Will the pig solve the transplantation backlog?

Annual Review of Medicine

Volumn 53, Issue , 2002, Pages 133-147

  Cooper, David K C ^a   Gollackner, Bernd ^a   Sachs, David H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Antibodies; Complement; Primate; Rejection; Xenotransplantation

Indexed keywords

ANTIBODY;

BLOOD CLOTTING; CELLULAR IMMUNITY; GRAFT REJECTION; HISTOCOMPATIBILITY; HUMAN; HUMORAL IMMUNITY; IMMUNOLOGICAL TOLERANCE; NONHUMAN; ORGAN TRANSPLANTATION; PRIMATE; PRIORITY JOURNAL; REVIEW; SWINE; XENOTRANSPLANTATION;

ANIMALS; FORECASTING; GRAFT REJECTION; HUMANS; ORGAN TRANSPLANTATION; SWINE; TISSUE DONORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0036181018     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.53.082901.103900     Document Type: Review

References (46)

1. Clinical xenotransplantation - Past, present and future
2. Renal heterotransplantation in man
3. The pig as potential organ donor for man
4. The pig as a potential xenograft donor
5. MHC homozygous miniature swine
6. The generation of transgenic pigs as potential organ donors for humans
7. The interaction between the human natural anti-α-galactosyl IgG (anti-Gal) and bacteria of the human flora
8. Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation
9. Experimental renal transplantation. 1. In widely divergent species
10. Identification of carbohydrate structures which bind human antiporcine antibodies: Implications for discordant xenografting in man
11. Oligosaccharides and discordant xenotransplantation
12. Venular thrombosis is the key event in the pathogenesis of antibody-mediated cardiac rejection
13. Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon
14. Xenotransplantation of pig kidneys to nonhuman primates: Development of the model
15. Anti-Gal IgG antibodies in sera of newborn humans and baboons and its significance in pig xenotransplantation
16. Binding of natural antibodies to non alpha Gal xeno-antigens on porcine erythrocytes
17. Discordant organ xenotransplantation in primates - World experience and current status
18. Xenotransplantation
19. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates
20. Acute humoral xenograft rejection: Destruction of the microvascular capillary endothelium in pig-to-nonhuman primate renal grafts
21. Differentiating acute humoral from acute cellular rejection histopathologically
22. High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response
23. The problem of anti-pig antibodies in pig-to-primate xenografting: Current and novel methods of depletion and/or suppression of production of anti-pig antibodies
24. Disordered regulation of coagulation and platelet activation in xenotransplantation
25. Evidence that intravenously administered α-galactosyl carbohydrates reduce baboon serum cytotoxicity to pig kidney cells (PK15) and transplanted pig hearts
26. In vivo immunoadsorption of anti-pig antibodies in baboons using a specific Galα 1-3Gal column
27. Depletion of anti-Galα 1-3Gal antibody in baboons by specific alpha-Gal immunoaffinity columns
28. Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galα1-3Galβ1-4βGlc-X immunoaffinity column
29. Depletion of anti-Gal antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to Gal oligosaccharides
30. Effects of specific anti-B and/or anti-plasma cell immunotherapy on antibody production in baboons: Depletion of CD20/CD22-positive B cells does not result in significant decreased production of anti-αGal antibody
31. Understanding the immune protection afforded by endogenous complement regulatory molecules
32. Cell-mediated xenograft rejection
33. Mixed chimerism as an approach to transplantation tolerance
34. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys
35. Inhibition of xenoreactive natural antibody production by retroviral gene therapy
36. Skin graft tolerance across a discordant xenogeneic barrier
37. Thymic transplantation in miniature swine. II. Induction of tolerance by transplantation of composite thymokidneys to thymectomized recipients
38. Evolution: Its complexity and impact on xenotransplantation
39. An assessment of the risk of xenozoonotic disease in pig-to-human xenotransplantation
40. Endogenous retroviruses in xenografts
41. Infection of human cells by an endogenous retrovirus of pigs
42. The dangers of xenotransplantation
43. Search for cross-species transmission of porcine endogenous retrovirus in patients with living pig tissue
44. Legal implications of xenotransplantation