Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation

Journal of Biological Chemistry

Volumn 283, Issue 19, 2008, Pages 12709-12716

  Boutilier, Jacqueline ^a   Ceni, Claire ^a   Pagdala, Promila C ^b   Forgie, Alison ^c   Neet, Kenneth E ^b   Barker, Philip A ^a  

^a MCGILL UNIVERSITY   (Canada)

^b ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^c Rinat Neuroscience   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; CHEMICAL REACTIONS; DIFFERENTIATION (CALCULUS); DIFFRACTIVE OPTICAL ELEMENTS; ENZYME INHIBITION; PHOSPHORYLATION;

ACTIVATION PROPERTIES; AKT ACTIVATIONS; CEREBELLAR GRANULE NEURONS; CLEAVAGE SITES; METALLO PROTEASES; NERVE GROWTH FACTORS; NEUROTROPHINS; P75 NEUROTROPHIN RECEPTORS; PC12 CELLS; PHYSIOLOGICAL CONDITIONS; PRE-REQUISITES; RECEPTOR BINDINGS; TYROSINE PHOSPHORYLATIONS;

BIOACTIVITY;

ALKALINE PHOSPHATASE; BIOTIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; FURIN; HYBRID PROTEIN; METALLOPROTEINASE; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR P75; PRONEUROTROPHIN; PROTEIN TYROSINE KINASE A; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; PEPTIDE HYDROLASE; PROTEIN PRECURSOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN; CELL STRAIN HEK293; CEREBELLUM; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME PHOSPHORYLATION; GRANULE CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NERVE CELL; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; ANIMAL; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROTEIN BINDING; RAT; SECRETION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE; ENDOCYTOSIS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; NERVE GROWTH FACTOR; PEPTIDE HYDROLASES; PROTEIN BINDING; PROTEIN PRECURSORS; RATS; RECEPTOR, TRKA; SIGNAL TRANSDUCTION;

EID: 45149132553     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M710018200     Document Type: Article

References (38)

1. Huang, E. J., and Reichardt, L. F. (2001) Annu. Rev. Neurosci. 24, 677-736
2. Chao, M. V. (2003) Nat. Rev. Neurosci. 4, 299-309
3. Roux, P. P., and Barker, P. A. (2002) Prog. Neurobiol. (Oxf.) 67, 203-233
4. Seidah, N. G., Benjannet, S., Pareek, S., Chretien, M., and Murphy, R. A. (1996) FEBS Lett. 379, 247-250
5. Paoletti, F., Konarev, P. V., Covaceuszach, S., Schwarz, E., Cattaneo, A., Lamba, D., and Svergun, D. I. (2006) Biochem. Soc. Trans. 34, 605-606
6. Kliemannel, M., Golbik, R., Rudolph, R., Schwarz, E., and Lilie, H. (2007) Protein Sci. 16, 411-419
7. Hauburger, A., Kliemannel, M., Madsen, P., Rudolph, R., and Schwarz, E. (2007) FEBS Lett. 581, 4159-4164
8. Beattie, M. S., Harrington, A. W., Lee, R., Kim, J. Y., Boyce, S. L., Longo, F. M., Bresnahan, J. C., Hempstead, B. L., and Yoon, S. O. (2002) Neuron 36, 375-386
9. Lee, R., Kermani, P., Teng, K. K., and Hempstead, B. L. (2001) Science 294, 1945-1948
10. Hasan, W., Pedchenko, T., Krizsan-Agbas, D., Baum, L., and Smith, P. G. (2003) J. Neurobiol. 57, 38-53
11. Harrington, A. W., Leiner, B., Blechschmitt, C., Arevalo, J. C., Lee, R., Morl, K., Meyer, M., Hempstead, B. L., Yoon, S. O., and Giehl, K. M. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 6226-6230
12. Peng, S., Wuu, J., Mufson, E. J., and Fahnestock, M. (2005) J. Neurochem. 93, 1412-1421
13. Fahnestock, M., Michalski, B., Xu, B., and Coughlin, M. D. (2001) Mol. Cell. Neurosci. 18, 210-220
14. Bierl, M. A., Jones, E. E., Crutcher, K. A., and Isaacson, L. G. (2005) Neurosci. Lett. 380, 133-137
15. Nykjaer, A., Lee, R., Teng, K. K., Jansen, P., Madsen, P., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., Hempstead, B. L., and Petersen, C. M. (2004) Nature 427, 843-848
16. Fahnestock, M., Yu, G., Michalski, B., Mathew, S., Colquhoun, A., Ross, G. M., and Coughlin, M. D. (2004) J. Neurochem. 89, 581-592
17. Fayard, B., Loeffler, S., Weis, J., Vogelin, E., and Kruttgen, A. (2005) J. Neurosci. Res. 80, 18-28
18. Flanagan, J. G., and Cheng, H. J. (2000) Methods Enzymol. 327, 198-210
19. Pagadala, P. C., Dvorak, L. A., and Neet, K. E. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 17939-17943
20. Roux, P. P., Colicos, M. A., Barker, P. A., and Kennedy, T. E. (1999) J. Neurosci. 19, 6887-6896
21. Bronfman, F. C., Tcherpakov, M., Jovin, T. M., and Fainzilber, M. (2003) J. Neurosci. 23, 3209-3220
22. Heuser, J. E., and Anderson, R. G. (1989) J. Cell Biol. 108, 389-400
23. Howe, C. L., Valletta, J. S., Rusnak, A. S., and Mobley, W. C. (2001) Neuron 32, 801-814
24. Howe, C. L., and Mobley, W. C. (2004) J. Neurobiol. 58, 207-216
25. Zhang, Y., Moheban, D. B., Conway, B. R., Bhattacharyya, A., and Segal, R. A. (2000) J. Neurosci. 20, 5671-5678
26. Iglesias-Bartolome, R., Crespo, P. M., Gomez, G. A., and Daniotti, J. L. (2006) FEBS J. 273, 1744-1758
27. Michalski, B., and Fahnestock, M. (2003) Brain Res. Mol. Brain Res. 111, 148-154
28. Peters, E. M., Hendrix, S., Golz, G., Klapp, B. F., Arck, P. C., and Paus, R. (2006) J. Histochem. Cytochem. 54, 275-288
29. Woo, N. H., Teng, H. K., Siao, C. J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., and Lu, B. (2005) Nat. Neurosci. 8, 1069-1077
30. Althaus, H. H., and Klöppner, S. (2006) J. Neurochem. 98, 506-517
31. Thomas, G. (2002) Nat. Rev. Mol. Cell Biol. 3, 753-766
32. Chen, C. D., Huff, M. E., Matteson, J., Page, L., Phillips, R., Kelly, J. W., and Balch, W. E. (2001) EMBO J. 20, 6277-6287
33. Chen, Y., Molloy, S. S., Thomas, L., Gambee, J., Bachinger, H. P., Ferguson, B., Zonana, J., Thomas, G., and Morris, N. P. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 7218-7223
34. Band, A. M., Maatta, J., Kaariainen, L., and Kuismanen, E. (2001) FEBS Lett. 505, 118-124
35. Scott, G. K., Gu, F., Crump, C. M., Thomas, L., Wan, L., Xiang, Y., and Thomas, G. (2003) EMBO J. 22, 6234-6244
36. Scott, G. K., Fei, H., Thomas, L., Medigeshi, G. R., and Thomas, G. (2006) EMBO J. 25, 4423-4435
37. Le Borgne, R. (2006) Curr. Opin. Cell Biol. 18, 213-222
38. Jeanneteau, F., and Chao, M. V. (2006) Novartis Found. Symp. 276, 181-189; Discussion 189-192, 187-233, 181-275