Effect of chronic alcohol consumption on total plasma homocysteine level in rats

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 3, 2000, Pages 259-264

  Stickel, Felix ^a   Choi, Sang Woon ^b   Kim, Young In ^c   Bagley, Pamela J ^b   Seitz, Helmut K ^d   Russell, Robert M ^b   Selhub, Jacob ^b   Mason, Joel B ^b  

^a Klinik Augustinum Munchen   (Germany)

^b TUFTS UNIVERSITY   (United States)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Alcohol; Folate; Hyperhomocysteinemia; One Carbon Metabolism; Rat

Indexed keywords

ALCOHOL; FOLIC ACID; HOMOCYSTEINE; MALTODEXTRIN; PYRIDOXAL 5 PHOSPHATE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENERGY; HYPERHOMOCYSTEINEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VITAMIN BLOOD LEVEL; VITAMIN DEFICIENCY; VITAMIN SUPPLEMENTATION;

ANIMALIA;

EID: 0034024169     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000374-200003000-00002     Document Type: Article

References (51)

1. Amagasaki T, Green R, Jacobsen DW (1990) Expression of Transcobalamin II receptors by human leukemia K562 and HL-60 cells. Blood 76:1380-1386.
2. Barak AJ, Beckenhauer HC, Hidiroglou N, Camilo ME, Selhub J, Tuma DJ (1993) The relationship of ethanol feeding to the methyl folate trap. Alcohol 10:495-497.
3. Barak AJ, Beckenhauer HC, Tuma DJ, Badakhsh S (1987) Effects of prolonged ethanol feeding on methionine metabolism in rat liver. Biochem Cell Biol 65:230-233.
4. Barak AJ, Beckenhauer HC, Tuma DJ (1994) S-adenosylmethionine generation and prevention of alcoholic fatty liver by betaine. Alcohol 11:501-503.
5. Barak AJ, Beckenhauer HC (1988) The influenf ethanol on hepatic transmethylation. Alcohol Alcohol 23:73-77.
6. Barak AJ, Tuma DJ, Beckenhauer HC (1985) Ethanol, the choline requirement, methylation and liver injury. Life Sci 37:789-791.
7. Bonjour JP (1980) Vitamins and alcoholism. Folate and vitamin B12. Int J Vitam Nutr Res 50:96-121.
8. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 274: 1049-1057.
9. Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-253.
10. Brattström LE, Israelsson B, Jeppsson JO, Hultberg BL (1998) Folic acid: An innocuous means to reduce plasma homocysteine. Scand J Clin Lab Invest 448:215-221.
11. Brouwer IA, van Dusseldrop M, Thomas CM, Duran M, Hautvast JG, Eskes TX, Steegers-Theunissen RP (1999) Low-dose folic acid supplementation decreases plasma homocysteine concentrations: A randomized trial. Am J Clin Nutr 69:99-104.
12. Camp VM. Chipponi J, Faray BA (1983) Radioenzymatic assay for direct measurement of pyridoxal 5′-phosphate. Clin Chem 29:43-52.
13. Cravo ML, Glória LM, Selhub J, Nadeau MR, Camilo ME, Cardoso JN, Resende MP, Cardoso JN, Leitao CN, Mira FC (1996) Homocysteinemia in chronic alcoholism: Correlation with folate, vitamin B12 and vitamin B6 status. Am J Clin Nutr 63:220-224.
14. Eichner ER, Hillman RS (1973) Effect of alcohol on serum folate level. J Clin Invest 52:584-591.
15. Fell D, Benjamin LE, Steele RD (1985) Determination of adenosine and S-adenosyl derivatives of sulfur amino acids in rat liver by high performance liquid chromatography. J Chromatogr 345:150-156.
16. Fonda ML, Brown SG, Pendleton MW (1989) Concentration of vitamin B6 and activity of enzymes of B6 metabolism in the blood of alcoholic and nonalcoholic men. Alcohol Clin Exp Res 3:804-809.
17. Frank O, Baker H (1980) Vitamin profile in rats fed stock or liquid ethanolic diets. Am J Clin Nutr 33:221-226.
18. Garcea R, Daino L, Pascale R, Simile MM, Puddu M, Ruggiu ME, Seddaiu MA, Satta G, Sequenza MJ, Feo F (1989) Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: Effect of variation of S-adenosylmethionine:S-adenosylhomocysteine ratio. Carcinogenesis 10:1183-1192.
19. Glória L, Cravo M, Camilo ME, Resende M, Cardoso JN, Oliveira AG, Leião CN, Mira FC (1997) Nutritional deficiencies in chronic alcoholics: Relation to dietary intake and alcohol consumption. Am J Gastroenterol 92:485-489.
20. Halsted CH, Keen CL (1990) Alcohol and micronutrient metabolism and deficiencies. Eur J Gastroenterol Hepatol 2:399-405.
21. Hidiroglou N, Camilo ME, Beckenhauer HC, Tuma DJ, Barak AJ, Nixon PF, Selhub J (1994) Effect of chronic alcohol ingestion on hepatic folate distribution in the rat. Biochem Pharm 47:1561-1566.
22. Hoffman DR, Marion DW, Cornatzer WE, Duerre JA (1980) S-adenosylmethionine and S-adenosylhomocysteine metabolism in isolated rat liver. J Biol Chem 25:10822-10827.
23. Hultberg B, Berglund M, Andersson A, Frank A (1993) Elevated plasma homocysteine in alcoholics. Alcohol Clin Exp Res 17:687-689.
24. Kang SS, Wong PW, Malinow MR (1992) Hyperhomocysteinemia as a risk factor for occlusive vascular disease. Annu Rev Nutr 12:279-298.
25. Kim YI, Christman JK, Fleet JC, Cravo ML, Salomon RN, Smith D, Ordovas J, Selhub J, Mason JB (1995) Moderate folate deficiency does not cause global hypomethylation of hepatic and colonie DNA or c-myc-specific hypomethylation of colonic DNA in rats. Am J Clin Nutr 61:1083-1090.
26. Kim YI, Salomon RN, Graeme-Cook F, Choi SW, Smith DE, Dallal GE, Mason JB (1996) Dietry folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats. Gut 39:732-740.
27. Labadarios D, Rossouw JE, McConnell JB, Davis M, Williams R (1977) Vitamin B6 deficiency in chronic liver disease-evidence for increased degradation of pyridoxal-5′-phosphate. Gut 18:23-27.
28. Leevy CM, Baker H, Frank O, Cherrick GRB (1965) B complex vitamins in liver disease of alcoholics. Am J Clin Nutr 16:339-346.
29. Leibman D, Furth-Walker D, Smolen TN, Smolen A (1990) Pyridoxal 5′-phosphate and pyridoxamine 5′-phosphate concentrations in blood and tissues of mice fed ethanol-containing liquid diets. Alcohol 7:61-68.
30. Lieber CS, Jones DP, DeCarli LM (1989) Liquid diet technique for alcohol administration: 1989 Update. Alcohol Clin Exp Res 24:197-214.
31. Lin JY, Kang SS, Zhou J, Wong PWK (1989) Homocysteinemia in rats induced by folic acid deficiency. Life Sci 44:319-325.
32. 6 metabolism in chronic alcohol abuse. J Clin Invest 53:693-704.
33. 6-deficiency vs. folate deficiency: Comparison of responses to methionine loading in rats. Am J Clin Nutr 59:1033-1039.
34. Miller JW, Nadeau MR, Smith J, Smith D, Selhub J (1994b) Folate-deficiency-induced homocysteinemia in rats: Disruption of S-adenosylmethionine's coordinate regulation of homocysteine metabolism. Biochem J 290:415-419.
35. Parker TH, Marshall II JP, Roberts RK, Wang S, Schiff ER, Wilkinson GR, Schenker S (1979) Effect of acute alcohol ingestion on plasma pyridoxal 5′-phosphate. Am J Clin Nutr 32:1246-1252.
36. Selhub J, Jacques PF, Bostom AG, D'Agostino RB, Wilson PWF, Belanger AJ, O'Leary DH, Wolf PA, Schaefer EJ, Rosenberg IH (1995) Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med 332:286-291.
37. Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270:2693-2698.
38. Selhub J, Miller JW (1991) The pathogenesis of homocysteinemia: Interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 55:131-138.
39. Stabler SP, Marcell PD, Podell ER, Allen RH, Savage DG, Lindenbaum J (1988) Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J Clin Invest 81:466-474.
40. Stampfer MJ, Malinow MR, Willet WC (1992) A prospective study of plasma homocysteine and risk of myocardial infarction in U.S. physicians. JAMA 268:877-881.
41. Steinberg SE, Campbell CL, Hillman RS (1982) Effect of alcohol on tumor folate supply. Biochem Pharmacol 31:1461-1462.
42. Tamura T, Halsted CH (1983) Folate turnover in chronic alcoholic monkeys. J Lab Clin Med 101:623-628.
43. Tamura T (1990) Microbiological assay of folate, in Folic Acid Metabolism in Health and Disease (Picciano M, Stokstad E, Gregory J eds), pp. 121-137, Wiley-Liss, New York.
44. Trimble KC, Molloy AM, Scott JM, Weir DG (1993) The effect of ethanol on one-carbon metabolism: Increased methionine catabolism and lipotrope methyl-group wastage. Hepatology 18:984-989.
45. 6, and folate nutritional status in man with hyperhomocysteinemia. Am J Clin Nutr 57:47-53.
46. Ubbink JB, Vermaack WJH, Van der Merwe A, Becker PJ, Delport R, Potgieter HC (1994) Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr 124:1927-1933.
47. Ueland PM, Refsum H, Brattström L (1992) Plasma homocysteine and cardiovascular disease, in Atherosclerotic Vascular Disease, Hemostasis, and Endothelial Function (Francis RB Jr ed), pp 183-236, Marcel Dekker, New York.
48. Vester B, Rasmussen K (1991) High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum. Eur J Clin Chem Clin Biochem 29:549-554.
49. Walzem RL, Clifford AJ (1988) Folate deficiency in rats fed diets containing free amino acids or intact proteins. J Nutr 118:1089-1096.
50. Wilkinson JA, Shane B (1982) Folate metabolism in the ethanol-fed rat. J Nutr 112:604-609.
51. Wilson SD, Horne DW (1982) Use of glycerol-protected Lactobacillus casei for microbiological assay of folic acid. Clin Chem 28:1198-1200.