Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon

British Journal of Nutrition

Volumn 104, Issue 1, 2010, Pages 24-30

  Sauer, Julia ^a   Jang, Hyeran ^a   Zimmerly, Ella M ^a   Kim, Kyong Chol ^a,b   Liu, Zhenhua ^a   Chanson, Aurelie ^a   Smith, Donald E ^a   Mason, Joel B ^a   Friso, Simonetta ^c   Choi, Sang Woon ^a  

^a TUFTS UNIVERSITY   (United States)

^b Mizmedi Hospital   (South Korea)

^c UNIVERSITY OF VERONA   (Italy)

Author keywords

Ageing; Alcohol; Colon; DNA methylation; Folate; p16

Indexed keywords

ALCOHOL; FOLIC ACID; GENOMIC DNA; PROTEIN P16; DNA;

AGING; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CALORIC INTAKE; COLON CANCER; CONTROLLED STUDY; DIETARY INTAKE; DNA METHYLATION; GENE EXPRESSION; GENETIC CORRELATION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; AGE; ANIMAL; C57BL MOUSE; CPG ISLAND; DRINKING BEHAVIOR; DRUG EFFECT; FOLIC ACID DEFICIENCY; GENETICS; GENOME; METABOLISM; POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

MURINAE; MUS;

AGE FACTORS; AGING; ALCOHOL DRINKING; ANIMALS; CPG ISLANDS; DNA; DNA METHYLATION; FOLIC ACID DEFICIENCY; GENE EXPRESSION; GENES, P16; GENOME; MALE; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC;

EID: 77954686280     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510000322     Document Type: Article

References (44)

1. Cummings JH & Bingham SA (1998) Diet and the prevention of cancer. BMJ 317, 1636-1640.
2. Norat T, Bingham S, Ferrari P, et al. (2005) Meat, fish, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition. J Natl Cancer Inst 97, 906-916. (Pubitemid 41417942)
3. Riboli E & Norat T (2003) Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 78, Suppl. 3, 559S-569S.
4. Brown LM (2005) Epidemiology of alcohol-associated cancers. Alcohol 35, 161-168.
5. Morgan TR, Mandayam S & Jamal MM (2004) Alcohol and hepatocellular carcinoma. Gastroenterology 127, Suppl. 1, S87-S96.
6. Roy HK, Gulizia JM, Karolski WJ, et al. (2002) Ethanol promotes intestinal tumorigenesis in the MIN mouse multiple intestinal neoplasia. Cancer Epidemiol Biomarkers Prev 11, 1499-1502.
7. Seitz HK, Maurer B & Stickel F (2005) Alcohol consumption and cancer of the gastrointestinal tract. Dig Dis 23, 297-303.
8. Seitz HK & Stickel F (2007) Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 7, 599-612.
9. Lu SC, Huang ZZ, Yang H, et al. (2000) Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol 279, G178-G185.
10. Schalinske KL & Nieman KM (2005) Disruption of methyl group metabolism by ethanol. Nutr Rev 63, 387-391.
11. Feinberg AP, Gehrke CW, Kuo KC, et al. (1988) Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res 48, 1159-1161.
12. Guerrero-Preston R, Santella RM, Blanco A, et al. (2007) Global DNA hypomethylation in liver cancer cases and controls: a phase I preclinical biomarker development study. Epigenetics 2, 223-226.
13. Goelz SE, Vogelstein B, Hamilton SR, et al. (1985) Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228, 187-190.
14. Choi SW & Mason JB (2000) Folate and carcinogenesis: an integrated scheme. J Nutr 130, 129-132.
15. Razin A & Shemer R (1995) DNA methylation in early development. Hum Mol Genet 4, 1751-1755.
16. Liu L, Wylie RC, Andrews LG, et al. (2003) Aging, cancer and nutrition: the DNA methylation connection. Mech Ageing Dev 124, 989-998.
17. Wilson VL, Smith RA, Ma S, et al. (1987) Genomic 5-methyl-deoxycytidine decreases with age. J Biol Chem 262, 9948-9951.
18. Catania J & Fairweather DS (1991) DNA methylation and cellular ageing. Mutat Res 256, 283-293.
19. Gloria L, Cravo M, Pinto A, et al. (1996) DNA hypomethylation and proliferative activity are increased in the rectal mucosa of patients with long-standing ulcerative colitis. Cancer 78, 2300-2306.
20. Shukla SD, Velazquez J, French SW, et al. (2008) Emerging role of epigenetics in the actions of alcohol. Alcohol Clin Exp Res 32, 1525-1534.
21. Keyes MK, Jang H, Mason JB, et al. (2007) Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon. J Nutr 137, 1713-1717.
22. Richardson B (2003) Impact of aging on DNA methylation. Ageing Res Rev 2, 245-261.
23. Issa JP (2000) CpG-island methylation in aging and cancer. Curr Top Microbiol Immunol 249, 101-118.
24. Esteller M, Corn PG, Baylin SB, et al. (2001) A gene hyper-methylation profile of human cancer. Cancer Res 61, 3225-3229.
25. Collins CJ & Sedivy JM (2003) Involvement of the INK4a/Arf gene locus in senescence. Aging Cell 2, 145-150.
26. Krishnamurthy J, Ramsey MR, Ligon KL, et al. (2006) p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443, 453-457.
27. Choi SW, Friso S, Dolnikowski GG, et al. (2003) Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific. J Nutr 133, 1206-1212.
28. Jang H, Mason JB & Choi SW (2005) Genetic and epigenetic interactions between folate and aging in carcinogenesis. J Nutr 135, Suppl. 12, 2967S-2971S.
29. Lieber CS, DeCarli LM & Sorrell MF (1989) Experimental methods of ethanol administration. Hepatology 10, 501-510.
30. Tamura T (1990) Microbiological assay of folates. In Folic Acid Metabolism in Health and Diseases, pp. 121-137 [MF Picciano, ELR Stokstad and JF Gregory III, editors]. New York: Wiley-Liss.
31. Friso S, Choi SW, Dolnikowski GG, et al. (2002) A method to assess genomic DNA methylation using high-performance liquid chromatography/ electrospray ionization mass spectrometry. Anal Chem 74, 4526-4531.
32. Herman JG, Graff JR, Myohanen S, et al. (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci \USA 93, 9821-9826.
33. Sharpless NE, Bardeesy N, Lee KH, et al. (2001) Loss of p16Ink4a with retention of p19Arf predisposes mice to tumori-genesis. Nature 413, 86-91.
34. Lo YM, Wong IH, Zhang J, et al. (1999) Quantitative analysis of aberrant p16 methylation using real-time quantitative methyl-ation-specific polymerase chain reaction. Cancer Res 59, 3899-3903.
35. Suzuki K, Suzuki I, Leodolter A, et al. (2006) Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage. Cancer Cell 9, 199-207.
36. Choi SW, Stickel F, Baik HW, et al. (1999) Chronic alcohol consumption induces genomic but not p53-specific DNA hypomethylation in rat colon. J Nutr 129, 1945-1950.
37. Wilkinson JA & Shane B (1982) Folate metabolism in the ethanol-fed rat. J Nutr 112, 604-609.
38. Frank O & Baker H (1980) Vitamin profile in rats fed stock or liquid ethanolic diets. Am J Clin Nutr 33, 221-226.
39. Mason JB & Choi SW (2005) Effects of alcohol on folate metabolism: implications for carcinogenesis. Alcohol 35, 235-241.
40. Herman JG, Merlo A, Mao L, et al. (1995) Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55, 4525-4530.
41. Krakowczyk L, Strzelczyk JK, Adamek B, et al. (2008) Methylation of the MGMT and p16 genes in sporadic colorectal carcinoma and corresponding normal colonic mucosa. Med Sci Monit 14, BR219-BR225.
42. Kim BN, Yamamoto H, Ikeda K, et al. (2005) Methylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissues. Int J Oncol 26, 1217-1226.
43. Stickel F, Choi SW, Kim YI, et al. (2000) Effect of chronic alcohol consumption on total plasma homocysteine level in rats. Alcohol Clin Exp Res 24, 259-264.
44. Pirola RC & Lieber CS (1972) The energy cost of the metabolism of drugs, including ethanol. Pharmacology 7, 185-196.