Predictive genetic testing for coronary artery disease

Critical Reviews in Clinical Laboratory Sciences

Volumn 46, Issue 5-6, 2009, Pages 343-360

  Johansen, Christopher T ^a   Hegele, Robert A ^a  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Algorithm; Cardiovascular diagnostic techniques; Cardiovascular disease; Epidemiology; Forecasting; Genetic variation; Genomics; Odds ratios; Predisposition testing; Risk; Risk assessment; Risk factors

Indexed keywords

C REACTIVE PROTEIN; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN;

ALGORITHM; BLOOD PRESSURE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY RISK; DIABETES MELLITUS; DIAGNOSTIC VALUE; DISEASE COURSE; DISEASE PREDISPOSITION; FAMILY HISTORY; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HUMAN; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING;

ALGORITHMS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 9; CORONARY ARTERY DISEASE; FAMILY HEALTH; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENETIC VARIATION; HUMANS; MOLECULAR DIAGNOSTIC TECHNIQUES; PREDICTIVE VALUE OF TESTS; RISK ASSESSMENT;

EID: 71849117072     PISSN: 10408363     EISSN: 1549781X     Source Type: Journal    
DOI: 10.3109/07388550903422075     Document Type: Review

References (112)

1. Roy H, Bhardwaj S, Yla-Herttuala S. Molecular genetics of atherosclerosis. Hum Genet 2009; 126: 467-491.
2. Libby P, Teroux P. Pathophysiology of coronary artery disease. Circulation 2005; 111: 3481-3488.
3. Rader DJ, Daugherty A. Translating molecular discoveries into new therapies for atherosclerosis. Nature 2008; 451: 904-913.
4. Lusis AJ, Fogelman AM, Fonarow GC. Genetic basis of atherosclerosis: part I: new genes and pathways. Circulation 2004; 110: 1868-1873.
5. Pollex RL, Hegele RA. Copy number variation in the human genome and its implications for cardiovascular disease. Circulation 2007; 115: 3130-3138.
6. Redon R, Ishikawa S, Fitch KR, Feuk L, Perry GH, Andrews TD et al. Global variation in copy number in the human genome. Nature 2006; 444: 444-454. (Pubitemid 44809057)
7. Hurles ME, Dermitzakis ET, Tyler-Smith C. Te functional impact of structural variation in humans. Trends Genet 2008; 24: 238-245.
8. Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, Mannucci PM et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 2009; 41: 334-341.
9. Belmont JW, Leal SM. Complex phenotypes and complex genetics: an introduction to genetic studies of complex traits. Curr Atheroscler Rep 2005; 7: 180-187.
10. Pollex RL, Hegele RA. Complex trait locus linkage mapping in atherosclerosis: time to take a step back before moving forward? Arterioscler Tromb Vasc Biol 2005; 25: 1541-1544.
11. Yamada Y, Ichihara S, Nishida T. Molecular genetics of myo-cardial infarction. Genomic Med 2008; 2: 7-22.
12. Tousoulis D, Briasoulis A, Papageorgiou N, Antoniades C, Stefanadis C. Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes. Trends Mol Med 2008; 14: 441-449.
13. Iles MM. What can genome-wide association studies tell us about the genetics of common disease? PLoS Genet 2008; 4: e33.
14. Pearson TA, Manolio TA. How to interpret a genome-wide association study. JAMA 2008; 299: 1335-1344.
15. Hegele RA. SNP judgments and freedom of association. Arterioscler Tromb Vasc Biol 2002; 22: 1058-1061.
16. Attia J, Ioannidis JP, Takkinstian A, McEvoy M, Scott RJ, Minelli C et al. How to use an article about genetic association: C: What are the results and will they help me in caring for my patients? JAMA 2009; 301: 304-308.
17. Attia J, Ioannidis JP, Takkinstian A, McEvoy M, Scott RJ, Minelli C et al. How to use an article about genetic association: B: Are the results of the study valid? JAMA 2009; 301: 191-197.
18. Attia J, Ioannidis JP, Takkinstian A, McEvoy M, Scott RJ, Minelli C et al. How to use an article about genetic association: A: Background concepts. JAMA 2009; 301: 74-81.
19. Ioannidis JPA. Prediction of Cardiovascular Disease Outcomes and Established Cardiovascular Risk Factors by Genome-Wide Association Markers. Circ Cardiovasc Genet 2009; 2: 7-15.
20. McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR et al. A common allele on chromosome 9 associated with coronary heart disease. Science 2007; 316: 1488-1491
21. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661-678.
22. Helgadottir A, Torleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A et al. A common variant on chromosome 9p21 afects the risk of myocardial infarction. Science 2007; 316: 1491-1493. (Pubitemid 46906618)
23. Broadbent HM, Peden JF, Lorkowski S, Goel A, Ongen H, Green F et al. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Hum Mol Genet 2008; 17: 806-814.
24. Jarinova O, Stewart AF, Roberts R, Wells G, Lau P, Naing T et al. Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus. Arterioscler Tromb Vasc Biol 2009; 29: 1671-1677.
25. Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B et al. Genomewide association analysis of coronary artery disease. N Engl J Med 2007; 357: 443-453. (Pubitemid 47204873)
26. Helgadottir A, Torleifsson G, Magnusson KP, Gretarsdottir S, Steinthorsdottir V, Manolescu A et al. Te same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 2008; 40: 217-224.
27. Schunkert H, Gotz A, Braund P, McGinnis R, Tregouet DA, Mangino M et al. Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation 2008; 117: 1675-1684.
28. Ye S, Willeit J, Kronenberg F, Xu Q, Kiechl S. Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study. J Am Coll Cardiol 2008; 52: 378-384.
29. Tompson AR, Golledge J, Cooper JA, Hafez H, Norman PE, Humphries SE. Sequence variant on 9p21 is associated with the presence of abdominal aortic aneurysm disease but does not have an impact on aneurysmal expansion. Eur J Hum Genet 2009; 17: 391-394.
30. Abdullah KG, Li L, Shen GQ, Hu Y, Yang Y, MacKinlay KG et al. Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest). Ann Hum Genet 2008; 72: 654-657.
31. Muendlein A, Saely CH, Rhomberg S, Sonderegger G, Loacker S, Rein P et al. Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease. Atherosclerosis 2009; 205: 174-180.
32. Lemmens R, Abboud S, Robberecht W, Vanhees L, Pandolfo M, Tijs V et al. Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke. Eur J Hum Genet 2009; 17: 1287-1293.
33. Karvanen J, Silander K, Kee F, Tiret L, Salomaa V, Kuulasmaa K et al. Te impact of newly identifed loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol 2009; 33: 237-246.
34. Shen GQ, Li L, Rao S, Abdullah KG, Ban JM, Lee BS et al. Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease. Arterioscler Tromb Vasc Biol 2008; 28: 360-365.
35. Shen GQ, Rao S, Martinelli N, Li L, Olivieri O, Corrocher R et al. Association between four SNPs on chromosome. 9p21 and myocardial infarction is replicated in an Italian population. J Hum Genet 2008; 53: 144-150.
36. Zhou L, Zhang X, He M, Cheng L, Chen Y, Hu FB et al. Associations between single nucleotide polymorphisms on chromosome 9p21 and risk of coronary heart disease in Chinese Han population. Arterioscler Tromb Vasc Biol 2008; 28: 2085-2089.
37. Assimes TL, Knowles JW, Basu A, Iribarren C, Southwick A, Tang H et al. Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. Hum Mol Genet 2008; 17: 2320-2328.
38. Horne BD, Carlquist JF, Muhlestein JB, Bair TL, Anderson JL. Association of Variation in the Chromosome 9p21 Locus With Myocardial Infarction Versus Chronic Coronary Artery Disease. Circ Cardiovasc Genet 2008; 1: 85-92.
39. Cluett C, McDermott MM, Guralnik J, et al. Te 9p21 Myocardial Infarction Risk Allele Increases Risk of Peripheral Artery Disease in Older People. Circ Cardiovasc Genet 2009; 2(4):347-353.
40. Bjorck HM, Lanne T, Alehagen U, Persson K, Rundkvist L, Hamsten A et al. Association of genetic variation on chromosome 9p21.3 and arterial stifness. J Intern Med 2009; 265: 373-381.
41. Samani NJ, Raitakari OT, Sipila K, Tobin MD, Schunkert H, Juonala M et al. Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis. Arterioscler Tromb Vasc Biol 2008; 28: 1679-1683.
42. Wahlstrand B, Orho-Melander M, Delling L, Kjeldsen S, Narkiewicz K, Almgren P et al. Te myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension. J Hypertens 2009; 27: 769-773.
43. Cunnington MS, Mayosi BM, Hall DH, Avery PJ, Farrall M, Vickers MA et al. Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes. Atherosclerosis 2009; 203: 41-44.
44. Smith JG, Melander O, Lovkvist H, Hedblad B, Engstrom G, Nilsson P et al. Common Genetic Variants on Chromosome 9p21 Confers Risk of Ischemic Stroke: A Large-Scale Genetic Association Study. Circ Cardiovasc Genet 2009; 2: 159-164.
45. Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP et al. Loci infuencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 2009; 41: 47-55.
46. Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 2008; 40: 189-197.
47. Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, Warnes GR et al. Genome-wide scan identifes variation in MLXIPL associated with plasma triglycerides. Nat Genet 2008; 40: 149-151.
48. Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 2009; 41: 35-46.
49. Sandhu MS, Waterworth DM, Debenham SL, Wheeler E, Papadakis K, Zhao JH et al. LDL-cholesterol concentrations: a genome-wide association study. Lancet 2008; 371: 483-491.
50. Saxena R, Voight B F, Lyssenko V, Burtt NP, de Bakker PI, Chen H et al. Genome-wide association analysis identifes loci for type 2 diabetes and triglyceride levels. Science 2007; 316: 1331-1336.
51. Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M et al. Genome-wide association study identifes genes for biomarkers of cardiovascular disease: serum urate and dys-lipidemia. Am J Hum Genet 2008; 82: 139-149.
52. Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R et al. Newly identifed loci that infuence lipid concentrations and risk of coronary artery disease. Nat Genet 2008; 40: 161-169.
53. Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2009; 41: 56-65.
54. Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A et al. Genome-wide association study of blood pressure and hypertension. Nat Genet 2009 (in press).
55. Hinney A, Nguyen TT, Scherag A, Friedel S, Bronner G, Muller TD et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS ONE 2007; 2: e1361.
56. Meyre D, Delplanque J, Chevre JC, Lecoeur C, Lobbens S, Gallina S et al. Genome-wide association study for early-onset and morbid adult obesity identifes three new risk loci in European populations. Nat Genet 2009; 41: 157-159.
57. Org E, Eyheramendy S, Juhanson P, Gieger C, Lichtner P, Klopp N et al. Genome-wide scan identifes CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. Hum Mol Genet 2009; 18: 2288-2296.
58. Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L et al. Genome-wide association study identifes eight loci associated with blood pressure. Nat Genet 2009 (in press).
59. Lanktree MB, Hegele RA. Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease. Genome Med 2009; 1: 28.
60. Lanktree MB, Anand SS, Yusuf S, Hegele RA. Replication of genetic associations with plasma lipoproteins and triglycer-ides in a multi-ethnic sample using a targeted cardiovascular SNP microarray. J Lipid Res 2009; 50: 1487-1496.
61. Niemiec P, Zak I, Wita K. Te risk of coronary artery disease associated with cigarette smoking and hypercholesterolemia is additionally increased by the presence of the AT1R gene 1166C allele. Biochem Genet 2008; 46: 799-809.
62. Manfredi S, Federici C, Picano E, Botto N, Rizza A, Andreassi MG. GSTM1, GSTT1 and CYP1A1 detoxifcation gene polymorphisms and susceptibility to smoking-related coronary artery disease: a case-only study. Mutat Res 2007; 621: 106-112.
63. Lanktree M, Oh J, Hegele RA. Genetic testing for atherosclerosis risk: inevitability or pipe dream? Can J Cardiol 2008; 24: 851-854.
64. Polychronakos C. Common and rare alleles as causes of complex phenotypes. Curr Atheroscler Rep 2008; 10: 194-200.
65. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation 1998; 97: 1837-1847.
66. Assmann G, Cullen P, Schulte H. Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Munster (PROCAM) study. Circulation 2002; 105: 310-315.
67. Morrison AC, Bare LA, Chambless LE, Ellis SG, Malloy M, Kane JP et al. Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. Am J Epidemiol 2007; 166: 28-35.
68. Vrentzos GE, Papadakis JA, Ganotakis ES, Paraskevas KI, Gazi IF, Tzanakis N et al. Predicting coronary heart disease risk using the Framingham and PROCAM equations in dyslipidaemic patients without overt vascular disease. Int J Clin Pract 2007; 61: 1643-1653
69. Executive Summary of Te Tird Report of Te National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001, 285, 2486-2497.
70. Ridker PM, Buring JE, Rifai N, Cook NR. Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA 2007; 297: 611-619.
71. Ridker PM, Paynter NP, Rifai N, Gaziano JM, Cook NR. C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men. Circulation 2008; 118: 2243-2251.
72. Zethelius B, Berglund L, Sundstrom J, Ingelsson E, Basu S, Larsson A et al. Use of multiple biomarkers to improve the prediction of death from cardiovascular causes. N Engl J Med 2008; 358: 2107-2116.
73. Appleby N, Edwards D, Batley J. New technologies for ultra-high throughput genotyping in plants. Methods Mol Biol 2009; 513: 19-39.
74. Shen Y, Wu BL. Microarray-based genomic DNA profling technologies in clinical molecular diagnostics. Clin Chem 2009; 55: 659-669.
75. Carter NP. Methods and strategies for analyzing copy number variation using DNA microarrays. Nat Genet 2007; 39: S16-21.
76. Estivill X, Armengol L. Copy number variants and common disorders: flling the gaps and exploring complexity in genome-wide association studies. PLoS Genet 2007; 3: 1787-1799.
77. Pencina MJ, D'Agostino RB, Sr., D'Agostino RB, Jr., Vasan RS. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassifcation and beyond. Stat Med 2008; 27: 157-172; discussion 207-1112.
78. Cook NR. Comments on 'Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassifcation and beyond' by M. J. Pencina et al., Statistics in Medicine (DOI: 10.1002/sim.2929). Stat Med 2008; 27: 191-195.
79. Paynter NP, Chasman DI, Buring JE, Shifman D, Cook NR, Ridker PM. Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med 2009; 150: 65-72.
80. Brautbar A, Ballantyne CM, Lawson K, Nambi V, Chambless L, Folsom AR et al. Impact of Adding a Single Allele in the 9p21 Locus to Traditional Risk Factors on Reclassifcation of Coronary Heart Disease Risk and Implications for Lipid-Modifying Terapy in the Atherosclerosis Risk in Communities Study. Circ Cardiovasc Genet 2009; 2: 279-285.
81. Kathiresan S, Melander O, Anevski D, Guiducci C, Burtt NP, Roos C et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med 2008; 358: 1240-1249.
82. Talmud PJ, Cooper JA, Palmen J, Lovering R, Drenos F, Hingorani AD et al. Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men. Clin Chem 2008; 54: 467-474.
83. Janssens AC, Aulchenko YS, Elefante S, Borsboom GJ, Steyerberg EW, van Duijn CM. Predictive testing for complex diseases using multiple genes: fact or fction? Genet Med 2006; 8: 395-400.
84. van Vliet J, Oates NA, Whitelaw E. Epigenetic mechanisms in the context of complex diseases. Cell Mol Life Sci 2007; 64: 1531-1538.
85. Arnett DK, Baird AE, Barkley RA, Basson CT, Boerwinkle E, Ganesh SK et al. Relevance of genetics and genomics for prevention and treatment of cardiovascular disease: a scientifc statement from the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group. Circulation 2007; 115: 2878-2901.
86. Lloyd-Jones DM, Nam BH, D'Agostino RB, Sr., Levy D, Murabito JM, Wang TJ et al. Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and ofspring. JAMA 2004; 291: 2204-2211.
87. Murabito JM, Pencina MJ, Nam BH, D'Agostino RB, Sr., Wang TJ, Lloyd-Jones D et al. Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults. JAMA 2005; 294: 3117-3123.
88. Michos ED, Vasamreddy CR, Becker DM, Yanek LR, Moy TF, Fishman EK et al. Women with a low Framingham risk score and a family history of premature coronary heart disease have a high prevalence of subclinical coronary atherosclerosis. Am Heart J 2005; 150: 1276-1281.
89. Taraboanta C, Wu E, Lear S, DiPalma S, Hill J, Mancini GB et al. Subclinical atherosclerosis in subjects with family history of premature coronary artery disease. Am Heart J 2008; 155: 1020-1026 e1021.
90. Myers RH, Kiely DK, Cupples LA, Kannel WB. Parental history is an independent risk factor for coronary artery disease: the Framingham Study. Am Heart J 1990; 120: 963-969.
91. Nasir K, Budof MJ, Wong ND, Scheuner M, Herrington D, Arnett DK et al. Family history of premature coronary heart disease and coronary artery calcifcation: Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2007; 116: 619-626.
92. Choi JC, Lee JS, Kang SY, Kang JH, Bae JM. Family history and risk for ischemic stroke: Sibling history is more strongly correlated with the disease than parental history. J Neurol Sci 2009; 284: 29-32.
93. Wang TJ, Nam BH, D'Agostino RB, Wolf PA, Lloyd-Jones DM, MacRae CA et al. Carotid intima-media thickness is associated with premature parental coronary heart disease: the Framingham Heart Study. Circulation 2003; 108: 572-576.
94. Goldstein DB. Common genetic variation and human traits. N Engl J Med 2009; 360: 1696-1698.
95. Hirschhorn JN. Genomewide association studies--illuminat-ing biologic pathways. N Engl J Med 2009; 360: 1699-1701.
96. Kraft P, Hunter DJ. Genetic risk prediction--are we there yet? N Engl J Med 2009; 360: 1701-1703.
97. Hardy J, Singleton A. Genomewide association studies and human disease. N Engl J Med 2009; 360: 1759-1768.
98. Janssens AC, van Duijn CM. Genome-based prediction of common diseases: methodological considerations for future research. Genome Med 2009; 1: 20.
99. Janssens AC, van Duijn CM. Genome-based prediction of common diseases: advances and prospects. Hum Mol Genet 2008; 17: R166-173.
100. Steinberg D, Glass CK, Witztum JL. Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation 2008; 118: 672-677.
101. Pencina MJ, D'Agostino RB, Sr., Larson MG, Massaro JM, Vasan RS. Predicting the 30-year risk of cardiovascular disease: the framingham heart study. Circulation 2009; 119: 3078-3084.
102. Costet P, Krempf M, Cariou B. PCSK9 and LDL cholesterol: unravelling the target to design the bullet. Trends Biochem Sci 2008; 33: 426-434.
103. Hegele RA. Plasma lipoproteins: genetic infuences and clinical implications. Nat Rev Genet 2009; 10: 109-121.
104. Cohen JC, Boerwinkle E, Mosley TH, Jr., Hobbs HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006; 354: 1264-1272.
105. Huang C-C, Fornage M, Lloyld-Jones DM, Wei GS, Boerwinkle E, Liu K. Longitudinal Association of PCSK9 Sequence Variations with Low-Density Lipoprotein Cholesterol Levels: Te Coronary Artery Risk Development in Young Adults Study. Circ Cardiovasc Genet 2009; 2(4):354-361.
106. Tuzcu EM, Kapadia SR, Tutar E, Ziada KM, Hobbs RE, McCarthy PM et al. High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasound. Circulation 2001; 103: 2705-2710.
107. Lloyd-Jones DM, Larson MG, Beiser A, Levy D. Lifetime risk of developing coronary heart disease. Lancet 1999; 353: 89-92.
108. Lloyd-Jones DM, Leip E P, Larson MG, D'Agostino RB, Beiser A, Wilson PW et al. Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age. Circulation 2006; 113: 791-798.
109. Anderson KM, Wilson PW, Odell PM, Kannel WB. An updated coronary risk profle. A statement for health professionals. Circulation 1991; 83: 356-362.
110. Kannel WB, Feinleib M, McNamara PM, Garrison RJ, Castelli WP. An investigation of coronary heart disease in families. Te Framingham ofspring study. Am J Epidemiol 1979; 110: 281-290.
111. Ridker PM, Cook NR, Lee IM, Gordon D, Gaziano JM, Manson JE et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 2005; 352: 1293-1304.
112. Christen WG, Gaziano JM, Hennekens CH. Design of Physicians' Health Study II--a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials. Ann Epidemiol 2000; 10: 125-134.