Multipoint interval mapping of quantitative trait loci, using sib pairs. Am J Hum Genet 56:1224-1233
    • (1995) Am J Hum Genet , vol.56 , pp. 1224-1233
    • Fulker, D.W.1    Cherny, S.S.2    Cardon, L.R.3
  • 35
    • 0030031579 scopus 로고    scopus 로고
    • Genetic analysis of NIDDM: The study of quantitative traits
    • Ghosh S, Schork NJ (1996) Genetic analysis of NIDDM: the study of quantitative traits. Diabetes 45:1-14
    • (1996) Diabetes , vol.45 , pp. 1-14
    • Ghosh, S.1    Schork, N.J.2
  • 37
    • 0025245437 scopus 로고
    • Multipoint analysis of human quantitative genetic variation
    • Goldgar DE (1990) Multipoint analysis of human quantitative genetic variation. Am J Hum Genet 47:957-967
    • (1990) Am J Hum Genet , vol.47 , pp. 957-967
    • Goldgar, D.E.1
  • 39
    • 0027248119 scopus 로고
    • Variance components/major locus likelihood approximation for quantitative, polychotomous, and multivariate data
    • Hasstedt SJ (1993) Variance components/major locus likelihood approximation for quantitative, polychotomous, and multivariate data. Genet Epidemiol 10:145-158
    • (1993) Genet Epidemiol , vol.10 , pp. 145-158
    • Hasstedt, S.J.1
  • 40
    • 0019920786 scopus 로고
    • Extensions to multivariate normal models for pedigree analysis
    • Hopper JL, Mathews JD (1982) Extensions to multivariate normal models for pedigree analysis. Ann Hum Genet 46:373-383
    • (1982) Ann Hum Genet , vol.46 , pp. 373-383
    • Hopper, J.L.1    Mathews, J.D.2
  • 41
    • 84889221264 scopus 로고    scopus 로고
    • An empirical test of the significance of an observed QTL effect that preserves additive genetic variation
    • (in press)
    • Iturria SJ, Williams JT, Almasy L, Dyer TD, Blangero J. An empirical test of the significance of an observed QTL effect that preserves additive genetic variation. Genet Epidemiol (in press)
    • Genet Epidemiol
    • Iturria, S.J.1    Williams, J.T.2    Almasy, L.3    Dyer, T.D.4    Blangero, J.5
  • 42
    • 0029022716 scopus 로고
    • Multiple trait analysis of genetic mapping for quantitative trait loci
    • Jiang C, Zeng Z-B (1995) Multiple trait analysis of genetic mapping for quantitative trait loci. Genetics 140:1111-1127
    • (1995) Genetics , vol.140 , pp. 1111-1127
    • Jiang, C.1    Zeng, Z.-B.2
  • 43
    • 0029060127 scopus 로고
    • Interval mapping of quantitative trait loci employing correlated trait complexes
    • Korol AB, Ronin YI, Kirzhner VM (1995) Interval mapping of quantitative trait loci employing correlated trait complexes. Genetics 140:1137-1147
    • (1995) Genetics , vol.140 , pp. 1137-1147
    • Korol, A.B.1    Ronin, Y.I.2    Kirzhner, V.M.3
  • 44
    • 0022219640 scopus 로고
    • Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information
    • Lalouel JM, Le Mignon L, Simon M, Fauchet R, Bourel M, Rao DC, Morton NE (1985) Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information. Am J Hum Genet 37:700-718
    • (1985) Am J Hum Genet , vol.37 , pp. 700-718
    • Lalouel, J.M.1    Le Mignon, L.2    Simon, M.3    Fauchet, R.4    Bourel, M.5    Rao, D.C.6    Morton, N.E.7
  • 45
    • 0024283662 scopus 로고
    • Splitting schizophrenia
    • Lander ES (1988) Splitting schizophrenia. Nature 336:105-106
    • (1988) Nature , vol.336 , pp. 105-106
    • Lander, E.S.1
  • 46
    • 0028090414 scopus 로고
    • Genetic dissection of complex traits
    • Lander ES, Schork NJ (1994) Genetic dissection of complex traits. Science 265:2037-2048
    • (1994) Science , vol.265 , pp. 2037-2048
    • Lander, E.S.1    Schork, N.J.2
  • 47
    • 0018179274 scopus 로고
    • Central limit theorems for pedigrees
    • Lange K (1978) Central limit theorems for pedigrees. J Math Biol 6:59-66
    • (1978) J Math Biol , vol.6 , pp. 59-66
    • Lange, K.1
  • 49
    • 0020608018 scopus 로고
    • Extensions to pedigree analysis. IV. Covariance components models for multivariate traits
    • Lange K, Boehnke M (1983) Extensions to pedigree analysis. IV. Covariance components models for multivariate traits. Am J Med Genet 14:513-524
    • (1983) Am J Med Genet , vol.14 , pp. 513-524
    • Lange, K.1    Boehnke, M.2
  • 50
  • 51
    • 0017165430 scopus 로고
    • Extensions to pedigree analysis. III. Variance components by the scoring method
    • Lange K, Westlake J, Spence MA (1976) Extensions to pedigree analysis. III. Variance components by the scoring method. Ann Hum Genet 39:485-491
    • (1976) Ann Hum Genet , vol.39 , pp. 485-491
    • Lange, K.1    Westlake, J.2    Spence, M.A.3
  • 52
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: Prospective studies of Pima Indians
    • Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, Knowler WC, et al (1993) Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: Prospective studies of Pima Indians. N Engl J Med 329:1988-1992
    • (1993) N Engl J Med , vol.329 , pp. 1988-1992
    • Lillioja, S.1    Mott, D.M.2    Spraul, M.3    Ferraro, R.4    Foley, J.E.5    Ravussin, E.6    Knowler, W.C.7
  • 54
    • 0031454584 scopus 로고    scopus 로고
    • GAW 10: Simulated family data for a common oligogenic disease with quantitative risk factors
    • MacCluer JW, Blangero J, Dyer TD, Speer MC (1997) GAW 10: simulated family data for a common oligogenic disease with quantitative risk factors. Genet Epidemiol 14:737-742
    • (1997) Genet Epidemiol , vol.14 , pp. 737-742
    • MacCluer, J.W.1    Blangero, J.2    Dyer, T.D.3    Speer, M.C.4
  • 56
    • 0015949193 scopus 로고
    • Multifactorial qualitative traits: Genetic analysis and prediction of recurrence risks
    • Mendell NR, RC Elston (1974) Multifactorial qualitative traits: genetic analysis and prediction of recurrence risks. Biometrics 30:41-57
    • (1974) Biometrics , vol.30 , pp. 41-57
    • Mendell, N.R.1    Elston, R.C.2
  • 57
    • 0028263159 scopus 로고
    • Indicators of liability to schizophrenia: Perspectives from genetic epidemiology
    • Moldin SO (1994) Indicators of liability to schizophrenia: perspectives from genetic epidemiology. Schizophr Bull 20:169-184
    • (1994) Schizophr Bull , vol.20 , pp. 169-184
    • Moldin, S.O.1
  • 59
    • 0016192958 scopus 로고
    • Analysis of family resemblance. III. Complex segregation of quantitative traits
    • Morton NE, MacLean CJ (1974) Analysis of family resemblance. III. Complex segregation of quantitative traits. Am J Hum Genet 26:489-503
    • (1974) Am J Hum Genet , vol.26 , pp. 489-503
    • Morton, N.E.1    MacLean, C.J.2
  • 60
    • 84984364838 scopus 로고
    • Discontinuity and quasi-continuity: Alternative hypotheses of multifactorial inheritance
    • Morton NE, Yee S, Elston RC, Lew R (1970) Discontinuity and quasi-continuity: alternative hypotheses of multifactorial inheritance. Clin Genet 1:81-94
    • (1970) Clin Genet , vol.1 , pp. 81-94
    • Morton, N.E.1    Yee, S.2    Elston, R.C.3    Lew, R.4
  • 61
    • 0029010152 scopus 로고
    • Linkage analysis with biological markers
    • Ott J (1995) Linkage analysis with biological markers. Hum Hered 45:169-174
    • (1995) Hum Hered , vol.45 , pp. 169-174
    • Ott, J.1
  • 62
    • 0002795621 scopus 로고
    • I. Mathematical contributions to the theory of evolution. XI. On the influence of natural selection on the avriability and correlation of organs
    • Pearson K (1903) I. Mathematical contributions to the theory of evolution. XI. On the influence of natural selection on the avriability and correlation of organs. Philos Trans R Soc Lond [A] 200:1-66
    • (1903) Philos Trans R Soc Lond [A] , vol.200 , pp. 1-66
    • Pearson, K.1
  • 63
    • 0027928961 scopus 로고
    • Meta-analysis of P300 amplitude from males at risk for alcoholism
    • Polich J, Pollock VE, Bloom FF. (1994) Meta-analysis of P300 amplitude from males at risk for alcoholism. Psychol Bull 115:55-73
    • (1994) Psychol Bull , vol.115 , pp. 55-73
    • Polich, J.1    Pollock, V.E.2    Bloom, F.F.3
  • 64
    • 0031659386 scopus 로고    scopus 로고
    • Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: Preliminary results from the COGA project
    • Porjesz. B, Begleiter H, Reich T, Van Eerdewegh P, Edenberg HJ, Foroud T, Goate A, et al (1998) Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: preliminary results from the COGA project. Alcohol Clin Exp Res 22:1317-1323
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 1317-1323
    • Porjesz, B.1    Begleiter, H.2    Reich, T.3    Van Eerdewegh, P.4    Edenberg, H.J.5    Foroud, T.6    Goate, A.7
  • 65
    • 0018363940 scopus 로고
    • An approximation to the multivariate normal integral: Its application to multifactorial qualitative traits
    • Rice J, Reich T, Cloninger CR, Wette R (1979) An approximation to the multivariate normal integral: its application to multifactorial qualitative traits. Biometrics 35:451-459
    • (1979) Biometrics , vol.35 , pp. 451-459
    • Rice, J.1    Reich, T.2    Cloninger, C.R.3    Wette, R.4
  • 66
    • 0001398562 scopus 로고
    • Linkage between loci of quantitative traits and marker loci: Multi-trait analysis with a single marker
    • Ronin YI, Kirzhner VM, Korol AB (1995) Linkage between loci of quantitative traits and marker loci: multi-trait analysis with a single marker. Theor Appl Genet 90:776-786
    • (1995) Theor Appl Genet , vol.90 , pp. 776-786
    • Ronin, Y.I.1    Kirzhner, V.M.2    Korol, A.B.3
  • 67
    • 0027362259 scopus 로고
    • Extended multipoint identity-by-descent analysis of human quantitative traits: Efficiency, power, and modeling considerations
    • Schork NJ (1993) Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations. Am J Hum Genet 53:1306-1319
    • (1993) Am J Hum Genet , vol.53 , pp. 1306-1319
    • Schork, N.J.1
  • 68
    • 0004242197 scopus 로고
    • John Wiley & Sons, New York
    • Searle SR (1971) Linear models. John Wiley & Sons, New York
    • (1971) Linear Models
    • Searle, S.R.1
  • 69
    • 84907319426 scopus 로고
    • Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions
    • Self SG, Liang K-Y (1987) Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions. J Am Stat Assoc 82:605-610
    • (1987) J Am Stat Assoc , vol.82 , pp. 605-610
    • Self, S.G.1    Liang, K.-Y.2
  • 70
    • 0030857325 scopus 로고    scopus 로고
    • Linkage of multilocus components of variance to polymorphic markers
    • Tiwari HK, Elston RC (1997) Linkage of multilocus components of variance to polymorphic markers. Ann Hum Genet 61:253-261
    • (1997) Ann Hum Genet , vol.61 , pp. 253-261
    • Tiwari, H.K.1    Elston, R.C.2
  • 73
    • 0029832891 scopus 로고    scopus 로고
    • Application of a canonical transformation to detection of quantitative trait loci with the aid of genetic markers in a multitrait experiment
    • Weller JI, Wiggans GR, VanRaden PM, Ron M (1996) Application of a canonical transformation to detection of quantitative trait loci with the aid of genetic markers in a multitrait experiment. Theor Appl Genet 92:998-1002
    • (1996) Theor Appl Genet , vol.92 , pp. 998-1002
    • Weller, J.I.1    Wiggans, G.R.2    VanRaden, P.M.3    Ron, M.4
  • 74
    • 0031469587 scopus 로고    scopus 로고
    • Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: Summary of GAW10 contributions
    • Wijsman EM, Amos CI (1997) Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: summary of GAW10 contributions. Genet Epidemiol 14:719-735
    • (1997) Genet Epidemiol , vol.14 , pp. 719-735
    • Wijsman, E.M.1    Amos, C.I.2
  • 75
    • 0033365229 scopus 로고    scopus 로고
    • Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials
    • (in this issue)
    • Williams JT, Begleiter H, Porjesz. B, Edenberg HJ, Foroud T, Reich T, Goate A, et al (1999) Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials. Am J Hum Genet 65:1148-1160 (in this issue)
    • (1999) Am J Hum Genet , vol.65 , pp. 1148-1160
    • Williams, J.T.1    Begleiter, H.2    Porjesz, B.3    Edenberg, H.J.4    Foroud, T.5    Reich, T.6    Goate, A.7
  • 76
    • 0032909574 scopus 로고    scopus 로고
    • Comparison of variance components and sibpair-based approaches to quantitative trait linkage analysis in unselected samples
    • Williams JT, Blangero J (1999) Comparison of variance components and sibpair-based approaches to quantitative trait linkage analysis in unselected samples. Genet Epidemiol 16:113-134
    • (1999) Genet Epidemiol , vol.16 , pp. 113-134
    • Williams, J.T.1    Blangero, J.2
  • 77
    • 0031472926 scopus 로고    scopus 로고
    • Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees
    • Williams JT, Duggirala K, Blangero J (1997) Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees. Genet Epidemiol 14:1065-1070
    • (1997) Genet Epidemiol , vol.14 , pp. 1065-1070
    • Williams, J.T.1    Duggirala, K.2    Blangero, J.3
  • 78
    • 0000386296 scopus 로고
    • An analysis of variability in number of digits in an inbred strain of guinea pigs
    • Wright S (1934a) An analysis of variability in number of digits in an inbred strain of guinea pigs. Genetics 19:506-536
    • (1934) Genetics , vol.19 , pp. 506-536
    • Wright, S.1
  • 79
    • 0001214314 scopus 로고
    • The results of crosses between inbred strains of guinea pigs, differing in number of digits
    • _ (1934b) The results of crosses between inbred strains of guinea pigs, differing in number of digits. Genetics 19:537-551
    • (1934) Genetics , vol.19 , pp. 537-551
  • 80
    • 0029903155 scopus 로고    scopus 로고
    • Mapping quantitative trait loci for complex binary diseases using line crosses
    • Xu S, Atchley WR (1996) Mapping quantitative trait loci for complex binary diseases using line crosses. Genetics 143:1417-1424
    • (1996) Genetics , vol.143 , pp. 1417-1424
    • Xu, S.1    Atchley, W.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.