Cyclosporin A-induced free radical generation is not mediated by cytochrome P-450

British Journal of Pharmacology

Volumn 135, Issue 4, 2002, Pages 977-986

  Krauskopf, Alexandra ^a   Buetler, Timo M ^a   Nguyen, Nathalie S D ^b   Macé, Katherine ^c   Ruegg, Urs T ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b Novartis Consumer Health SA   (Switzerland)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Cyclosporin A; Cytochrome P 450; Metabolism; Microsomes; NADPH cytochrome P 450 reductase; Reactive oxygen species; Smooth muscle cells

Indexed keywords

CYCLOSPORIN A; CYTOCHROME P450; CYTOCHROME P450 3A4; DIPHENYLIODONIUM SALT; FREE RADICAL; KETOCONAZOLE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MALE; MICROSOME; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER;

ANIMALS; AORTA; CELLS, CULTURED; CYCLOSPORINE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; EPITHELIAL CELLS; FREE RADICALS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICROSOMES, LIVER; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA, MESSENGER;

EID: 0036185635     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704544     Document Type: Article

References (68)

1. Oxygen radical formation during cytochrome P450-catalyzed cyclosporine metabolism in rat and human liver microsomes at varying hydrogen ion concentrations
2. Adrenochrome reaction implicates oxygen radicals in metabolism of cyclosporine A and FK-506 in rat and human liver microsomes
3. Calcineurin: From structure to function
4. A comparison of the effects of cyclosporine (CsA) on hepatic microsomal drug metabolism in three different strains of rat
5. The effects of cyclosporin A (CsA) on hepatic microsomal drug metabolism in the rat
6. Cyclosporine A up-regulates angiotensin II receptors and calcium responses in human vascular smooth muscle cells
7. Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species
8. In vivo pharmacological effects of ciclosporin and some analogues
9. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
10. Does cyclosporin A generate free radicals?
11. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450
12. Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450
13. Participation of reactive oxygen species in the lysophosphatidic acid-stimulated mitogen-activated protein kinase kinase activation pathway
14. Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily
15. Multiple activated oxygen species in P450 catalysis - Contributions to specificity in drug metabolism
16. Upregulation of vasopressin V 1A receptor mRNA and protein in vascular smooth muscle cells following cyclosporin A treatment
17. Serum cyclosporin levels, hepatic drug metabolism and renal tubulotoxicity
18. Regulation of gene expression by reactive oxygen
19. The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver
20. Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2′, 7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′, 7′ dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123
21. Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity
22. Cyclosporin-A-induced lipid peroxidation in human liver microsomes and its influence on cytochrome P-450
23. Cyclosporine A induced lipid peroxidation and influence on glucose-6-phosphatase in rat hepatic and renal microsomes
24. Detection of reactive nitrogen species using 2, 7-dichlorodihydrofluorescein and dihydrorhodamine 123
25. Changes in the amounts of cytochromes P450 in rat hepatic microsomes produced by cyclosporin A
26. Cyclosporine
27. Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs
28. Generation of superoxide anion as a source of hydrogen peroxide in a reconstituted monooxygenase system
29. Oxidase and oxygenase function of the microsomal cytochrome P450 monooxygenase system
30. Cyclosporine augments reactivity of isolated blood vessels
31. An essential role for free radicals and derived species in signal transduction
32. In vitro models to study mechanisms involved in cyclosporine A-mediated glomerular contraction
33. Effect of cyclosporin A and analogues on cytosolic calcium and vasoconstriction: Possible lack of relationship to immunosuppressive activity
34. c increase
35. Mechanism of enhanced vasoconstrictor hormone action in vascular smooth muscle ceils by cyclosporin A
36. Role of reactive oxygen species in the signalling cascade of cyclosporine A-mediated up-regulation of eNOS in vascular endothelial cells
37. 1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines
38. Effect of vitamin E on human aortic endothelial cell responses to oxidative injury
39. Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production
40. Pharmacology of cyclosporine (sandimmune). VII. Pathophysiology and toxicology of cyclosporine in humans and animals
41. The microestimation of succinate and the extinction coefficient of cytochrome c
42. The preparation and properties of microsomal TPNH-cytochrome c reductase from pig liver
43. Differential effects of cyclosporin on hepatic and renal heme, cytochrome P-450 and drug metabolism. Possible role in nephrotoxicity of the drug
44. H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
45. Metabolism-dependent stimulation of reactive oxygen species and DNA synthesis by cyclosporin A in rat smooth muscle cells
46. The carbon monoxide-binding pigment of liver microsomes I. Evidence for its hemoprotein nature
47. Paramagnetic resonance in detecting carcinogenic risk from cytochrome P450 overexpression
48. Cyclosporin A-induced hydrogen peroxide synthesis by cultured human mesangial cells is blocked by exogenous antioxidants
49. Electron shuttle between membrane-bound cytochrome P450 3A4 and b5 rules uncoupling mechanisms
50. Simian virus 40 large tumor antigen-immortalised normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens
51. Studies on the NADPH oxidase reaction of NADPH-cytochrome c reductase. I. The role of superoxide anion
52. Transcription factors of the NFAT family: Regulation and function
53. Generation of reactive oxygen intermediates by human liver microsomes in the presence of NADPH or NADH
54. Mechanism of cyclosporin potentiation of vasoconstriction of the isolated rat mesenteric arterial bed: Role of extracellular calcium
55. Regulation of hepatic cytochrome P-450 during infectious disease
56. A microplate assay for the detection of oxidative products using 2′, 7′-dichlorofluorescin-diacetate
57. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1
58. Antioxidant and redox regulation of gene transcription
59. Generation of oxygen free radicals during the metabolism of cyclosporine A: A cause-effect relationship with metabolism inhibition
60. Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity
61. Cyclosporin A increases nitric oxide activity in vivo
62. 2 for platelet-derived growth factor signal transduction
63. Cyclosporine-induced hypertension after transplantation
64. Preparation and properties of partially purified cytochrome P-450 and reduced NADPH-cytochrome P-450 reductase from rabbit liver
65. Lipid peroxidation accompanies cyclosporine nephrotoxicity: Effects of vitamin E
66. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader
67. Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin
68. Cyclosporin A increases hypoxia and free radical production in rat kidneys: Prevention by dietary glycine