Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling

Acta Pharmacologica Sinica

Volumn 31, Issue 7, 2010, Pages 765-774

  Wang, Tao ^a   Liu, Yan Yong ^a   Wang, Xin ^a   Yang, Nan ^a   Zhu, Hai Bo ^b   Zuo, Ping Ping ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

apoptosis; nerve growth factor; neuroprotection; octacosanol; oxidative stress; Parkinson's disease; proNGF

Indexed keywords

NERVE GROWTH FACTOR; NEUROPROTECTIVE AGENT; OCTACOSANOL; OXIDOPAMINE; PRO NERVE GROWTH FACTOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE A; SCAVENGER; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; 1-OCTACOSANOL; ANTIPARKINSON AGENT; FATTY ALCOHOL; NERVE GROWTH FACTOR RECEPTOR; PRO-NERVE GROWTH FACTOR, RAT; PROTEIN PRECURSOR; TNFRSF16 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ASSAY; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MALE; MICROENVIRONMENT; NEUROPROTECTION; NICK END LABELING; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; OXIDATIVE STRESS; PARKINSONISM; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PARKINSONIAN DISORDERS; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; TOXICITY;

ANIMALS; ANTIPARKINSON AGENTS; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ALCOHOLS; MALE; NERVE GROWTH FACTOR; NERVE GROWTH FACTORS; OXIDOPAMINE; PARKINSONIAN DISORDERS; PROTEIN PRECURSORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR;

EID: 77954473198     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.69     Document Type: Article

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