Adhesion Dynamics in Motile Cells

Cell Junctions: Adhesion, Development, and Disease

Volumn , Issue , 2008, Pages 71-88

  Cortesio, Christa L ^a   Chan, Keefe T ^b   Huttenlocher, Anna ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Adhesion dynamics; Cell junctions; Cell matrix junctions; Focal adhesion dynamics; Invadopodia dynamics; Motile cells; Podosome dynamics

Indexed keywords

EID: 77954625543     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527622092.ch4     Document Type: Chapter

References (137)

1. Linder, S., and Aepfelbacher, M. (2003). Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol. 13, 376-385.
2. Burridge, K., and Chrzanowska-Wodnicka, M. (1996). Focal adhesions, contractility, and signaling. Annu. Rev. Cell Dev. Biol. 12, 463-518.
3. Yamada, K.M., and Geiger, B. (1997). Molecular interactions in cell adhesion complexes. Curr. Opin. Cell Biol. 9, 76-85.
4. Abercrombie, M., Heaysman, J.E., and Pegrum, S.M. (1971). The locomotion of fibroblasts in culture. IV. Electron microscopy of the leading lamella. Exp. Cell Res. 67, 359-367.
5. Heath, J.P., and Dunn, G.A. (1978). Cell to substratum contacts of chick fibroblasts and their relation to the microfilament system. A correlated interference-reflexion and high-voltage electron-microscope study. J. Cell Sci. 29, 197-212.
6. Laukaitis, C.M., Webb, D.J., Donais, K., and Horwitz, A.F. (2001). Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells. J. Cell Biol. 153, 1427-1440.
7. Webb, D.J., Donais, K., Whitmore, L.A., Thomas, S.M., Turner, C.E., Parsons, J.T., and Horwitz, A.F. (2004). FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 6, 154-161.
8. Franco, S.J., Rodgers, M.A., Perrin, B.J., Han, J., Bennin, D.A., Critchley, D.R., and Huttenlocher, A. (2004). Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat. Cell Biol. 6, 977-983.
9. Kano, Y., Katoh, K., Masuda, M., and Fujiwara, K. (1996). Macromolecular composition of stress fiber-plasma membrane attachment sites in endothelial cells in situ. Circ. Res. 79, 1000-1006.
10. Turner, C.E., Kramarcy, N., Sealock, R., and Burridge, K. (1991). Localization of paxillin, a focal adhesion protein, to smooth muscle dense plaques, and the myotendinous and neuromuscular junctions of skeletal muscle. Exp. Cell Res. 192, 651-655.
11. Cypher, C., and Letourneau, P.C. (1991). Identification of cytoskeletal, focal adhesion, and cell adhesion proteins in growth cone particles isolated from developing chick brain. J. Neurosci. Res. 30, 259-265.
12. Cukierman, E., Pankov, R., Stevens, D.R., and Yamada, K.M. (2001). Taking cell-matrix adhesions to the third dimension. Science 294, 1708-1712.
13. Geiger, B., Bershadsky, A., Pankov, R., and Yamada, K.M. (2001). Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat. Rev. Mol. Cell. Biol. 2, 793-805.
14. Yamada, K.M., Pankov, R., and Cukierman, E. (2003). Dimensions and dynamics in integrin function. Braz. J. Med. Biol. Res. 36, 959-966.
15. Webb, D.J., Brown, C.M., and Horwitz, A.F. (2003). Illuminating adhesion complexes in migrating cells: moving toward a bright future. Curr. Opin. Cell Biol. 15, 614-620.
16. Bershadsky, A., Kozlov, M., and Geiger, B. (2006). Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize. Curr. Opin. Cell Biol. 18, 472-481.
17. Chen, C.S., Tan, J., and Tien, J. (2004). Mechanotransduction at cell-matrix and cell-cell contacts. Annu. Rev. Biomed. Eng. 6, 275-302.
18. Wehrle-Haller, B., and Imhof, B. (2002). The inner lives of focal adhesions. Trends Cell Biol. 12, 382-389.
19. Zamir, E., and Geiger, B. (2001). Components of cell-matrix adhesions. J. Cell Sci. 114, 3577-3579.
20. Romer, L.H., Birukov, K.G., and Garcia, J.G. (2006). Focal adhesions: paradigm for a signaling nexus. Circ. Res. 98, 606-616.
21. Cohen, M., Joester, D., Geiger, B., and Addadi, L. (2004). Spatial and temporal sequence of events in cell adhesion: from molecular recognition to focal adhesion assembly. Chembiochem 5, 1393-1399.
22. Wozniak, M.A., Modzelewska, K., Kwong, L., and Keely, P.J. (2004). Focal adhesion regulation of cell behavior. Biochim Biophys Acta 1692, 103-119.
23. Hynes, R.O. (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.
24. Hood, J.D., and Cheresh, D.A. (2002). Role of integrins in cell invasion and migration. Nat. Rev. Cancer 2, 91-100.
25. Luo, B.H., and Springer, T.A. (2006). Integrin structures and conformational signaling. Curr. Opin. Cell Biol. 18, 579-586.
26. Couchman, J.R., and Woods, A. (1999). Syndecan-4 and integrins: combinatorial signaling in cell adhesion. J. Cell Sci. 112 (Pt 20), 3415-3420.
27. Nayal, A., Webb, D.J., and Horwitz, A.F. (2004). Talin: an emerging focal point of adhesion dynamics. Curr. Opin. Cell Biol. 16, 94-98.
28. Critchley, D.R. (2005). Genetic, biochemical and structural approaches to talin function. Biochem. Soc. Trans. 33, 1308-1312.
29. Otey, C.A., and Carpen, O. (2004). Alpha-actinin revisited: a fresh look at an old player. Cell Motil. Cytoskeleton 58, 104-111.
30. Popowicz, G.M., Schleicher, M., Noegel, A.A., and Holak, T.A. (2006). Filamins: promiscuous organizers of the cytoskeleton. Trends Biochem. Sci. 31, 411-419.
31. Lo, S.H. (2004). Tensin. Int. J. Biochem. Cell Biol. 36, 31-34.
32. Mitra, S.K., Hanson, D.A., and Schlaepfer, D.D. (2005). Focal adhesion kinase: in command and control of cell motility. Nat. Rev. Mol. Cell. Biol. 6, 56-68.
33. Parsons, J.T. (2003). Focal adhesion kinase: the first ten years. J. Cell Sci. 116, 1409-1416.
34. Brown, M.C., and Turner, C.E. (2004). Paxillin: adapting to change. Physiol. Rev. 84, 1315-1339.
35. Legate, K.R., Montanez, E., Kudlacek, O., and Fassler, R. (2006). ILK, PINCH and parvin: the tIPP of integrin signalling. Nat. Rev. Mol. Cell. Biol. 7, 20-31.
36. Wu, C. (2001). ILK interactions. J. Cell Sci. 114, 2549-2550.
37. Ziegler, W.H., Liddington, R.C., and Critchley, D.R. (2006). The structure and regulation of vinculin. Trends Cell Biol. 16, 453-460.
38. Frame, M.C. (2004). Newest findings on the oldest oncogene; how activated src does it. J. Cell Sci. 117, 989-998.
39. Woods, A., and Couchman, J.R. (1992). Protein kinase C involvement in focal adhesion formation. J. Cell Sci. 101 (Pt 2), 277-290.
40. Ridley, A.J. (1994). Signal transduction through the GTP-binding proteins Rac and Rho. J. Cell Sci. Suppl. 18, 127-131.
41. Zhao, Z.S., Manser, E., Loo, T.H., and Lim, L. (2000). Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. Mol. Cell. Biol. 20, 6354-6363.
42. Beckerle, M.C., Burridge, K., DeMartino, G.N., and Croall, D.E. (1987). Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion. Cell 51, 569-577.
43. Yu, D.H., Qu, C.K., Henegariu, O., Lu, X., and Feng, G.S. (1998). Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J. Biol. Chem. 273, 21125-21131.
44. Miyamoto, S., Akiyama, S.K., and Yamada, K.M. (1995). Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267, 883-885.
45. Galbraith, C.G., Yamada, K.M., and Sheetz, M.P. (2002). The relationship between force and focal complex development. J. Cell Biol. 159, 695-705.
46. Kim, M., Carman, C.V., and Springer, T.A. (2003). Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 301, 1720-1725.
47. Ridley, A.J., Schwartz, M.A., Burridge, K., Firtel, R.A., Ginsberg, M.H., Borisy, G., Parsons, J.T., and Horwitz, A.R. (2003). Cell migration: integrating signals from front to back. Science 302, 1704-1709.
48. Yap, A.S., Stevenson, B.R., Cooper, V., and Manley, S.W. (1997). Protein tyrosine phosphorylation influences adhesive junction assembly and follicular organization of cultured thyroid epithelial cells. Endocrinology 138, 2315-2324.
49. Zaidel-Bar, R., Ballestrem, C., Kam, Z., and Geiger, B. (2003). Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J. Cell Sci. 116, 4605-4613.
50. Zaidel-Bar, R., Cohen, M., Addadi, L., and Geiger, B. (2004). Hierarchical assembly of cell-matrix adhesion complexes. Biochem. Soc. Trans. 32, 416-420.
51. Clark, E.A., King, W.G., Brugge, J.S., Symons, M., and Hynes, R.O. (1998). Integrin-mediated signals regulated by members of the rho family of GTPases. J. Cell Biol. 142, 573-586.
52. Nobes, C.D., and Hall, A. (1999). Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 144, 1235-1244.
53. Nobes, C.D., and Hall, A. (1995). Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.
54. Rottner, K., Hall, A., and Small, J.V. (1999). Interplay between Rac and Rho in the control of substrate contact dynamics. Curr. Biol. 9, 640-648.
55. Chrzanowska-Wodnicka, M., and Burridge, K. (1996). Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 133, 1403-1415.
56. Garcia-Mata, R., and Burridge, K. (2007). Catching a GEF by its tail. Trends Cell Biol. 17, 36-43.
57. Ridley, A.J. (2001). Rho GTPases and cell migration. J. Cell Sci. 114, 2713-2722.
58. Jaffe, A.B., and Hall, A. (2005). Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21, 247-269.
59. Sturge, J., Wienke, D., and Isacke, C.M. (2006). Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly. J. Cell Biol. 175, 337-347.
60. Amano, M., Fukata, Y., and Kaibuchi, K. (2000). Regulation and functions of Rho-associated kinase. Exp. Cell Res. 261, 44-51.
61. Beningo, K.A., Dembo, M., Kaverina, I., Small, J.V., and Wang, Y.L. (2001). Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J. Cell Biol. 153, 881-888.
62. Symons, M. (2000). Adhesion signaling: PAK meets Rac on solid ground. Curr. Biol. 10, R535-R537.
63. Riento, K., and Ridley, A.J. (2003). Rocks: multifunctional kinases in cell behaviour. Nat. Rev. Mol. Cell. Biol. 4, 446-456.
64. Critchley, D.R. (2000). Focal adhesions-the cytoskeletal connection. Curr. Opin. Cell Biol. 12, 133-139.
65. Priddle, H., Hemmings, L., Monkley, S., Woods, A., Patel, B., Sutton, D., Dunn, G.A., Zicha, D., and Critchley, D.R. (1998). Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cells. J. Cell Biol. 142, 1121-1133.
66. Giannone, G., Jiang, G., Sutton, D.H., Critchley, D.R., and Sheetz, M.P. (2003). Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation. J. Cell Biol. 163, 409-419.
67. Cram, E.J., and Schwarzbauer, J.E. (2004). The talin wags the dog: new insights into integrin activation. Trends Cell Biol. 14, 55-57.
68. Tadokoro, S., Shattil, S.J., Eto, K., Tai, V., Liddington, R.C., de Pereda, J.M., Ginsberg, M.H., and Calderwood, D.A. (2003). Talin binding to integrin beta tails: a final common step in integrin activation. Science 302, 103-106.
69. Calderwood, D.A., Zent, R., Grant, R., Rees, D.J., Hynes, R.O., and Ginsberg, M.H. (1999). The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J. Biol. Chem. 274, 28071-28074.
70. Vinogradova, O., Velyvis, A., Velyviene, A., Hu, B., Haas, T., Plow, E., and Qin, J. (2002). A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face. Cell 110, 587-597.
71. Ling, K., Doughman, R.L., Firestone, A.J., Bunce, M.W., and Anderson, R.A. (2002). Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature 420, 89-93.
72. Cluzel, C., Saltel, F., Lussi, J., Paulhe, F., Imhof, B.A., and Wehrle-Haller, B. (2005). The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells. J. Cell Biol. 171, 383-392.
73. Martel, V., Racaud-Sultan, C., Dupe, S., Marie, C., Paulhe, F., Galmiche, A., Block, M.R., and Albiges-Rizo, C. (2001). Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides. J. Biol. Chem. 276, 21217-21227.
74. Kong, X., Wang, X., Misra, S., and Qin, J. (2006). Structural basis for the phosphorylation-regulated focal adhesion targeting of type Igamma phosphatidylinositol phosphate kinase (PIPKIgamma) by talin. J. Mol. Biol. 359, 47-54.
75. Orr, A.W., Pallero, M.A., Xiong, W.C., and Murphy-Ullrich, J.E. (2004). Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly. J. Biol. Chem. 279, 48983-48992.
76. Bornfeldt, K.E., Raines, E.W., Graves, L.M., Skinner, M.P., Krebs, E.G., and Ross, R. (1995). Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation. Ann. N. Y. Acad. Sci. 766, 416-430.
77. Xie, H., Pallero, M.A., Gupta, K., Chang, P., Ware, M.F., Witke, W., Kwiatkowski, D.J., Lauffenburger, D.A., Murphy-Ullrich, J.E., and Wells, A. (1998). EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCgamma signaling pathway. J. Cell Sci. 111 (Pt 5), 615-624.
78. Krylyshkina, O., Kaverina, I., Kranewitter, W., Steffen, W., Alonso, M.C., Cross, R.A., and Small, J.V. (2002). Modulation of substrate adhesion dynamics via microtubule targeting requires kinesin-1. J. Cell Biol. 156, 349-359.
79. Small, J.V., and Kaverina, I. (2003). Microtubules meet substrate adhesions to arrange cell polarity. Curr. Opin. Cell Biol. 15, 40-47.
80. Ezratty, E.J., Partridge, M.A., and Gundersen, G.G. (2005). Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nat. Cell Biol. 7, 581-590.
81. Franco, S.J., and Huttenlocher, A. (2005). Regulating cell migration: calpains make the cut. J. Cell Sci. 118, 3829-3838.
82. Glading, A., Lauffenburger, D.A., and Wells, A. (2002). Cutting to the chase: calpain proteases in cell motility. Trends Cell Biol. 12, 46-54.
83. Huttenlocher, A., Palecek, S.P., Lu, Q., Zhang, W., Mellgren, R.L., Lauffenburger, D.A., Ginsberg, M.H., and Horwitz, A.F. (1997). Regulation of cell migration by the calcium-dependent protease calpain. J. Biol. Chem. 272, 32719-32722.
84. Dourdin, N., Bhatt, A.K., Dutt, P., Greer, P.A., Arthur, J.S., Elce, J.S., and Huttenlocher, A. (2001). Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts. J. Biol. Chem. 276, 48382-48388.
85. Bhatt, A., Kaverina, I., Otey, C., and Huttenlocher, A. (2002). Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain. J. Cell Sci. 115, 3415-3425.
86. Carragher, N.O., and Frame, M.C. (2002). Calpain: a role in cell transformation and migration. Int. J. Biochem. Cell Biol. 34, 1539-1543.
87. Franco, S., Perrin, B., and Huttenlocher, A. (2004). Isoform specific function of calpain 2 in regulating membrane protrusion. Exp. Cell Res. 299, 179-187.
88. Carragher, N.O., Levkau, B., Ross, R., and Raines, E.W. (1999). Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talin. J. Cell Biol. 147, 619-630.
89. Schoenwaelder, S.M., Yuan, Y., Cooray, P., Salem, H.H., and Jackson, S.P. (1997). Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clots. J. Biol. Chem. 272, 1694-1702.
90. Ilic, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M., and Yamamoto, T. (1995). Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-544.
91. Carragher, N.O., Westhoff, M.A., Fincham, V.J., Schaller, M.D., and Frame, M.C. (2003). A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src. Curr. Biol. 13, 1442-1450.
92. Vicente-Manzanares, M., Zareno, J., Whitmore, L., Choi, C.K., and Horwitz, A.F. (2007). Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells. J. Cell Biol. 176, 573-580.
93. Even-Ram, S., Doyle, A.D., Conti, M.A., Matsumoto, K., Adelstein, R.S., and Yamada, K.M. (2007). Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk. Nat. Cell Biol. 9, 299-309.
94. Tarone, G., Cirillo, D., Giancotti, F.G., Comoglio, P.M., and Marchisio, P.C. (1985). Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes. Exp. Cell Res. 159, 141-157.
95. Chen, W.T. (1989). Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells. J. Exp. Zool. 251, 167-185.
96. Hai, C.M., Hahne, P., Harrington, E.O., and Gimona, M. (2002). Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells. Exp. Cell Res. 280, 64-74.
97. Tatin, F., Varon, C., Genot, E., and Moreau, V. (2006). A signalling cascade involving PKC, Src and Cdc42 regulates podosome assembly in cultured endothelial cells in response to phorbol ester. J. Cell Sci. 119, 769-781.
98. Baldassarre, M., Pompeo, A., Beznoussenko, G., Castaldi, C., Cortellino, S., McNiven, M.A., Luini, A., and Buccione, R. (2003). Dynamin participates in focal extracellular matrix degradation by invasive cells. Mol. Biol. Cell 14, 1074-1084.
99. Linder, S. (2007). The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol. 17, 107-117.
100. Miyauchi, A., Hruska, K.A., Greenfield, E.M., Duncan, R., Alvarez, J., Barattolo, R., Colucci, S., Zambonin-Zallone, A., Teitelbaum, S.L., and Teti, A. (1990). Osteoclast cytosolic calcium, regulated by voltage-gated calcium channels and extracellular calcium, controls podosome assembly and bone resorption. J. Cell Biol. 111, 2543-2552.
101. Yamaguchi, H., and Condeelis, J. (2006). Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim. Biophys. Acta 1773, 642-652.
102. Linder, S., Wintergerst, U., Bender-Gotze, C., Schwarz, K., Pannicke, U., and Aepfelbacher, M. (2003). Macrophages of patients with X-linked thrombocytopenia display an attenuated Wiskott-Aldrich syndrome phenotype. Immunol. Cell Biol. 81, 130-136.
103. Linder, S., Nelson, D., Weiss, M., and Aepfelbacher, M. (1999). Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages. Proc. Natl. Acad. Sci. USA 96, 9648-9653.
104. Gimona, M., and Buccione, R. (2006). Adhesions that mediate invasion. Int. J. Biochem. Cell Biol. 38, 1875-1892.
105. Ayala, I., Baldassarre, M., Caldieri, G., and Buccione, R. (2006). Invadopodia: a guided tour. Eur. J. Cell Biol. 85, 159-164.
106. Buccione, R., Orth, J.D., and McNiven, M.A. (2004). Foot and mouth: podosomes, invadopodia and circular dorsal ruffles. Nat. Rev. Mol. Cell. Biol. 5, 647-657.
107. Gavazzi, I., Nermut, M.V., and Marchisio, P.C. (1989). Ultrastructure and gold-immunolabelling of cell-substratum adhesions (podosomes) in RSV-transformed BHK cells. J. Cell Sci. 94 (Pt 1), 85-99.
108. Mueller, S.C., Yeh, Y., and Chen, W.T. (1992). Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells. J. Cell Biol. 119, 1309-1325.
109. Marchisio, P.C., Bergui, L., Corbascio, G.C., C'mona, O., D'Urso, N., Schena, M., Tesio, L., and Caligaris-Cappio, F. (1988). Vinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes. Blood 72, 830-833.
110. Teti, A., Colucci, S., Grano, M., Argentino, L., and Zambonin Zallone, A. (1992). Protein kinase C affects microfilaments, bone resorption, and [Ca2 + ] sensing in cultured osteoclasts. Am. J. Physiol. 263, C130-C139.
111. Bruzzaniti, A., Neff, L., Sanjay, A., Horne, W.C., De Camilli, P., and Baron, R. (2005). Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity. Mol. Biol. Cell 16, 3301-3313.
112. Brabek, J., Constancio, S.S., Siesser, P.F., Shin, N.Y., Pozzi, A., and Hanks, S.K. (2005). Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells. Mol. Cancer Res. 3, 307-315.
113. Chellaiah, M.A. (2006). Regulation of podosomes by integrin alphavbeta3 and Rho GTPase-facilitated phosphoinositide signaling. Eur. J. Cell Biol. 85, 311-317.
114. Luxenburg, C., Parsons, J.T., Addadi, L., and Geiger, B. (2006). Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts. J. Cell Sci. 119, 4878-4888.
115. Gatesman, A., Walker, V.G., Baisden, J.M., Weed, S.A., and Flynn, D.C. (2004). Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110. Mol. Cell. Biol. 24, 7578-7597.
116. Tehrani, S., Faccio, R., Chandrasekar, I., Ross, F.P., and Cooper, J.A. (2006). Cortactin has an essential and specific role in osteoclast actin assembly. Mol. Biol. Cell 17, 2882-2895.
117. Webb, B.A., Eves, R., and Mak, A.S. (2006). Cortactin regulates podosome formation: roles of the protein interaction domains. Exp. Cell Res. 312, 760-769.
118. Chou, H.C., Anton, I.M., Holt, M.R., Curcio, C., Lanzardo, S., Worth, A., Burns, S., Thrasher, A.J., Jones, G.E., and Calle, Y. (2006). WIP regulates the stability and localization of WASP to podosomes in migrating dendritic cells. Curr. Biol. 16, 2337-2344.
119. Berdeaux, R.L., Diaz, B., Kim, L., and Martin, G.S. (2004). Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function. J. Cell Biol. 166, 317-323.
120. Chellaiah, M.A., Soga, N., Swanson, S., McAllister, S., Alvarez, U., Wang, D., Dowdy, S.F., and Hruska, K.A. (2000). Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. J. Biol. Chem. 275, 11993-12002.
121. Yamaguchi, H., Lorenz, M., Kempiak, S., Sarmiento, C., Coniglio, S., Symons, M., Segall, J., Eddy, R., Miki, H., Takenawa, T., and Condeelis, J. (2005). Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J. Cell Biol. 168, 441-452.
122. Hiratsuka, S., Watanabe, A., Aburatani, H., and Maru, Y. (2006). Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat. Cell Biol. 8, 1369-1375.
123. Kaverina, I., Stradal, T.E., and Gimona, M. (2003). Podosome formation in cultured A7r5 vascular smooth muscle cells requires Arp2/3-dependent de-novo actin polymerization at discrete microdomains. J. Cell Sci. 116, 4915-4924.
124. Mizutani, K., Miki, H., He, H., Maruta, H., and Takenawa, T. (2002). Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts. Cancer Res. 62, 669-674.
125. Olivier, A., Jeanson-Leh, L., Bouma, G., Compagno, D., Blondeau, J., Seye, K., Charrier, S., Burns, S., Thrasher, A.J., Danos, O., Vainchenker, W., and Galy, A. (2006). A partial down-regulation of WASP is sufficient to inhibit podosome formation in dendritic cells. Mol. Ther. 13, 729-737.
126. Tsuboi, S. (2007). Requirement for a complex of Wiskott-Aldrich Syndrome Protein (WASP) with WASP interacting protein in podosome formation in macrophages. J. Immunol. 178, 2987-2995.
127. Webb, B.A., Jia, L., Eves, R., and Mak, A.S. (2007). Dissecting the functional domain requirements of cortactin in invadopodia formation. Eur. J. Cell Biol. 86, 189-206.
128. Bokoch, G.M., and Der, C.J. (1993). Emerging concepts in the Ras superfamily of GTP-binding proteins. FASEB J. 7, 750-759.
129. Linder, S., Hufner, K., Wintergerst, U., and Aepfelbacher, M. (2000). Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages. J. Cell Sci. 113 (Pt 23), 4165-4176.
130. Ory, S., Munari-Silem, Y., Fort, P., and Jurdic, P. (2000). Rho and Rac exert antagonistic functions on spreading of macrophage-derived multinucleated cells and are not required for actin fiber formation. J. Cell Sci. 113 (Pt 7), 1177-1188.
131. Burns, S., Thrasher, A.J., Blundell, M.P., Machesky, L., and Jones, G.E. (2001). Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation. Blood 98, 1142-1149.
132. Suzuki, T., Shoji, S., Yamamoto, K., Nada, S., Okada, M., Yamamoto, T., and Honda, Z. (1998). Essential roles of Lyn in fibronectin-mediated filamentous actin assembly and cell motility in mast cells. J. Immunol. 161, 3694-3701.
133. Hauck, C.R., Hsia, D.A., Ilic, D., and Schlaepfer, D.D. (2002). V-Src SH3-enhanced interaction with focal adhesion kinase at beta 1 integrin-containing invadopodia promotes cell invasion. J. Biol. Chem. 277, 12487-12490
134. van Helden, S.F., Krooshoop, D.J., Broers, K.C., Raymakers, R.A., Figdor, C.G., and Van Leeuwen, F.N. (2006). A critical role for prostaglandin E2 in podosome dissolution and induction of high-speed migration during dendritic cell maturation. J. Immunol. 177, 1567-1574.
135. Calle, Y., Carragher, N.O., Thrasher, A.J., and Jones, G.E. (2006). Inhibition of calpain stabilises podosomes and impairs dendritic cell motility. J. Cell Sci. 119, 2375-2385.
136. Marzia, M., Chiusaroli, R., Neff, L., Kim, N.Y., Chishti, A.H., Baron, R., and Horne, W.C. (2006). Calpain is required for normal osteoclast function and is down-regulated by calcitonin. J. Biol. Chem. 281, 9745-9754.
137. Shyu, J.F., Shih, C., Tseng, C.Y., Lin, C.H., Sun, D.T., Liu, H.T., Tsung, H. C., Chen, T.H., and Lu, R.B. (2007). Calcitonin induces podosome disassembly and detachment of osteoclasts by modulating Pyk2 and Src activities. Bone 40, 1329-1342.