메뉴 건너뛰기




Volumn 30, Issue 2, 2008, Pages 151-158

Toxicodynamic therapeutic drug monitoring of immunosuppressants: Promises, reality, and challenges

Author keywords

Combinatorial biomarkers; Immunosuppressants; Metabolomics; Nephrotoxicity; Proteomics; Therapeutic drug monitoring; Toxicodynamics; Transcriptomics

Indexed keywords

BIOLOGICAL MARKER; CALCINEURIN INHIBITOR; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN; TACROLIMUS;

EID: 42049112365     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/FTD.0b013e31816b9063     Document Type: Conference Paper
Times cited : (45)

References (33)
  • 1
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definition Working Group
    • Biomarkers Definition Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69:89-95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 2
    • 19744374994 scopus 로고    scopus 로고
    • Combinatorial biomarkers: From early toxicology assays to patient population profiling
    • Koop R. Combinatorial biomarkers: from early toxicology assays to patient population profiling. Drug Discov Today. 2005;10:781-788.
    • (2005) Drug Discov Today , vol.10 , pp. 781-788
    • Koop, R.1
  • 3
    • 3342964033 scopus 로고    scopus 로고
    • Biomarker discovery and validation: Technologies and integrative approaches
    • Ilyin SE, Belkowski SM, Plata-Salamán CR. Biomarker discovery and validation: technologies and integrative approaches. Trends Biotechnol. 2004;22:411-416.
    • (2004) Trends Biotechnol , vol.22 , pp. 411-416
    • Ilyin, S.E.1    Belkowski, S.M.2    Plata-Salamán, C.R.3
  • 5
    • 27744599092 scopus 로고    scopus 로고
    • American Society of Nephrology Renal Research Report
    • Berl T. American Society of Nephrology Renal Research Report. J Am Soc Nephrol. 2005;16:1886-1903.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1886-1903
    • Berl, T.1
  • 6
    • 0034594881 scopus 로고    scopus 로고
    • Improved graft survival after renal transplantation in the United States, 1988 to 1996
    • Hariharan S, Johnson CP, Bresnahan BA, et al. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med. 2000;342:605-612.
    • (2000) N Engl J Med , vol.342 , pp. 605-612
    • Hariharan, S.1    Johnson, C.P.2    Bresnahan, B.A.3
  • 7
    • 1442338509 scopus 로고    scopus 로고
    • Lack of improvement in allograft survival despite a marked decrease in acute rejection rates over the most recent era
    • Meier-Kriesche HU, Schold JD, Srinivas TR, et al. Lack of improvement in allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant. 2004;4:378-383.
    • (2004) Am J Transplant , vol.4 , pp. 378-383
    • Meier-Kriesche, H.U.1    Schold, J.D.2    Srinivas, T.R.3
  • 8
    • 33645319718 scopus 로고    scopus 로고
    • Overcoming barriers to long-term graft survival
    • Kaplan B. Overcoming barriers to long-term graft survival. Am J Kidney Dis. 2006; 47(4 Suppl 2):S52-S64.
    • (2006) Am J Kidney Dis , vol.47 , Issue.4 SUPPL. 2
    • Kaplan, B.1
  • 9
    • 1942488666 scopus 로고    scopus 로고
    • Management of the transplant recipient
    • Davision AM, Cameron JS, Grunfeld J-P, et al, eds, ed 2. Oxford: Oxford University Press
    • Kreis H. Management of the transplant recipient. In: Davision AM, Cameron JS, Grunfeld J-P, et al, eds. Oxford Textbook of Clinical Nephrology, ed 2. Oxford: Oxford University Press, 1998:2153-2176.
    • (1998) Oxford Textbook of Clinical Nephrology , pp. 2153-2176
    • Kreis, H.1
  • 11
    • 0035876629 scopus 로고    scopus 로고
    • Exploring treatment options in renal transplantation: The problems of chronic allograft dysfunction and drug-related nephrotoxicity
    • Campistol JM, Grinyo JM. Exploring treatment options in renal transplantation: the problems of chronic allograft dysfunction and drug-related nephrotoxicity. Transplantation. 2001;71(Suppl 11)SS42-SS51.
    • (2001) Transplantation , vol.71 , Issue.SUPPL. 11
    • Campistol, J.M.1    Grinyo, J.M.2
  • 12
    • 33746904087 scopus 로고    scopus 로고
    • Treatment of subclinical rejection diagnosed by protocol biopsy of kidney transplants
    • Kee TY, Chapman JR, O'Connell PJ, et al. Treatment of subclinical rejection diagnosed by protocol biopsy of kidney transplants. Transplantation. 2006;82:36-42.
    • (2006) Transplantation , vol.82 , pp. 36-42
    • Kee, T.Y.1    Chapman, J.R.2    O'Connell, P.J.3
  • 13
    • 16444362802 scopus 로고    scopus 로고
    • Combating chronic renal allograft dysfunction. Optimal immunosuppressive regimens
    • Merville P. Combating chronic renal allograft dysfunction. Optimal immunosuppressive regimens. Drugs. 2005;65:615-631.
    • (2005) Drugs , vol.65 , pp. 615-631
    • Merville, P.1
  • 14
    • 22344455242 scopus 로고    scopus 로고
    • Significance of subclinical rejection in early renal allograft biopsies for chronic allograft dysfunction
    • Miyagi M, Ishikawa Y, Mizuiri S, et al. Significance of subclinical rejection in early renal allograft biopsies for chronic allograft dysfunction. Clin Transplant. 2005;19:456-465.
    • (2005) Clin Transplant , vol.19 , pp. 456-465
    • Miyagi, M.1    Ishikawa, Y.2    Mizuiri, S.3
  • 16
    • 28044465127 scopus 로고    scopus 로고
    • Novel biomarkers of allograft rejection: 'omics' approaches start to deliver
    • Raulf F. Novel biomarkers of allograft rejection: 'omics' approaches start to deliver. Curr Opin Organ Transplant. 2005;10:295-300.
    • (2005) Curr Opin Organ Transplant , vol.10 , pp. 295-300
    • Raulf, F.1
  • 17
    • 33745504163 scopus 로고    scopus 로고
    • Proteomic research in renal transplantation
    • Clarke W. Proteomic research in renal transplantation. Ther Drug Monit. 2006;28:19-22.
    • (2006) Ther Drug Monit , vol.28 , pp. 19-22
    • Clarke, W.1
  • 18
    • 34447642181 scopus 로고    scopus 로고
    • Detection of subclinical tubular injury after renal transplantation: Comparison of urine protein analysis with allograft histopathology
    • Schaub S, Mayr M, Hönger G, et al. Detection of subclinical tubular injury after renal transplantation: comparison of urine protein analysis with allograft histopathology. Transplantation. 2007;84:104-112.
    • (2007) Transplantation , vol.84 , pp. 104-112
    • Schaub, S.1    Mayr, M.2    Hönger, G.3
  • 19
    • 2542568705 scopus 로고    scopus 로고
    • The human plasma proteome: A nonredundant list developed by combination of four separate sources
    • Anderson NL, Polanski M, Pieper R, et al. The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics. 2004;3:311-326.
    • (2004) Mol Cell Proteomics , vol.3 , pp. 311-326
    • Anderson, N.L.1    Polanski, M.2    Pieper, R.3
  • 20
    • 0032694577 scopus 로고    scopus 로고
    • Metabolomics: Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson JK, Lindon JC, Holmes E. "Metabolomics": understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 1999;29:1181-1189.
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 21
    • 0142138236 scopus 로고    scopus 로고
    • Metabolomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterization of xenobiotics toxicity and disease diagnostic
    • Griffin JL. Metabolomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterization of xenobiotics toxicity and disease diagnostic. Curr Opin Chem Biol. 2003;7:648-654.
    • (2003) Curr Opin Chem Biol , vol.7 , pp. 648-654
    • Griffin, J.L.1
  • 22
    • 12244269071 scopus 로고    scopus 로고
    • High-resolution NMR for metabolomics
    • Pelczer I. High-resolution NMR for metabolomics. Curr Opin Drug Discov Dev. 2005;8:127-133.
    • (2005) Curr Opin Drug Discov Dev , vol.8 , pp. 127-133
    • Pelczer, I.1
  • 23
    • 18844406001 scopus 로고    scopus 로고
    • Measuring the metabolome: Current analytical technologies
    • Dunn WB, Bailey NJ, Johnson SE. Measuring the metabolome: current analytical technologies. Analyst. 2005;130:606-625.
    • (2005) Analyst , vol.130 , pp. 606-625
    • Dunn, W.B.1    Bailey, N.J.2    Johnson, S.E.3
  • 24
    • 0036463681 scopus 로고    scopus 로고
    • Metabolomics: A platform for studying drug toxicity and gene function
    • Nicholson JK, Connelly J, Lindon JC, et al. Metabolomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov. 2002;1:153-161.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 153-161
    • Nicholson, J.K.1    Connelly, J.2    Lindon, J.C.3
  • 25
    • 0002301232 scopus 로고    scopus 로고
    • Metabolomic applications in toxicity screening and disease diagnosis
    • Shockcor JP, Holmes E. Metabolomic applications in toxicity screening and disease diagnosis. Curr Top Med Chem. 2002;2:35-51.
    • (2002) Curr Top Med Chem , vol.2 , pp. 35-51
    • Shockcor, J.P.1    Holmes, E.2
  • 26
    • 4344583771 scopus 로고    scopus 로고
    • Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes
    • Flechner SM, Kurian SM, Head SR, et al. Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant. 2004;4:1475-1489.
    • (2004) Am J Transplant , vol.4 , pp. 1475-1489
    • Flechner, S.M.1    Kurian, S.M.2    Head, S.R.3
  • 27
    • 34247391990 scopus 로고    scopus 로고
    • Early loss of renal transcripts in kidney allografts: Relationship to the development of histologic lesions and alloimmune effector mechanisms
    • Einecke G, Broderick G, Sis B, et al. Early loss of renal transcripts in kidney allografts: relationship to the development of histologic lesions and alloimmune effector mechanisms. Am J Transplant. 2007;7:1121-1130.
    • (2007) Am J Transplant , vol.7 , pp. 1121-1130
    • Einecke, G.1    Broderick, G.2    Sis, B.3
  • 28
    • 33644830965 scopus 로고    scopus 로고
    • Microarrays and transcriptome analysis in renal transplantation
    • Halloran PF, Einecke G. Microarrays and transcriptome analysis in renal transplantation. Nat Clin Pract Nephrol. 2006;2:2-3.
    • (2006) Nat Clin Pract Nephrol , vol.2 , pp. 2-3
    • Halloran, P.F.1    Einecke, G.2
  • 29
    • 33947390388 scopus 로고    scopus 로고
    • 2t-isoprostane in human urine and plasma using high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry
    • 2t-isoprostane in human urine and plasma using high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. Clin Chem. 2007;53:489-497.
    • (2007) Clin Chem , vol.53 , pp. 489-497
    • Haschke, M.1    Zhang, Y.L.2    Kahle, C.3
  • 30
    • 0032916919 scopus 로고    scopus 로고
    • A simple, nonradioactive method for evaluating single-nephron filtration rate using FITC-inulin
    • Lorenz JN, Gruenstein E. A simple, nonradioactive method for evaluating single-nephron filtration rate using FITC-inulin. Am J Physiol. 1999;276:F172-F177.
    • (1999) Am J Physiol , vol.276
    • Lorenz, J.N.1    Gruenstein, E.2
  • 32
    • 0028258492 scopus 로고
    • Enhancement of FK506 nephrotoxicity by sodium depletion in an experimental rat model
    • Andoh TF, Burdmann EA, Lindsley J, et al. Enhancement of FK506 nephrotoxicity by sodium depletion in an experimental rat model. Transplantation. 1994;57:483-489.
    • (1994) Transplantation , vol.57 , pp. 483-489
    • Andoh, T.F.1    Burdmann, E.A.2    Lindsley, J.3
  • 33
    • 7044236807 scopus 로고    scopus 로고
    • Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: Interactions with mTOR inhibitors
    • Christians U, Gottschalk S, Miljus J, et al. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Br J Pharmacol. 2004;143:388-396.
    • (2004) Br J Pharmacol , vol.143 , pp. 388-396
    • Christians, U.1    Gottschalk, S.2    Miljus, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.