An investigation of the specificity of induced anti-pig antibodies in baboons

Xenotransplantation

Volumn 10, Issue 1, 2003, Pages 88-93

  Buhler, L ^a   Xu, Y ^b   Li, W ^b   Zhu, A ^c   Cooper, D K C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Immerge Biotherapeutics Inc   (United States)

^c NEW YORK BLOOD CENTER   (United States)

Author keywords

Natural antibody; Pig to non human primate; Sensitization; Xenotransplantation

Indexed keywords

ALPHA 1,3 GALACTOSYLGALACTOSE ANTIBODY; ALPHA GALACTOSIDASE; ANTIBODY; CARBOHYDRATE; EPITOPE; GALACTOSYLGALACTOSE; LEUKOCYTE ANTIGEN; OLIGOSACCHARIDE; UNCLASSIFIED DRUG; ALPHA N ACETYLGALACTOSAMINIDASE; BETA GALACTOSIDASE; BETA N ACETYLHEXOSAMINIDASE; HETEROPHILE ANTIBODY; HETEROPHILE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCING CELL; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; BABOON; BLOOD TRANSFUSION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE; FLOW CYTOMETRY; HEART GRAFT; IN VITRO STUDY; KIDNEY GRAFT; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; STEM CELL; SWINE; XENOTRANSPLANTATION; ANIMAL; ARTICLE; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNOLOGY; KIDNEY TRANSPLANTATION; PAPIO; XENOGRAFT;

ALPHA-GALACTOSIDASE; ALPHA-N-ACETYLGALACTOSAMINIDASE; ANIMALS; ANTIBODIES, HETEROPHILE; ANTIBODY SPECIFICITY; ANTIGENS, HETEROPHILE; BETA-GALACTOSIDASE; BETA-N-ACETYLHEXOSAMINIDASE; GRAFT REJECTION; HEART TRANSPLANTATION; HEXOSAMINIDASES; KIDNEY TRANSPLANTATION; PAPIO; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0037997322     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3089.2003.01122.x     Document Type: Conference Paper

References (15)

1. GOOD AH, COOPER DKC, MALCOLM AJ et al. Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans. Transplant Proc 1992; 24: 559.
2. ZHU A. Binding of human natural antibodies to non-αGal xenoantigens on porcine erythrocytes. Transplantation 2000; 69: 2422.
3. COOPER DKC. Xenoantigens and xenoantibodies. Xenotransplantation 1998; 5: 6.
4. KOZLOWSKI T, SHIMIZU A, LAMBRIGTS D et al. Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption. Transplantation 1999; 67: 18.
5. BUHLER L, YAMADA K, KITAMURA H et al. Pig kidney transplantation in baboons: anti-Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. Transplantation 2001; 72: 1743.
6. GALILI U, LATEMPLE DC, WALGENBACH AW, STONE KR. Porcine and bovine cartilage transplants in cynomolgus monkeys. II. Changes in anti-gal response during chronic rejection. Transplantation 1997; 63: 646.
7. SACHS DH, LEIGHT G, CONE J, SCHWARZ S, STUART L, ROSENBERG S. Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. Transplantation 1976; 22: 559.
8. KOZLOWSKI T, MONROY R, XU Y et al. Anti-alphaGal antibody response to porcine bone marrow in unmodified baboons and baboons conditioned for tolerance induction. Transplantation 1998; 66: 176.
9. HOLGERSSON J, BREIMER ME, SAMUELSSON BE. Basic biochemistry of cell surface carbohydrates and aspects of the tissue distribution of histo-blood group ABH and related glycosphinglolipids. APMIS Suppl 1992; 27: 18.
10. GOLDSTEIN J. Conversion of ABO blood groups. Transfus Med Rev 1989; 3: 206.
11. XU Y, LORF T, SABLINSKI T et al. Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galα1Galβ1βGlc-X immunoaffinity column. Transplantation 1998; 65: 172.
12. MAGNUSSON S, STROKAN V, MANSSON JE et al. N-glycolylneuraminic acid terminated ganglioside xenoantigens of pig lymphocytes elicit immune response in humans after pig kidney xenoperfusion. Nagoya, Japan: Presented at the 5th Congress of the International Xenotransplantation Association, 1999.
13. KOBAYASHI T, YOKOYAMA I, SUZUKI A et al. Lack of antibody production against Hanganutziu-Deicher (H-D) antigens with N-glycolylneuraminic acid in patients with porcine exposure history. Xenotransplantation 2000; 7: 177.
14. GOLLACKNER B, GOH S-K, DANIEL S et al. Porcine endothelial cell tissue factor-induction by baboon xenoreactive antibodies in vitro: evidence for pathogenic role of non-Gal elicited antibodies. Chicago, USA: Presented at the 6th Congress of the International Xenotransplantation Association, 2001 (Abstract 064).
15. BUHLER L, AWWAD M, BASKER M et al. High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation 2000; 69: 2296.