Methylxanthine reversal of opioid-evoked inspiratory depression via phosphodiesterase-4 blockade

Respiratory Physiology and Neurobiology

Volumn 172, Issue 3, 2010, Pages 94-105

  Ruangkittisakul, Araya ^a   Ballanyi, Klaus ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Breathing; Caffeine; PDE; Respiratory rhythm; Rolipram; Theophylline

Indexed keywords

3,7 DIMETHYL 1 PROPARGYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; CAFFEINE; CYCLIC AMP; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; FENTANYL; METHYLXANTHINE; MU OPIATE RECEPTOR; NALOXONE; OPIATE; PHOSPHODIESTERASE IV; PROTIRELIN; ROLIPRAM; THEOPHYLLINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; NARCOTIC ANALGESIC AGENT; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; XANTHINE DERIVATIVE;

AMPLITUDE MODULATION; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; BRAIN STEM; BREATHING PATTERN; CONTROLLED STUDY; DRUG EFFICACY; INSPIRATORY CAPACITY; NEWBORN; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RAT; RESPIRATION DEPRESSION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DRUG EFFECTS; ELECTROPHYSIOLOGY; IN VITRO STUDY; INTERNEURON; NERVE CELL NETWORK; PHYSIOLOGY; RESPIRATORY FUNCTION; RESPIRATORY INSUFFICIENCY; SPRAGUE DAWLEY RAT; WISTAR RAT;

ANALGESICS, OPIOID; ANIMALS; ANIMALS, NEWBORN; CAFFEINE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; ELECTROPHYSIOLOGY; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; FENTANYL; INTERNEURONS; NERVE NET; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTOR, ADENOSINE A1; RECEPTORS, ADENOSINE A2; RECEPTORS, OPIOID, MU; RECEPTORS, PURINERGIC P1; RESPIRATORY INSUFFICIENCY; RESPIRATORY PHYSIOLOGICAL PHENOMENA; ROLIPRAM; THEOPHYLLINE; XANTHINES; ADENOSINE A1 RECEPTOR ANTAGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; IN VITRO TECHNIQUES; PHOSPHODIESTERASE 4 INHIBITORS; PURINERGIC P1 RECEPTOR ANTAGONISTS;

EID: 77954383190     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2010.04.025     Document Type: Article

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