2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 1, 2007, Pages 57-62

  Pissarnitski, Dmitri A ^a   Asberom, Theodros ^a   Bara, Thomas A ^a   Buevich, Alex V ^a   Clader, John W ^a   Greenlee, William J ^a   Guzik, Henry S ^a   Josien, Hubert B ^a   Li, Wei ^a   McEwan, Michael ^a   McKittrick, Brian A ^a   Nechuta, Terry L ^a   Parker, Eric M ^a   Sinning, Lisa ^a   Smith, Elizabeth M ^a   Song, Lixin ^a   Vaccaro, Henry A ^a   Voigt, Johannes H ^a   Zhang, Lili ^a   Zhang, Qi ^a   Zhao, Zhiqiang ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Secretase; Alzheimer's disease; Carbamate; Inhibitor; Mosher ester; Piperidine; Sulfonamide

Indexed keywords

GAMMA SECRETASE INHIBITOR; PIPERIDINE DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; BIOASSAY; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; IC 50; PROTEINASE INHIBITION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; INHIBITORY CONCENTRATION 50; PIPERIDINES; PROTEASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845655456     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.094     Document Type: Article

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