Xenotransplantation and the Future of Renal Replacement

Journal of the American Society of Nephrology

Volumn 15, Issue 5, 2004, Pages 1106-1112

  Cascalho, Marilia ^a,b   Ogle, Brenda M ^a   Platt, Jeffrey L ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

CELLULAR IMMUNITY; CLINICAL FEATURE; DIAGNOSTIC PROCEDURE; GENOMICS; HUMAN; HYPERACUTE GRAFT REJECTION; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOSUPPRESSIVE TREATMENT; INFECTION RISK; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; NONHUMAN; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; PROTEOMICS; REVIEW; SURGICAL APPROACH; SURGICAL TECHNIQUE; TECHNOLOGY; TREATMENT INDICATION; VASCULARIZATION; XENOGRAFT; XENOTRANSPLANTATION;

EID: 1942506757     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000113298.28480.7E     Document Type: Review

References (83)

1. Ullman E: Tissue and organ transplantation. Ann Surg 60: 195-219, 1914
2. Jaboulay M, Briau E: Recherches expeimentales sur la suture et la greffe arterielles. Lyon Med 81: 97-99, 1896
3. Carrel A: La technique operatoire des anastamoses vasculaires et la transplantation des visceres. Lyon Med 98: 858, 1902
4. Guthrie CC: Blood-Vessel Surgery and Its Applications, New York, Longmans, Green, 1912
5. Jaboulay M: De reins au pli du coude par soutures arterielles et veineuses. Lyon Med 107: 575-577, 1906
6. Evans RW: Coming to terms with reality: Why xenotransplantation is a necessity. In: Xenotransplantation, edited by Platt JL, Washington, DC, ASM Press, 2001, pp 29-51
7. Mann JFE, Gerstein HC, Pogue J, Bosch J, Yusuf S: Renal insufficiency as a predictor of cardiovascular outcomes and the impact of Ramipril: The HOPE randomized trial. Ann Intern Med 134: 629-636, 2001
8. Kasiske BL: The kidney in cardiovascular disease. Ann Intern Med 134: 707-709, 2001
9. Bro S, Bentzon JF, Falk E, Andersen CB, Olgaard K, Nielsen LB: Chronic renal failure accelerates atherogenesis in apolipoprotein e-deficient mice. J Am Soc Nephrol 14: 2466-74, 2003
10. Reemtsma K: Xenotransplantation: A brief history of clinical experiences: 1900-1965. In: Xenotransplantation: The Transplantation of Organs and Tissues between Species, edited by Cooper DKC, Kemp E, Reemtsma K, White DJG, New York, Springer-Verlag, 1991, pp 9-22
11. Cascalho M, Platt JL: The immunological barrier to xenotransplantation. Immunity 14: 437-446, 2001
12. Dorling A, Lombardi G, Binns R, Lechler RI: Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur J Immunol 26: 1378-1387, 1996
13. Nagayasu T, Platt JL: Immune aspects of xenotransplantation. In: Transplantation Immunobiology, edited by Duquesnoy R, Youping L, Beijing, Scientific Publishing, 2000, pp 577-585
14. Nagayasu T, Platt JL: A perspective on xenotransplantation. Graft 2(Suppl 2):S152-S158, 1999.
15. Kaufman DB, Platt JL, Rabe FL, Stock PG, Sutherland DER: The immunological basis of islet allograft primary non-function. J Exp Med 172: 291-302, 1990
16. Gritsch HA, Glaser RM, Emery DW, Lee LA, Smith CV, Sablinski T, Am JS, Sachs DH, Sykes M: The importance of non-immune factors in reconstitution by discordant xenogeneic hematopoietic cells. Transplantation 57: 906-917, 1994
17. Bennet W, Bjorkland A, Sundberg B, Brandhorst D, Brendel MD, Richards A, White DJ, Nilsson B, Groth CG, Korsgren O: Expression of complement regulatory proteins on islets of langerhans: A comparison between human islets and islets isolated from normal and hDAF transgenic pigs. Transplantation 72: 312-319, 2001
18. Murray AG, Khodadoust MM, Pober JS, Bothwell ALM: Porcine aortic endothelial cells activate human T cells: Direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1: 57-63, 1994
19. Yamada K, Sachs DH, DerSimonian H: Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J Immunol 155: 5249-5256, 1995
20. Platt JL, Lin SS: The future promises of xenotransplantation. Ann N Y Acad Sci 862: 5-18, 1998
21. Platt JL, Vercellotti GM, Dalmasso AP, Matas AJ, Bolman RM, Najarian JS, Bach FH: Transplantation of discordant xenografts: A review of progress. Immunol Today 11: 450-456, 1990
22. Auchincloss H Jr: Xenogeneic transplantation. Transplantation 46: 1-20, 1988
23. Auchincloss H Jr, Sachs DH: Xenogeneic transplantation. Annu Rev Immunol 16: 433-470, 1998
24. Platt JL: Hyperacute Xenograft Rejection. Austin, TX, R.G. Landes, 1995
25. Marchetti P, Scharp DW, Finke EH, Swanson CJ, Olack BJ, Gerasimidi-Vazeou D, Giannarelli R, Navalesi R, Lacy PE: Prolonged survival of discordant porcine islet xenografts. Transplantation 61: 1100-1102, 1996
26. Gunsalus JR, Brady DA, Coulter SM, Gray BM, Edge ASB: Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation. Nat Med 3: 48-53, 1997
27. Nagata H, Ito M, Cai J, Edge A, Platt JL, Fox IJ: Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation. Gastroenterology 124: 422-431, 2003
28. Cascalho M, Platt JL: Xenotransplantation and other means of organ replacement. Nat Rev Immunol 1: 154-160, 2001
29. Platt JL, Fischel RJ, Matas AJ, Reif SA, Bolman RM, Bach FH: Immunopathology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation 52: 214-220, 1991
30. Galili U, Clark MR, Shohet SB, Buehler J, Macher BA: Evolutionary relationship between the natural anti-Gal antibody and the Gal α1-3Gal epitope in primates. Proc Natl Acad Sci U S A 84: 1369-1373, 1987
31. Dalmasso AP, Vercellotti GM, Platt JL, Bach FH: Inhibition of complement-mediated endothelial cell cytotoxicity by decay accelerating factor: Potential for prevention of xenograft hyperacute rejection. Transplantation 52: 530-533, 1991
32. Hinchliffe SJ, Rushmere NK, Hanna SM, Morgan BP: Molecular cloning and functional characterization of the pig analogue of CD59: Relevance to xenotransplantation. J Immunol 160: 3924-3932, 1998
33. McCurry KR, Kooyman DL, Alvarado CG, Cotterell AH, Martin MJ, Logan JS, Platt JL: Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat Med 1: 423-427, 1995
34. Zaidi A, Schmoeckel M, Bhatti F, Waterworth P, Tolan M, Cozzi E, Chavez G, Langford G, Thiru S, Wallwork J, White D, Friend P: Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors. Transplantation 65: 1584-1590, 1998
35. Diamond LE, Quinn CM, Martin MJ, Lawson J, Platt JL, Logan JS: A human CD46 transgenic pig model system for the study of discordant xenotransplantation. Transplantation 71: 132-142, 2001
36. Leventhal JR, Matas AJ, Sun LH, Reif S, Bolman RM, Dalmasso AP, Platt JL: The immunopathology of cardiac xenograft rejection in the guinea pig-to-rat model. Transplantation 56: 1-8, 1993
37. Magee JC, Collins BH, Harland RC, Lindman BJ, Bollinger RR, Frank MM, Platt JL: Immunoglobulin prevents complement mediated hyperacute rejection in swine-to-primate xenotransplantation. J Clin Invest 96: 2404-2412, 1995
38. Holzknecht ZE, Kuypers KL, T. B. P, Williams J, Bustos M, Gores GJ, Brunn GJ, Platt JL: Apoptosis and cellular activation in the pathogenesis of acute vascular rejection. Circ Res 91: 1135-1141, 2002
39. Parker W, Saadi S, Lin SS, Holzknecht ZE, Bustos M, Platt JL: Transplantation of discordant xenografts: A challenge revisited. Immunol Today 17: 373-378, 1996
40. Platt JL: New directions for organ transplantation. Nature 392(Suppl):11-17, 1998.
41. Blakely ML, Van Der Werf WJ, Berndt MC, Dalmasso AP, Bach FH, Hancock WW: Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 58: 1059-1066, 1994
42. Lin SS, Weidner BC, Byrne GW, Diamond LE, Lawson JH, Hoopes CW, Daniels LJ, Daggett CW, Parker W, Harland RC, Davis RD, Bollinger RR, Logan JS, Platt JL: The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. J Clin Invest 101: 1745-1756, 1998
43. Cooper DKC, Human PA, Lexer G, Rose AG, Rees J, Keraan M, Du Toit E: Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon. J Heart Transpl 7: 238-246, 1988
44. Sachs DH, Sablinski T: Tolerance across discordant xenogeneic barriers. Xenotransplantation 2: 234-239, 1995
45. Sablinski T, Emery DW, Monroy R, Hawley RJ, Xu Y, Gianello P, Lorf T, Kozlowski T, Bailin M, Cooper DK, Cosimi AB, Sachs DH: Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors. Transplantation 67: 972-977, 1999
46. Betthauser J, Forsberg E, Augenstein M, Childs L, Eilertsen K, Enos J, Forsythe T, Golueke P, Jurgella G, Koppang R, Lesmeister T, Mallon K, Mell G, Misica P, Pace M, Pfister-Genskow M, Strelchenko N, Voelker G, Watt S, Thompson S, Bishop M: Production of cloned pigs from in vitro systems. Nat Biotechnol 18: 1055-1059, 2000
47. Onishi A, Iwamoto M, Akita T, Mikawa S, Takeda K, Awata T, Hanada H, Perry ACF: Pig cloning by microinjection of fetal fibroblast nuclei. Science 289: 1188-1190, 2000
48. Polejaeva IA, Chen S, Vaught TD, Page RL, Mullins J, Ball S, Dai Y, Boone J, Walker S, Ayares DL, Colman A, Campbell KHS: Cloned piglets produced by nuclear transfer from adult somatic cells. Nature 407: 86-90, 2000
49. Denning C, Burl S, Ainslie A, Bracken J, Dinnyes A, Fletcher J, King T, Ritchie M, Ritchie WA, Rollo M, de Sousa P, Travers A, Wilmut I, Clark AJ: Deletion of the a(1,3) galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep. Nat Biotechnol 19: 559-562, 2001
50. Dai Y, Vaught TD, Boone J, Chen S, Phelps CJ, Ball S, Monahan JA, Jobst PM, McCreath KJ, Lamborn AE, Cowell LJL, Wells KD, Colman A, Polejaeva IA, Ayares DL: Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs. Nat Biotechnol 20: 251-5, 2002
51. Lai L, Kolber-Simonds D, Park KW, Cheong HT, Greenstein JL, Im GS, Samuel M, Bonk A, Rieke A, Day BN, Murphy CN, Carter DB, Hawley RJ, Prather RS: Production of α-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 295: 1089-1092, 2002
52. Phelps CJ, Koike C, Vaught TD, Boone J, Wells KD, Chen SH, Ball S, Specht SM, Polejaeva IA, Monahan JA, Jobst PM, Sharma SB, Lamborn AE, Garst AS, Moore M, Demetris AJ, Rudert WA, Bottino R, Bertera S, Trucco M, Starzl TE, Dai Y, Ayares DL: Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 299: 411-4, 2003
53. Chopek MW, Simmons RL, Platt JL: ABO-incompatible renal transplantation: Initial immunopathologic evaluation. Transplant Proc 19: 4553-4557, 1987
54. Bannett AD, McAlack RF, Morris M, Chopek M, Platt JL: ABO incompatible renal transplantation: A qualitative analysis of native endothelial tissue ABO antigens after transplant. Transplant Proc 21: 783-785, 1989
55. Lin Y, Vandeputte M, Waer M: Accommodation and T-independent B cell tolerance in rats with long term surviving hamster heart xenografts. J Immunol 160: 369-375, 1998
56. Lin SS, Hanaway MJ, Gonzalez-Stawinski GV, Lau CL, Parker W, Davis RD, Byrne GW, Diamond LE, Logan JS, Platt JL: The role of anti-Galα1-3Gal antibodies in acute vascular rejection and accommodation of xenografts. Transplantation 70: 1667-1674, 2000
57. Andres G, Yamaguchi N, Brett J, Caldwell PRB, Godman G, Stem D: Cellular mechanisms of adaptation of grafts to antibody. Transpl Immunol 4: 1-17, 1996
58. Dalmasso AP, Benson BA, Johnson JS, Lancto C, Abrahamsen MS: Resistance against the membrane attack complex of complement induced in porcine endothelial cells with a Gal alpha(1-3)Gal binding lectin: Up-regulation of CD59 expression. J Immunol 164: 3764-3773, 2000
59. Delikouras A, Hayes M, Malde P, Lechler RI, Dorling A: Nitric oxide-mediated expression of Bcl-2 and Bcl-x1 and protection from TNFα-mediated apoptosis in porcine endothelial cells after exposure to low concentrations of xenoreactive natural antibody. Transplantation 71: 599-605, 2001
60. Bach FH, Ferran C, Hechenleitner P, Mark W, Koyamada N, Miyatake T, Winkler H, Badrichani A, Cardinas D, Hancock WH: Accommodation of vascularized xenografts: Expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment. Nat Med 3: 196-204, 1997
61. Sato K, Balla J, Otterbein L, Smith RN, Brouard S, Lin Y, Csizmadia E, Sevigny J, Robson SC, Vercellotti G, Choi AM, Bach FH, Soares MP: Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol 166: 4185-94, 2001
62. Diamond LE, McCurry KR, Oldham ER, McClellan SB, Martin MJ, Platt JL, Logan JS: Characterization of transgenic pigs expressing functionally active human CD59 on cardiac endothelium. Transplantation 61: 1241-1249, 1996
63. Imai T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H, Suematsu M, Katayama S: Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice. Circ Res 89: 55-62, 2001
64. Holzknecht ZE, Platt JL: Accommodation and the reversibility of biological systems. Transplantation 71: 594-595, 2001
65. Sebille F, Guillet M, Brouard S, Gagne K, Petzold T, Blancho G, Vanhove B, Soulillou JP: T-cell-mediated rejection of vascularized xenografts in the absence of induced anti-donor antibody response. Am J Transplant 1: 21-8, 2001
66. Sablinski T, Latinne D, Gianello P, Bailin M, Bergen K, Colvin RB, Foley A, Hong H, Lorf T, Meehan S, et al: Xenotransplantation of pig kidneys to nonhuman primates: Development of the model. Xenotransplantation 2: 264-270, 1995
67. Platt JL: Genetic therapies and xenotransplantation. Exp Opin Investig Drugs 8: 1653-1662, 1999
68. Takeuchi Y, Weiss RA: Xenotransplantation: Reappraising the risk of retroviral zoonosis. Curr Opin Immunol 12: 504-507, 2000
69. Boneva R, Folks TM, Chapman LE: Infectious disease issues in xenotransplantation. Clin Microbiol Rev 14: 1-14, 2001
70. Patience C, Takeuchi Y, Weiss RA: Zoonosis in xenotransplantation. Curr Opin Immunol 10: 539-542, 1998
71. Van der Laan LJW, Lockey C, Griffeth BC, Frasier FS, Wilson CA, Onions DE, Hering BJ, Long Z, Otto E, Torbett BE, Salomon DR: Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice. Nature 407: 501-504, 2000
72. Paradis K, Langford G, Long Z, Heneine W, Sandstrom P, Switzer WM, Chapman LE, Lockey C, Onions D: Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. Science 285: 1236-1241, 1999
73. + T cells. J Exp Med 170: 991-996, 1989
74. Deacon T, Schumacher J, Dinsmore J, Thomas C, Palmer P, Kott S, Edge A, Penney D, Kassissieh S, Dempsey P, Isacson O: Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nat Med 3: 350-353, 1997
75. Sariola H: Interspecies chimeras: An experimental approach for studies on embryonic angiogenesis. Med Biol 63: 43-65, 1985
76. Dekel B, Burakova T, Ben-Hur H, Marcus H, Oren R, Laufer J, Reisner Y: Engraftment of human kidney tissue in rat radiation chimera: II. Human fetal kidneys display reduced immunogenicity to adoptively transferred human peripheral blood mononuclear cells and exhibit rapid growth and development. Transplantation 64: 1550-1558, 1997
77. Rogers SA, Lowell JA, Hammerman NA, Hammerman MR: Transplantation of developing metanephroi into adult rats. Kidney Int 54: 27-37, 1998
78. Rogers SA, Hammerman MR: Transplantation of rat metanephroi into mice. Am J Physiol 280: R1865-R1869, 2001
79. Dekel B, Burakova T, Arditti FD, Reich-Zeliger S, Milstein O, Aviel-Ronen S, Rechavi G, Friedman N, Kaminski N, Passwell JH, Reisner Y: Human and porcine early kidney precursors as a new source for transplantation. Nat Med 9: 53-60, 2003
80. Hammerman MR: Xenotransplantation of renal primordia. Curr Opin Nephrol Hypertens 11: 11-6, 2002
81. Hammerman MR: Transplantation of embryonic organs. Am J Transplant 4: 14-24, 2004
82. Lanza RP, Chung HY, Yoo JJ, Wettstein PJ, Blackwell C, Borson N, Hofmeister E, Schuch G, Soker S, Moraes CT, West MD, Atala A: Generation of histocompatible tissues using nuclear transplantation. Nat Biotechnol 20: 689-96, 2002
83. Ogle BM, Cascalho M, Platt JL: Fusion of approaches to the treatment of organ failure. Am J Transplant 4: 74-77, 2004