Protein expression patterns associated with progression of chronic obstructive pulmonary disease in bronchoalveolar lavage of smokers

Clinical Chemistry

Volumn 53, Issue 4, 2007, Pages 636-644

  Plymoth, Amelie ^a   Löfdahl, Claes Göran ^a   Ekberg Jansson, Ann ^b   Dahlbäck, Magnus ^c   Broberg, Per ^c   Foster, Martyn ^d   Fehniger, Thomas E ^c   Marko Varga, György ^c  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRONCHUS BIOPSY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FOLLOW UP; HUMAN; HUMAN TISSUE; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; PROTEOMICS; SMOKING; TWO DIMENSIONAL GEL ELECTROPHORESIS;

BRONCHOALVEOLAR LAVAGE FLUID; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FOLLOW-UP STUDIES; HUMANS; MALE; MASS SPECTROMETRY; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROTEOME; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING;

EID: 34147200716     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2006.076075     Document Type: Article

References (18)

1. Services USDoHaH. The Health Consequences of Smoking: A Report of the Surgeon General. Vol. Atlanta, Georgia: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2004b.
2. Churg A, Wright JL. Proteases and emphysema. Curr Opin Pulm Med 2005;11:153-9.
3. Wattiez R, Falmagne P. Proteomics of bronchoalveolar lavage fluid. J Chromatogr B Analyt Technol Biomed Life Sci 2005;815:169-78.
4. Lindahl M, Ekstrom T, Sorensen J, Tagesson C. Two dimensional protein patterns of bronchoalveolar lavage fluid from non-smokers, smokers, and subjects exposed to asbestos. Thorax 1996;51:1028-35.
5. Marko-Varga G, Lindberg H, Lofdahl CG, Jonsson P, Hansson L, Dahlback M, et al. Discovery of biomarker candidates within disease by protein profiling: principles and concepts. J Proteome Res 2005;4:1200-12.
6. Plymoth A, Yang Z, Lofdahl CG, Ekberg-Jansson A, Dahlback M, Fehniger TE, et al. Rapid proteome analysis of bronchoalveolar lavage samples of lifelong smokers and never-smokers by microscale liquid chromatography and mass spectrometry. Clin Chem 2006;52:671-9.
7. Spira A, Beane J, Shah V, Liu G, Schembri F, Yang X, et al. Effects of cigarette smoke on the human airway epithelial cell transcriptome. Proc Natl Acad Sci U S A 2004;101:10143-8.
8. Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, et al. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A 2004;101:14895-900.
9. Rosengren A, Orth-Gomer K, Wedel H, Wilhelmsen L. Stressful life events, social support, and mortality in men born in 1933. [see comment]. BMJ 1993;307:1102-5.
10. Ekberg-Jansson A, Andersson B, Bake B, Boijsen M, Enander I, Rosengren A, et al. Neutrophil-associated activation markers in healthy smokers relates to a fall in DL(CO) and to emphysematous changes on high resolution CT. Respir Med 2001;95:363-73.
11. Vikgren J, Boijsen M, Andelid K, Ekberg-Jansson A, Larsson S, Bake B, et al. High-resolution computed tomography in healthy smokers and never-smokers: a 6-year follow-up study of men born in 1933. [erratum appears in Acta Radiol. 2004 May;45(3): following 663]. Acta Radiol 2004;45:44-52.
12. Global IfCOLD. www.goldcopd.com (Accessed September 2006).
13. Pauwels RA, Buist AS, Ma P, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: National Heart, Lung, and Blood Institute and World Health Organization Global Initiative for Chronic Obstructive Lung Disease (GOLD): executive summary. Respir Care 2001;46:798-825.
14. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
15. Amin K, Ekberg-Jansson A, Lofdahl CG, Venge P. Relationship between inflammatory cells and structural changes in the lungs of asymptomatic and never smokers: a biopsy study. Thorax 2003;58:135-42.
16. Plymoth A, Lofdahl CG, Ekberg-Jansson A, Dahlback M, Lindberg H, Fehniger TE, et al. Human bronchoalveoiar lavage: biofluid analysis with special emphasis on sample preparation. Proteomics 2003;3:962-72.
17. Malmstrom J, Larsen K, Hansson L, Lofdahl CG, Norregard-Jensen O, Marko-Varga G, et al. Proteoglycan and proteome profiling of central human pulmonary fibrotic tissue utilizing miniaturized sample preparation: a feasibility study. Proteomics 2002;2:394-404.
18. Eriksson J, Chait BT, Fenyo D. A statistical basis for testing the significance of mass spectrometric protein identification results. Anal Chem 2000;72:999-1005.