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Volumn 6, Issue 4, 2010, Pages 507-521

Translating genomic analyses into improved management of coronary artery disease

Author keywords

9p21; coronary artery disease; genetic risk prediction; genetic variation; genome wide association study; lifetime risk prediction; myocardial infarction

Indexed keywords

CARDIOVASCULAR RISK; CORONARY ARTERY DISEASE; DISEASE PREDISPOSITION; FAMILY HISTORY; FUTUROLOGY; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOMICS; HUMAN; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; FORECASTING; GENETIC PREDISPOSITION; GENETICS; RISK ASSESSMENT;

EID: 77954491927     PISSN: 14796678     EISSN: 17448298     Source Type: Journal    
DOI: 10.2217/fca.10.28     Document Type: Review
Times cited : (4)

References (110)
  • 1
    • 67349165856 scopus 로고    scopus 로고
    • Molecular genetics of atherosclerosis
    • Roy H, Bhardwaj S, Yla-Herttuala S: Molecular genetics of atherosclerosis. Hum. Genet. 125(5-6), 467-491 (2009).
    • (2009) Hum. Genet. , vol.125 , Issue.5-6 , pp. 467-491
    • Roy, H.1    Bhardwaj, S.2    Yla-Herttuala, S.3
  • 2
    • 4644276327 scopus 로고    scopus 로고
    • Genetic basis of atherosclerosis: Part I: New genes and pathways
    • Lusis AJ, Fogelman AM, Fonarow GC: Genetic basis of atherosclerosis: part I: new genes and pathways. Circulation 110(13), 1868-1873 (2004).
    • (2004) Circulation , vol.110 , Issue.13 , pp. 1868-1873
    • Lusis, A.J.1    Fogelman, A.M.2    Fonarow, G.C.3
  • 3
    • 50249090436 scopus 로고    scopus 로고
    • Molecular genetics of myocardial infarction
    • Yamada Y, Ichihara S, Nishida T: Molecular genetics of myocardial infarction. Genomic Med. 2(1-2), 7-22 (2008).
    • (2008) Genomic Med , vol.2 , Issue.1-2 , pp. 7-22
    • Yamada, Y.1    Ichihara, S.2    Nishida, T.3
  • 5
    • 0036065699 scopus 로고    scopus 로고
    • SNP judgments and freedom of association
    • Hegele RA: SNP judgments and freedom of association. Arterioscler. Thromb. Vasc. Biol. 22(7), 1058-1061 (2002).
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , Issue.7 , pp. 1058-1061
    • Hegele, R.A.1
  • 6
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • Lander ES, Linton LM, Birren B et al.: Initial sequencing and analysis of the human genome. Nature 409(6822), 860-921 (2001).
    • (2001) Nature , vol.409 , Issue.6822 , pp. 860-921
    • Lander, E.S.1    Linton, L.M.2    Birren, B.3
  • 7
    • 35348983887 scopus 로고    scopus 로고
    • A second generation human haplotype map of over 3.1 million SNPs
    • Frazer KA, Ballinger DG, Cox DR et al.: A second generation human haplotype map of over 3.1 million SNPs. Nature 449(7164), 851-861 (2007).
    • (2007) Nature , vol.449 , Issue.7164 , pp. 851-861
    • Frazer, K.A.1    Ballinger, D.G.2    Cox, D.R.3
  • 8
    • 77950461601 scopus 로고    scopus 로고
    • Origins and functional impact of copy number variation in the human genome
    • Conrad DF, Pinto D, Redon R et al.: Origins and functional impact of copy number variation in the human genome. Nature 464(7289), 704-712 (2010).
    • (2010) Nature , vol.464 , Issue.7289 , pp. 704-712
    • Conrad, D.F.1    Pinto, D.2    Redon, R.3
  • 9
    • 62549085618 scopus 로고    scopus 로고
    • Human genetic variation and its contribution to complex traits
    • Frazer KA, Murray SS, Schork NJ, Topol EJ: Human genetic variation and its contribution to complex traits. Nat. Rev. Genet. 10(4), 241-251 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , Issue.4 , pp. 241-251
    • Frazer, K.A.1    Murray, S.S.2    Schork, N.J.3    Topol, E.J.4
  • 10
    • 43049107147 scopus 로고    scopus 로고
    • The functional impact of structural variation in humans
    • Hurles ME, Dermitzakis ET, Tyler-Smith C: The functional impact of structural variation in humans. Trends Genet. 24(5), 238-245 (2008).
    • (2008) Trends Genet , vol.24 , Issue.5 , pp. 238-245
    • Hurles, M.E.1    Dermitzakis, E.T.2    Tyler-Smith, C.3
  • 12
    • 58149387637 scopus 로고    scopus 로고
    • How to use an article about genetic association: A: Background concepts
    • Attia J, Ioannidis JP, Thakkinstian A et al.: How to use an article about genetic association: A: background concepts. JAMA 301(1), 74-81 (2009).
    • (2009) JAMA , vol.301 , Issue.1 , pp. 74-81
    • Attia, J.1    Ioannidis, J.P.2    Thakkinstian, A.3
  • 13
    • 58249089746 scopus 로고    scopus 로고
    • How to use an article about genetic association: B: Are the results of the study valid?
    • Attia J, Ioannidis JP, Thakkinstian A et al.: How to use an article about genetic association: B: are the results of the study valid? JAMA 301(2), 191-197 (2009).
    • (2009) JAMA , vol.301 , Issue.2 , pp. 191-197
    • Attia, J.1    Ioannidis, J.P.2    Thakkinstian, A.3
  • 14
    • 58749099119 scopus 로고    scopus 로고
    • How to use an article about genetic association: C: What are the results and will they help me in caring for my patients?
    • Attia J, Ioannidis JP, Thakkinstian A et al.: How to use an article about genetic association: C: what are the results and will they help me in caring for my patients? JAMA 301(3), 304-308 (2009).
    • (2009) JAMA , vol.301 , Issue.3 , pp. 304-308
    • Attia, J.1    Ioannidis, J.P.2    Thakkinstian, A.3
  • 15
    • 0035451780 scopus 로고    scopus 로고
    • On the allelic spectrum of human disease
    • Reich DE, Lander ES: On the allelic spectrum of human disease. Trends Genet. 17(9), 502-510 (2001).
    • (2001) Trends Genet , vol.17 , Issue.9 , pp. 502-510
    • De, R.1    Lander, E.S.2
  • 16
    • 0034969437 scopus 로고    scopus 로고
    • Are rare variants responsible for susceptibility to complex diseases?
    • Pritchard JK: Are rare variants responsible for susceptibility to complex diseases? Am. J. Hum. Genet. 69(1), 124-137 (2001).
    • (2001) Am. J. Hum. Genet. , vol.69 , Issue.1 , pp. 124-137
    • Pritchard, J.K.1
  • 18
    • 79959503826 scopus 로고    scopus 로고
    • The international HapMap project
    • International HapMap Consortium
    • International HapMap Consortium: The international HapMap project. Nature 426(6968), 789-796 (2003).
    • (2003) Nature , vol.426 , Issue.6968 , pp. 789-796
  • 19
    • 40949127393 scopus 로고    scopus 로고
    • How to interpret a genome-wide association study
    • Pearson TA, Manolio TA: How to interpret a genome-wide association study. JAMA 299(11), 1335-1344 (2008).
    • (2008) JAMA , vol.299 , Issue.11 , pp. 1335-1344
    • Pearson, T.A.1    Manolio, T.A.2
  • 20
    • 34249996115 scopus 로고    scopus 로고
    • A common allele on chromosome 9 associated with coronary heart disease
    • McPherson R, Pertsemlidis A, Kavaslar N et al.: A common allele on chromosome 9 associated with coronary heart disease. Science 316(5830), 1488-1491 (2007).
    • (2007) Science , vol.316 , Issue.5830 , pp. 1488-1491
    • McPherson, R.1    Pertsemlidis, A.2    Kavaslar, N.3
  • 22
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145), 661-678 (2007).
    • (2007) Nature , vol.447 , Issue.7145 , pp. 661-678
  • 23
    • 40549109924 scopus 로고    scopus 로고
    • Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p
    • Broadbent HM, Peden JF, Lorkowski S et al.: Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Hum. Mol. Genet. 17(6), 806-814 (2008).
    • (2008) Hum. Mol. Genet. , vol.17 , Issue.6 , pp. 806-814
    • Broadbent, H.M.1    Peden, J.F.2    Lorkowski, S.3
  • 24
    • 77649166974 scopus 로고    scopus 로고
    • ANRIL expression is associated with atherosclerosis risk at chromosome 9p21
    • Holdt LM, Beutner F, Scholz M et al.: ANRIL expression is associated with atherosclerosis risk at chromosome 9p21. Arterioscler. Thromb. Vasc. Biol. 30(3), 620-627 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , Issue.3 , pp. 620-627
    • Holdt, L.M.1    Beutner, F.2    Scholz, M.3
  • 25
    • 70349569056 scopus 로고    scopus 로고
    • Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus
    • Jarinova O, Stewart AF, Roberts R et al.: Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus. Arterioscler. Thromb. Vasc. Biol. 29(10), 1671-1677 (2009).
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , Issue.10 , pp. 1671-1677
    • Jarinova, O.1    Stewart, A.F.2    Roberts, R.3
  • 26
    • 77949775636 scopus 로고    scopus 로고
    • Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice
    • Visel A, Zhu Y, May D et al.: Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 464(7287), 409-412 (2010).
    • (2010) Nature , vol.464 , Issue.7287 , pp. 409-412
    • Visel, A.1    Zhu, Y.2    May, D.3
  • 28
    • 38649091662 scopus 로고    scopus 로고
    • The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
    • Helgadottir A, Thorleifsson G, Magnusson KP et al.: The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat. Genet. 40(2), 217-224 (2008).
    • (2008) Nat. Genet. , vol.40 , Issue.2 , pp. 217-224
    • Helgadottir, A.1    Thorleifsson, G.2    Kp, M.3
  • 29
    • 41649085340 scopus 로고    scopus 로고
    • Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
    • Schunkert H, Gotz A, Braund P et al.: Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation 117(13), 1675-1684 (2008).
    • (2008) Circulation , vol.117 , Issue.13 , pp. 1675-1684
    • Schunkert, H.1    Gotz, A.2    Braund, P.3
  • 30
    • 47349129207 scopus 로고    scopus 로고
    • Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: A population-based, prospective study
    • Ye S, Willeit J, Kronenberg F, Xu Q, Kiechl S: Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study. J. Am. Coll. Cardiol. 52(5), 378-384 (2008).
    • (2008) J. Am. Coll. Cardiol. , vol.52 , Issue.5 , pp. 378-384
    • Ye, S.1    Willeit, J.2    Kronenberg, F.3    Xu, Q.4    Kiechl, S.5
  • 31
    • 60749104192 scopus 로고    scopus 로고
    • Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion
    • Thompson AR, Golledge J, Cooper JA et al.: Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion. Eur. J. Hum. Genet. 17(3), 391-394 (2009).
    • (2009) Eur. J. Hum. Genet. , vol.17 , Issue.3 , pp. 391-394
    • Thompson, A.R.1    Golledge, J.2    Cooper, J.A.3
  • 32
    • 49549087336 scopus 로고    scopus 로고
    • Four SNPs on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest)
    • Abdullah KG, Li L, Shen GQ et al.: Four SNPs on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest). Ann. Hum. Genet. 72(Pt 5), 654-657 (2008).
    • (2008) Ann. Hum. Genet. , vol.72 , Issue.PART 5 , pp. 654-657
    • Abdullah, K.G.1    Li, L.2    Shen, G.Q.3
  • 33
    • 67449103171 scopus 로고    scopus 로고
    • Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease
    • Muendlein A, Saely CH, Rhomberg S et al.: Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease. Atherosclerosis 205(1), 174-180 (2009).
    • (2009) Atherosclerosis , vol.205 , Issue.1 , pp. 174-180
    • Muendlein, A.1    Ch, S.2    Rhomberg, S.3
  • 34
    • 38549092257 scopus 로고    scopus 로고
    • Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease
    • Shen GQ, Li L, Rao S et al.: Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 28(2), 360-365 (2008).
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , Issue.2 , pp. 360-365
    • Shen, G.Q.1    Li, L.2    Rao, S.3
  • 35
    • 38949209549 scopus 로고    scopus 로고
    • Association between four SNPSs on chromosome 9p21 and myocardial infarction is replicated in an Italian population
    • Shen GQ, Rao S, Martinelli N et al.: Association between four SNPSs on chromosome 9p21 and myocardial infarction is replicated in an Italian population. J. Hum. Genet. 53(2), 144-150 (2008).
    • (2008) J. Hum. Genet. , vol.53 , Issue.2 , pp. 144-150
    • Shen, G.Q.1    Rao, S.2    Martinelli, N.3
  • 36
    • 55449112465 scopus 로고    scopus 로고
    • Associations between single nucleotide polymorphisms on chromosome 9p21 and risk of coronary heart disease in Chinese Han population
    • Zhou L, Zhang X, He M et al.: Associations between single nucleotide polymorphisms on chromosome 9p21 and risk of coronary heart disease in Chinese Han population. Arterioscler. Thromb. Vasc. Biol. 28(11), 2085-2089 (2008).
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , Issue.11 , pp. 2085-2089
    • Zhou, L.1    Zhang, X.2    He, M.3
  • 37
    • 48049115182 scopus 로고    scopus 로고
    • Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic advance study
    • Assimes TL, Knowles JW, Basu A et al.: Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic advance study. Hum. Mol. Genet. 17(15), 2320-2328 (2008).
    • (2008) Hum. Mol. Genet. , vol.17 , Issue.15 , pp. 2320-2328
    • Assimes, T.L.1    Knowles, J.W.2    Basu, A.3
  • 38
    • 75649149885 scopus 로고    scopus 로고
    • Methodological challenges of genome-wide association analysis in Africa
    • Teo YY, Small KS, Kwiatkowski DP: Methodological challenges of genome-wide association analysis in Africa. Nat. Rev. Genet. 11(2), 149-160 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , Issue.2 , pp. 149-160
    • Teo, Y.Y.1    Small, K.S.2    Kwiatkowski, D.P.3
  • 39
    • 71849099015 scopus 로고    scopus 로고
    • The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people
    • Cluett C, McDermott MM, Guralnik J et al.: The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ. Cardiovasc. Genet. 2(4), 347-353 (2009).
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , Issue.4 , pp. 347-353
    • Cluett, C.1    McDermott, M.M.2    Guralnik, J.3
  • 40
    • 60349120503 scopus 로고    scopus 로고
    • Association of genetic variation on chromosome 9p21.3 and arterial stiffness
    • Bjorck HM, Lanne T, Alehagen U et al.: Association of genetic variation on chromosome 9p21.3 and arterial stiffness. J. Intern. Med. 265(3), 373-381 (2009).
    • (2009) J. Intern. Med. , vol.265 , Issue.3 , pp. 373-381
    • Bjorck, H.M.1    Lanne, T.2    Alehagen, U.3
  • 41
    • 70349622023 scopus 로고    scopus 로고
    • Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke
    • Lemmens R, Abboud S, Robberecht W et al.: Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke. Eur. J. Hum. Genet. 17(10), 1287-1293 (2009).
    • (2009) Eur. J. Hum. Genet. , vol.17 , Issue.10 , pp. 1287-1293
    • Lemmens, R.1    Abboud, S.2    Robberecht, W.3
  • 42
    • 51649112475 scopus 로고    scopus 로고
    • Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis
    • Samani NJ, Raitakari OT, Sipila K et al.: Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 28(9), 1679-1683 (2008).
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , Issue.9 , pp. 1679-1683
    • Samani, N.J.1    Raitakari, O.T.2    Sipila, K.3
  • 43
    • 67649657744 scopus 로고    scopus 로고
    • The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension
    • Wahlstrand B, Orho-Melander M, Delling L et al.: The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension. J. Hypertens. 27(4), 769-773 (2009).
    • (2009) J. Hypertens. , vol.27 , Issue.4 , pp. 769-773
    • Wahlstrand, B.1    Orho-Melander, M.2    Delling, L.3
  • 44
    • 66249120705 scopus 로고    scopus 로고
    • The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts
    • Karvanen J, Silander K, Kee F et al.: The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet. Epidemiol. 33(3), 237-246 (2009).
    • (2009) Genet. Epidemiol. , vol.33 , Issue.3 , pp. 237-246
    • Karvanen, J.1    Silander, K.2    Kee, F.3
  • 45
    • 60649106158 scopus 로고    scopus 로고
    • Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes
    • Cunnington MS, Mayosi BM, Hall DH et al.: Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes. Atherosclerosis 203(1), 41-44 (2009).
    • (2009) Atherosclerosis , vol.203 , Issue.1 , pp. 41-44
    • Cunnington, M.S.1    Mayosi, B.M.2    Hall, D.H.3
  • 46
    • 70449110469 scopus 로고    scopus 로고
    • Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: A large-scale genetic association study
    • Smith JG, Melander O, Lovkvist H et al.: Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study. Circ. Cardiovasc. Genet. 2(2), 159-164 (2009).
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , Issue.2 , pp. 159-164
    • Smith, J.G.1    Melander, O.2    Lovkvist, H.3
  • 47
    • 70349682421 scopus 로고    scopus 로고
    • Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray
    • Lanktree MB, Hegele RA, Yusuf S, Anand SS: Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray. Stroke 40(10), 3173-3179 (2009).
    • (2009) Stroke , vol.40 , Issue.10 , pp. 3173-3179
    • Lanktree, M.B.1    Hegele, R.A.2    Yusuf, S.3    Anand, S.S.4
  • 48
    • 70749096913 scopus 로고    scopus 로고
    • Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    • Kathiresan S, Voight BF, Purcell S et al.: Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat. Genet. 41(3), 334-341 (2009).
    • (2009) Nat. Genet. , vol.41 , Issue.3 , pp. 334-341
    • Kathiresan, S.1    Voight, B.F.2    Purcell, S.3
  • 49
    • 38649125868 scopus 로고    scopus 로고
    • Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    • Willer CJ, Sanna S, Jackson AU et al.: Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat. Genet. 40(2), 161-169 (2008).
    • (2008) Nat. Genet. , vol.40 , Issue.2 , pp. 161-169
    • Willer, C.J.1    Sanna, S.2    Jackson, A.U.3
  • 50
    • 73649141739 scopus 로고    scopus 로고
    • Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease
    • Linsel-Nitschke P, Heeren J, Aherrahrou Z et al.: Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease. Atherosclerosis 208(1), 183-189 (2010).
    • (2010) Atherosclerosis , vol.208 , Issue.1 , pp. 183-189
    • Linsel-Nitschke, P.1    Heeren, J.2    Aherrahrou, Z.3
  • 51
    • 35548930820 scopus 로고    scopus 로고
    • Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
    • Jansen P, Giehl K, Nyengaard JR et al.: Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat. Neurosci. 10(11), 1449-1457 (2007).
    • (2007) Nat. Neurosci. , vol.10 , Issue.11 , pp. 1449-1457
    • Jansen, P.1    Giehl, K.2    Nyengaard, J.R.3
  • 52
    • 0033605593 scopus 로고    scopus 로고
    • Sortilin/ neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase
    • Nielsen MS, Jacobsen C, Olivecrona G, Gliemann J, Petersen CM: Sortilin/ neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J. Biol. Chem. 274(13), 8832-8836 (1999).
    • (1999) J. Biol. Chem. , vol.274 , Issue.13 , pp. 8832-8836
    • Nielsen, M.S.1    Jacobsen, C.2    Olivecrona, G.3    Gliemann, J.4    Petersen, C.M.5
  • 53
    • 54449087031 scopus 로고    scopus 로고
    • Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families
    • Nilsson SK, Christensen S, Raarup MK et al.: Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families. J. Biol. Chem. 283(38), 25920-25927 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.38 , pp. 25920-25927
    • Nilsson, S.K.1    Christensen, S.2    Raarup, M.K.3
  • 54
    • 45149108420 scopus 로고    scopus 로고
    • Mapping the genetic architecture of gene expression in human liver
    • Schadt EE, Molony C, Chudin E et al.: Mapping the genetic architecture of gene expression in human liver. PLoS Biol. 6(5), E107 (2008).
    • (2008) PLoS Biol , vol.6 , Issue.5
    • Schadt, E.E.1    Molony, C.2    Chudin, E.3
  • 55
    • 58549109632 scopus 로고    scopus 로고
    • Plasma lipoproteins: Genetic influences and clinical implications
    • Hegele RA: Plasma lipoproteins: genetic influences and clinical implications. Nat. Rev. Genet. 10(2), 109-121 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , Issue.2 , pp. 109-121
    • Hegele, R.A.1
  • 56
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH: Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N. Engl. J. Med. 354(12), 1264-1272 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , Issue.12 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Hobbs, H.H.3
  • 57
    • 61349177857 scopus 로고    scopus 로고
    • New susceptibility locus for coronary artery disease on chromosome 3q22.3
    • Erdmann J, Grosshennig A, Braund PS et al.: New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat. Genet. 41(3), 280-282 (2009).
    • (2009) Nat. Genet. , vol.41 , Issue.3 , pp. 280-282
    • Erdmann, J.1    Grosshennig, A.2    Braund, P.S.3
  • 58
    • 58149163149 scopus 로고    scopus 로고
    • Common variants at 30 loci contribute to polygenic dyslipidemia
    • Kathiresan S, Willer CJ, Peloso GM et al.: Common variants at 30 loci contribute to polygenic dyslipidemia. Nat. Genet. 41(1), 56-65 (2009).
    • (2009) Nat. Genet. , vol.41 , Issue.1 , pp. 56-65
    • Kathiresan, S.1    Willer, C.J.2    Peloso, G.M.3
  • 59
    • 61349137526 scopus 로고    scopus 로고
    • Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
    • Tregouet DA, Konig IR, Erdmann J et al.: Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat. Genet. 41(3), 283-285 (2009).
    • (2009) Nat. Genet. , vol.41 , Issue.3 , pp. 283-285
    • Tregouet, D.A.1    Konig, I.R.2    Erdmann, J.3
  • 60
    • 38049177286 scopus 로고    scopus 로고
    • Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population: The Copenhagen City Heart Study
    • Kamstrup PR, Benn M, Tybjaerg-Hansen A, Nordestgaard BG: Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population: the Copenhagen City Heart Study. Circulation 117(2), 176-184 (2008).
    • (2008) Circulation , vol.117 , Issue.2 , pp. 176-184
    • Kamstrup, P.R.1    Benn, M.2    Tybjaerg-Hansen, A.3    Nordestgaard, B.G.4
  • 62
    • 67651210632 scopus 로고    scopus 로고
    • Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality
    • Erqou S, Kaptoge S, Perry PL et al.: Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA 302(4), 412-423 (2009).
    • (2009) JAMA , vol.302 , Issue.4 , pp. 412-423
    • Erqou, S.1    Kaptoge, S.2    Perry, P.L.3
  • 63
    • 1842609781 scopus 로고    scopus 로고
    • Structure- function relationships in apolipoprotein(a): Insights into lipoprotein(a) assembly and pathogenicity
    • Koschinsky ML, Marcovina SM: Structure- function relationships in apolipoprotein(a): insights into lipoprotein(a) assembly and pathogenicity. Curr. Opin. Lipidol. 15(2), 167-174 (2004).
    • (2004) Curr. Opin. Lipidol. , vol.15 , Issue.2 , pp. 167-174
    • Koschinsky, M.L.1    Marcovina, S.M.2
  • 64
    • 28044467143 scopus 로고    scopus 로고
    • Lipoprotein(a) and atherosclerosis: New perspectives on the mechanism of action of an enigmatic lipoprotein
    • Koschinsky ML: Lipoprotein(a) and atherosclerosis: new perspectives on the mechanism of action of an enigmatic lipoprotein. Curr. Atheroscler. Rep. 7(5), 389-395 (2005).
    • (2005) Curr. Atheroscler. Rep. , vol.7 , Issue.5 , pp. 389-395
    • Koschinsky, M.L.1
  • 65
    • 0035806916 scopus 로고    scopus 로고
    • Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: The Atherosclerosis Risk in Communities (ARIC) study
    • Sharrett AR, Ballantyne CM, Coady SA et al.: Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: the Atherosclerosis Risk in Communities (ARIC) study. Circulation 104(10), 1108-1113 (2001).
    • (2001) Circulation , vol.104 , Issue.10 , pp. 1108-1113
    • Sharrett, A.R.1    Ballantyne, C.M.2    Coady, S.A.3
  • 66
    • 77952487856 scopus 로고    scopus 로고
    • Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians
    • Lanktree MB, Anand SS, Yusuf S, Hegele RA: Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians. Circ. Cardiovasc. Genet. 3(1), 39-46 (2010).
    • (2010) Circ. Cardiovasc. Genet. , vol.3 , Issue.1 , pp. 39-46
    • Lanktree, M.B.1    Anand, S.S.2    Yusuf, S.3    Hegele, R.A.4
  • 67
    • 0026667073 scopus 로고
    • Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations
    • Boerwinkle E, Leffert CC, Lin J et al.: Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J. Clin. Invest. 90(1), 52-60 (1992).
    • (1992) J. Clin. Invest. , vol.90 , Issue.1 , pp. 52-60
    • Boerwinkle, E.1    Leffert, C.C.2    Lin, J.3
  • 68
    • 67049167090 scopus 로고    scopus 로고
    • Genetically elevated lipoprotein(a) and increased risk of myocardial infarction
    • Kamstrup PR, Tybjaerg-Hansen A, Steffensen R, Nordestgaard BG: Genetically elevated lipoprotein(a) and increased risk of myocardial infarction. JAMA 301(22), 2331-2339 (2009).
    • (2009) JAMA , vol.301 , Issue.22 , pp. 2331-2339
    • Kamstrup, P.R.1    Tybjaerg-Hansen, A.2    Steffensen, R.3    Nordestgaard, B.G.4
  • 69
    • 73549097512 scopus 로고    scopus 로고
    • Genetic variants associated with LP(a) lipoprotein level and coronary disease
    • Clarke R, Peden JF, Hopewell JC et al.: Genetic variants associated with LP(a) lipoprotein level and coronary disease. N. Engl. J. Med. 361(26), 2518-2528 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.26 , pp. 2518-2528
    • Clarke, R.1    Peden, J.F.2    Hopewell, J.C.3
  • 70
    • 65549091967 scopus 로고    scopus 로고
    • Large scale association analysis of novel genetic loci for coronary artery disease
    • Samani NJ, Deloukas P, Erdmann J et al.: Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 29(5), 774-780 (2009).
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , Issue.5 , pp. 774-780
    • Samani, N.J.1    Deloukas, P.2    Erdmann, J.3
  • 71
    • 70349662968 scopus 로고    scopus 로고
    • Gene-gene and gene-environment interactions: New insights into the prevention, detection and management of coronary artery disease
    • Lanktree MB, Hegele RA: Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease. Genome Med. 1(2), 28 (2009).
    • (2009) Genome Med , vol.1 , Issue.2 , pp. 28
    • Lanktree, M.B.1    Hegele, R.A.2
  • 72
    • 0032510639 scopus 로고    scopus 로고
    • Prediction of coronary heart disease using risk factor categories
    • Wilson PW, D'Agostino RB, Levy D et al.: Prediction of coronary heart disease using risk factor categories. Circulation 97(18), 1837-1847 (1998).
    • (1998) Circulation , vol.97 , Issue.18 , pp. 1837-1847
    • Wilson, P.W.1    D'Agostino, R.B.2    Levy, D.3
  • 73
    • 33846996345 scopus 로고    scopus 로고
    • Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: The Reynolds Risk Score
    • Ridker PM, Buring JE, Rifai N, Cook NR: Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA 297(6), 611-619 (2007).
    • (2007) JAMA , vol.297 , Issue.6 , pp. 611-619
    • Ridker, P.M.1    Buring, J.E.2    Rifai, N.3    Cook, N.R.4
  • 74
    • 57749210419 scopus 로고    scopus 로고
    • C-reactive protein and parental history improve global cardiovascular risk prediction: The Reynolds Risk Score for men
    • 2244P following 2251
    • Ridker PM, Paynter NP, Rifai N, Gaziano JM, Cook NR: C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men. Circulation 118(22), 2243-2251, 2244P following 2251 (2008).
    • (2008) Circulation , vol.118 , Issue.22 , pp. 2243-2251
    • Ridker, P.M.1    Paynter, N.P.2    Rifai, N.3    Gaziano, J.M.4    Cook, N.R.5
  • 75
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 285(19), 2486-2497 (2001).
    • (2001) JAMA , vol.285 , Issue.19 , pp. 2486-2497
  • 76
    • 43549117072 scopus 로고    scopus 로고
    • Use of multiple biomarkers to improve the prediction of death from cardiovascular causes
    • Zethelius B, Berglund L, Sundstrom J et al.: Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. N. Engl. J. Med. 358(20), 2107-2116 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , Issue.20 , pp. 2107-2116
    • Zethelius, B.1    Berglund, L.2    Sundstrom, J.3
  • 77
    • 74049138315 scopus 로고    scopus 로고
    • Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    • Li S, Zhao JH, Luan J et al.: Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am. J. Clin. Nutr. 91(1), 184-190 (2010).
    • (2010) Am. J. Clin. Nutr. , vol.91 , Issue.1 , pp. 184-190
    • Li, S.1    Zhao, J.H.2    Luan, J.3
  • 78
    • 56349096931 scopus 로고    scopus 로고
    • Assessing the combined impact of 18 common genetic variants of modest effect sizes on Type 2 diabetes risk
    • Lango H, Palmer CN, Morris AD et al.: Assessing the combined impact of 18 common genetic variants of modest effect sizes on Type 2 diabetes risk. Diabetes 57(11), 3129-3135 (2008).
    • (2008) Diabetes , vol.57 , Issue.11 , pp. 3129-3135
    • Lango, H.1    Palmer, C.N.2    Morris, A.D.3
  • 79
    • 38849091997 scopus 로고    scopus 로고
    • Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond
    • discussion 207-1112
    • Pencina MJ, D'Agostino RB Sr, D'Agostino RB Jr, Vasan RS: Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat. Med. 27(2), 157-172; discussion 207-1112 (2008).
    • (2008) Stat. Med. , vol.27 , Issue.2 , pp. 157-172
    • Pencina, M.J.1    D'Agostino Sr., R.B.2    D'Agostino Jr., R.B.3    Vasan, R.S.4
  • 80
    • 71849117072 scopus 로고    scopus 로고
    • Predictive genetic testing for coronary artery disease
    • Johansen CT, Hegele RA: Predictive genetic testing for coronary artery disease. Crit. Rev. Clin. Lab. Sci. 46(5-6), 343-360 (2009).
    • (2009) Crit. Rev. Clin. Lab. Sci. , vol.46 , Issue.5-6 , pp. 343-360
    • Johansen, C.T.1    Hegele, R.A.2
  • 81
    • 58749087343 scopus 로고    scopus 로고
    • Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3
    • Paynter NP, Chasman DI, Buring JE et al.: Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann. Intern. Med. 150(2), 65-72 (2009).
    • (2009) Ann. Intern. Med. , vol.150 , Issue.2 , pp. 65-72
    • Paynter, N.P.1    Chasman, D.I.2    Buring, J.E.3
  • 82
    • 40449095630 scopus 로고    scopus 로고
    • Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men
    • Talmud PJ, Cooper JA, Palmen J et al.: Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men. Clin. Chem. 54(3), 467-474 (2008).
    • (2008) Clin. Chem. , vol.54 , Issue.3 , pp. 467-474
    • Talmud, P.J.1    Cooper, J.A.2    Palmen, J.3
  • 83
    • 70449513058 scopus 로고    scopus 로고
    • Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the atherosclerosis risk in communities study
    • Brautbar A, Ballantyne CM, Lawson K et al.: Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the atherosclerosis risk in communities study. Circ. Cardiovasc. Genet. 2(3), 279-285 (2009).
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , Issue.3 , pp. 279-285
    • Brautbar, A.1    Ballantyne, C.M.2    Lawson, K.3
  • 84
    • 40949149395 scopus 로고    scopus 로고
    • Polymorphisms associated with cholesterol and risk of cardiovascular events
    • Kathiresan S, Melander O, Anevski D et al.: Polymorphisms associated with cholesterol and risk of cardiovascular events. N. Engl. J. Med. 358(12), 1240-1249 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , Issue.12 , pp. 1240-1249
    • Kathiresan, S.1    Melander, O.2    Anevski, D.3
  • 85
    • 34249906772 scopus 로고    scopus 로고
    • Relevance of genetics and genomics for prevention and treatment of cardiovascular disease: A scientific statement from the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group
    • Arnett DK, Baird AE, Barkley RA et al.: Relevance of genetics and genomics for prevention and treatment of cardiovascular disease: a scientific statement from the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group. Circulation 115(22), 2878-2901 (2007).
    • (2007) Circulation , vol.115 , Issue.22 , pp. 2878-2901
    • Arnett, D.K.1    Baird, A.E.2    Barkley, R.A.3
  • 86
    • 2342486731 scopus 로고    scopus 로고
    • Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: A prospective study of parents and offspring
    • Lloyd-Jones DM, Nam BH, D'Agostino RB Sr et al.: Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA 291(18), 2204-2211 (2004).
    • (2004) JAMA , vol.291 , Issue.18 , pp. 2204-2211
    • Lloyd-Jones, D.M.1    Nam, B.H.2    D'Agostino Sr., R.B.3
  • 87
    • 29544440820 scopus 로고    scopus 로고
    • Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults
    • Murabito JM, Pencina MJ, Nam BH et al.: Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults. JAMA 294(24), 3117-3123 (2005).
    • (2005) JAMA , vol.294 , Issue.24 , pp. 3117-3123
    • Murabito, J.M.1    Pencina, M.J.2    Nam, B.H.3
  • 88
    • 28844499541 scopus 로고    scopus 로고
    • Women with a low Framingham Risk Score and a family history of premature coronary heart disease have a high prevalence of subclinical coronary atherosclerosis
    • Michos ED, Vasamreddy CR, Becker DM et al.: Women with a low Framingham Risk Score and a family history of premature coronary heart disease have a high prevalence of subclinical coronary atherosclerosis. Am. Heart J. 150(6), 1276-1281 (2005).
    • (2005) Am. Heart J. , vol.150 , Issue.6 , pp. 1276-1281
    • Michos, E.D.1    Vasamreddy, C.R.2    Becker, D.M.3
  • 89
    • 44349155333 scopus 로고    scopus 로고
    • Subclinical atherosclerosis in subjects with family history of premature coronary artery disease
    • Taraboanta C, Wu E, Lear S et al.: Subclinical atherosclerosis in subjects with family history of premature coronary artery disease. Am. Heart J. 155(6), 1020.E1-1026.E1 (2008).
    • (2008) Am. Heart J. , vol.155 , Issue.6
    • Taraboanta, C.1    Wu, E.2    Lear, S.3
  • 90
    • 67849111532 scopus 로고    scopus 로고
    • Family history and risk for ischemic stroke: Sibling history is more strongly correlated with the disease than parental history
    • Choi JC, Lee JS, Kang SY, Kang JH, Bae JM: Family history and risk for ischemic stroke: sibling history is more strongly correlated with the disease than parental history. J. Neurol. Sci. 284(1-2), 29-32 (2009).
    • (2009) J. Neurol. Sci. , vol.284 , Issue.1-2 , pp. 29-32
    • Choi, J.C.1    Lee, J.S.2    Kang, S.Y.3    Kang, J.H.4    Bae, J.M.5
  • 91
    • 34548168900 scopus 로고    scopus 로고
    • Family history of premature coronary heart disease and coronary artery calcification: Multi-Ethnic Study of Atherosclerosis (MESA)
    • Nasir K, Budoff MJ, Wong ND et al.: Family history of premature coronary heart disease and coronary artery calcification: Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 116(6), 619-626 (2007).
    • (2007) Circulation , vol.116 , Issue.6 , pp. 619-626
    • Nasir, K.1    Budoff, M.J.2    Wong, N.D.3
  • 92
    • 0041572910 scopus 로고    scopus 로고
    • Carotid intima-media thickness is associated with premature parental coronary heart disease: The Framingham Heart Study
    • Wang TJ, Nam BH, D'Agostino RB et al.: Carotid intima-media thickness is associated with premature parental coronary heart disease: the Framingham Heart Study. Circulation 108(5), 572-576 (2003).
    • (2003) Circulation , vol.108 , Issue.5 , pp. 572-576
    • Wang, T.J.1    Nam, B.H.2    D'Agostino, R.B.3
  • 93
    • 0025167629 scopus 로고
    • Parental history is an independent risk factor for coronary artery disease: The Framingham Study
    • Myers RH, Kiely DK, Cupples LA, Kannel WB: Parental history is an independent risk factor for coronary artery disease: the Framingham Study. Am. Heart J. 120(4), 963-969 (1990).
    • (1990) Am. Heart J. , vol.120 , Issue.4 , pp. 963-969
    • Myers, R.H.1    Kiely, D.K.2    Cupples, L.A.3    Kannel, W.B.4
  • 94
    • 67649516627 scopus 로고    scopus 로고
    • Predicting the 30-year risk of cardiovascular disease: The Framingham Heart Study
    • Pencina MJ, D'Agostino RB Sr, Larson MG, Massaro JM, Vasan RS: Predicting the 30-year risk of cardiovascular disease: the Framingham Heart Study. Circulation 119(24), 3078-3084 (2009).
    • (2009) Circulation , vol.119 , Issue.24 , pp. 3078-3084
    • Pencina, M.J.1    D'Agostino Sr., R.B.2    Larson, M.G.3    Massaro, J.M.4    Vasan, R.S.5
  • 95
    • 0035811026 scopus 로고    scopus 로고
    • High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: Evidence from intravascular ultrasound
    • Tuzcu EM, Kapadia SR, Tutar E et al.: High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasound. Circulation 103(22), 2705-2710 (2001).
    • (2001) Circulation , vol.103 , Issue.22 , pp. 2705-2710
    • Tuzcu, E.M.1    Kapadia, S.R.2    Tutar, E.3
  • 96
    • 34548736492 scopus 로고    scopus 로고
    • Association of apolipoprotein e genotypes with lipid levels and coronary risk
    • Bennet AM, Di Angelantonio E, Ye Z et al.: Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA 298(11), 1300-1311 (2007).
    • (2007) JAMA , vol.298 , Issue.11 , pp. 1300-1311
    • Bennet, A.M.1    Di Angelantonio, E.2    Ye, Z.3
  • 97
    • 52349083201 scopus 로고    scopus 로고
    • Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease - A Mendelian randomisation study
    • Linsel-Nitschke P, Gotz A, Erdmann J et al.: Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease - a Mendelian randomisation study. PLoS One 3(8), E2986 (2008).
    • (2008) PLoS One , vol.3 , Issue.8
    • Linsel-Nitschke, P.1    Gotz, A.2    Erdmann, J.3
  • 98
    • 65949099120 scopus 로고    scopus 로고
    • Genetic risk prediction - Are we there yet?
    • Kraft P, Hunter DJ: Genetic risk prediction - are we there yet? N. Engl. J. Med. 360(17), 1701-1703 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.17 , pp. 1701-1703
    • Kraft, P.1    Hunter, D.J.2
  • 99
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies - The next generation
    • Metzker ML: Sequencing technologies - the next generation. Nat. Rev. Genet. 11(1), 31-46 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , Issue.1 , pp. 31-46
    • Metzker, M.L.1
  • 100
    • 32444441330 scopus 로고    scopus 로고
    • Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels
    • Cohen JC, Pertsemlidis A, Fahmi S et al.: Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels. Proc. Natl Acad. Sci. USA 103(6), 1810-1815 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.6 , pp. 1810-1815
    • Cohen, J.C.1    Pertsemlidis, A.2    Fahmi, S.3
  • 101
    • 3843056691 scopus 로고    scopus 로고
    • Multiple rare alleles contribute to low plasma levels of HDL cholesterol
    • Cohen JC, Kiss RS, Pertsemlidis A et al.: Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science 305(5685), 869-872 (2004).
    • (2004) Science , vol.305 , Issue.5685 , pp. 869-872
    • Cohen, J.C.1    Kiss, R.S.2    Pertsemlidis, A.3
  • 102
    • 34047177395 scopus 로고    scopus 로고
    • Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL
    • Romeo S, Pennacchio LA, Fu Y et al.: Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat. Genet. 39(4), 513-516 (2007).
    • (2007) Nat. Genet. , vol.39 , Issue.4 , pp. 513-516
    • Romeo, S.1    Pennacchio, L.A.2    Fu, Y.3
  • 103
    • 61749090233 scopus 로고    scopus 로고
    • Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans
    • Romeo S, Yin W, Kozlitina J et al.: Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. J. Clin. Invest. 119(1), 70-79 (2009).
    • (2009) J. Clin. Invest. , vol.119 , Issue.1 , pp. 70-79
    • Romeo, S.1    Yin, W.2    Kozlitina, J.3
  • 104
    • 36048975597 scopus 로고    scopus 로고
    • Resequencing genomic DNA of patients with severe hypertriglyceridemia (MIM 144650)
    • Wang J, Cao H, Ban MR et al.: Resequencing genomic DNA of patients with severe hypertriglyceridemia (MIM 144650). Arterioscler. Thromb. Vasc. Biol. 27(11), 2450-2455 (2007).
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , Issue.11 , pp. 2450-2455
    • Wang, J.1    Cao, H.2    Ban, M.R.3
  • 106
    • 34250735539 scopus 로고    scopus 로고
    • Copy number variation in the human genome and its implications for cardiovascular disease
    • Pollex RL, Hegele RA: Copy number variation in the human genome and its implications for cardiovascular disease. Circulation 115(24), 3130-3138 (2007).
    • (2007) Circulation , vol.115 , Issue.24 , pp. 3130-3138
    • Pollex, R.L.1    Hegele, R.A.2
  • 107
    • 41649090385 scopus 로고    scopus 로고
    • 'Deep phenotyping': Characterizing populations in the era of genomics and systems biology
    • Tracy RP: 'Deep phenotyping': characterizing populations in the era of genomics and systems biology. Curr. Opin. Lipidol. 19(2), 151-157 (2008).
    • (2008) Curr. Opin. Lipidol. , vol.19 , Issue.2 , pp. 151-157
    • Tracy, R.P.1
  • 108
    • 77954407941 scopus 로고    scopus 로고
    • Phenomics: Expanding the role of clinical evaluation in genomic studies
    • Lanktree MB, Hassell RG, Lahiry P, Hegele RA: Phenomics: expanding the role of clinical evaluation in genomic studies. J. Investig. Med. 58(5), 700-706 (2010).
    • (2010) J. Investig. Med. , vol.58 , Issue.5 , pp. 700-706
    • Lanktree, M.B.1    Hassell, R.G.2    Lahiry, P.3    Hegele, R.A.4
  • 109
    • 0037322022 scopus 로고    scopus 로고
    • 'Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease?
    • Davey Smith G, Ebrahim S: 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int. J. Epidemiol. 32(1), 1-22 (2003).
    • (2003) Int. J. Epidemiol. , vol.32 , Issue.1 , pp. 1-22
    • Davey Smith, G.1    Ebrahim, S.2
  • 110
    • 84925568290 scopus 로고    scopus 로고
    • International HapMap Consortium website
    • International HapMap Consortium website http://hapmap.ncbi.nlm.nih.gov/ guidelines- hapmap-data.html


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.