Lower numbers of FoxP3 and CCR4 co-expressing cells in an elevated subpopulation of CD4+CD25high regulatory T cells from Wegener's granulomatosis

Clinical and Experimental Rheumatology

Volumn 28, Issue 1 SUPPL. 57, 2010, Pages

  Klapa, Sebastian ^a,b   Mueller, Antje ^a,b   Csernok, Elena ^a,b   Fagin, Ursula ^a,b   Klenerman, Paul ^c   Holl Ulrich, Konstanze ^a   Gross, Wolfgang L ^a,b   Lamprecht, Peter ^a,b  

^a UNIVERSITY OF LÜBECK   (Germany)

^b Clinical Centre Bad Bramstedt   (Germany)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Regulatory Treg cells; Wegener's granulomatosis

Indexed keywords

ALPHA INTERFERON; AZATHIOPRINE; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR4; CYCLOPHOSPHAMIDE; INTERFERON RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; LEFLUNOMIDE; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; MYELOBLASTIN; PREDNISOLONE; TRANSCRIPTION FACTOR FOXP3; INTERFERON RECEPTOR I; UNCLASSIFIED DRUG; CCR4 PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL2RA PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; WEGENER GRANULOMATOSIS; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MIDDLE AGED; NASAL BIOPSY; NOSE MUCOSA; SINUSITIS; VERY ELDERLY; CELL DIVISION; CYTOLOGY; IMMUNOLOGY; METABOLISM;

ADULT; AGED; ANTIGENS, CD4; CELL DIVISION; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; RECEPTORS, CCR4; RECEPTORS, INTERFERON; T-LYMPHOCYTES, REGULATORY; WEGENER GRANULOMATOSIS; YOUNG ADULT;

EID: 77954579189     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. SAKAGUCHI S, YAMAGUCHI T, NOMURA T, ONO M: Regulatory T cells and immune tolerance. Cell 2008; 133: 775-87.
2. + T regulatory cell-mediated suppression. Immunity 2009; 30: 636-45.
3. CORTHAY A: How do regulatory T cells work? Scand J Immunol 2009; 70: 326-36.
4. + T cells. Eur J Immunol 2007; 37: 129-38.
5. high regulatory cells in human peripheral blood. J Immunol 2001; 167: 1245-53.
6. + regulatory T cells. Nat Immunol 2003; 4: 330-6.
7. TANG Q, BLUESTONE JA: The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol 2008; 3: 239-44.
8. EHRENSTEIN MR, EVANS JG, SINGH A et al.: Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF-α therapy. J Exp Med 2004; 200: 277-85.
9. high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol 2005; 35: 3343-52.
10. MIYARA M, AMOURA Z, PARIZOT C et al.: Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005; 175: 8392-400.
11. high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007; 178: 2579-88.
12. high T cells in patients with new-onset systemic lupus erythematodes. Clin Exp Immunol 2008; 153: 182-7.
13. + regulatory T cells in systemic lupus erythematosus. Rheumatology 2008; 47: 789-94.
14. + regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-α-producing antigen-presenting cells. Arthritis Rheum 2008; 58: 801-12.
15. MIYARA M, AMOURA Z, PARIZOT C et al.: The immune paradox of sarcoidosis and regulatory T cells. J Exp Med 2006; 203: 359-70.
16. + regulatory T cells suppress early stages of granuloma formation but have little impact on sarcoidosis lesions. Am J Pathol 2009; 174: 497-508.
17. CHEN M, KALLENBERG CG: New advances in the pathogenesis of ANCA-associated vasculitides. Clin Exp Rheumatol 2009; 27 (Suppl. 52): S108-14.
18. REINHOLD-KELLER E, BEUGE N. LATZA U et al.: An interdisciplinary approach to the care of patients with Wegener's Granulomatosis: long-term outcame in 155 patients. Arthritis Rheum 2000; 43: 1021-32.
19. SCHMITT WH, HEESEN C, CSERNOK E, RAUTMANN A, GROSS WL: Elevated serum levels of soluble interleukin-2 receptor in patients with Wegener's granulomatosis. Association with disease activity. Arthritis Rheum 1992; 35: 1088-96.
20. + T cell subsets in Wegener's granulomatosis. Rheumatol Int 1995; 14: 213-9.
21. POPA ER, STEGEMAN CA. BOS NA, KALLENBERG CG, TERVAERT JW: Differential B- and T-cell activation in Wegener's granulomatosis. J Allergy Clin Immunol 1999; 103: 885-94.
22. + T cell subpopulations in ANCA-associated vasculitis. Clin Exp Immunol 2005; 140: 181-91.
23. + regulatory T cells. J Exp Med 2001; 194: 847-53.
24. + T cells in patients with Wegener's granulomatosis in remission. Arthritis Rheum 2007; 56: 2080-91.
25. MORGAN MD, DAY CJ, PIPER KP et al.: Patients with Wegener's granulomatosis demonstrate a relative deficiency and functional impairment of T-regulatory cells. Immunology 2010 epub.
26. LANG KS, RECHER M, JUNT T et al.: Toll-like receptor engagement converts T-cell autore-activity into overt autoimmune disease. Nat Med 2005; 11: 138-45.
27. RÖNNBLOM L, ELORANTA ML, ALM GV: The type I interferon system in systemic lupus erythematosus. Arthritis Rheum 2006; 54: 408-20.
28. BURCHERT A, WÖLFL S, SCHMIDT M et al.: Interferon-α, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia. Blood 2003; 101: 259-64.
29. LEAVITT RY, FAUCI AS, BLOCH DA et al.: The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. Arthritis Rheum 1990; 33: 1101-07.
30. JENNETTE JC, FALK RJ, ANDRASSY K et al.: Nomenclature of systemic vasculitides: The proposal of an International Consensus Conference. Arthritis Rheum 1994; 37: 187-92.
31. HELLMICH B, FLOSSMANN O, GROSS WL et al.: EULAR recommendations for conducting clinical studies and/or clinical trials in systemic vasculitis: focus on anti-neutrophil cytoplasm antibody-associated vasculitis. Ann Rheum Dis 2007; 66: 605-17.
32. + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 2005; 105: 2862-68.
33. hiFoxp3 regulatory T cells are derived by rapid turnover of memory populations in vivo. JCI 2006; 116: 2423-33.
34. OBERG HH, WESCH D. LENKE J, KABELITZ D: An optimized method for the functional analysis of human regulatory T cells. Scand J Immunol Methods 2006; 64: 353-60.
35. + regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses. J Immunol Methods 2007; 322: 1-11.
36. + T regulatory cells. J Immunol 2007; 179: 154-61.
37. BOLLINGER T, BOLLINGER A, SKRUM L, DIMITROV S, LANGET, SOLBACH W: Sleep-dependent activity of T cells and regulatory T cells. Clin Exp Immunol 2008; 155: 231-8.
38. MOOSIG F, CSERNOK E, WANG G, GROSS WL: Costimulatory molecules in Wegener's granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells. Clin Exp Immunol 1998; 114: 113-8.
39. + effector memory T cells in Wegener's granulomatosis. Kidney Int 2006; 70: 938-47.
40. + T cells in patients with systemic lupus erythematosus. J Immunol 2009; 182: 1689-95.
41. + effector memory T-cells and expression of NKG2D-ligand MIC in granulomatous lesions in Wegener's granulomatosis. Clin Immunol 2008; 127: 144-50.
42. + T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener's granulomatosis. Nephrol Dial Transplant 2009; 24: 161-71.
43. BERDEN AE, KALLENBERG CGM, SAVAGE CO et al.: Cellular Immunity in Wegener's granulomatosis. Characterizing T lymphocytes. Arthritis Rheum 2009; 60: 1578-87.
44. + regulatory T cells. J Immunol 2008; 180: 122-9.
45. + regulatory T cells bear functional skin homing receptors. J Immunol 2006; 177: 4488-94.
46. GRAU GE. ROUX-LOMBARD P, GYSLER C et al.: Serum cytokine changes in systemic vasculitis. Immunology 1989; 68: 196-8.
47. hi T-regulatory cells. Blood 2006; 108: 253-61.
48. KORN T, REDDY J, GAO W et al.: Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med 2007; 13: 423-31.
49. + regulatory cells in inflamed synovia. J Exp Med 2005; 201: 1793-803.
50. DE GROOT K, GROSS WL, HERLYN K, REINHOLD-KELLER E: Development and validation of a disease extent index for Wegener's granulomatosis. Clin Nephrol 2001; 55: 31-8.