Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: The Rotterdam Study

Journal of Bone and Mineral Research

Volumn 22, Issue 11, 2007, Pages 1781-1790

  Rivadeneira, Fernando ^a,b   Zillikens, M Carola ^a   De Laet, Chris E D H ^c   Hofman, Albert ^a   Uitterlinden, André G ^a   Beck, Thomas J ^d   Pols, Huibert A P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b PONTIFICIA UNIVERSIDAD JAVERIANA   (Colombia)

^c BELGIAN HEALTH CARE KNOWLEDGE CENTRE KCE   (Belgium)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BMD; Bone geometry; Bone instability; Buckling ratio; Fracture risk; Sexual dimorphism

Indexed keywords

AGED; ARTICLE; BONE DENSITY; CORTICAL BONE; DISEASE PREDISPOSITION; FEMALE; FEMUR NECK; FOLLOW UP; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL MODEL; POPULATION RESEARCH; PREDICTOR VARIABLE; PROSPECTIVE STUDY; SEX DIFFERENCE; INCIDENCE; NETHERLANDS; PROGNOSIS; RADIOGRAPHY; RISK;

AGED; BONE DENSITY; FEMALE; FEMUR NECK; HIP FRACTURES; HUMANS; INCIDENCE; MALE; NETHERLANDS; PROGNOSIS; RISK;

EID: 38449106930     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.070712     Document Type: Article

References (51)

1. Melton LJ III 1993 Hip fractures: A worldwide problem today and tomorrow. Bone 14(Suppl 1):S1-S8.
2. De Laet CE, van Hout BA, Burger H, Hofman A, Pols HA 1997 Bone density and risk of hip fracture in men and women: Cross sectional analysis. BMJ 315:221-225.
3. Marshall D, Johnell O, Wedel H 1996 Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312:1254-1259.
4. Johnell O, Kanis JA, Oden A, Johansson H, De Laet C, Delmas P, Eisman JA, Fujiwara S, Kroger H, Mellstrom D, Meunier PJ, Melton LJ III, O'Neill T, Pols H, Reeve J, Silman A, Tenenhouse A 2005 Predictive value of BMD for hip and other fractures. J Bone Miner Res 20:1185-1194.
5. Cummings SR, Black DM, Nevitt MC, Browner WS, Cauley JA, Genant HK, Mascioli SR, Scott JC, Seeley DG, Steiger P 1990 Appendicular bone density and age predict hip fracture in women. The Study of Osteoporotic Fractures Research Group. JAMA 263:665-668.
6. Schuit SC, van der Klift M, Weel AE, de Laet CE, Burger H, Seeman E, Hofman A, Uitterlinden AG, van Leeuwen JP, Pols HA 2004 Fracture incidence and association with bone mineral density in elderly men and women: The Rotterdam Study. Bone 34:195-202.
7. Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, Genant HK, Palermo L, Scott J, Vogt TM 1993 Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet 341:72-75.
8. Kanis JA, Melton LJ III, Christiansen C, Johnston CC, Khaltaev N 1994 The diagnosis of osteoporosis. J Bone Miner Res 9:1137-1141.
9. Melton LJ III, Orwoll ES, Wasnich RD 2001 Does bone density predict fractures comparably in men and women? Osteoporos Int 12:707-709.
10. Orwoll E 2000 Assessing bone density in men. J Bone Miner Res 15:1867-1870.
11. de Laet CE, van der Klift M, Hofman A, Pols HA 2002 Osteoporosis in men and women: A story about bone mineral density thresholds and hip fracture risk. J Bone Miner Res 17:2231-2236.
12. Duan Y, Beck TJ, Wang XF, Seeman E 2003 Structural and biomechanical basis of sexual dimorphism in femoral neck fragility has its origins in growth and aging. J Bone Miner Res 18:1766-1774.
13. Beck TJ, Oreskovic TL, Stone KL, Ruff CB, Ensrud K, Nevitt MC, Genant HK, Cummings SR 2001 Structural adaptation to changing skeletal load in the progression toward hip fragility: The study of osteoporotic fractures. J Bone Miner Res 16:1108-1119.
14. Heaney RP 2005 BMD: The problem. Osteoporos Int 16:1013-1015.
15. De Laet CE, Van Hout BA, Burger H, Weel AE, Hofman A, Pols HA 1998 Hip fracture prediction in elderly men and women: Validation in the Rotterdam study. J Bone Miner Res 13:1587-1593.
16. Hofman A, Grobbee DE, de Jong PT, van den Ouweland FA 1991 Determinants of disease and disability in the elderly: The Rotterdam Elderly Study. Eur J Epidemiol 7:403-422.
17. Burger H, van Daele PL, Algra D, van den Ouweland FA, Grobbee DE, Hofman A, van Kuijk C, Schutte HE, Birkenhager JC, Pols HA 1994 The association between age and bone mineral density in men and women aged 55 years and over: The Rotterdam Study. Bone Miner 25:1-13.
18. Looker AC, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP, Johnston CC Jr, Lindsay R 1998 Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 8:468-489.
19. Beck TJ, Looker AC, Ruff CB, Sievanen H, Wahner HW 2000 Structural trends in the aging femoral neck and proximal shaft: Analysis of the Third National Health and Nutrition Examination Survey dual-energy X-ray absorptiometry data. J Bone Miner Res 15:2297-2304.
20. Beck TJ, Ruff CB, Warden KE, Scott WW Jr, Rao GU 1990 Predicting femoral neck strength from bone mineral data. A structural approach. Invest Radiol 25:6-18.
21. Khoo BC, Beck TJ, Qiao QH, Parakh P, Semanick L, Prince RL, Singer KP, Price RI 2005 In vivo short-term precision of hip structure analysis variables in comparison with bone mineral density using paired dual-energy X-ray absorptiometry scans from multi-center clinical trials. Bone 37:112-121.
22. Duboeuf F, Hans D, Schott AM, Kotzki PO, Favier F, Marcelli C, Meunier PJ, Delmas PD 1997 Different morphometric and densitometric parameters predict cervical and trochanteric hip fracture: The EPIDOS Study. J Bone Miner Res 12:1895-1902.
23. Karlamangla AS, Barrett-Connor E, Young J, Greendale GA 2004 Hip fracture risk assessment using composite indices of femoral neck strength: The Rancho Bernardo study. Osteoporos Int 15:62-70.
24. Crabtree NJ, Kroger H, Martin A, Pols HA, Lorenc R, Nijs J, Stepan JJ, Falch JA, Miazgowski T, Grazio S, Raptou P, Adams J, Collings A, Khaw KT, Rushton N, Lunt M, Dixon AK, Reeve J 2002 Improving risk assessment: Hip geometry, bone mineral distribution and bone strength in hip fracture cases and controls. The EPOS study. European Prospective Osteoporosis Study. Osteoporos Int 13:48-54.
25. Szulc P, Seeman E, Duboeuf F, Sornay-Rendu E, Delmas PD 2006 Bone fragility: Failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women. J Bone Miner Res 21:1856-1863.
26. Gnudi S, Ripamonti C, Gualtieri G, Malavolta N 1999 Geometry of proximal femur in the prediction of hip fracture in osteoporotic women. Br J Radiol 72:729-733.
27. Boonen S, Koutri R, Dequeker J, Aerssens J, Lowet G, Nijs J, Verbeke G, Lesaffre E, Geusens P 1995 Measurement of femoral geometry in type I and type II osteoporosis: Differences in hip axis length consistent with heterogeneity in the pathogenesis of osteoporotic fractures. J Bone Miner Res 10:1908-1912.
28. Bergot C, Bousson V, Meunier A, Laval-Jeantet M, Laredo JD 2002 Hip fracture risk and proximal femur geometry from DXA scans. Osteoporos Int 13:542-550.
29. Alonso CG, Curiel MD, Carranza FH, Cano RP, Perez AD 2000 Femoral bone mineral density, neck-shaft angle and mean femoral neck width as predictors of hip fracture in men and women. Multicenter Project for Research in Osteoporosis. Osteoporos Int 11:714-720.
30. Karlsson KM, Sernbo I, Obrant KJ, Redlund-Johnell I, Johnell O 1996 Femoral neck geometry and radiographic signs of osteoporosis as predictors of hip fracture. Bone 18:327-330.
31. Balena R, Shih MS, Parfitt AM 1992 Bone resorption and formation on the periosteal envelope of the ilium: A histomorphometric study in healthy women. J Bone Miner Res 7:1475-1482.
32. Kaptoge S, Dalzell N, Loveridge N, Beck TJ, Khaw KT, Reeve J 2003 Effects of gender, anthropometric variables, and aging on the evolution of hip strength in men and women aged over 65. Bone 32:561-570.
33. Ahlborg HG, Johnell O, Turner CH, Rannevik G, Karlsson MK 2003 Bone loss and bone size after menopause. N Engl J Med 349:327-334.
34. Seeman E 2003 Periosteal bone formation - a neglected determinant of bone strength. N Engl J Med 349:320-323.
35. Looker AC, Beck TJ, Orwoll ES 2001 Does body size account for gender differences in femur bone density and geometry? J Bone Miner Res 16:1291-1299.
36. Jarvinen TL, Kannus P, Sievanen H 2003 Estrogen and bone - a reproductive and locomotive perspective. J Bone Miner Res 18:1921-1931.
37. Pulkkinen P, Eckstein F, Lochmuller EM, Kuhn V, Jamsa T 2006 Association of geometric factors and failure load level with the distribution of cervical vs. trochanteric hip fractures. J Bone Miner Res 21:895-901.
38. Seeman E, Delmas PD 2006 Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med 354:2250-2261.
39. Crabtree N, Loveridge N, Parker M, Rushton N, Power J, Bell KL, Beck TJ, Reeve J 2001 Intracapsular hip fracture and the region-specific loss of cortical bone: Analysis by peripheral quantitative computed tomography. J Bone Miner Res 16:1318-1328.
40. Zebaze RM, Jones A, Welsh F, Knackstedt M, Seeman E 2005 Femoral neck shape and the spatial distribution of its mineral mass varies with its size: Clinical and biomechanical implications. Bone 37:243-252.
41. Mayhew PM, Thomas CD, Clement JG, Loveridge N, Beck TJ, Bonfield W, Burgoyne CJ, Reeve J 2005 Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet 366:129-135.
42. Riggs BL, Melton Iii LJ III, Robb RA, Camp JJ, Atkinson EJ, Peterson JM, Rouleau PA, McCollough CH, Bouxsein ML, Khosla S 2004 Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res 19:1945-1954.
43. Jarvinen TL, Sievanen H, Jokihaara J, Einhorn TA 2005 Revival of bone strength: The bottom line. J Bone Miner Res 20:717-720.
44. Faulkner KG, Wacker WK, Barden HS, Simonelli C, Burke PK, Ragi S, Del Rio L 2006 Femur strength index predicts hip fracture independent of bone density and hip axis length. Osteoporos Int 17:593-599.
45. Ahlborg HG, Nguyen ND, Nguyen TV, Center JR, Eisman JA 2005 Contribution of hip strength indices to hip fracture risk in elderly men and women. J Bone Miner Res 20:1820-1827.
46. Melton LJ III, Beck TJ, Amin S, Khosla S, Achenbach SJ, Oberg AL, Riggs BL 2005 Contributions of bone density and structure to fracture risk assessment in men and women. Osteoporos Int 16:460-467.
47. Uusi-Rasi K, Beck TJ, Semanick LM, Daphtary MM, Crans GG, Desaiah D, Harper KD 2006 Structural effects of raloxifene on the proximal femur: Results from the multiple outcomes of raloxifene evaluation trial. Osteoporos Int 17:575-586.
48. Uusi-Rasi K, Semanick LM, Zanchetta JR, Bogado CE, Eriksen EF, Sato M, Beck TJ 2005 Effects of teriparatide [rhPTH (1-34)] treatment on structural geometry of the proximal femur in elderly osteoporotic women. Bone 36:948-958.
49. Uusi-Rasi K, Beck TJ, Sievanen H, Heinonen A, Vuori I 2003 Associations of hormone replacement therapy with bone structure and physical performance among postmenopausal women. Bone 32:704-710.
50. Rivadeneira F, Houwing-Duistermaat JJ, Beck TJ, Janssen JA, Hofman A, Pols HA, Van Duijn CM, Uitterlinden AG 2004 The influence of an insulin-like growth factor I gene promoter polymorphism on hip bone geometry and the risk of nonvertebral fracture in the elderly: The Rotterdam Study. J Bone Miner Res 19:1280-1290.
51. Rivadeneira F, van Meurs JB, Kant J, Zillikens MC, Stolk L, Beck TJ, Arp P, Schuit SC, Hofman A, Houwing-Duistermaat JJ, van Duijn CM, van Leeuwen JP, Pols HA, Uitterlinden AG 2006 Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women. J Bone Miner Res 21:1443-1456.