Proteomics-based biomarkers in chronic obstructive pulmonary disease

Journal of Proteome Research

Volumn 9, Issue 6, 2010, Pages 2798-2808

  Chen, Hong ^a   Wang, Diane ^a   Bai, Chunxue ^a   Wang, Xiangdong ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

biomarker; biopsy; COPD; lungs; proteomics

Indexed keywords

ACTIN; ALBUMIN; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; APOLIPOPROTEIN A1; BIOLOGICAL MARKER; CALGRANULIN A; CALGRANULIN B; CALMODULIN; CALRETICULIN; CATHEPSIN D; CENTRIN; CERULOPLASMIN; COFILIN 1; COLLAGENASE 3; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3B; ELONGATION FACTOR 1BETA; GELSOLIN; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 27; HEPATOMA DERIVED GROWTH FACTOR; LIPOCORTIN 2; LUNG RESISTANCE PROTEIN; MALATE DEHYDROGENASE; PEROXIREDOXIN 6; PROTEIN DISULFIDE ISOMERASE; RGS PROTEIN; SURFACTANT PROTEIN A; THIOREDOXIN 2; UNINDEXED DRUG;

BREATH ANALYSIS; CELL COUNT; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; EXPIRED AIR; FEASIBILITY STUDY; HUMAN; LIQUID CHROMATOGRAPHY; LUNG ALVEOLUS EPITHELIUM; LUNG BIOPSY; LUNG LAVAGE; LUNG PARENCHYMA; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEOMICS; REVIEW; SENSITIVITY AND SPECIFICITY; SERUM; SPUTUM ANALYSIS; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY;

BIOLOGICAL MARKERS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; MASS SPECTROMETRY; PROTEOME; PROTEOMICS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SIGNAL TRANSDUCTION;

EID: 77954619669     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100063r     Document Type: Review

References (102)

1. Celli, B. R.; MacNee, W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur. Respir. J. 2004, 23 (6), 932-946
2. Pauwels, R. A.; Rabe, K. F. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 2004, 364 (9434), 613-620
3. Hogg, J. C.; Chu, F.; Utokaparch, S.; Woods, R.; Elliott, W. M.; Buzatu, L.; Cherniack, R. M.; Rogers, R. M.; Sciurba, F. C.; Coxson, H. O.; Pare, P. D. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 2004, 350 (26), 2645-2653
4. Rabe, K. F.; Hurd, S.; Anzueto, A.; Barnes, P. J.; Buist, S. A.; Calverley, P.; Fukuchi, Y.; Jenkins, C.; Rodriguez-Roisin, R.; van Weel, C.; Zielinski, J. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am. J. Respir. Crit. Care Med. 2007, 176 (6), 532-555
5. Lopez, A. D.; Murray, C. C. The global burden of disease, 1990-2020. Nat. Med. 1998, 4 (11), 1241-1243
6. Bon, J. M.; Leader, J. K.; Weissfeld, J. L.; Coxson, H. O.; Zheng, B.; Branch, R. A.; Kondragunta, V.; Lee, J. S.; Zhang, Y.; Choi, A. M.; Lokshin, A. E.; Kaminski, N.; Gur, D.; Sciurba, F. C. The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease. PLoS One 2009, 4 (8), e6865.
7. Plymoth, A.; Lofdahl, C. G.; Ekberg-Jansson, A.; Dahlback, M.; Broberg, P.; Foster, M.; Fehniger, T. E.; Marko-Varga, G. Protein expression patterns associated with progression of chronic obstructive pulmonary disease in bronchoalveolar lavage of smokers. Clin. Chem. 2007, 53 (4), 636-644
8. Plymoth, A.; Yang, Z.; Lofdahl, C. G.; Ekberg-Jansson, A.; Dahlback, M.; Fehniger, T. E.; Marko-Varga, G.; Hancock, W. S. Rapid proteome analysis of bronchoalveolar lavage samples of lifelong smokers and neversmokers by micro-scale liquid chromatography and mass spectrometry. Clin. Chem. 2006, 52 (4), 671-679
9. Plymoth, A.; Lofdahl, C. G.; Ekberg-Jansson, A.; Dahlback, M.; Lindberg, H.; Fehniger, T. E.; Marko-Varga, G. Human bronchoalveolar lavage: biofluid analysis with special emphasis on sample preparation. Proteomics 2003, 3 (6), 962-972
10. Kelsen, S. G.; Duan, X.; Ji, R.; Perez, O.; Liu, C.; Merali, S. Cigarette smoke induces an unfolded protein response in the human lung: a proteomic approach. Am. J. Respir. Cell Mol. Biol. 2008, 38 (5), 541-550
11. Ohlmeier, S.; Vuolanto, M.; Toljamo, T.; Vuopala, K.; Salmenkivi, K.; Myllarniemi, M.; Kinnula, V. L. Proteomics of human lung tissue identifies surfactant protein a as a marker of chronic obstructive pulmonary disease. J. Proteome Res. 2008, 7 (12), 5125-5132
12. Lee, E. J.; In, K. H.; Kim, J. H.; Lee, S. Y.; Shin, C.; Shim, J. J.; Kang, K. H.; Yoo, S. H.; Kim, C. H.; Kim, H. K.; Lee, S. H.; Uhm, C. S. Proteomic analysis in lung tissue of smokers and COPD patients. Chest 2009, 135 (2), 344-352
13. Rutgers, S. R.; Timens, W.; Kaufmann, H. F.; van der Mark, T. W.; Koeter, G. H.; Postma, D. S. Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD. Eur. Respir. J. 2000, 15 (1), 109-115
14. Wattiez, R.; Hermans, C.; Cruyt, C.; Bernard, A.; Falmagne, P. Human bronchoalveolar lavage fluid protein two-dimensional database: study of interstitial lung diseases. Electrophoresis 2000, 21 (13), 2703-2712
15. Casado, B.; Iadarola, P.; Luisetti, M.; Kussmann, M. Proteomicsbased diagnosis of chronic obstructive pulmonary disease: the hunt for new markers. Expert Rev. Proteomics 2008, 5 (5), 693-704.
16. Paggiaro, P. L.; Chanez, P.; Holz, O.; Ind, P. W.; Djukanovic, R.; Maestrelli, P.; Sterk, P. J. Sputum induction. Eur. Respir. J. Suppl. 2002, 37, 3s-8s.
17. Antoniou, K. M.; Alexandrakis, M.; Tzanakis, N.; Tsiligianni, I.; Tzortzaki, E. G.; Siafakas, N. M.; Bouros, D. E. Induced sputum versus bronchoalveolar lavage fluid in the evaluation of patients with idiopathic pulmonary fibrosis. Respiration 2005, 72 (1), 32-38 (Pubitemid 40470275)
18. Tsiligianni, J.; Tzanakis, N.; Kyriakou, D.; Chrysofakis, G.; Siafakas, N.; Bouros, D. Comparison of sputum induction with bronchoalveolar lavage cell differential counts in patients with sarcoidosis. Sarcoidosis Vasc. Diffuse Lung Dis. 2002, 19 (3), 205-210
19. Sobiecka, M.; Kus, J.; Demkow, U.; Filewska, M.; Jozwik, A.; Radwan-Rohrenschef, P.; Chorostowska-Wynimko, J. Induced sputum in patients with interstitial lung disease: a non-invasive surrogate for certain parameters in bronchoalveolar lavage fluid. J. Physiol. Pharmacol. 2008, 59 (Suppl. 6), 645-657
20. Mroz, R. M.; Chyczewska, E.; Korniluk, M.; Stasiak-Barmuta, A.; Ossolinska, M. [Comparison of cellular composition of induced sputum, bronchial washings and bronchoalveolar lavage fluid in sarcoidosis, hypersensitivity pneumonitis and COPD]. Pneumonol. Alergol. Pol. 2002, 70 (9-10), 468-477
21. Olivieri, D.; D'Ippolito, R.; Chetta, A. Induced sputum: diagnostic value in interstitial lung disease. Curr. Opin. Pulm. Med. 2000, 6 (5), 411-414
22. Pinto-Plata, V.; Toso, J.; Lee, K.; Bilello, J.; Mullerova, H.; De Souza, M.; Vessey, R.; Celli, B. Use of proteomic patterns of serum biomarkers in patients with chronic obstructive pulmonary disease: correlation with clinical parameters. Proc Am Thorac Soc 2006, 3 (6), 465-466
23. Rose, K.; Bougueleret, L.; Baussant, T.; Bohm, G.; Botti, P.; Colinge, J.; Cusin, I.; Gaertner, H.; Gleizes, A.; Heller, M.; Jimenez, S.; Johnson, A.; Kussmann, M.; Menin, L.; Menzel, C.; Ranno, F.; Rodriguez-Tome, P.; Rogers, J.; Saudrais, C.; Villain, M.; Wetmore, D.; Bairoch, A.; Hochstrasser, D. Industrial-scale proteomics: from liters of plasma to chemically synthesized proteins. Proteomics 2004, 4 (7), 2125-2150
24. Pauwels, R. A.; Buist, A. S.; Calverley, P. M.; Jenkins, C. R.; Hurd, S. S. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J. Respir. Crit. Care Med. 2001, 163 (5), 1256-1276
25. Tonge, R.; Shaw, J.; Middleton, B.; Rowlinson, R.; Rayner, S.; Young, J.; Pognan, F.; Hawkins, E.; Currie, I.; Davison, M. Validation and development of fluorescence two-dimensional differential gel electrophoresis proteomics technology. Proteomics 2001, 1 (3), 377-396
26. Hirsch, J.; Hansen, K. C.; Burlingame, A. L.; Matthay, M. A. Proteomics: current techniques and potential applications to lung disease. Am. J. Physiol.: Lung Cell. Mol. Physiol. 2004, 287 (1), L1-23.
27. Magi, B.; Bini, L.; Perari, M. G.; Fossi, A.; Sanchez, J. C.; Hochstrasser, D.; Paesano, S.; Raggiaschi, R.; Santucci, A.; Pallini, V.; Rottoli, P. Bronchoalveolar lavage fluid protein composition in patients with sarcoidosis and idiopathic pulmonary fibrosis: a two-dimensional electrophoretic study. Electrophoresis 2002, 23 (19), 3434-3444
28. Wattiez, R.; Hermans, C.; Bernard, A.; Lesur, O.; Falmagne, P. Human bronchoalveolar lavage fluid: two-dimensional gel electrophoresis, amino acid microsequencing and identification of major proteins. Electrophoresis 1999, 20 (7), 1634-1645
29. Tang, N.; Tornatore, P.; Weinberger, S. R. Current developments in SELDI affinity technology. Mass Spectrom. Rev. 2004, 23 (1), 34-44.
30. Li, J.; Zhang, Z.; Rosenzweig, J.; Wang, Y. Y.; Chan, D. W. Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer. Clin. Chem. 2002, 48 (8), 1296-1304
31. Jr, G. W.; Cazares, L. H.; Leung, S. M.; Nasim, S.; Adam, B. L.; Yip, T. T.; Schellhammer, P. F.; Gong, L.; Vlahou, A. Proteinchip(R) surface enhanced laser desorption/ionization (SELDI) mass spectrometry: a novel protein biochip technology for detection of prostate cancer biomarkers in complex protein mixtures. Prostate Cancer Prostatic Dis. 1999, 2 (5/6), 264-276.
32. Merchant, M.; Weinberger, S. R. Recent advancements in surfaceenhanced laser desorption/ionization-time of flight-mass spectrometry. Electrophoresis 2000, 21 (6), 1164-1177
33. Diamandis, E. P. Point: Proteomic patterns in biological fluids: do they represent the future of cancer diagnostics. Clin. Chem. 2003, 49 (8), 1272-1275
34. Kriegova, E.; Melle, C.; Kolek, V.; Hutyrova, B.; Mrazek, F.; Bleul, A.; du Bois, R. M.; von Eggeling, F.; Petrek, M. Protein profiles of bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. Am. J. Respir. Crit. Care Med. 2006, 173 (10), 1145-1154
35. Aivado, M.; Spentzos, D.; Alterovitz, G.; Otu, H. H.; Grall, F.; Giagounidis, A. A.; Wells, M.; Cho, J. Y.; Germing, U.; Czibere, A.; Prall, W. C.; Porter, C.; Ramoni, M. F.; Libermann, T. A. Optimization and evaluation of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) with reversed-phase protein arrays for protein profiling. Clin. Chem. Lab. Med. 2005, 43 (2), 133-140
36. Banks, R. E.; Stanley, A. J.; Cairns, D. A.; Barrett, J. H.; Clarke, P.; Thompson, D.; Selby, P. J. Influences of blood sample processing on low-molecular-weight proteome identified by surface-enhanced laser desorption/ionization mass spectrometry. Clin. Chem. 2005, 51 (9), 1637-1649
37. Semmes, O. J.; Feng, Z.; Adam, B. L.; Banez, L. L.; Bigbee, W. L.; Campos, D.; Cazares, L. H.; Chan, D. W.; Grizzle, W. E.; Izbicka, E.; Kagan, J.; Malik, G.; McLerran, D.; Moul, J. W.; Partin, A.; Prasanna, P.; Rosenzweig, J.; Sokoll, L. J.; Srivastava, S.; Srivastava, S.; Thompson, I.; Welsh, M. J.; White, N.; Winget, M.; Yasui, Y.; Zhang, Z.; Zhu, L. Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility. Clin. Chem. 2005, 51 (1), 102-112
38. Karsan, A.; Eigl, B. J.; Flibotte, S.; Gelmon, K.; Switzer, P.; Hassell, P.; Harrison, D.; Law, J.; Hayes, M.; Stillwell, M.; Xiao, Z.; Conrads, T. P.; Veenstra, T. Analytical and preanalytical biases in serum proteomic pattern analysis for breast cancer diagnosis. Clin. Chem. 2005, 51 (8), 1525-1528
39. Diamandis, E. P. Analysis of serum proteomic patterns for early cancer diagnosis: drawing attention to potential problems. J. Natl. Cancer Inst. 2004, 96 (5), 353-356
40. Marko-Varga, G.; Lindberg, H.; Lofdahl, C. G.; Jonsson, P.; Hansson, L.; Dahlback, M.; Lindquist, E.; Johansson, L.; Foster, M.; Fehniger, T. E. Discovery of biomarker candidates within disease by protein profiling: principles and concepts. J. Proteome Res. 2005, 4 (4), 1200-1212
41. Gray, R. D.; MacGregor, G.; Noble, D.; Imrie, M.; Dewar, M.; Boyd, A. C.; Innes, J. A.; Porteous, D. J.; Greening, A. P. Sputum proteomics in inflammatory and suppurative respiratory diseases. Am. J. Respir. Crit. Care Med. 2008, 178 (5), 444-452
42. Merkel, D.; Rist, W.; Seither, P.; Weith, A.; Lenter, M. C. Proteomic study of human bronchoalveolar lavage fluids from smokers with chronic obstructive pulmonary disease by combining surfaceenhanced laser desorption/ionization-mass spectrometry profiling with mass spectrometric protein identification. Proteomics 2005, 5 (11), 2972-2980
43. Bai, Y.; Galetskiy, D.; Damoc, E.; Paschen, C.; Liu, Z.; Griese, M.; Liu, S.; Przybylski, M. High resolution mass spectrometric alveolar proteomics: identification of surfactant protein SP-A and SP-D modifications in proteinosis and cystic fibrosis patients. Proteomics 2004, 4 (8), 2300-2309
44. Witt, M.; Fuchser, J.; Baykut, G. Fourier transform ion cyclotron resonance mass spectrometry with NanoLC/microelectrospray ionization and matrix-assisted laser desorption/ionization: analytical performance in peptide mass fingerprint analysis. J. Am. Soc. Mass Spectrom. 2003, 14 (6), 553-561
45. Conrads, T. P.; Anderson, G. A.; Veenstra, T. D.; Pasa-Tolic, L.; Smith, R. D. Utility of accurate mass tags for proteome-wide protein identification. Anal. Chem. 2000, 72 (14), 3349-3354
46. Albach, C.; Damoc, E.; Denzinger, T.; Schachner, M.; Przybylski, M.; Schmitz, B. Identification of N-glycosylation sites of the murine neural cell adhesion molecule NCAM by MALDI-TOF and MALDI-FTICR mass spectrometry. Anal. Bioanal. Chem. 2004, 378 (4), 1129-1135
47. Damoc, E.; Youhnovski, N.; Crettaz, D.; Tissot, J. D.; Przybylski, M. High resolution proteome analysis of cryoglobulins using Fourier transform-ion cyclotron resonance mass spectrometry. Proteomics 2003, 3 (8), 1425-1433
48. Vignali, D. A. Multiplexed particle-based flow cytometric assays. J. Immunol. Methods 2000, 243 (1-2), 243-255
49. Marko-Varga, G.; Fehniger, T. E. Proteomics and diseasesthe challenges for technology and discovery. J. Proteome Res. 2004, 3 (2), 167-178
50. Berlett, B. S.; Stadtman, E. R. Protein oxidation in aging, disease, and oxidative stress. J. Biol. Chem. 1997, 272 (33), 20313-20316
51. Rahman, I. The role of oxidative stress in the pathogenesis of COPD: implications for therapy. Treat. Respir. Med. 2005, 4 (3), 175-200.
52. Wallace, A. M.; Sandford, A. J.; English, J. C.; Burkett, K. M.; Li, H.; Finley, R. J.; Muller, N. L.; Coxson, H. O.; Pare, P. D.; Abboud, R. T. Matrix metalloproteinase expression by human alveolar macrophages in relation to emphysema. COPD 2008, 5 (1), 13-23. (Pubitemid 351225520)
53. Sloane, A. J.; Lindner, R. A.; Prasad, S. S.; Sebastian, L. T.; Pedersen, S. K.; Robinson, M.; Bye, P. T.; Nielson, D. W.; Harry, J. L. Proteomic analysis of sputum from adults and children with cystic fibrosis and from control subjects. Am. J. Respir. Crit. Care Med. 2005, 172 (11), 1416-1426
54. Rottoli, P.; Magi, B.; Perari, M. G.; Liberatori, S.; Nikiforakis, N.; Bargagli, E.; Cianti, R.; Bini, L.; Pallini, V. Cytokine profile and proteome analysis in bronchoalveolar lavage of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis and idiopathic pulmonary fibrosis. Proteomics 2005, 5 (5), 1423-1430
55. Sepper, R.; Prikk, K. Proteomics: is it an approach to understand the progression of chronic lung disorders. J. Proteome Res. 2004, 3 (2), 277-281
56. Bracke, K.; Cataldo, D.; Maes, T.; Gueders, M.; Noel, A.; Foidart, J. M.; Brusselle, G.; Pauwels, R. A. Matrix metalloproteinase-12 and cathepsin D expression in pulmonary macrophages and dendritic cells of cigarette smoke-exposed mice. Int. Arch. Allergy Immunol. 2005, 138 (2), 169-179
57. Wang, Z.; Zheng, T.; Zhu, Z.; Homer, R. J.; Riese, R. J.; Chapman, H. A., Jr.; Shapiro, S. D.; Elias, J. A. Interferon gamma induction of pulmonary emphysema in the adult murine lung. J. Exp. Med. 2000, 192 (11), 1587-1600
58. Burnett, D.; Crocker, J.; Stockley, R. A. Cathepsin B-like cysteine proteinase activity in sputum and immunohistologic identification of cathepsin B in alveolar macrophages. Am. Rev. Respir. Dis. 1983, 128 (5), 915-919
59. Hoshino, T.; Kato, S.; Oka, N.; Imaoka, H.; Kinoshita, T.; Takei, S.; Kitasato, Y.; Kawayama, T.; Imaizumi, T.; Yamada, K.; Young, H. A.; Aizawa, H. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am. J. Respir. Crit. Care Med. 2007, 176 (1), 49-62.
60. Kang, M. J.; Homer, R. J.; Gallo, A.; Lee, C. G.; Crothers, K. A.; Cho, S. J.; Rochester, C.; Cain, H.; Chupp, G.; Yoon, H. J.; Elias, J. A. IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J. Immunol. 2007, 178 (3), 1948-1959
61. Piccioni, P. D.; Kramps, J. A.; Rudolphus, A.; Bulgheroni, A.; Luisetti, M. Proteinase/proteinase inhibitor imbalance in sputum sol phases from patients with chronic obstructive pulmonary disease. Suggestions for a key role played by antileukoprotease. Chest 1992, 102 (5), 1470-1476
62. Yousefi, S.; Cooper, P. R.; Mueck, B.; Potter, S. L.; Jarai, G. cDNA representational difference analysis of human neutrophils stimulated by GM-CSF. Biochem. Biophys. Res. Commun. 2000, 277 (2), 401-409
63. Geraghty, P.; Greene, C. M.; O'Mahony, M.; O'Neill, S. J.; Taggart, C. C.; McElvaney, N. G. Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression. J. Biol. Chem. 2007, 282 (46), 33389-33395
64. Zheng, T.; Zhu, Z.; Wang, Z.; Homer, R. J.; Ma, B.; Riese, R. J., Jr.; Chapman, H. A., Jr.; Shapiro, S. D.; Elias, J. A. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase-and cathepsin-dependent emphysema. J. Clin. Invest. 2000, 106 (9), 1081-1093
65. de Garavilla, L.; Greco, M. N.; Sukumar, N.; Chen, Z. W.; Pineda, A. O.; Mathews, F. S.; Di Cera, E.; Giardino, E. C.; Wells, G. I.; Haertlein, B. J.; Kauffman, J. A.; Corcoran, T. W.; Derian, C. K.; Eckardt, A. J.; Damiano, B. P.; Andrade-Gordon, P.; Maryanoff, B. E. A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and antiinflammatory activity in vivo. J. Biol. Chem. 2005, 280 (18), 18001-18007
66. Maryanoff, B. E.; de Garavilla, L.; Greco, M. N.; Haertlein, B. J.; Wells, G. I.; Andrade-Gordon, P.; Abraham, W. M. Dual inhibition of cathepsin G and chymase is effective in animal models of pulmonary inflammation. Am. J. Respir. Crit. Care Med. 2010, 181 (3), 247-253
67. Thurmond, R. L.; Sun, S.; Karlsson, L.; Edwards, J. P. Cathepsin S inhibitors as novel immunomodulators. Curr. Opin. Invest. Drugs 2005, 6 (5), 473-482
68. Liu, S. F.; Chin, C. H.; Wang, C. C.; Lin, M. C. Correlation between serum biomarkers and BODE index in patients with stable COPD. Respirology 2009, 14 (7), 999-1004.
69. Bulut, I.; Arbak, P.; Coskun, A.; Balbay, O.; Annakkaya, A. N.; Yavuz, O.; Gulcan, E. Comparison of serum CA 19.9, CA 125 and CEA levels with severity of chronic obstructive pulmonary disease. Med. Princ. Pract. 2009, 18 (4), 289-293
70. Hiemstra, P. S.; van Wetering, S.; Stolk, J. Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. Eur. Respir. J. 1998, 12 (5), 1200-1208
71. Pastva, A. M.; Wright, J. R.; Williams, K. L. Immunomodulatory roles of surfactant proteins A and D: implications in lung disease. Proc. Am. Thorac. Soc. 2007, 4 (3), 252-257
72. Kishore, U.; Greenhough, T. J.; Waters, P.; Shrive, A. K.; Ghai, R.; Kamran, M. F.; Bernal, A. L.; Reid, K. B.; Madan, T.; Chakraborty, T. Surfactant proteins SP-A and SP-D: structure, function and receptors. Mol. Immunol. 2006, 43 (9), 1293-1315
73. Hu, Q.; Zhang, H.; Xiong, S.; Shi, X.; Xu, Y.; Zhang, Z.; Zhen, G.; Zhao, J. The alteration and significance of surfactant protein A in rats chronically exposed to cigarette smoke. J. Huazhong Univ. Sci. Technol., Med. Sci. 2008, 28 (2), 128-131
74. Honda, Y.; Takahashi, H.; Kuroki, Y.; Akino, T.; Abe, S. Decreased contents of surfactant proteins A and D in BAL fluids of healthy smokers. Chest 1996, 109 (4), 1006-1009
75. Betsuyaku, T.; Kuroki, Y.; Nagai, K.; Nasuhara, Y.; Nishimura, M. Effects of ageing and smoking on SP-A and SP-D levels in bronchoalveolar lavage fluid. Eur. Respir. J. 2004, 24 (6), 964-970
76. Sims, M. W.; Tal-Singer, R. M.; Kierstein, S.; Musani, A. I.; Beers, M. F.; Panettieri, R. A.; Haczku, A. Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study. Respir. Res. 2008, 9, 13.
77. Li, L.; Ruan, Y. M.; Meng, Y.; Chen, Y. [Protective and therapeutic effect of pulmonary surfactant on the experimental chronic obstructive pulmonary disease in hamsters]. Zhongguo Yixue Kexueyuan Xuebao 2004, 26 (3), 279-284
78. Kobayashi, H.; Kanoh, S.; Motoyoshi, K. Serum surfactant protein-A, but not surfactant protein-D or KL-6, can predict preclinical lung damage induced by smoking. Biomarkers 2008, 13 (4), 385-392
79. Behera, D.; Balamugesh, T.; Venkateswarlu, D.; Gupta, A.; Majumdar, S. Serum surfactant protein-A levels in chronic bronchitis and its relation to smoking. Indian J. Chest Dis. Allied Sci. 2005, 47 (1), 13-17
80. Hirama, N.; Shibata, Y.; Otake, K.; Machiya, J.; Wada, T.; Inoue, S.; Abe, S.; Takabatake, N.; Sata, M.; Kubota, I. Increased surfactant protein-D and foamy macrophages in smokinginduced mouse emphysema. Respirology 2007, 12 (2), 191-201.
81. Lomas, D. A.; Silverman, E. K.; Edwards, L. D.; Locantore, N. W.; Miller, B. E.; Horstman, D. H.; Tal-Singer, R. Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD. Eur. Respir. J. 2009, 34 (1), 95-102.
82. Sin, D. D.; Leung, R.; Gan, W. Q.; Man, S. P. Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study. BMC Pulm. Med. 2007, 7, 13.
83. Sun, H. Q.; Yamamoto, M.; Mejillano, M.; Yin, H. L. Gelsolin, a multifunctional actin regulatory protein. J. Biol. Chem. 1999, 274 (47), 33179-33182
84. Candiano, G.; Bruschi, M.; Pedemonte, N.; Caci, E.; Liberatori, S.; Bini, L.; Pellegrini, C.; Vigano, M.; O'Connor, B. J.; Lee, T. H.; Galietta, L. J.; Zegarra-Moran, O. Gelsolin secretion in interleukin-4-treated bronchial epithelia and in asthmatic airways. Am. J. Respir. Crit. Care Med. 2005, 172 (9), 1090-1096
85. Boutin, M.; Berthelette, C.; Gervais, F. G.; Scholand, M. B.; Hoidal, J.; Leppert, M. F.; Bateman, K. P.; Thibault, P. High-Sensitivity NanoLC-MS/MS Analysis of Urinary Desmosine and Isodesmosine. Anal. Chem. 2009, 81 (5), 1881-1887
86. Deslee, G.; Woods, J. C.; Moore, C. M.; Liu, L.; Conradi, S. H.; Milne, M.; Gierada, D. S.; Pierce, J.; Patterson, A.; Lewit, R. A.; Battaile, J. T.; Holtzman, M. J.; Hogg, J. C.; Pierce, R. A. Elastin expression in very severe human COPD. Eur. Respir. J. 2009, 34 (2), 324-331
87. Luisetti, M.; Ma, S.; Iadarola, P.; Stone, P. J.; Viglio, S.; Casado, B.; Lin, Y. Y.; Snider, G. L.; Turino, G. M. Desmosine as a biomarker of elastin degradation in COPD: current status and future directions. Eur. Respir. J. 2008, 32 (5), 1146-1157
88. Watz, H.; Waschki, B.; Kirsten, A.; Muller, K. C.; Kretschmar, G.; Meyer, T.; Holz, O.; Magnussen, H. The metabolic syndrome in patients with chronic bronchitis and COPD: frequency and associated consequences for systemic inflammation and physical inactivity. Chest 2009, 136 (4), 1039-1046
89. Higashimoto, Y.; Iwata, T.; Okada, M.; Satoh, H.; Fukuda, K.; Tohda, Y. Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease. Respir. Med. 2009, 103 (8), 1231-1238
90. Koutsokera, A.; Kiropoulos, T. S.; Nikoulis, D. J.; Daniil, Z. D.; Tsolaki, V.; Tanou, K.; Papaioannou, A. I.; Germenis, A.; Gourgoulianis, K. I.; Kostikas, K. Clinical, functional and biochemical changes during recovery from COPD exacerbations. Respir. Med. 2009, 103 (6), 919-926
91. Valipour, A.; Schreder, M.; Wolzt, M.; Saliba, S.; Kapiotis, S.; Eickhoff, P.; Burghuber, O. C. Circulating vascular endothelial growth factor and systemic inflammatory markers in patients with stable and exacerbated chronic obstructive pulmonary disease. Clin. Sci. 2008, 115 (7), 225-232
92. Groenewegen, K. H.; Postma, D. S.; Hop, W. C.; Wielders, P. L.; Schlosser, N. J.; Wouters, E. F. Increased systemic inflammation is a risk factor for COPD exacerbations. Chest 2008, 133 (2), 350-357
93. Minarowska, A.; Minarowski, L.; Karwowska, A.; Sands, D.; Dabrowska, E. The activity of cathepsin D in saliva of cystic fibrosis patients. Folia Histochem. Cytobiol. 2007, 45 (3), 165-168 (Pubitemid 350018131)
94. Mori, M.; Morishita, H.; Nakamura, H.; Matsuoka, H.; Yoshida, K.; Kishima, Y.; Zhou, Z.; Kida, H.; Funakoshi, T.; Goya, S.; Yoshida, M.; Kumagai, T.; Tachibana, I.; Yamamoto, Y.; Kawase, I.; Hayashi, S. Hepatoma-derived growth factor is involved in lung remodeling by stimulating epithelial growth. Am. J. Respir. Cell Mol. Biol. 2004, 30 (4), 459-469
95. Chilosi, M.; Zamo, A.; Doglioni, C.; Reghellin, D.; Lestani, M.; Montagna, L.; Pedron, S.; Ennas, M. G.; Cancellieri, A.; Murer, B.; Poletti, V. Migratory marker expression in fibroblast foci of idiopathic pulmonary fibrosis. Respir. Res. 2006, 7, 95.
96. Budde, I. K.; Aalberse, R. C. Histamine-releasing factors, a heterogeneous group of different activities. Clin. Exp. Allergy 2003, 33 (9), 1175-1182
97. Bucki, R.; Levental, I.; Kulakowska, A.; Janmey, P. A. Plasma gelsolin: function, prognostic value, and potential therapeutic use. Curr. Protein Pept. Sci. 2008, 9 (6), 541-551
98. Silva, E.; Bourin, S.; Sabounchi-Schutt, F.; Laurin, Y.; Barker, E.; Newman, L.; Eriksson, H.; Eklund, A.; Grunewald, J. A quantitative proteomic analysis of soluble bronchoalveolar fluid proteins from patients with sarcoidosis and chronic beryllium disease. Sarcoidosis Vasc. Diffuse Lung Dis. 2007, 24 (1), 24-32.
99. Konishi, K.; Gibson, K. F.; Lindell, K. O.; Richards, T. J.; Zhang, Y.; Dhir, R.; Bisceglia, M.; Gilbert, S.; Yousem, S. A.; Song, J. W.; Kim, D. S.; Kaminski, N. Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2009, 180 (2), 167-175
100. McMorran, B. J.; Patat, S. A.; Carlin, J. B.; Grimwood, K.; Jones, A.; Armstrong, D. S.; Galati, J. C.; Cooper, P. J.; Byrnes, C. A.; Francis, P. W.; Robertson, C. F.; Hume, D. A.; Borchers, C. H.; Wainwright, C. E.; Wainwright, B. J. Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. Clin. Chem. 2007, 53 (10), 1782-1791
101. Chen, C. I.; Schaller-Bals, S.; Paul, K. P.; Wahn, U.; Bals, R. Betadefensins and LL-37 in bronchoalveolar lavage fluid of patients with cystic fibrosis. J. Cystic Fibrosis 2004, 3 (1), 45-50.
102. Rottoli, P.; Magi, B.; Cianti, R.; Bargagli, E.; Vagaggini, C.; Nikiforakis, N.; Pallini, V.; Bini, L. Carbonylated proteins in bronchoalveolar lavage of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis and idiopathic pulmonary fibrosis. Proteomics 2005, 5 (10), 2612-2618 (Pubitemid 40966488)