Biophysical Methods to Study Tight Junction Permeability

Current Topics in Membranes

Volumn 65, Issue C, 2010, Pages 41-76

  Günzel, Dorothee ^a   Krug, Susanne M ^a   Rosenthal, Rita ^a   Fromm, Michael ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77954644230     PISSN: 10635823     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1063-5823(10)65003-X     Document Type: Book

References (132)

1. Agre P., Preston G.M., Smith B.L., Jung J.S., Raina S., Moon C., et al. Aquaporin CHIP: The archetypal molecular water channel. American Journal of Physiology 1993, 265:463-476.
2. Almeida R., Allshire R.C. RNA silencing and genome regulation. Trends in Cell Biology 2005, 15:251-258.
3. Amasheh S., Meiri N., Gitter A.H., Schöneberg T., Mankertz J., Schulzke J.D., et al. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. Journal of Cell Science 2002, 115:4969-4976.
4. + absorption defends from paracellular back-leakage by claudin-8 upregulation. Biochemical and Biophysical Research Communications 2009, 378:45-50.
5. Amasheh S., Schmidt T., Mahn M., Florian P., Mankertz J., Tavalali S., et al. Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells. Cell and Tissue Research 2005, 321:89-96.
6. Ammann D. Ion-selective microelectrode and application 1986, Springer Verlag, Berlin.
7. Anderson W.J., Zhou Q., Alcalde V., Kaneko O.F., Blank L.J., Sherwood R.I., et al. Genetic targeting of the endoderm with claudin-6CreER. Developmental Dynamics 2008, 237:504-512.
8. Angelow S., Kim K.J., Yu A.S. Claudin-8 modulates paracellular permeability to acidic and basic ions in MDCK II cells. The Journal of Physiology 2006, 571:15-26.
9. Artursson P., Ungell A.L., Lofroth J.E. Selective paracellular permeability in two models of intestinal absorption: Cultured monolayers of human intestinal epithelial cells and rat intestinal segments. Pharmaceutical Research 1993, 10:1123-1129.
10. Balasubramanian S., Lynch J.W., Barry P.H. Concentration dependence of sodium permeation and sodium ion interactions in the cyclic AMP-gated channels of mammalian olfactory receptor neurons. The Journal of Membrane Biology 1997, 159:41-52.
11. Barry P.H. The reliability of relative anion-cation permeabilities deduced from reversal (dilution) potential measurements in ion channel studies. Cell Biochemistry and Biophysics 2006, 46:143-154.
12. Barry P.H., Diamond J.M. Junction potentials, electrode standard potentials, and other problems in interpreting electrical properties of membranes. The Journal of Membrane Biology 1970, 3:93-122.
13. Barry P.H., Lynch J.W. Liquid junction potentials and small cell effects in patch-clamp analysis. The Journal of Membrane Biology 1991, 121:101-117.
14. Ben-Yosef T., Belyantseva I.A., Saunders T.L., Hughes E.D., Kawamoto K., Van Itallie C.M., et al. Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration. Human Molecular Genetics 2003, 12:2049-2061.
15. 2+ transport in plasma membrane vesicles of renal epithelium of the Mozambique tilapia (Oreochromis mossambicus). The Journal of Experimental Biology 1997, 200:1931-1939.
16. Bijvelds M.J.C., Kolar Z.I., Wendelaar-Bonga S.E., Flik G. Magnesium transport across the basolateral plasma membrane of the fish enterocyte. The Journal of Membrane Biology 1996, 154:217-222.
17. Bojarski C., Gitter A.H., Bendfeldt K., Mankertz J., Schmitz H., Wagner S., et al. Permeability of HT-29/B6 colonic epithelium as a function of apoptosis. The Journal of Physiology 2001, 535:541-552.
18. Brown D.R., O'Grady S.M. The Ussing chamber and measurement of drug actions on mucosal ion transport. Current Protocols in Pharmacology 2008, 41:7121-71217.
19. Bürgel N., Bojarski C., Mankertz J., Zeitz M., Fromm M., Schulzke J.D. Mechanisms of diarrhea in collagenous colitis. Gastroenterology 2002, 123:433-443.
20. Carpi-Medina P., Whittembury G. Comparison of transcellular and transepithelial water osmotic permeabilities (Pos) in the isolated proximal straight tubule (PST) of the rabbit kidney. Pflügers Archiv. 1988, 412:66-74.
21. Cereijido M., Stefani E., Palomo A.M. Occluding junctions in a cultured transporting epithelium: Structural and functional heterogeneity. The Journal of Membrane Biology 1980, 53:19-32.
22. Clarke L.L. A guide to Ussing chamber studies of mouse intestine. American Journal of Physiology. Gastrointestinal and Liver Physiology 2009, 296:G1151-G1166.
23. Claude P. Morphological factors influencing transepithelial permeability: A model for the resistance of the zonula occludens. The Journal of Membrane Biology 1978, 39:219-232.
24. Claude P., Goodenough D.A. Fracture faces of zonulae occludentes from "tight" and "leaky" epithelia. The Journal of Cell Biology 1973, 58:390-400.
25. Clausen C., Lewis S.A., Diamond J.M. Impedance analysis of a tight epithelium using a distributed resistance model. Biophysical Journal 1979, 26:291-318.
26. Cole K.S., Curtis H.J. Electrical impedance of nerve during activity. Nature 1938, 142:209-210.
27. Cole K.S., Curtis H.J. Electrical impedance of Nitella during activity. The Journal of General Physiology 1938, 21:37-64.
28. Cole K.S., Curtis H.J. Electrical impedance of single marine eggs. The Journal of General Physiology 1938, 21:591-599.
29. Curtis H.J., Cole K.S. Transverse electric impedance of the squid giant axon. The Journal of General Physiology 1938, 21:757-765.
30. Dwyer T.M., Adams D.J., Hille B. The permeability of the endplate channel to organic cations in frog muscle. The Journal of General Physiology 1980, 75:469-492.
31. Eisenman G. Cation selective glass electrodes and their mode of operation. Biophysical Journal 1962, 2:259-323.
32. Elkouby-Naor L., Abassi Z., Lagziel A., Gow A., Ben-Yosef T. Double gene deletion reveals lack of cooperation between claudin 11 and claudin 14 tight junction proteins. Cell and Tissue Research 2008, 333:427-438.
33. Farquhar M.G., Palade G.E. Junctional complexes in various epithelia. The Journal of Cell Biology 1963, 17:375-412.
34. Feil R., Wagner J., Metzger D., Chambon P. Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochemical and Biophysical Research Communications 1997, 237:752-757.
35. Flamion B., Spring K.R., Abramow M. Adaptation of inner medullary collecting duct to dehydration involves a paracellular pathway. American Journal of Physiology 1995, 268:53-63.
36. Florian P., Schöneberg T., Schulzke J.D., Fromm M., Gitter A.H. Single-cell epithelial defects close rapidly by an actinomyosin purse string mechanism with functional tight junctions. The Journal of Physiology 2002, 545:485-499.
37. Foskett J.K., Scheffey C. Scanning electrode localization of transport pathways in epithelial tissues. Methods in Enzymology 1989, 171:792-813.
38. Fricke H. The electric capacity of suspensions of red corpuscles of a dog. Physical Review 1925, 26:682-687.
39. Fromm M., Krug S.M., Zeissig S., Richter J.F., Rosenthal R., Schulzke J.D., et al. High resolution analysis of barrier function. Annals of the New York Academy of Sciences 2009, 1165:74-81.
40. Frömter E. The route of passive ion movement through the epithelium of Necturus gallbladder. The Journal of Membrane Biology 1972, 8:259-301.
41. Frömter E., Diamond J. Route of passive ion permeation in epithelia. Nature: New Biology 1972, 235:9-13.
42. Furuse M., Fujimoto K., Sato N., Hirase T., Tsukita S., Tsukita S. Overexpression of occludin, a tight junction-associated integral membrane protein, induces the formation of intracellular multilamellar bodies bearing tight junction-like structures. Journal of Cell Science 1996, 109:429-435.
43. Furuse M., Furuse K., Sasaki H., Tsukita S. Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. The Journal of Cell Biology 2001, 153:263-272.
44. Furuse M., Hata M., Furuse K., Yoshida Y., Haratake A., Sugitani Y., et al. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: A lesson from claudin-1-deficient mice. The Journal of Cell Biology 2002, 156:1099-1111.
45. Furuse M., Hirase T., Itoh M., Nagafuchi A., Yonemura S., Tsukita S., et al. Occludin: A novel integral membrane protein localizing at tight junctions. The Journal of Cell Biology 1993, 123:1777-1788.
46. Ghandehari H., Smith P.L., Ellens H., Yeh P.Y., Kopecek J. Size-dependent permeability of hydrophilic probes across rabbit colonic epithelium. The Journal of Pharmacology and Experimental Therapeutics 1997, 280:747-753.
47. Gitter A.H., Bendfeldt K., Schulzke J.D., Fromm M. Leaks in the epithelial barrier caused by spontaneous and TNFa-induced single-cell apoptosis. FASEB Journal 2000, 14:1749-1753.
48. Gitter A.H., Bendfeldt K., Schulzke J.D., Fromm M. Trans-/paracellular, surface/crypt, and epithelial/subepithelial resistances of mammalian colonic epithelia. Pflügers Archiv 2000, 439:477-482.
49. Gitter A.H., Bertog M., Schulzke J.D., Fromm M. Measurement of paracellular epithelial conductivity by conductance scanning. Pflügers Archiv 1997, 434:830-840.
50. Gitter A.H., Wullstein F., Fromm M., Schulzke J.D. Epithelial barrier defects in ulcerative colitis: Characterization and quantification by electrophysiological imaging. Gastroenterology 2001, 121:1320-1328.
51. Gordon J.W., Scangos G.A., Plotkin D.J., Barbosa J.A., Ruddle F.H. Genetic transformation of mouse embryos by microinjection of purified DNA. Proceedings of the National Academy of Sciences of the United States of America 1980, 77:7380-7384.
52. Gossen M., Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proceedings of the National Academy of Sciences of the United States of America 1992, 89:5547-5551.
53. Gossen M., Freundlieb S., Bender G., Muller G., Hillen W., Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science 1995, 268:1766-1769.
54. Goulding E.H., Tibbs G.R., Liu D., Siegelbaum S.A. Role of H5 domain in determining pore diameter and ion permeation through cyclic nucleotide-gated channels. Nature 1993, 364:61-64.
55. Gow A., Davies C., Southwood C.M., Frolenkov G., Chrustowski M., Ng L., et al. Deafness in Claudin 11-null mice reveals the critical contribution of basal cell tight junctions to stria vascularis function. The Journal of Neuroscience 2004, 24:7051-7062.
56. Gow A., Southwood C.M., Li J.S., Pariali M., Riordan G.P., Brodie S.E., et al. CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell 1999, 99:649-659.
57. Greger R. Cation selectivity of the isolated perfused cortical thick ascending limb of Henle's loop of rabbit kidney. Pflügers Archiv 1981, 390:30-37.
58. + secretion in rat distal colon by conductance scanning. The Journal of Physiology 1998, 507:561-570.
59. Gu H., Marth J.D., Orban P.C., Mossmann H., Rajewsky K. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 1994, 265:103-106.
60. - secretion in MDCK cells. The Journal of Physiology (London) 2009, 587:3777-3793.
61. Günzel D., Florian P., Richter J.F., Troeger H., Schulzke J.D., Fromm M., et al. Restitution of single-cell defects in the mouse colon epithelium differs from that of cultured cells. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2006, 290:R1496-R1507.
62. Günzel D., Stuiver M., Kausalya P.J., Haisch L., Krug S.M., Rosenthal R., et al. Claudin-10 exists in six alternatively spliced isoforms which exhibit distinct localization and function. Journal of Cell Science 2009, 122:1507-1517.
63. Günzel D., Yu A.S.L. Function and regulation of claudins in the thick ascending limb of Henle. Pflügers Archiv 2009, 458:77-88.
64. Hernandez C.S., Gonzalez E., Whittembury G. The paracellular channel for water secretion in the upper segment of the Malpighian tubule of Rhodnius prolixus. The Journal of Membrane Biology 1995, 148:233-242.
65. Höber R. Eine Methode, die elektrische Leitfähigkeit im Innern von Zellen zu messen. Pflügers Archiv 1910, 133:237-253.
66. Hou J., Paul D.L., Goodenough D.A. Paracellin-1 and the modulation of ion selectivity of tight junctions. Journal of Cell Science 2005, 118:5109-5118.
67. Hou J., Renigunta A., Gomes A.S., Hou M., Paul D.L., Waldegger S., et al. Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:15350-15355.
68. Hou J., Shan Q., Wang T., Gomes A.S., Yan Q., Paul D.L., et al. Transgenic RNAi depletion of claudin-16 and the renal handling of magnesium. The Journal of Biological Chemistry 2007, 282:17114-17122.
69. Hudspeth A.J. Establishment of tight junctions between epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 1975, 72:2711-2713.
70. Hunziker W., Kiener T.K., Xu J. Vertebrate animal models unravel physiological roles for zonula occludens tight junction adaptor proteins. Annals of the New York Academy of Sciences 2009, 1165:28-33.
71. Ikari A., Hirai N., Shiroma M., Harada H., Sakai H., Hayashi H., et al. Association of paracellin-1 with ZO-1 augments the reabsorption of divalent cations in renal epithelial cells. The Journal of Biological Chemistry 2004, 279:54826-54832.
72. Ikenouchi J., Furuse M., Furuse K., Sasaki H., Tsukita S., Tsukita S. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. The Journal of Cell Biology 2005, 171:939-945.
73. Jaffe L.F., Nuccitelli R. An ultrasensitive vibrating probe for measuring steady extracellular currents. The Journal of Cell Biology 1974, 63:614-628.
74. Jovov B., Wills N.K., Lewis S.A. A spectroscopic method for assessing confluence of epithelial cell cultures. American Journal of Physiology 1991, 261:C1196-C1203.
75. Katsuno T., Umeda K., Matsui T., Hata M., Tamura A., Itoh M., et al. Deficiency of ZO-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Molecular Biology of the Cell 2008, 19:2465-2475.
76. 2+ transport function of claudin-16. The Journal of Clinical Investigation 2006, 116:878-891.
77. Knepper M.A. The aquaporin family of molecular water channels. Proceedings of the National Academy of Sciences of the United States of America 1994, 91:6255-6258.
78. Knipp G.T., Ho N.F., Barsuhn C.L., Borchardt R.T. Paracellular diffusion in Caco-2 cell monolayers: Effect of perturbation on the transport of hydrophilic compounds that vary in charge and size. Journal of Pharmaceutical Sciences 1997, 86:1105-1110.
79. - secretion from both crypts and surface epithelia of rat intestine. American Journal of Physiology 1993, 264:C1294-C1301.
80. + absorption of rat distal colon is confined to surface epithelium. A voltage scanning study. The American Journal of Physiology 1993, 264:C1285-C1293.
81. Kottra G., Frömter E. Rapid determination of intraepithelial resistance barriers by alternating current spectroscopy: Experimental procedures. Pflügers Archiv 1984, 402:409-420.
82. Kovbasnjuk O., Leader J.P., Weinstein A.M., Spring K.R. Water does not flow across the tight junctions of MDCK cell epithelium. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:6526-6530.
83. Kroesen A.J., Dullat S., Schulzke J.D., Fromm M., Buhr H.J. Permanently increased mucosal permeability in patients with backwashileitis after ileoanal pouch for ulcerative colitis. Scandinavian Journal of Gastroenterology 2008, 43:704-711.
84. Krug S.M., Amasheh S., Richter J.F., Milatz S., Günzel D., Westphal J.K., et al. Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Molecular Biology of the Cell 2009, 20:3713-3724.
85. Krug S.M., Fromm M., Günzel D. Two-path impedance spectroscopy for measurement of paracellular and transcellular epithelial resistance. Biophysical Journal 2009, 97:2202-2211.
86. Lewis S.A., Eaton D.C., Clausen C., Diamond J.M. Nystatin as a probe for investigating the electrical properties of a tight epithelium. The Journal of General Physiology 1977, 70:427-440.
87. Madara J.L., Dharmsathaphorn K. Occluding junction structure-function relationships in a cultured epithelial monolayer. The Journal of Cell Biology 1985, 101:2124-2133.
88. Mankertz J., Amasheh M., Krug S.M., Fromm A., Hillenbrand B., Tavalali S., et al. Tumour necrosis factor alpha up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol 3-kinase signaling. Cell and Tissue Research 2009, 336:67-77.
89. Martinez-Palomo A., Meza I., Beaty G., Cereijido M. Experimental modulation of occluding junctions in a cultured transporting epithelium. The Journal of Cell Biology 1980, 87:736-745.
90. Mazaud-Guittot S., Meugnier E., Pesenti S., Wu X., Vidal H., Gow A., et al. Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis. Biology of Reproduction 2010, 82:202-213.
91. McClendon J.F. Colloid properties of the surface of the living cell: III. Electrical impedance and reactance of blood and muscle to alternating currents of 0-1, 500, 000 cycles per second. American Journal of Physiology 1927, 82:525-532.
92. McClendon J.F. Electric impedance and permeability of living cells. Science 1936, 84:184-185.
93. Meier P.C., Ammann D., Morf W.E., Simon W. Liquid-membrane ion-selective electrodes and their biomedical applications. Medical and biological applications of electrochemical applications of electrochemical devices 1980, 13. Wiley, New York. J. Koryta (Ed.).
94. Metzger D., Chambon P. Site- and time-specific gene targeting in the mouse. Methods 2001, 24:71-80.
95. Miyamoto T., Morita K., Takemoto D., Takeuchi K., Kitano Y., Miyakawa T., et al. Tight junctions in Schwann cells of peripheral myelinated axons: A lesson from claudin-19-deficient mice. The Journal of Cell Biology 2005, 169:527-538.
96. Morf W.E. The principles of ion-selective electrodes and of membrane transport 1981, Akadémiai Kiadó, Budapest/Elsevier, Amsterdam, New York.
97. Ng B., Barry P.H. The measurement of ionic conductivities and mobilities of certain less common organic ions needed for junction potential corrections in electrophysiology. Journal of Neuroscience Methods 1995, 56:37-41.
98. Nitta T., Hata M., Gotoh S., Seo Y., Sasaki H., Hashimoto N., et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. The Journal of Cell Biology 2003, 161:653-660.
99. Ouellet D.L., Perron M.P., Plante P., Provost P. MicroRNAs in gene regulation: When the smallest governs it all. Journal of Biomedicine and Biotechnology 2006, 2006:69616.
100. - permeability in gallbladder epithelium. American Journal of Physiology 1987, 253:662-671.
101. Reiter B., Kraft R., Günzel D., Zeissig S., Schulzke J.D., Fromm M., et al. TRPV4-mediated regulation of epithelial permeability. FASEB Journal 2006, 20:1802-1812.
102. Robinson R.A., Stokes R.H. Electrolyte solutions 1959, Dover, Mineola, NY. 2nd ed.
103. Rosenthal R., Milatz S., Krug S.M., Oelrich B., Schulzke J.D., Amasheh S., et al. Claudin-2, a component of the tight junction, forms a paracellular water channel. Journal of Cell Science 2010, 123:1913-1921.
104. Saitou M., Fujimoto K., Doi Y., Itoh M., Fujimoto T., Furuse M., et al. Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. The Journal of Cell Biology 1998, 141:397-408.
105. Saitou M., Furuse M., Sasaki H., Schulzke J.D., Fromm M., Takano H., et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Molecular Biology of the Cell 2000, 11:4131-4142.
106. Sanders S.E., Madara J.L., McGuirk D.K., Gelman D.S., Colgan S.P. Assessment of inflammatory events in epithelial permeability: A rapid screening method using fluorescein dextrans. Epithelial Cell Biology 1995, 4:25-34.
107. Schulzke J.D., Gitter A.H., Mankertz J., Spiegel S., Seidler U., Amasheh S., et al. Epithelial transport and barrier function in occludin-deficient mice. Biochimica et Biophysica Acta 2005, 1669:34-42.
108. Segawa A., Yamashina S., Murakami M. Visualization of 'water secretion' by confocal microscopy in rat salivary glands: Possible distinction of para- and transcellular pathway. European Journal of Morphology 2002, 40:241-246.
109. Shachar-Hill B., Hill A.E. Convective fluid flow through the paracellular system of Necturus gall-bladder epithelium as revealed by dextran probes. The Journal of Physiology 1993, 468:463-486.
110. 2+ resorption. Science 1999, 285:103-106.
111. Spring K.R. Routes and mechanism of fluid transport by epithelia. Annual Review of Physiology 1998, 60:105-119.
112. Steward M.C. Paracellular non-electrolyte permeation during fluid transport across rabbit gall-bladder epithelium. The Journal of Physiology 1982, 322:419-439.
113. Sugiharto S., Lewis T.M., Moorhouse A.J., Schofield P.R., Barry P.H. Anion-cation permeability correlates with hydrated counterion size in glycine receptor channels. Biophysical Journal 2008, 95:4698-4715.
114. Tamura A., Kitano Y., Hata M., Katsuno T., Moriwaki K., Sasaki H., et al. Megaintestine in claudin-15-deficient mice. Gastroenterology 2008, 134:523-534.
115. Tang V.W., Goodenough D.A. Paracellular Ion Channel at the Tight Junction. Biophysical Journal 2003, 84:1660-1673.
116. Tatum R., Zhang Y., Salleng K., Lu Z., Lin J.J., Lu Q., et al. Renal salt wasting and chronic dehydration in claudin-7-deficient mice. American Journal of Physiology. Cell Physiology 2010, 298:F24-F34.
117. Tavelin S., Taipalensuu J., Soderberg L., Morrison R., Chong S., Artursson P. Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers. Pharmaceutical Research 2003, 20:397-405.
118. Teorell T. Application of "square wave analysis" to bioelectric studies. Acta Physiologica Scand. 1946, 12:235-254.
119. Thomas R.C. Ion-Sensitive Intracellular Microelectrto Make and Use Them 1978, Academic Press, London.
120. Troeger H., Epple H.J., Schneider T., Wahnschaffe U., Ullrich R., Burchard G.D., et al. Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum. Gut 2007, 56:328-335.
121. Tunggal J.A., Helfrich I., Schmitz A., Schwarz H., Günzel D., Fromm M., et al. E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO Journal 2005, 24:1146-1156.
122. Ussing H.H. The distinction by means of tracers between active transport and diffusion. Acta Physiologica Scand. 1949, 19:43-56.
123. Van Itallie C.M., Holmes J., Bridges A., Gookin J.L., Coccaro M.R., Proctor W., et al. The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. Journal of Cell Science 2008, 121:298-305.
124. Van Itallie C., Rahner C., Anderson J.M. Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. The Journal of Clinical Investigation 2001, 107:1319-1327.
125. Van Itallie C.M., Rogan S., Yu A., Vidal L.S., Holmes J., Anderson J.M. Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities. American Journal of Physiology. Cell Physiology 2006, 291:F1288-F1299.
126. Watson C.J., Rowland M., Warhurst G. Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers. American Journal of Physiology. Cell Physiology 2001, 281:388-397.
127. Whittembury G., Malnic G., Mello-Aires M., Amorena C. Solvent drag of sucrose during absorption indicates paracellular water flow in the rat kidney proximal tubule. Pflügers Archiv 1988, 412:541-547.
128. Wills N.K., Lewis S.A., Eaton D.C. Active and passive properties of rabbit descending colon: A microelectrode and nystatin study. The Journal of Membrane Biology 1979, 45:81-108.
129. Xu J., Kausalya P.J., Phua D.C., Ali S.M., Hossain Z., Hunziker W. Early embryonic lethality of mice lacking ZO-2, but not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development. Molecular and Cellular Biology 2008, 28:1669-1678.
130. Yu A.S.L., Cheng M.H., Angelow S., Günzel D., Kanzawa S.A., Schneeberger E.E., et al. Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site. The Journal of General Physiology 2009, 133:111-127.
131. Yu A.S., McCarthy K.M., Francis S.A., McCormack J.M., Lai J., Rogers R.A., et al. Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells. American Journal of Physiology. Cell Physiology 2005, 288:C1231-C1241.
132. Zeissig S., Bürgel N., Günzel D., Richter J.F., Mankertz J., Wahnschaffe U., et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 2007, 56:61-72.