Human anti-pig T-cell mediated cytotoxicity

Xenotransplantation

Volumn 3, Issue 2, 1996, Pages 179-187

  Yamada, Kazuhiko ^a   Seebach, Jörg D ^a   DerSimonian, Harout ^a   Sachs, David H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

CTL; Human; MHC; Miniature swine; NK cell; T cell; Xenograft

Indexed keywords

EID: 0000200036     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3089.1996.tb00136.x     Document Type: Article

References (20)

1. PLATT JL, VERCELLOTTI GM, DALMASSO AP, MATAS AJ, BOLMAN RM, NAJARIAN JS, BACH FH. Transplantation of discordant xenografts: A review of progress. Immunol Today 1990; 11:450.
2. SANDRIN MS, MCKENZIE IF. Gal alpha (1,3)Gal, the major xenoantigen(s) recognized in pigs by human natural antibodies. Immunol Rev 1994; 141:169.
3. SACHS DH, SABLINSKI T. Tolerance across discordant xenogeneic barriers. Xenotransplant 1995; 2:234.
4. MCCURRY KR, KOOYMAN DL, ALVARADO CG, COTTERELL AH, MARTIN MJ, LOGAN JS, PLATT JL. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nature Med 1995; 1:423.
5. ROSENGARD AM, CARY N, HORSLEY J, BELCHER C, LANGFORD G, COZZI E, WALLWORK J, WHITE DJ. Endothelial expression of human decay accelerating factor in transgenic pig tissue: a potential approach for human complement inactivation in discordant xenografts. Transplant Proc 1995; 27:326.
6. BLAKELY ML, VAN DER WERF WJ, BERNDT MC, DALMASSO AP, BACH FH, HANCOCK WW. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 1994; 58:1059.
7. FRYER JP, LEVENTHAL JR, DALMASSO AP, CHEN S, SIMONE PA, GOSWITZ JJ, REINSMOEN NL, MATAS AJ. Beyond hyperacute rejection: Accelerated rejection in a discordant xenograft model by adoptive transfer of specific cell subsets. Transplantation 1995; 59:171.
8. + helper T cells and self antigen-presenting cells in the mouse. J Exp Med 1990; 172:567.
9. LUCAS PJ, SHEARER GM, NEUDORF S, GRESS RE. The human antimurine xenogeneic cytotoxic response. I. dependence on responder antigen-presenting cells. J Immunol 1990; 144:4548.
10. ALTER BJ, BACH FH. Cellular basis of the proliferative response of human T cells to mouse xenoantigens. J Exp Med 1990; 171:333.
11. SACHS DH. The pig as a potential xenograft donor. Path Biol 1994; 42:217.
12. SACHS DH. MHC Homozygous Miniature Swine. In: Swindle MM, Moody DC, Phillips LD, eds. Swine as Models in Biomedical Research. Ames: Iowa State University Press, 1992, pp.3-15.
13. YAMADA K, SACHS DH, DERSIMONIAN H. The human anti-porcine xenogeneic T-cell response: Evidence for allelic specificity of MLR and for both direct and indirect pathways of recognition. J Immunol 1995; 155:5249.
14. SEEBACH JD, YAMADA K, MCMORROW I, SACHS DH, DERSIMONIAN H. Xenogeneic human anti-pig cytotoxicity mediated by natural killer (NK) cells. Xenotransplant 1996; (Submitted)
15. MARTIN PJ, LONGTON G, LEDBETTER JA, NEWMAN W, BRAUN MP, BEATTY PG, HANSEN JA. Identification and functional characterization of two distinct epitopes on the human T cell surface protein Tp50. J Immunol 1983; 131:180.
16. OZATO K, MAYER NM, SACHS DH. Monoclonal antibodies to mouse major histocompatibility complex antigens. Transplantation 1982; 34:113.
17. CUNNINGHAM A. Cellular aspects of xenotransplantation. Transpl Immunol 1994; 2:160.
18. KIRK AD, LI RA, KINCH MS, ABERNETHY KA, DOYLE C, BOLLINGER RR. The human antiporcine cellular repertoire. In vitro studies of acquired and innate cellular responsiveness. Transplantation 1993; 55:924.
19. ELSEN M, SOARES M, LATINNE D, CORNET A, BAZIN H. Role of activated natural killer and CD4+, CD8+ cells in the cellular rejection of a discordant xenograft. Transplant Proc 1993; 25:447.
20. MURRAY AG, KHODADOUST MM, POBER JS, BOTHWELL AL. Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1994; 1:57.