Size-dependent permeability of hydrophilic probes across rabbit colonic epithelium

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 2, 1997, Pages 747-753

  Ghandehari, Hamidreza ^a,b   Smith, Philip L ^a,c   Ellens, Harma ^a,c   Yeh, Ping Yang ^a,c   Kopeček, Jindřich ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c SmithKline Beecham ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INULIN; LACTULOSE; MACROGOL; MACROGOL 400; MANNITOL;

ANIMAL TISSUE; ARTICLE; COLON MUCOSA; DIFFUSION COEFFICIENT; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; CARBON RADIOISOTOPES; COLON; INTESTINAL MUCOSA; INULIN; KINETICS; LACTULOSE; MANNITOL; PERMEABILITY; POLYETHYLENE GLYCOLS; RABBITS; TRITIUM;

EID: 0030899605     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. ARTURSSON, P., UNGELL, A. -L. AND LOFROTH, J. -E.: Selective paracellular permeability in two models of intestinal absorption: Cultured monolayers of human intestinal epithelial cells and rat intestinal segments, Pharm. Res. 10: 1123-1129, 1993.
2. BJARNASON, I.: Intestinal permeability. Gut 1: S18-S22, 1994.
3. BRØNDSTED, H. AND KOPEČ̌EK, J.: Hydrogels for site-specific oral drug delivery: Synthesis and characterization. Biomaterials 12: 584-592, 1991.
4. CHADWICK, V. S., PHILIPS, S. F., AND HOFMANN, A. F.: Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400): I. Chemical analysis and biological properties of PEG 400. Gastroenterology 73: 241-246, 1977.
5. CONRADI, R. A., HILGERS, A. R., Ho, N. F. H., AND BURTON, P. S.: The influence of peptide structure on transport across Caco-2 cells. Pharm. Res. 8: 1453-1460, 1991.
6. CONSTANTINIDES, P. P., SCALART, J. -P., LANCASTER, C., MARCELLO, J., MARKS, G., ELLENS, H. AND SMITH, P. L.: Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides. Pharm. Res. 11: 1385-1390, 1994.
7. EAGLAND, D., CROWTHER, N. J., AND BUTLER, C. J.: Interaction of poly(oxyethylene) with water as a function of molar mass. Polymer 34: 2804-2808, 1993.
8. FRIEND, D. R.: Glycosides in colonie drug delivery. In Oral Colon-Specific Drug Delivery, ed. by E. R. Friend, pp. 153-187, CRC Press, Boca Raton, Florida 1992.
9. FRIEND, D. R., AND CHANG, G. W.: A colon-specific drug delivery system based on drug glycosides and glycosidases of colonie bacteria. J. Med. Chem. 27: 261-266, 1984.
10. GOSTING, L. J., MORRIS, M. S.: Diffusion studies on dilute solutions by Gouy interference. J. Am. Chem. Soc. 71: 1998-2006, 1949.
11. HAMILTON, I., ROTHWELL, J., ARCHER, D. AND AXON, A. T. R.: Permeability of the rat small intestine to carbohydrate probe molecules. Clin. Sci. 73: 189-196, 1987.
12. HANDBOOK OF CHEMISTRY AND PHYSICS, P. F-40, CRC Press, Boca Raton, Florida, 1988.
13. HOLLANDER, D., RICKETTS, D., AND BOYD, C. A. R.: Importance of "probe" molecular geometry in determining intestinal permeability. Can. J. Gastroenterol. 2: suppl. A, 35A-38A, 1988.
14. JETT M., MARSHALL, P., FONDACARO, J. D. AND SMITH P. L.; Action of peptidoleukotrienes on ion transport in rabbit distal colon in vitro. J. Pharmacol. Exp. Ther. 257: 698-705, 1991.
15. JOHANSSON, L., ELVINGSON, C. AND LOFROTH, J. -E.: Diffusion and interaction in gels and solutions. 3. Theoretical results on the obstruction effect. Macromolecules 24: 6024-6029, 1991a.
16. JOHANSSON, L., SKANTZE, U. AND LOFROTH, J. -E.: Diffusion and interaction in gels and solutions. 2. Experimental results on the obstruction effect. Macromolecules 24: 6019-6023, 1991b.
17. KIMURA, T., SUDO, K., KANZAKI, Y., MIKI, K., TAKEICHI, Y., KUROSAKI, Y., AND NAKAYAMA, T.: Drug absorption from large intestine: Physicochemical factors governing drug absorption. Biol. Pharm. Bull. 17: 327-333, 1994.
18. KOPEČEK, J., KOPEČKOVÁ, P., BRØNDSTED, H., RATHI, R., RÍHOVÁ, B., YEH, P. -Y., AND IKESUE, K.: Polymers for colon-specific drug delivery. J. Controlled Rel. 19: 121-130, 1992.
19. LIAW, J., AND ROBINSON, J. R.: The effect of polyethylene glycol molecular weight on corneal transport and the related influence of penetration enhancers. Int. J. Pharm. 88: 125-140, 1992.
20. Lui, K. -J., AND PARSONS, J. L.: Solvent effect on the preferred conformation of poly(ethylene glycols). Macromolecules 2: 529-533, 1969.
21. MA T. Y., HOLLANDER, D., BHALLA, D., NGUYEN, H. AND KRUGLIAK, P.: IEC-18, a nontransformed small intestinal cell line for studying epithelial permeability, J. Lab. Clin. Med. 120: 329-341, 1992.
22. MADARA, J. L.: Loosening tight junctions. J. Clin. Invest. 83: 1089-1094, 1989.
23. MARKS, G. J., RYAN, F. M., HIDALUO, I. J. AND SMITH, P. L.: Mannitol as a marker for intestinal integrity in in vitro absorption studies. Gastroenterology 100: suppl, A697, 1991.
24. MIDDLETON, E.: The molecular configuration of inulin: Implications for ultrafiltration theory and glornerular permeability. J. Membrane Biol. 34: 93-101, 1977.
25. NASRALLAH, S. M. AND IBER, F. L.: Mannitol absorption and metabolism in man. Amer. J. Med. Sci. 258: 80-88, 1969.
26. PANTZAR, N., LUNDIN, S., WESTER, L. AND WESTROM, B. R.; Bidirectional small intestinal permeability in the rat to some common marker molecules in vitro. Scand. J. Gastroenterol. 29: 703-709, 1994.
27. PHILIPSEN, E. K., BATSBERG, W. AND CHRISTENSEN, A. B.: Gastrointestinal permeability to polyethylene glycol: An evaluation of urinary recovery of an oral load of polyethylene glycol as a parameter of intestinal permeability in man. Eur. J. Clin. Invest. 18: 139-145, 1987.
28. RUBAS, W., JEZYK, N. AND GRASS, G. M.: Comparison of the permeability characteristics of a human colonie epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption. Pharm. Res. 10: 113-118, 1993.
29. RUBINSTEIN, A., NAKAR, D. AND SINTOV, A.: Colonie drug delivery: Enhanced release of indomethacin from cross-linked chondroitin matrix in rat cecal content. Pharm. Res. 9: 276-278, 1992.
30. SAWADA, T., TOMITA, M., HAYASHI, M. AND AWAZU, S.: Paracellular channel characterized by non-electrolyte permeation through the colonie membrane of the rat. J. Pharmacobio-Dyn. 12: 634-639, 1989.
31. SEKINE, M., SASAHARA, K., OKADA, R. AND AWAZU, S.: Improvement of bioavailability of poorly absorbed drugs. IV. Mechanism of the promoting effect of medium chain glyceride on the rectal absorption of water soluble drugs. J. Pharmacobio-Dyn. 8: 645-652, 1985.
32. SMITH, P. L., WALL, D. A., GOCHOCO, C. H. AND WILSON, G.: Oral absorption of peptides and proteins. Adv. Drug Del. Rev. 8: 253-290, 1992.
33. STEWARD, M. C.: Paracellular non-electrolyte permeation during fluid transport across rabbit gall-bladder epithelium. J. Physiol. 322: 419-439, 1982.
34. TRAVIS, S., AND MENZIES, L: Intestinal permeability: Functional assessment and significance. Clin. Sci. 82: 471-488, 1992.
35. YEH, P. -Y., BERENSON, M. M., SAMOWITZ, W. S., KOPEČKOVÁ, P. AND KOPECEK, J.: Site-specific drug delivery and penetration enhancement in the gastrointestinal tract. J. Controlled Rel. 36: 109-124, 1995.