Abnormalities of CD4+ T cell subpopulations in ANCA-associated vasculitis

Clinical and Experimental Immunology

Volumn 140, Issue 1, 2005, Pages 181-191

  Marinaki, S ^a   Neumann, I ^a   Kalsch A I ^a   Grimminger, P ^a   Breedijk, A ^a   Birck, R ^a   Schmitt, W ^a   Waldherr, R ^a   Yard, Benito A ^a   Van Der Woude, F J ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

ANCA; CD4 subsets; Pathogenesis; T cells; Vasculitis

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; IONOMYCIN; MESSENGER RNA; NEUTROPHIL CYTOPLASMIC ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANCA ASSOCIATED VASCULITIS; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; KIDNEY TRANSPLANTATION; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; MALE; MEMORY CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIGENS, CD45; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DNA-BINDING PROTEINS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOPHENOTYPING; INTERFERON TYPE II; INTERLEUKINS; KIDNEY; KIDNEY TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-2; RNA, MESSENGER; VASCULITIS;

EID: 20144388308     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02731.x     Document Type: Article

References (34)

1. Hagen EC, Daha MR, Hermans J et al. Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. EC/BCR project for ANCA assay standardization. Kidney Int 1998; 53:743-53.
2. Xiao H, Heeringa P, Hu P et al. Antineutrophil cytoplasmic antibodies specific for myeloperoxidase cause glomerulonepritis and vasculitis in mice. J Clin Invest 2002; 110:955-65.
3. + T cells. J Exp Med 1993; 178:237-44.
4. Jonuleit H, Schmitt E, Kakirman H, Stassen M Knop J, Enk EH. Infectious tolerance: CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med 2002; 196:255-60.
5. Asano M, Toda M, Sakaguchi N, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell population. J Exp Med 1996; 184:387-96.
6. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155:1151-64.
7. Kojima A, Tanka-Kojima Y, Sakakura T, Nishizuka Y. Spontaneous development of autoimmune thyreoiditis in neonatally thymectomized mice. Lab Invest 1976; 34:550-7.
8. Sakaguchi S, Fukuma K, Kuribayashi K, Masuda T. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence of for the active participation of T cells in natural self-tolerance: deficit of a T cell subset as a possible cause of autoimmune disease. J Exp Med 1985; 161:72-87.
9. Cunningham MA, Huang XR, Dowling JP, Tipping PG, Holdsworth SR. Prominence of cell-mediated immunity effectors in 'pauci-immune' glomerulonephritis. J Am Soc Nephrol 1999; 10:499-506.
10. Csernok E, Trabandt A, Müller A et al. Cytokine profiles in Wegener's granulomatosis: predominance of type 1 (Th1) in the granulomatous inflammation. Arthritis Rheum 1919; 42:742-50.
11. Schmitt WH, Heesen C, Csernok E, Rautmann A, Gross WL. Elevated serum levels of soluble interleukin-2 receptor in patients with Wegener's granulomatosis. Association with disease activity. Arthritis Rheum 1992; 35:1088-96.
12. Wang G, Hansen H, Tatsis E, Csernok E, Lemke H, Gross WL. High plasma levels of the soluble form of CD30 activation molecule reflect disease activity in patients with Wegener's granulomatosis. Am J Med 1997; 102:517-23.
13. Popa ER, Stegeman CA, Nicolaas AB, Kallenbeig CGM, Cohen Tervaert JW. Differential B- and T cell activation in Wegener's granulomatosis. J Allergy Clin Immunol 1999; 103:885-94.
14. Giscombe R, Nityanand S, Lewin N, Grunevald J, Lefvert AK. Expanded T cell populations in patients with Wegener's granulomatosis: characteristics and correlation with diseases activity. J Clin Immunol 1998; 18:404-13.
15. Steiner K, Moosing F, Csernok E et al. Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis. Clin Exp Immunol 2001; 126:143-50.
16. Moosig F, Csernok E, Wang G, Gross WL. Co stimulatory molecules in Wegener's granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells. Clin Exp Immunol 1998; 114:113-18.
17. Iking-Konert C, Vogt S, Radsak M, Wagner C, Hansch GM, Andrassy K. Polymorphonuclear neutrophils in Wegener's granulomatosis acquire characteristics of antigen presenting cells. Kidney Int 2001; 60:2247-62.
18. Lockwood CM, Thiru S, Isaacs JD, Hale G, Waldmann H. Longterm remission of intractable systemic vasculitis with monoclonal antibody therapy. Lancet 1993; 341:1620-2.
19. Schmitt WH, Hagen EC, Neumann I, Nowack R, Flores-Suarez LF, van der Woude FJ for the European Vasculitis Study Group. Treatment of refractory Wegener's granulomatosis with antithymocyte globulin (ATG): an open study in 15 patients. Kid Int 2004; 65:1440-8.
20. Jennette JC, Falk RJ, Andrassy K et al. Nomenclature of systemic vasculitis: proposal of an international consensus conference. Arthritis Rheum 1994; 37:187-92.
21. Luqmani R, Bacon PA, Moots RJ et al. Birmingham vasculitis activity score (BVAS) in systemic necrotizing vasculitis. Q J Med 1994; 87:671-8.
22. Birck R, Warnak K, Lorenz HM et al. 15-Deoxyspergualin in patients with refractory ANCA associated systemic vasculitis: a six month open-label trial to evaluate safety and efficacy. J Am Soc Nephrol 2003; 14:440-7.
23. + T cell subsets in Wegener's granulomatosis. Rheumatol Int 1995; 14:213-19.
24. Christensson M, Pettersson E, Sundqist KG, Christensson B. T cell activation in patients with ANCA-associated vasculitis: inefficient immune suppression by therapy. Clin Nephrol 2000; 54:435-42.
25. Bijl M, Horst G, Limburg PC, Kallenberg CGM. Expression of costimulatory molecules on peripheral blood lymphocytes of patients with systemic lupus erythematodes. Ann Rheum Dis 2001; 60:523-6.
26. King WJ, Brooks CJ, Holder R, Hughes P, Adu D, Savage CO. T-lymphocyte responses to anti-neutrophil cytoplasmic autoantibody (ANCA) antigens are present in patients with ANCA associated vasculitis and persist during disease remission. Clin Exp Immunol 1998; 112:539-46.
27. Popa ER, Franssen CF, Limburg PC, Huitema MG, Kallenberg CG, Tervaert JW. In vitro cytokine production and proliferation of T cells from patients with anti-proteinase 3- and antimyeloperoxidase associated vasculitis, in response to proteinase 3 and myeloperoxidase. Arthritis Rheum 2002; 46:1894-904.
28. Van der Geld YM, Huitema MG, Franssen CF, van der Zee R, Limburg PC, Kallenberg CG. In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG). Clin Exp Immunol 2000; 122:504-13.
29. + T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: reversal with IL-10. J Immunol 1998; 160:3602-9.
30. + T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol 2003; 33:215-23.
31. + T cells induce or protect from chronic intestinal inflammation in C.B-17 scid mice. Int Immunol 1993; 5:1461-71.
32. + T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 1994; 179:589-600.
33. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol 2001; 166:3008-18.
34. King C, Ilic A, Koelsch K, Sarvetnick N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 2004; 117:265-77.