Association of immunosuppressant-induced protein changes in the rat kidney with changes in urine metabolite patterns: A proteo-metabonomic study

Journal of Proteome Research

Volumn 9, Issue 2, 2010, Pages 865-875

  Klawitter, Jost ^a,b,c   Klawitter, Jelena ^a,c   Kushner, Erich ^a   Jonscher, Karen ^a   Bendrick Peart, Jamie ^b   Leibfritz, Dieter ^c   Christians, Uwe ^a   Schmitz, Volker ^a,d  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Eurofins Medinet Inc   (Germany)

^c UNIVERSITY OF BREMEN   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Calbindin; Cyclosporine; Immunosuppressants; Kidney dysfunction markers; Metabolomics; Nephrotoxicity; Proteomics; Regucalcin; Sirolimus; Tacrolimus

Indexed keywords

AMINOACYLASE; ARGININE; CALBINDIN; CALCINEURIN INHIBITOR; CALDESMON; CREATININE; CYCLOSPORIN A; CYTOSKELETON PROTEIN; FRUCTOSE BISPHOSPHATASE; GLYCINE AMIDINOTRANSFERASE; HIPPURIC ACID; IMMUNOSUPPRESSIVE AGENT; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEASOME; PROTEOME; PYRUVATE DEHYDROGENASE; RAPAMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REGUCALCIN; TACROLIMUS; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM HOMEOSTASIS; CELL FUNCTION; CELL METABOLISM; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG INDUCED DISEASE; ENZYME INDUCTION; GLOMERULUS FILTRATION RATE; GLUCOSE METABOLISM; HYPOXIA; KIDNEY CONCENTRATING CAPACITY; MALE; METABOLITE; METABOLOMICS; MITOCHONDRION; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TWO DIMENSIONAL GEL ELECTROPHORESIS; URINALYSIS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GLOMERULAR FILTRATION RATE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; MALE; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEINURIA; PROTEOMICS; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY;

RATTUS; RATTUS NORVEGICUS;

EID: 76149139441     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr900761m     Document Type: Article

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