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Volumn 10, Issue 4, 2005, Pages 284-294

Biomarkers of immunosuppressive drug toxicity

Author keywords

Biochemical profiling; Calcineurin inhibitors; Chronic allograft dysfunction; Everolimus; Immunosuppressant toxicity; Metabolomics; Metabonomics; Mycophenolic acid; Pharmacogenetics; Proteomics; Sirolimus; Toxicogenomics

Indexed keywords

AZATHIOPRINE; BIOLOGICAL MARKER; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN; TACROLIMUS;

EID: 28044440038     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/01.mot.0000184018.31573.34     Document Type: Review
Times cited : (8)

References (91)
  • 1
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definition Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001; 69:89-95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 2
    • 19744374994 scopus 로고    scopus 로고
    • Combinatorial biomarkers: From early toxicology assays to patient population profiling
    • Koop R. Combinatorial biomarkers: from early toxicology assays to patient population profiling. Drug Discov Today 2005; 10:781-788. This concise status report discusses systems biology and its potential use and impact on drug development in the near future.
    • (2005) Drug Discov Today , vol.10 , pp. 781-788
    • Koop, R.1
  • 3
    • 3342964033 scopus 로고    scopus 로고
    • Biomarker discovery and validation: Technologies and integrative approaches
    • Ilyin SE, Belkowski SM, Plata-Salaman CR. Biomarker discovery and validation: technologies and integrative approaches. Trends Biotechnol 2004; 22:411-416. The authors discuss the advantages of integrating different 'omics' technologies as a strategy for high-throughput biomarker identification and validation during drug development.
    • (2004) Trends Biotechnol , vol.22 , pp. 411-416
    • Ilyin, S.E.1    Belkowski, S.M.2    Plata-Salaman, C.R.3
  • 4
    • 2542568705 scopus 로고    scopus 로고
    • The human plasma proteome: A nonredundant list developed by combination of four separate sources
    • Anderson NL, Polanski M, Pieper R, et al. The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 2004; 3:311-326. In this manuscript, a list of all proteins for which evidence in the human plasma exists is compiled and the potential for development of plasma proteome-based diagnostic tools is discussed.
    • (2004) Mol Cell Proteomics , vol.3 , pp. 311-326
    • Anderson, N.L.1    Polanski, M.2    Pieper, R.3
  • 5
    • 1442338509 scopus 로고    scopus 로고
    • Lack of improvement in allograft survival despite a marked decrease in acute rejection rates over the most recent era
    • Meier-Kriesche HU, Schold JD, Srinivas TR, Kaplan BD. Lack of improvement in allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant 2004; 4:378-383.
    • (2004) Am J Transplant , vol.4 , pp. 378-383
    • Meier-Kriesche, H.U.1    Schold, J.D.2    Srinivas, T.R.3    Kaplan, B.D.4
  • 6
    • 27744599092 scopus 로고    scopus 로고
    • American Society of Nephrology Renal Research Report
    • Berl T. American Society of Nephrology Renal Research Report. J Am Soc Nephrol 2005; 16:1886-1903. This position paper describes the status of kidney transplantation and emphasizes the importance and potential of biomarkers in the prevention of chronic allograft dysfunction as well as in other areas in the field of nephrology.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1886-1903
    • Berl, T.1
  • 7
    • 16444362802 scopus 로고    scopus 로고
    • Combating chronic renal allograft dysfunction. Optimal immunosuppressive regimens
    • Merville P. Combating chronic renal allograft dysfunction. Optimal immunosuppressive regimens. Drugs 2005; 65:615-631. The author summarizes the pathophysiology and pathology and discusses current therapeutic strategies to avoid or reduce chronic allograft dysfunction in kidney transplant patients.
    • (2005) Drugs , vol.65 , pp. 615-631
    • Merville, P.1
  • 8
    • 0037759067 scopus 로고    scopus 로고
    • Potential therapeutic interventions to avoid or treat chronic allograft dysfunction
    • Kahan BD. Potential therapeutic interventions to avoid or treat chronic allograft dysfunction. Transplantation 2001; 71:SS52-SS57.
    • (2001) Transplantation , vol.71
    • Kahan, B.D.1
  • 9
    • 0035876629 scopus 로고    scopus 로고
    • Exploring treatment options in renal transplantation: The problems of chronic allograft dysfunction and drug-related nephrotoxicity
    • Campistol JM, Grinyo JM. Exploring treatment options in renal transplantation: the problems of chronic allograft dysfunction and drug-related nephrotoxicity. Transplantation 2001;71(11 Suppl.):SS42-SS51.
    • (2001) Transplantation , vol.71 , Issue.11 SUPPL.
    • Campistol, J.M.1    Grinyo, J.M.2
  • 10
    • 18844368491 scopus 로고    scopus 로고
    • Chronic allograft nephropathy
    • Cornell LD, Colvin RB. Chronic allograft nephropathy. Curr Opin Nephrol Hypertens 2005; 14:229-234. This is a review of the mechanisms leading to chronic kidney allograft dysfunction.
    • (2005) Curr Opin Nephrol Hypertens , vol.14 , pp. 229-234
    • Cornell, L.D.1    Colvin, R.B.2
  • 12
    • 3042826806 scopus 로고    scopus 로고
    • Surrogate markers and risk factors for lung allograft dysfunction
    • Bowdish ME, Arcasoy SM, Wilt JS, et al. Surrogate markers and risk factors for lung allograft dysfunction. Am J Transplant 2004; 4:1171-1178.
    • (2004) Am J Transplant , vol.4 , pp. 1171-1178
    • Bowdish, M.E.1    Arcasoy, S.M.2    Wilt, J.S.3
  • 13
    • 1842581699 scopus 로고    scopus 로고
    • Arteriopathy in chronic allograft rejection in liver transplantation
    • Miyagawa-Hayashino A, Tsuruyama T, Haga H, et al. Arteriopathy in chronic allograft rejection in liver transplantation. Liver Transpl 2004; 10:513-519.
    • (2004) Liver Transpl , vol.10 , pp. 513-519
    • Miyagawa-Hayashino, A.1    Tsuruyama, T.2    Haga, H.3
  • 14
    • 4143127834 scopus 로고    scopus 로고
    • Calcineurin inhibitor nephrotoxicity: Longitudinal assessment by protocol histology
    • Nankivell BJ, Borrow RJ, Fung CLS, et al. Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology. Transplantation 2004; 78:557-565. A key clinical trial documents for the first time the role of cyclosporine in progressive kidney graft dysfunction based on histological analysis of protocol kidney biopsies collected regularly in 99 kidney graft patients over a period of 10 years.
    • (2004) Transplantation , vol.78 , pp. 557-565
    • Nankivell, B.J.1    Borrow, R.J.2    Fung, C.L.S.3
  • 15
    • 11144301278 scopus 로고    scopus 로고
    • The impact of immunosuppression on endothelial function
    • Trapp A, Weiss M. The impact of immunosuppression on endothelial function. J Cardiovasc Pharmacol 2005; 45:81-87. This study compares the effect of all immunosuppressants on endothelial function in an in-vitro model based on human microvascular endothelial cells.
    • (2005) J Cardiovasc Pharmacol , vol.45 , pp. 81-87
    • Trapp, A.1    Weiss, M.2
  • 16
    • 22344455242 scopus 로고    scopus 로고
    • Significance of subclinical rejection in early renal allograft biopsies for chronic allograft dysfunction
    • Miyagi M, Ishikawa Y, Mizuiri S, et al. Significance of subclinical rejection in early renal allograft biopsies for chronic allograft dysfunction. Clin Transplant 2005; 19:456-465. The authors found that early subclinical rejection correlated with subsequent allograft dysfunction and that high-dose steroids were effective to suppress subclinical rejection.
    • (2005) Clin Transplant , vol.19 , pp. 456-465
    • Miyagi, M.1    Ishikawa, Y.2    Mizuiri, S.3
  • 17
    • 21344469284 scopus 로고    scopus 로고
    • Workshop on late renal allograft dysfunction
    • Meyers CM, Kirk AD. Workshop on late renal allograft dysfunction. Am J Transplant 2005; 5:1600-1605. This report of an expert meeting discusses information on late allograft loss and strategies relevant to future clinical studies of allograft function.
    • (2005) Am J Transplant , vol.5 , pp. 1600-1605
    • Meyers, C.M.1    Kirk, A.D.2
  • 18
    • 17444425361 scopus 로고    scopus 로고
    • The relative importance of cytokine gene polymorphisms in the development of early and acute rejection and six-month renal allograft pathology
    • 1, interferon-γ, and interleukin-10 genotypes correlated with outcome.
    • (2005) Transplantation , vol.79 , pp. 836-841
    • Tinckham, K.1    Rush, D.2    Hutchinson, I.3
  • 19
    • 9244228985 scopus 로고    scopus 로고
    • Cytokine gene polymorphism and risks of acute rejection and delayed graft function after kidney transplantation
    • Alakulppi NS, Kyllönen LE, Jäntti VT, et al. Cytokine gene polymorphism and risks of acute rejection and delayed graft function after kidney transplantation. Transplantation 2004; 78:1422-1428.
    • (2004) Transplantation , vol.78 , pp. 1422-1428
    • Alakulppi, N.S.1    Kyllönen, L.E.2    Jäntti, V.T.3
  • 20
    • 12344316001 scopus 로고    scopus 로고
    • Cytokine gene polymorphisms and acute liver graft rejection: A meta-analysis
    • Warlé MC, Metselaar HJ, Hop WCJ, Tilanus HW. Cytokine gene polymorphisms and acute liver graft rejection: a meta-analysis. Liver Transpl 2005; 11:19-26. This recent meta-analysis suggests that IL-10 polymorphism plays a role in liver graft rejection.
    • (2005) Liver Transpl , vol.11 , pp. 19-26
    • Warlé, M.C.1    Metselaar, H.J.2    Hop, W.C.J.3    Tilanus, H.W.4
  • 21
    • 0035479925 scopus 로고    scopus 로고
    • Gene polymorphisms and transplantation
    • Akatin E, Murphy B. Gene polymorphisms and transplantation. Curr Opin Immunol 2001; 13:572-576.
    • (2001) Curr Opin Immunol , vol.13 , pp. 572-576
    • Akatin, E.1    Murphy, B.2
  • 22
    • 10344261473 scopus 로고    scopus 로고
    • Genetic polymorphisms predicting the outcome of bone marrow transplants
    • Dickinson AM, Middelton PG, Rocha V, et al. Genetic polymorphisms predicting the outcome of bone marrow transplants. Br J Haematol 2004; 127:479-490.
    • (2004) Br J Haematol , vol.127 , pp. 479-490
    • Dickinson, A.M.1    Middelton, P.G.2    Rocha, V.3
  • 23
    • 27644539046 scopus 로고    scopus 로고
    • Beyond the HLA typing age: Genetic polymorphisms predicting transplant outcome
    • in press
    • Dickinson AM, Middleton PG. Beyond the HLA typing age: genetic polymorphisms predicting transplant outcome. Blood Rev 2005. (in press) This review summarizes the latest research regarding single nucleotide polymorphisms of non-HLA encoded genes and the prediction of outcome hematopoietic stem cell transplantation.
    • (2005) Blood Rev
    • Dickinson, A.M.1    Middleton, P.G.2
  • 25
    • 0034902836 scopus 로고    scopus 로고
    • Chronic graft dysfunction: Donor factors
    • Barbari A, Stephan A, Masri MA, et al. Chronic graft dysfunction: donor factors. Transplant Proc 2001; 33:2695-2698.
    • (2001) Transplant Proc , vol.33 , pp. 2695-2698
    • Barbari, A.1    Stephan, A.2    Masri, M.A.3
  • 26
    • 4644344876 scopus 로고    scopus 로고
    • Donor genomics influences graft events: The effect of donor polymorphisms on acute rejection and chronic allograft nephropathy
    • Hoffmann S, Park J, Jacobson LM, et al. Donor genomics influences graft events: The effect of donor polymorphisms on acute rejection and chronic allograft nephropathy. Kidney Int 2004; 66:1686-1693. Polymorphisms from 244 renal allograft donors were analyzed and correlated with graft events such as chronic allograft nephropathy.
    • (2004) Kidney Int , vol.66 , pp. 1686-1693
    • Hoffmann, S.1    Park, J.2    Jacobson, L.M.3
  • 27
    • 0036664288 scopus 로고    scopus 로고
    • Ethnicity greatly influences gene polymorphism distribution
    • Hoffmann SC, Stanley EM, Cox ED, et al. Ethnicity greatly influences gene polymorphism distribution. Am J Transplant 2002; 2:560-567.
    • (2002) Am J Transplant , vol.2 , pp. 560-567
    • Hoffmann, S.C.1    Stanley, E.M.2    Cox, E.D.3
  • 28
    • 21644434696 scopus 로고    scopus 로고
    • Differentiation between chronic rejection and chronic cyclosporine toxicity by analysis of renal cortical mRNA
    • 2 and transforming growth factor-β (TGF-β) mRNA expression in the renal cortex, that allow for distinguishing between chronic rejection and chronic cyclosporine toxicity with high specificity and sensitivity.
    • (2004) Kidney Int , vol.66 , pp. 2038-2046
    • Koop, K.1    Bakker, R.C.2    Eikmans, M.3
  • 29
    • 4143049173 scopus 로고    scopus 로고
    • Pharmacogenetics in solid organ transplantation: Present knowledge and future perspectives
    • Anglicheau D, Legendre C, Thervet E. Pharmacogenetics in solid organ transplantation: present knowledge and future perspectives. Transplantation 2004; 78:311-315. This article gives an overview over the pharmacogenetic basis of inter-individual variability of
    • (2004) Transplantation , vol.78 , pp. 311-315
    • Anglicheau, D.1    Legendre, C.2    Thervet, E.3
  • 30
    • 28044457103 scopus 로고    scopus 로고
    • Functional interactions between p-glycoprotein and CYP3A in drug metabolism
    • in press
    • Christians U, Schmitz V, Haschke M. Functional interactions between p-glycoprotein and CYP3A in drug metabolism. Exp Opin Drug Metab Toxicol 2005. (in press) This review article summarizes the status of transporter/drug metabolizing enzyme interactions.
    • (2005) Exp Opin Drug Metab Toxicol
    • Christians, U.1    Schmitz, V.2    Haschke, M.3
  • 31
    • 21444438304 scopus 로고    scopus 로고
    • The pharmacogenetics of calcineurin inhibitors: One step closer toward individualized immunosuppression?
    • Hesselink DA, van Gelder T, van Schaik RH. The pharmacogenetics of calcineurin inhibitors: one step closer toward individualized immunosuppression? Pharmacogenetics 2005; 6:323-337. The authors review the potential of identifying single nucleotide polymorphisms in transplant patients for avoiding under-immunosuppression or toxicity.
    • (2005) Pharmacogenetics , vol.6 , pp. 323-337
    • Hesselink, D.A.1    Van Gelder, T.2    Van Schaik, R.H.3
  • 32
    • 3342906725 scopus 로고    scopus 로고
    • Pharmacogenetics in immunosuppressive therapy: The best thing since TDM?
    • van Gelder T, Hesselink DA, van Hest RM, et al. Pharmacogenetics in immunosuppressive therapy: the best thing since TDM? Ther Drug Monit 2004; 26:343-346.
    • (2004) Ther Drug Monit , vol.26 , pp. 343-346
    • Van Gelder, T.1    Hesselink, D.A.2    Van Hest, R.M.3
  • 33
    • 0032532599 scopus 로고    scopus 로고
    • The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukaemia
    • Coulthard S, Howell C, Robson J, Hall A. The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukaemia. Blood 1998; 92:2856-2862.
    • (1998) Blood , vol.92 , pp. 2856-2862
    • Coulthard, S.1    Howell, C.2    Robson, J.3    Hall, A.4
  • 34
    • 0036790212 scopus 로고    scopus 로고
    • Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease
    • Yan L, Zhang S, Eiff B, et al. Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease. Aliment Pharmacol Ther 2002; 16:1743-1750.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1743-1750
    • Yan, L.1    Zhang, S.2    Eiff, B.3
  • 35
    • 0141564760 scopus 로고    scopus 로고
    • In vitro characterization of four novel non-functional variants of the thiopurine S-methyltransferase gene
    • Hamdan-Khalil R, Allorge D, Lo-Guidie J, et al. In vitro characterization of four novel non-functional variants of the thiopurine S-methyltransferase gene. Biochem Biophys Res Commun 2003; 309:1005-1010.
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 1005-1010
    • Hamdan-Khalil, R.1    Allorge, D.2    Lo-Guidie, J.3
  • 36
    • 22144482338 scopus 로고    scopus 로고
    • Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation
    • Breen DP, Marinaki AM, Arenas M, Hayes PC. Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation. Liver Transpl 2005; 11:826-833. This study underlines the importance of taking donor and recipient pharmacogenetics into account. The genotype for thiopurine S-methyltransferase of liver transplant patients was not correlated with myelosuppression. Azathioprine is mainly metabolized in the liver.
    • (2005) Liver Transpl , vol.11 , pp. 826-833
    • Breen, D.P.1    Marinaki, A.M.2    Arenas, M.3    Hayes, P.C.4
  • 37
    • 0041831261 scopus 로고    scopus 로고
    • Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus
    • Hesselink DA, Van Schaik RHN, Van Der Heiden IP, et al. Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus. Clin Pharmacol Ther 2003; 74:245-254.
    • (2003) Clin Pharmacol Ther , vol.74 , pp. 245-254
    • Hesselink, D.A.1    Van Schaik, R.H.N.2    Van Der Heiden, I.P.3
  • 38
    • 10044294681 scopus 로고    scopus 로고
    • Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphism in the MDR-1, CYP3A4 and CYP3A5 genes
    • Hesselink DA, Van Gelder T, Van Schaik RHN, et al. Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphism in the MDR-1, CYP3A4 and CYP3A5 genes. Clin Pharmacol Ther 2004; 76:545-556.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 545-556
    • Hesselink, D.A.1    Van Gelder, T.2    Van Schaik, R.H.N.3
  • 39
    • 12144286933 scopus 로고    scopus 로고
    • The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients
    • Haufroid V, Mourad M, Van Kerckhove V, et al. The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients. Pharmacogenetics 2004; 14:147-154.
    • (2004) Pharmacogenetics , vol.14 , pp. 147-154
    • Haufroid, V.1    Mourad, M.2    Van Kerckhove, V.3
  • 40
    • 11144358432 scopus 로고    scopus 로고
    • CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation
    • Anglicheau D, Thervet E, Etienne I, et al. CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation. Clin Pharmacol Ther 2004; 75:422-433.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 422-433
    • Anglicheau, D.1    Thervet, E.2    Etienne, I.3
  • 41
    • 3142734959 scopus 로고    scopus 로고
    • MDR-1 C3435T polymorphism influences cyolosporine A dose requirement in liver transplant recipients
    • Bonhomme-Faivre L, Devocelle A, Saliba F, et al. MDR-1 C3435T polymorphism influences cyolosporine A dose requirement in liver transplant recipients. Transplantation 2004; 78:21-25.
    • (2004) Transplantation , vol.78 , pp. 21-25
    • Bonhomme-Faivre, L.1    Devocelle, A.2    Saliba, F.3
  • 42
    • 0037330517 scopus 로고    scopus 로고
    • Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporine disposition in heart transplant recipients
    • Chowbay B, Cumaraswamy S, Cheung YB, et al. Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporine disposition in heart transplant recipients. Pharmacogenetics 2003; 13:89-95.
    • (2003) Pharmacogenetics , vol.13 , pp. 89-95
    • Chowbay, B.1    Cumaraswamy, S.2    Cheung, Y.B.3
  • 43
    • 14644393732 scopus 로고    scopus 로고
    • Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy
    • Anglicheau D, Le Corre D, Lechaton S, et al. Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy. Am J Transplant 2005; 5:595-603.
    • (2005) Am J Transplant , vol.5 , pp. 595-603
    • Anglicheau, D.1    Le Corre, D.2    Lechaton, S.3
  • 44
    • 0242332169 scopus 로고    scopus 로고
    • Impact of cytochrome p450 3A5 polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients
    • Thervet E, Anglicheau D, King B, et al. Impact of cytochrome p450 3A5 polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients. Transplantation 2003; 76:1233-1235.
    • (2003) Transplantation , vol.76 , pp. 1233-1235
    • Thervet, E.1    Anglicheau, D.2    King, B.3
  • 45
    • 0038304548 scopus 로고    scopus 로고
    • Association of the multidrug resistance-1 gene single-nucleotide polymorphism with the tacrolimus dose requirements in renal transplant recipients
    • Anglicheau D, Verstuyft C, Laurent-Puig P, et al. Association of the multidrug resistance-1 gene single-nucleotide polymorphism with the tacrolimus dose requirements in renal transplant recipients. J Am Soc Nephrol 2003; 14:1889-1896.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1889-1896
    • Anglicheau, D.1    Verstuyft, C.2    Laurent-Puig, P.3
  • 46
    • 14044278166 scopus 로고    scopus 로고
    • Tacrolimus pharmacogenetics: The CYP3A5*1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians
    • Macphee IA, Fredericks S, Mohamed M, et al. Tacrolimus pharmacogenetics: the CYP3A5*1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians. Transplantation 2005; 79:499-502.
    • (2005) Transplantation , vol.79 , pp. 499-502
    • Macphee, I.A.1    Fredericks, S.2    Mohamed, M.3
  • 47
    • 20344375240 scopus 로고    scopus 로고
    • Impact of CYP3A5 and MDR1 (ABCB1) C3435T polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients
    • Tada H, Tsuchiya N, Satoh S, et al. Impact of CYP3A5 and MDR1 (ABCB1) C3435T polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients. Transplant Proc 2005; 37:1730-1732.
    • (2005) Transplant Proc , vol.37 , pp. 1730-1732
    • Tada, H.1    Tsuchiya, N.2    Satoh, S.3
  • 48
    • 3242779991 scopus 로고    scopus 로고
    • CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation
    • Goto M, Masuda S, Kiuchi T, et al. CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation. Pharmacogenetics 2004; 14:471-478. This study shows that for the pharmacokinetics of tacrolimus in liver transplant patients the genotype of the donor and not of the recipient is of greater importance. Thus, liver transplant patients with different donor CYP3A4, CYP3A5, and ABCB1 genotypes may be an interesting model to understand the importance of the roles of CYP3A and P-glycoprotein and their functional interactions.
    • (2004) Pharmacogenetics , vol.14 , pp. 471-478
    • Goto, M.1    Masuda, S.2    Kiuchi, T.3
  • 49
    • 16844380388 scopus 로고    scopus 로고
    • Sequential analysis of tacrolimus dosing in adult lung transplant patients in adult lung transplant patients with ABCB1 haplotypes
    • Zheng HX, Schuetz E, Zeevi A, et al. Sequential analysis of tacrolimus dosing in adult lung transplant patients in adult lung transplant patients with ABCB1 haplotypes. J Clin Pharmacol 2005; 45:404-410. This study analyses ABCB1 geno- and haplotypes and the results suggest that haplotype analysis may be clinically relevant and may explain some of the controversial results in the literature.
    • (2005) J Clin Pharmacol , vol.45 , pp. 404-410
    • Zheng, H.X.1    Schuetz, E.2    Zeevi, A.3
  • 51
    • 12644272784 scopus 로고    scopus 로고
    • Role of intestinal p-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine
    • Lown KS, Mayo RR, Leichtman AB, et al. Role of intestinal p-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther 1997; 62:248-260.
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 248-260
    • Lown, K.S.1    Mayo, R.R.2    Leichtman, A.B.3
  • 52
    • 0345144025 scopus 로고    scopus 로고
    • Quantification of immunosuppression by flow cytometry in stable renal transplant recipients
    • Stalder M, Brisan M, Holm B, et al. Quantification of immunosuppression by flow cytometry in stable renal transplant recipients. Ther Drug Monit 2003; 25:22-27.
    • (2003) Ther Drug Monit , vol.25 , pp. 22-27
    • Stalder, M.1    Brisan, M.2    Holm, B.3
  • 53
    • 2942659561 scopus 로고    scopus 로고
    • P-glycoprotein activity is increased in CD4+ but not CD8+ lung allograft-infiltrating T cells during acute cellular rejection
    • Donnenberg VS, Burckhart GJ, Zeevi A. P-glycoprotein activity is increased in CD4+ but not CD8+ lung allograft-infiltrating T cells during acute cellular rejection. Transplantation 2004; 77:1699-1706.
    • (2004) Transplantation , vol.77 , pp. 1699-1706
    • Donnenberg, V.S.1    Burckhart, G.J.2    Zeevi, A.3
  • 54
    • 0037353758 scopus 로고    scopus 로고
    • Quantitative determination of MDR mRNA expression in peripheral blood lymphocytes: A possible role of genetic polymorphisms in the MDR1 gene
    • Oselin K, Nowakowski-Gashaw I, Mronzikiewicz PM, et al. Quantitative determination of MDR mRNA expression in peripheral blood lymphocytes: a possible role of genetic polymorphisms in the MDR1 gene. Eur J Clin Invest 2003; 33:261-267.
    • (2003) Eur J Clin Invest , vol.33 , pp. 261-267
    • Oselin, K.1    Nowakowski-Gashaw, I.2    Mronzikiewicz, P.M.3
  • 55
    • 21444449731 scopus 로고    scopus 로고
    • ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation
    • e-publication ahead of print
    • Hauser IA, Schaeffeler E, Gauer S, et al. ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation. J Am Soc Nephrol 2005; 16: e-publication ahead of print. This clinical study showed for the first time that the ABCB1 genotype of the donor determines the susceptibility of the kidney to immunosuppressant toxicity probably by decreasing calcineurin inhibitor distribution into donor kidneys with high P-glycorpotein expression.
    • (2005) J Am Soc Nephrol , vol.16
    • Hauser, I.A.1    Schaeffeler, E.2    Gauer, S.3
  • 56
    • 0037183584 scopus 로고    scopus 로고
    • Neurotoxicity induced by tacrolimus after liver transplantation: Relation to genetic polymorphisms of the ABCB1 (MDR1) gene
    • Yamauchi A, Ieiri I, Kataoka Y, et al. Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene. Transplantation 2002; 571-578.
    • (2002) Transplantation , pp. 571-578
    • Yamauchi, A.1    Ieiri, I.2    Kataoka, Y.3
  • 57
    • 0028825399 scopus 로고
    • Absence of the mdr1a p-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
    • Schinkel AH, Wagenaar E, van Deemter L, et al. Absence of the mdr1a p-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest 1995; 96:1698-1705.
    • (1995) J Clin Invest , vol.96 , pp. 1698-1705
    • Schinkel, A.H.1    Wagenaar, E.2    Van Deemter, L.3
  • 58
    • 4344583771 scopus 로고    scopus 로고
    • Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes
    • Flechner SM, Kurian SM, Head SR, et al. Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant 2004; 4:1475-1489. This is the first true genomic approach to monitoring transplant patients and has great potential to evolve into a clinical managing tool.
    • (2004) Am J Transplant , vol.4 , pp. 1475-1489
    • Flechner, S.M.1    Kurian, S.M.2    Head, S.R.3
  • 59
    • 21244460388 scopus 로고    scopus 로고
    • Proteomics: The next revolution in laboratory medicine
    • Plebani M. Proteomics: The next revolution in laboratory medicine. Clin Chim Acta 2005; 357:113-122. The author discusses recent developments in proteomics that could lead to a new era of diagnostics test in clinical laboratories.
    • (2005) Clin Chim Acta , vol.357 , pp. 113-122
    • Plebani, M.1
  • 60
    • 20444477520 scopus 로고    scopus 로고
    • Proteomics and disease: Opportunities and challenges
    • Kavallaris M, Marshall GM. Proteomics and disease: opportunities and challenges. Med J Aust 2005; 182:575-579. This is a review of the status of proteomics in identifying proteins that offer promise as diagnostic and prognostic markers or as therapeutic targets.
    • (2005) Med J Aust , vol.182 , pp. 575-579
    • Kavallaris, M.1    Marshall, G.M.2
  • 61
    • 0038355369 scopus 로고    scopus 로고
    • Detection and analysis of urinary peptides by on-line liquid chromatography and mass spectrometry: Application to patients with renal Fanconi syndrome
    • Lond
    • Cutillas PR, Norden AG, Cramer R, et al. Detection and analysis of urinary peptides by on-line liquid chromatography and mass spectrometry: application to patients with renal Fanconi syndrome. Clin Sci (Lond) 2003; 104:483-490.
    • (2003) Clin Sci , vol.104 , pp. 483-490
    • Cutillas, P.R.1    Norden, A.G.2    Cramer, R.3
  • 62
    • 2442670130 scopus 로고    scopus 로고
    • Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes
    • Weissinger EM, Wittke S, Kaiser T, et al. Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes. Kidney Int 2004; 65:2426-2434. This is part of a series of publications by the same group of investigators systematically exploring CE-MS-based proteomics as a tool for the diagnosis of kidney diseases.
    • (2004) Kidney Int , vol.65 , pp. 2426-2434
    • Weissinger, E.M.1    Wittke, S.2    Kaiser, T.3
  • 63
    • 23044462246 scopus 로고    scopus 로고
    • Urine protein patterns can serve as diagnostic tools in patients with IgA nephropathy
    • Haubitz M, Wittke S, Weissinger EM, et al. Urine protein patterns can serve as diagnostic tools in patients with IgA nephropathy. Kidney Int 2005; 67:2313-2120. This study shows that CE-MS-based proteomics in urine allows for differentiation of patients with IgA nephropathy and healthy subjects.
    • (2005) Kidney Int , vol.67 , pp. 2313-12120
    • Haubitz, M.1    Wittke, S.2    Weissinger, E.M.3
  • 64
    • 0037844820 scopus 로고    scopus 로고
    • Characterization of renal allograft reception by urinary proteomic analysis
    • Clarke W, Silverman BC, Zhang Z, et al. Characterization of renal allograft reception by urinary proteomic analysis. Ann Surg 2003; 237:660-665.
    • (2003) Ann Surg , vol.237 , pp. 660-665
    • Clarke, W.1    Silverman, B.C.2    Zhang, Z.3
  • 65
    • 28044460957 scopus 로고    scopus 로고
    • Detection of acute tubulointerstitial rejection by proteomic analysis of urinary samples in renal transplant recipients
    • in press
    • Wittke S, Haubitz M, Walden M, et al. Detection of acute tubulointerstitial rejection by proteomic analysis of urinary samples in renal transplant recipients. Am J Transplant 2005. (in press) The authors present an analysis of the urine proteome using CE-TOF to diagnostically distinguish kidney graft patients with rejection from those without rejection and from patients with urinary tract infections and healthy subjects.
    • (2005) Am J Transplant
    • Wittke, S.1    Haubitz, M.2    Walden, M.3
  • 66
    • 9644254213 scopus 로고    scopus 로고
    • Bioinformatic analysis of the urine proteome of acute allograft rejection
    • O'Riordan E, Orlova TN, Mei J J, et al. Bioinformatic analysis of the urine proteome of acute allograft rejection. J Am Soc Nephrol 2004; 15:3240-3248. This study is a comparison of the urinary proteome in kidney graft patients with and without acute rejection and in healthy volunteers using SELDI-TOF.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3240-3248
    • O'Riordan, E.1    Orlova, T.N.2    Mei, J.J.3
  • 67
    • 9144260705 scopus 로고    scopus 로고
    • Proteomic-based detection of urine proteins associated with acute renal allograft rejection
    • Schaub S, Rush D, Wilkins J, et al. Proteomic-based detection of urine proteins associated with acute renal allograft rejection. J Am Soc Nephrol 2004; 15:219-227. The authors identify polypeptide/protein clusters in the urine of kidney graft patients with acute rejection that are absent in healthy subjects and kidney graft patients without rejection using SELDI-TOF.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 219-227
    • Schaub, S.1    Rush, D.2    Wilkins, J.3
  • 68
    • 16244419727 scopus 로고    scopus 로고
    • Proteomic-based identification of cleaved urinary β2-microglobulin as a potential marker for acute injury in renal allografts
    • Schaub S, Wilkins JA, Antonovici M, et al. Proteomic-based identification of cleaved urinary β2-microglobulin as a potential marker for acute injury in renal allografts. Am J Transplant 2005; 5:729-738. This study follows up on the findings that were reported in reference [67] and shows that β2-microglobulin is the major protein underlying the protein clusters that were able to distinguish between kidney graft patients with and without acute rejection in the previous study.
    • (2005) Am J Transplant , vol.5 , pp. 729-738
    • Schaub, S.1    Wilkins, J.A.2    Antonovici, M.3
  • 69
    • 3142557616 scopus 로고    scopus 로고
    • Proteomics applied to the clinical follow-up of patients after allogeneic hematopoietic stem cell transplantation
    • Kaiser T, Kamal H, Rank A, et al. Proteomics applied to the clinical follow-up of patients after allogeneic hematopoietic stem cell transplantation. Blood 2004; 104:340-349. This is the first study to describe the analysis of the urine proteome using CE-TOF to diagnostically distinguish patients with and without graft-versus-host disease after hematopoietic stem cell transplantation and healthy subjects.
    • (2004) Blood , vol.104 , pp. 340-349
    • Kaiser, T.1    Kamal, H.2    Rank, A.3
  • 70
    • 0346101481 scopus 로고    scopus 로고
    • Urine protein profiling with surface-enhanced laser-desorption/ ionization time-of-flight mass spectrometry
    • Schaub S, Wilkins J, Weiler T, et al. Urine protein profiling with surface-enhanced laser-desorption/ ionization time-of-flight mass spectrometry. Kidney Int 2004; 65:232-332. This is a critical evaluation of different proteomics tools regarding their potential for clinical diagnostics and evaluation of factors that influence reproducibility of SELDI-TOF analysis.
    • (2004) Kidney Int , vol.65 , pp. 232-332
    • Schaub, S.1    Wilkins, J.2    Weiler, T.3
  • 71
    • 10744228656 scopus 로고    scopus 로고
    • Determination of peptides and proteins in human urine with capillary electrophoresis-mass spectrometry, a suitable tool for the establishment of new diagnostic markers
    • Wittke S, Fliser D, Haubitz M, et al. Determination of peptides and proteins in human urine with capillary electrophoresis-mass spectrometry, a suitable tool for the establishment of new diagnostic markers. J Chromatogr A 2003; 1013:173-181.
    • (2003) J Chromatogr A , vol.1013 , pp. 173-181
    • Wittke, S.1    Fliser, D.2    Haubitz, M.3
  • 72
    • 13644269317 scopus 로고    scopus 로고
    • Protein biochips: The calm before the storm
    • Bodovitz S, Joos T, Bachmann J. Protein biochips: the calm before the storm. Drug Discov Today 2005; 10:283-287. The authors review the status and future developments in the field of protein biochips.
    • (2005) Drug Discov Today , vol.10 , pp. 283-287
    • Bodovitz, S.1    Joos, T.2    Bachmann, J.3
  • 73
    • 1642579024 scopus 로고    scopus 로고
    • The human proteome organization plasma proteome pilot phase: Reference specimens, technology platform comparisons, and standard data submissions and analyses
    • Omenn GS. The human proteome organization plasma proteome pilot phase: reference specimens, technology platform comparisons, and standard data submissions and analyses. Proteomics 2004; 4:1235-1240. This overview article summarizes the activities of the Human Proteome Organization (HUPO) in terms of setting up reference databases, validation, and standardization of sample and data handling and analysis as well as cross-validation of participating laboratories.
    • (2004) Proteomics , vol.4 , pp. 1235-1240
    • Omenn, G.S.1
  • 74
    • 0031823995 scopus 로고    scopus 로고
    • New insights into cyclosporine A nephrotoxicity by proteome analysis
    • Aicher L, Wahl D, Arce A,Grenet O. Steiner S. New insights into cyclosporine A nephrotoxicity by proteome analysis. Electrophoresis 1998; 19:1998-2003.
    • (1998) Electrophoresis , vol.19 , pp. 1998-2003
    • Aicher, L.1    Wahl, D.2    Arce, A.3    Grenet, O.4    Steiner, S.5
  • 75
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson JK, Lindon JC, Holmes E.'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999; 29:1181-1189.
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 76
    • 0142138236 scopus 로고    scopus 로고
    • Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterization of xenobiotics toxicity and disease diagnostic
    • Griffin JL. Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterization of xenobiotics toxicity and disease diagnostic. Curr Opin Chem Biol 2003; 7:648-654.
    • (2003) Curr Opin Chem Biol , vol.7 , pp. 648-654
    • Griffin, J.L.1
  • 77
    • 12244269071 scopus 로고    scopus 로고
    • High-resolution NMR for metabonomics
    • Pelczer I. High-resolution NMR for metabonomics. Curr Opin Drug Discov Dev 2005; 8:127-133.
    • (2005) Curr Opin Drug Discov Dev , vol.8 , pp. 127-133
    • Pelczer, I.1
  • 78
    • 18844406001 scopus 로고    scopus 로고
    • Measuring the metabolome: Current analytical technologies
    • Dunn WB, Bailey NJ, Johnson SE. Measuring the metabolome: current analytical technologies. Analyst 2005; 130:606-625. The authors present a complete review of analytical technologies used in metabonomics.
    • (2005) Analyst , vol.130 , pp. 606-625
    • Dunn, W.B.1    Bailey, N.J.2    Johnson, S.E.3
  • 79
    • 28044449855 scopus 로고    scopus 로고
    • Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics on the blood
    • in press
    • Serkova NJ, Christians U. Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics on the blood. Ther Drug Monit 2005. (in press) This review summarizes the current status on nuclear magnetic resonance-based metabonomics and its application for assessing the mechanisms of immunosuppressant toxicity and detection of the effects of on cell metabolism in vivo.
    • (2005) Ther Drug Monit
    • Serkova, N.J.1    Christians, U.2
  • 81
    • 0002301232 scopus 로고    scopus 로고
    • Metabonomic applications in toxicity screening and disease diagnosis
    • Shokcor JP, Holmes E. Metabonomic applications in toxicity screening and disease diagnosis. Curr Top Med Chem 2002; 2:35-51.
    • (2002) Curr Top Med Chem , vol.2 , pp. 35-51
    • Shokcor, J.P.1    Holmes, E.2
  • 82
    • 2342560435 scopus 로고    scopus 로고
    • Biochemical mechanisms of cyclosporine neurotoxicity
    • Serkova NJ, Christians U, Benet LZ. Biochemical mechanisms of cyclosporine neurotoxicity. Mol Interv 2004; 4:97-107. This publication describes the recent literature evaluating cyclosporine neurotoxicity in in vitro, ex vivo and in rat studies using metabolic profiling technologies.
    • (2004) Mol Interv , vol.4 , pp. 97-107
    • Serkova, N.J.1    Christians, U.2    Benet, L.Z.3
  • 83
    • 0345832398 scopus 로고    scopus 로고
    • Transplantation: Toxicokinetics and mechanisms of toxicity of cyclosporine and macrolides
    • Serkova N, Christians U. Transplantation: Toxicokinetics and mechanisms of toxicity of cyclosporine and macrolides. Curr Opin Investig Drugs 2003; 4:1287-1296.
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 1287-1296
    • Serkova, N.1    Christians, U.2
  • 84
    • 2342483689 scopus 로고    scopus 로고
    • 1H NMR spectroscopy, HPLC-TOF/MS and chemometrics
    • 1H NMR spectroscopy, HPLC-TOF/MS and chemometrics. J Pharm Biomed Anal 2004; 35:599-608. The authors used nuclear magnetic resonance spectroscopy and mass spectrometry to characterize biochemical profiles in rats treated with cyclosporine in comparison to controls. However, very high cyclosporine doses of 45 mg/kg/day were administered.
    • (2004) J Pharm Biomed Anal , vol.35 , pp. 599-608
    • Lenz, E.M.1    Bright, J.2    Knight, R.3
  • 85
    • 1542327740 scopus 로고    scopus 로고
    • Influence of donor pretreatment with N-acetylcysteine on ischemia/reperfusion injury in rat kidney grafts
    • Fuller TF, Serkova N, Niemann CU, Freise CE. Influence of donor pretreatment with N-acetylcysteine on ischemia/reperfusion injury in rat kidney grafts. J Urol 2004; 171:1296-1300.
    • (2004) J Urol , vol.171 , pp. 1296-1300
    • Fuller, T.F.1    Serkova, N.2    Niemann, C.U.3    Freise, C.E.4
  • 86
    • 20844461344 scopus 로고    scopus 로고
    • 1H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants
    • 1H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. Kidney Int 2005; 67:1142-1151.
    • (2005) Kidney Int , vol.67 , pp. 1142-1151
    • Serkova, N.1    Fuller, T.F.2    Klawitter, J.3
  • 88
    • 0027426219 scopus 로고
    • Proton nuclear magnetic resonance spectroscopy of urine and plasma in renal transplantation follow up
    • Le Moyec L, Pruna A, Eugene M, et al. Proton nuclear magnetic resonance spectroscopy of urine and plasma in renal transplantation follow up. Nephron 1993; 65:433-439.
    • (1993) Nephron , vol.65 , pp. 433-439
    • Le Moyec, L.1    Pruna, A.2    Eugene, M.3
  • 89
    • 24944444149 scopus 로고    scopus 로고
    • Summary recommendations for standardization and reporting of metabolic analyses
    • Lindon JC, Nicholson JK, Holmes E, et al. Summary recommendations for standardization and reporting of metabolic analyses. Nat Biotechnol 2005; 23:833-838. In this commentary, The Standard Metabolic Reporting Structures working group outlines its vision regarding standardization and reporting of metabolic studies. See also: http://www.smsgroup.org/documents.
    • (2005) Nat Biotechnol , vol.23 , pp. 833-838
    • Lindon, J.C.1    Nicholson, J.K.2    Holmes, E.3
  • 90
    • 0037444362 scopus 로고    scopus 로고
    • Contemporary issues in toxicology. the role of metabonomics in toxicology and its evaluation by the COMET project
    • Lindon JC, Nicholson JK, Holmes E, et al. Contemporary issues in toxicology. The role of metabonomics in toxicology and its evaluation by the COMET project. Toxicol Appl Pharmacol 2003; 187:137-146.
    • (2003) Toxicol Appl Pharmacol , vol.187 , pp. 137-146
    • Lindon, J.C.1    Nicholson, J.K.2    Holmes, E.3
  • 91
    • 0003484310 scopus 로고    scopus 로고
    • May
    • CDER. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research and Center for Veterinary Medicine (CVM). Guidance for the Industry. Bioanalytical Method Validation, May 2001. (http://www.fda.gov/cder)
    • (2001) Guidance for the Industry. Bioanalytical Method Validation


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