Cellular modelling: Experiments and simulation to develop a physiological model of G-protein control of muscarinic K+ channels in mammalian atrial cells

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Volumn 368, Issue 1921, 2010, Pages 2983-3000

  Murakami, Shingo ^a,b   Suzuki, Shingo ^a,b   Ishii, Masaru ^a,c   Inanobe, Atsushi ^a,b   Kurachi, Yoshihisa ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Atria; Computational model; G protein; GIRK channel; Heart; Relaxation

Indexed keywords

COMPUTER SIMULATION; ENZYME ACTIVITY; MAMMALS; PROTEINS;

ALLOSTERIC MODEL; ATRIAL CELLS; CHANNEL ACTIVITY; CHANNEL INTERACTIONS; COMPUTATIONAL MODEL; CYCLE MODEL; ESSENTIAL ELEMENTS; EXTRACELLULAR CONCENTRATION; G PROTEIN; GUANOSINES; K+ CHANNELS; PHYSIOLOGICAL RANGE; ROYAL SOCIETY; TRIPHOSPHATE;

PHYSIOLOGICAL MODELS;

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; POTASSIUM CHANNEL;

ALLOSTERISM; ANIMAL; ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; CYTOLOGY; ELECTRIC CONDUCTIVITY; HEART ATRIUM; KINETICS; MALE; METABOLISM; RAT; WISTAR KYOTO RAT;

ALLOSTERIC REGULATION; ANIMALS; COMPUTER SIMULATION; ELECTRIC CONDUCTIVITY; GTP-BINDING PROTEINS; GUANOSINE TRIPHOSPHATE; HEART ATRIA; KINETICS; MALE; MODELS, BIOLOGICAL; POTASSIUM CHANNELS; RATS; RATS, INBRED WKY;

EID: 77954473197     PISSN: 1364503X     EISSN: None     Source Type: Journal    
DOI: 10.1098/rsta.2010.0093     Document Type: Article

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